Abstract: Techniques are disclosed for providing a content selecting mode in electronic touch screen devices. The content may be, for instance, text, graphics, images, files, and/or other consumable content. The user can engage the mode with a combination of gestures and touch points on the touch screen. The combination may include, for example, multiple initial touch points within a given content block, followed by a dragging gesture that moves the touch points into or otherwise within the given content block, wherein the entire content block is then highlighted/selected. The initial touch points may touch, for instance, any piece of content within that block and the subsequent dragging gesture moves those initial touch points toward another piece of content within that block. As the drag continues into other blocks, so does selecting. The techniques can be used, for example, to select entire sentences or paragraphs or other content blocks.

Abstract: The present invention generally provides semiconductor substrates having submicronsized surface features generated by irradiating the surface with ultra short laser pulses. In one aspect, a method of processing a semiconductor substrate is disclosed that includes placing at least a portion of a surface of the substrate in contact with a fluid, and exposing that surface portion to one or more femtosecond pulses so as to modify the topography of that portion. The modification can include, e.g., generating a plurality of submicron-sized spikes in an upper layer of the surface.

Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.

Abstract: The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques, including imaging in three dimensions. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. In some cases, the position of the entities can be determined in all three spatial dimensions (i.e., in the x, y, and z directions), and in certain cases, the position in all three dimensions can be determined to an accuracy of less than about 1000 nm. In some cases, the z positions may be determined using one of a variety of techniques that uses intensity information or focal information (e.g., a lack of focus) to determine the z position. Non-limiting examples of such techniques include astigmatism imaging, off-focus imaging, or multi-focal plane imaging.

Abstract: A combination therapy and kit including an agent that inhibit the interaction between CAL and mutant CFTR proteins, in combination with a CFTR corrector, CFTR potentiator, mucolytic, anti-inflammatory agent or a combination thereof are provided as is a method for preventing or treating cystic fibrosis.

Abstract: The present invention provides novel nickel complexes. These complexes are in providing fluorinating organic compounds. The invention is particularly useful for fluorinating compounds with 18F for PET imaging.

Abstract: Compounds and compositions comprising epoxyeicosatrienoic acid (EET) analogs that act as EET agonists and are useful as medications in the treatment of drug-induced nephrotoxicity, hypertension and other related conditions. Methods of making and using the compounds and compositions are further described.

Abstract: On-chip non-reciprocity can be achieved by employing micron-sized optomechanical (OM) devices that are fabricated on-chip and which can be integrated with other optical elements. Non-linear coupling between light and a mechanical mode inside a resonator can provide a non-reciprocal response of the OM system, which can be induced and fully controlled by an external driving electromagnetic field. By choosing different resonator and/or waveguide configurations and by tuning different system parameters, the same OM coupling mechanism can be used to provide isolation (e.g., as an optical diode), non-reciprocal phase shifting, and/or routing applications. Even in the presence of a finite intrinsic mode coupling inside the resonator, non-reciprocal effects remain large for a sufficiently strong OM coupling. The disclosed systems, methods, and devices can be applied on a single photon level, which may find use for various non-reciprocal applications in the classical optical as well as the quantum regime.

Abstract: A coherent anti-Stokes Raman spectroscopy (CARS) system comprises a laser light source for emitting pulsed light, a dichroic beam splitter for splitting a light pulse from the light source into a pump pulse and a Stokes pulse and directing these pulses along respective distinct paths, chirping means, e.g. dispersive glass blocks for chirping the pump and Stokes pulses, directing means for directing the chirped pump and Stokes samples to a sample in time overlap, and detecting means for detecting light stimulated from the sample by the interaction of the pump and Stokes pulses. The system may comprise a reflector connected to a linear motor, for adjusting the period between the arrival at the sample of the starts of the chirped pump and Stokes pulses. The system may further comprise a pulse replicating unit for converting a pulse from the light source into a plurality of pulses distributed in time.

Abstract: The present invention provides a specific binding molecule raised against the human Anx-A1 protein having the amino acid sequence shown in FIG. 2A. The present invention also relates to the sue of such a specific binding molecule in the treatment of T cell-mediated disease.

Abstract: The present invention relates to analogs of cortistatin A, J, K, and L, having the general formula: I and salts thereof, wherein R1, R2, R3, R4, n, and m are as defined herein; processes for preparing such compounds and intermediates thereto; pharmaceutical compositions comprising such compounds; methods for treating a proliferative disease; methods for treating a disease associated with aberrant angiogenesis; methods for inhibiting angiogenesis; and processes for preparing cortistatin A, J, K, and L, and analogs thereof.

Abstract: Embodiments of the invention provide a simple and robust system that allows non-resonant background to be removed from anti-Stokes signals generated during coherent anti-Stokes Raman spectroscopy (CARS) even when using cheaper laser systems, which do not have transform limited pulses. In particular, resonant CARS signals have a real and imaginary component. The imaginary component is directly related to the spontaneous Raman spectrum, for which there are already large spectral databases to allow chemical identification. The NRB signal, on the other hand, only has a real component. Within embodiments of the invention we recover the imaginary component of the entire CARS signal by simultaneously generating two CARS signals at orthogonal polarisations: one has the imaginary components destructively interfering with (i.e. subtracted from) the real components, the other has them constructively interfering.

