Abstract: A semiconductor lasing device (10) for emitting radiation at multiple distinct wavelengths, the device (10) comprising an active layer (16) having first portion (20) and a second portion (21), the first and second portions (20, 21) being separated by a Bragg grating (19) extending through the entire depth of the active layer (16), the first portion (20) defining a first lasing cavity (29) for emitting electromagnetic radiation at a first wavelength ?1 and the first and second portions (20, 21) together defining a second lasing cavity (31) for emitting electromagnetic radiation at a second wavelength ?2.

Abstract: The present invention features methods for stimulating clearance of amyloid beta in microglia, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by selectively inhibiting the expression or activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.

Abstract: The invention relates to a method of detecting the coincidence of two biomolecular structures in a solid phase sample, said method comprising: (i) providing a first and a second fusion protein, each fusion protein comprising (a) a detection domain, said detection domain comprising a DNA binding domain; said detection domain capable of binding a cognate specific nucleotide sequence in co-operation with a further detection domain; (b) a recognition domain, said recognition domain capable of binding a target biomolecular structure; and (c) a connector domain; said connector domain being fused at one end to the detection domain and being fused at the other end to the recognition domain; wherein at least two of (a), (b) and (c) are heterologous to one another; wherein the recognition domains of said first and said second fusion proteins are capable of binding to first and second biomolecular structures; (ii) contacting the sample with said first and second fusion proteins; (iii) incubating to allow binding; (iv) r

Abstract: Aggregation is a major cause of the misbehavior of proteins. A system for modifying a protein to create a more stable variant is provided. The method involves identifying non-conserved hydrophobic amino acid residues on the surface of a protein, suitable for mutating to more hydrophilic residues (e.g., charged amino acids). Any number of residues on the surface may be changed to create a variant that is more soluble, resistant to aggregation, has a greater ability to re-fold, and/or is more stable under a variety of conditions. The invention also provides GFP, streptavidin, and GST variants with an increased theoretical net charge created by the inventive technology. Kits are also provided for carrying out such modifications on any protein of interest.

Abstract: Techniques are disclosed for providing a duplicate content mode in touch sensitive computing devices. The duplicate content mode can be used to copy content or objects to a target location using a multiple contact point drag and drop gesture. For example, the duplicate content mode may be used to copy files from a first folder to a second folder. In some cases, the duplicate content mode drag and drop gesture is initiated using multiple contact points, such as two or more fingers, but may transition to a smaller number of contact points, such as one finger, once initiated. In some cases, the user may be able to select additional content after initiating the drag and drop gesture. Once the content has been copied to the target location, the user can then share or organize the content to the users liking.

Abstract: Fluorinated prodrug compounds as can be used for selective streptococcal mevalonate pathway inhibition.

Abstract: The present invention provides for engineered molecular opsonins that may be used to bind biological pathogens or identify subclasses or specific pathogen species for use in devices and systems for treatment and diagnosis of patients with infectious diseases, blood-borne infections or sepsis. An aspect of the invention provides for mannose-binding lectin (MBL), which is an abundant natural serum protein that is part of the innate immune system. The ability of this protein lectin to bind to surface molecules on virtually all classes of biopathogens (viruses, bacteria, fungi, protozoans) make engineered forms of MBL extremely useful in diagnosing and treating infectious diseases and sepsis.

Abstract: Methods for fluorinating organic compounds are described herein.

Abstract: The invention provides novel and versatile classes of riboregulators, including inter alia activating and repressing riboregulators, switches, and trigger and sink RNA, and methods of their use for detecting RNAs in a sample such as a well and in modulating protein synthesis and expression.

Abstract: The present invention discloses generalizable methods of evolving nucleic acids and proteins utilizing continuous directed evolution. The invention discloses methods of passing a nucleic acid from cell to cell in a desired function-dependent manner. The linkage of the desired function and passage of the nucleic acid from cell to cell allows for continuous selection and mutation of the nucleic acid.

Abstract: The present invention generally relates to prostaglandin transport. More specifically, the invention is directed to compounds that inhibit prostaglandin transport and subsequent COX-2 induction, and methods relating thereto.