Abstract: Fuel-air premixing is the accepted technology for reducing NOx emissions from combustors and burners. In view of this complex burner-nozzle designs involving multiple swirlers have been designed and developed. I have developed a high-premixing fuel-air nozzle that involves micro-fabricated porous swirl panels with distributed fuel injection. The design and fabrication of the fuel injector has been completed, the injector assembly has been set up in a combustor test-rig, and a variety of tests have been undertaken. The tests have clearly established that compared to a traditional solid swirler with a premixing length the micro-fabricated swirl injector-assembly lowers the Lean Blowout Limit, enhances mixing and volumetric heat release, and for the same temperature levels as the solid swirler, reduces NOx levels.

Abstract: Solid electrolytes compositions, methods of making the solid electrolytes, and methods of using the solid electrolytes in batteries and other electrochemical technologies are disclosed. The method of producing a solid electrolyte comprises (a) ball milling Na2CO3, SiO2, NH4H2PO4, a zirconium source, and a dopant to produce a ball milled powder; (b) calcining the ball milled powder to produce a calcined powder; and (c) sintering the calcined powder to produce a solid electrolyte. The zirconium source for the solid electrolyte may be ZrO2. The dopant for the solid electrolyte may be AI2O3, Fe2O3, Sb2O3, Yb2O3, or Dy2O3.

Abstract: A substrate having a second material on a surface of the substrate or embedded as a layer within the substrate are described. The second material has a different index of refraction and/or stiffness than the substrate so that stretching and unstretching of the substrate and the second material can induce wrinkles in the second material that interacts with light thereby allowing reversible change from a transparent state to an opaque or iridescent state, and vice versa. The present disclosure is useful as a shading system and/or displays.

Abstract: The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces (SLIPS). Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as Liquid B to repel a wide range of materials, referred to herein as Object A (Solid A or Liquid A). SLIPS outperforms other conventional surfaces in its capability to repel various simple and complex liquids (water, hydrocarbons, crude oil and blood), maintain low-contact-angle hysteresis (<2.5°), quickly restore liquid-repellency after physical damage (within 0.1-1 s), resist ice, microorganisms and insects adhesion, and function at high pressures (up to at least 690 atm). Some exemplary application where SLIPS will be useful include energy-efficient fluid handling and transportation, optical sensing, medicine, and as self-cleaning, and anti-fouling materials operating in extreme environments.

Abstract: The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces (SLIPS). Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as Liquid B to repel a wide range of materials, referred to herein as Object A (Solid A or Liquid A). SLIPS outperforms other conventional surfaces in its capability to repel various simple and complex liquids (water, hydrocarbons, crude oil and blood), maintain low-contact-angle hysteresis (<2.5°), quickly restore liquid-repellency after physical damage (within 0.1-1 s), resist ice, microorganisms and insects adhesion, and function at high pressures (up to at least 690 atm). Some exemplary application where SLIPS will be useful include energy-efficient fluid handling and transportation, optical sensing, medicine, and as self-cleaning, and anti-fouling materials operating in extreme environments.

Abstract: According to some aspects, an adaptive lens is provided. One such adaptive lens comprises at least one fluid-filled chamber located within an optical and/or acoustic path of the lens, and at least one elastomeric and substantially optically and/or acoustically transparent membrane, located within an optical and/or acoustic path of the lens and at least partially bounding one or more of the at least one fluid-filled chambers, wherein one or more of the at least one membranes is configured such that a shape of the membrane is altered upon receipt of an electric field. Some aspects provide a method of producing a lens comprising providing at least one chamber bounded at least in part by first and second membranes, and providing a fluid into the at least one chamber such that the fluid is located within an optical and/or acoustic path of the lens.

Abstract: The invention provides an electrochemical cell based on a new chemistry for a flow battery for large scale, e.g., grid-scale, electrical energy storage. Electrical energy is stored chemically at an electrochemical electrode by the protonation of small organic molecules called quinones to hydroquinones. The proton is provided by a complementary electrochemical reaction at the other electrode. These reactions are reversed to deliver electrical energy. A flow battery based on this concept can operate as a closed system. The flow battery architecture has scaling advantages over solid electrode batteries for large scale energy storage.

Abstract: The present invention provides a new type of alpha-helix nucleating cross-link (“staple”) formed by olefin metathesis of a proline derivative with an alkenyl side chain and another amino acid derivative with an alkenyl side chain. The proline derivatives as described herein have been found to be strong nucleators of alpha-helix formation. The invention also provides moieties for shielding the free amide N—H's at the N-terminus of an alpha-helix, thereby further stabilizing the helix. The proline derivatives, precursors prior to cross-linking, and the cross-linked peptides are provided as well as methods of using and preparing these compounds and peptides.