Abstract: A compound of formula I wherein Ar1 is a bicyclic aryl or heteroaryl, which may be optionally substituted; X and Y are each independently a group of formula II: -L1-Ar2-L2-Ar3-Q-(CH2)n-NR1R2 L1 and L2 are each independently selected from NR3, C2H2, CH2, —O—, —S— and a bond; Ar2 and Ar3 are independently optionally substituted C5 or C6 aryl or heteroaryl; Q is selected from NH(C?O), NR3, S, O; n is an integer from 1 to 5; R1 and R2 are optionally substituted and are independently hydrogen, C1-7 alkyl, C3-20 heterocyclyl, or C5-20 aryl, or R1 and R2, taken together with the nitrogen atom to which they are attached, form a heterocyclic ring having from 3 to 8 ring atoms; R3 is H or C1-7 alkyl.

Abstract: Techniques are disclosed for providing a multidirectional swipe key for a virtual keyboard of a touch sensitive computing device. The multidirectional swipe key can be used to translate one or more swipe gestures started from the key into cursor movement (or directional input). The characteristics of the multidirectional swipe key gestures, such as the swipe direction and/or swipe length, may affect the resulting cursor movement (or directional input). The multidirectional swipe key may be configured such that held swipe gestures cause continual cursor movement (or directional input). The multidirectional swipe key may also be configured such that dragging the gesture to make a longer swipe accelerates cursor movement (or directional input) and vice versa.

Abstract: The present invention relates to methods of storing data using one or more nucleic acids.

Abstract: Provided herein are prebiotic compositions comprising a combination of oligosaccharides such as sialyated oligosaccharides and fusocylated oligosaccharides, and uses thereof in stimulating the proliferation of beneficial intestinal micro biota, for example, of bifidobacteria, and/or in decreasing the abundance of enteric pathogens. The prebiotic compositions can further contain a probiotic, which can be a population of bifidobacteria, lactobacilli, Bacteriodes fragilis, Bacteriodes thetaiotaomicron, Enterococcus faecalis (pro biotic strains thereof), Staphylococcus epidermides, Enterobacter aerogenes, Enterobacter cloacae, or related bacteria having similar functions.

Abstract: An absorption spectroscopy instrument with a light source for providing a beam of light, a modulator to produce a modulated beam of light, a high finesse optical cavity, means for injecting the modulated beam of light off-axis into the high finesse optical cavity and a detector positioned to receive and measure light exiting through said optical cavity. The detector may be a highly sensitive and high bandwidth detector. The modulator may be a one or two-tone modulator having means, such as a plurality of RF synthesizers, for modulating the light source by one or two tones. If one tone of applied modulation is used, the frequency is larger than the absorption bandwidth of the target chemical. In the case where two tones are used, the first frequency is larger than the absorption bandwidth of the target chemical and the second frequency is small relative to the first frequency.

Abstract: The invention is directed compositions and methods related to bacterial cells physically associated with ceramide-like glycolipids. The invention allows for delivery of ceramide-like glycolipid adjuvants directly to the same cells that become infected with a bacterial vaccine. The compositions and methods of the present invention are useful for the prevention and treatment of diseases.

Abstract: This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is placed on the head or other body organ of interest of a patient (P) during a scan, such as an MRI scan. The marker (30) makes it possible to measure the six degrees of freedom (x, y, and z-translations, and pitch, yaw, and roll), or “pose”, required to track motion of the organ of interest. A detector, preferably a camera (40), observes the marker (30) and continuously extracts its pose. The pose from the camera (40) is sent to the scanner (120) via an RGR processing computer (50) and a scanner control and processing computer (100), allowing for continuous correction of scan planes and position (in real-time) for motion of the patient (P).

Abstract: The present invention relates to bifunctional compounds, the bifunctional compounds for use in molecular imaging and therapy, methods of molecular imaging using the bifunctional compounds and kits including the bifunctional compounds for use molecular imaging. The bifunctional compounds have a tripodal hydroxypyridinone chelating portion and may be conjugated to a targeting group so that the compounds target specific cells or tissues in a subject.

Abstract: The invention provides novel surface coat proteins of Clostridium spp. spores, and nucleic acids encoding such proteins. The invention extends to various uses of these nucleic acids and proteins, as antigens for use in vaccine design and construction, and to vaccines per se, and in diagnostic test kits and methods for the detection of Clostridium spp. infections. In addition, the nucleic acids and proteins can be used as potential targets for therapeutic drugs for the prevention or treatment of Clostridium spp. infections.