Abstract: A microcalorimeter device capable of measuring cellular bioenergetics and systems that are limited in analytic volume. The microcalorimeter device provides sub-nWatt resolution and even tens of pico-Watt resolution, thus enabling resolution of the metabolic rate of a single cell.
Type:
Grant
Filed:
November 13, 2017
Date of Patent:
February 20, 2024
Assignee:
President and Fellows of Harvard College
Abstract: Isolated polypeptides comprising engineered mutant PD-1 polypeptide are provided, as are fusion polypeptides comprising the mutant and methods of use thereof. Bispecific PD-L1 and PD- L2 binding mutant PD-1 polypeptides are provided. PD-L2-specific binding mutant PD-1 polypeptides are also provided.
Type:
Grant
Filed:
May 3, 2021
Date of Patent:
February 20, 2024
Assignee:
Albert Einstein College of Medicine
Inventors:
Jonathan R. Lai, Steven Almo, Nina Liu, Julia Frei
Abstract: Some aspects of the present disclosure provide methods for evolving recombinases to recognize target sequences that differ from the canonical recognition sequences. Some aspects of this disclosure provide evolved recombinases, e.g., recombinases that bind and recombine naturally-occurring target sequences, such as, e.g., target sequences within the human Rosa26 locus. Methods for using such recombinases for genetically engineering nucleic acid molecules in vitro and in vivo are also provided. Some aspects of this disclosure also provide libraries and screening methods for assessing the target site preferences of recombinases, as well as methods for selecting recombinases that bind and recombine a non-canonical target sequence with high specificity.
Type:
Grant
Filed:
August 10, 2021
Date of Patent:
February 20, 2024
Assignee:
President and Fellows of Harvard College
Inventors:
David R. Liu, David B. Thompson, Jeffrey L. Bessen
Abstract: A method and system for label-free detection of pathogenic and antibiotic resistant bacteria is disclosed. The method includes fabricating a G-FET/peptide device having a synthesized peptide probe capable of recognizing and binding to a bacterial target; performing electric-field assisted binding of at least one bacterial cell of the bacterial target to the G-FET/peptide device; and electrically detecting the binding of the at least one bacterial cell to the G-FET/peptide device.
Type:
Application
Filed:
October 13, 2023
Publication date:
February 15, 2024
Applicant:
The Trustees of Boston College
Inventors:
Kenneth S. Burch, Tim van Opijnen, Jianmin Gao, Narendra Kumar, Juan C. Ortiz-Marquez, Wenjian Wang, Mason Gray
Abstract: The disclosure provides fusion proteins comprising a pleckstrin homology (PH) domain and a variant of Botulinum neurotoxin E (BoNT E) protease that cleaves certain non-canonical protein targets (e.g., PTEN). Fusion proteins described in the disclosure are useful for cleaving target proteins found in a cell, that is, in an intracellular environment. Aspects of the disclosure provide methods for inhibiting PTEN amount, activity, or function in a cell or subject, the methods comprising administering to a call or subject a fusion protein described herein.
Type:
Application
Filed:
December 17, 2021
Publication date:
February 15, 2024
Applicants:
The Board Institute, Inc., President and Fellows of Harvard College, Children's Medical Center Corporation
Inventors:
David R. Liu, Travis R. Blum, Min Dong, Hao Liu
Abstract: This invention relates to alkali metal (Li, Na, K) ion batteries, electrodes for alkali metal ion batteries, and methods for manufacturing electrodes for alkali metal ion batteries.
Type:
Application
Filed:
October 5, 2021
Publication date:
February 15, 2024
Applicants:
University of Southern California, The Board of Regents for the Oklahoma Agricultural and Mechanical Colleges
Inventors:
Stephen B. CRONIN, Sisi YANG, Özgür ÇAPRAZ, Bertan OZDOGRU
Abstract: A system and method for vestibular and/or balance rehabilitation by monitoring and measuring head motion data of a user having vestibular impairment. The system as includes a user device, a head tracking device, and a remote server device. The user device receives therapeutical configuration data prescribed by a therapist using the remote server device. A visual and auditory and/or haptic stimuli is generated in the user interface according to the received therapeutic configuration data during a training session or initial assessment session. Head motion data from the head tracking device during the training session is received along with user inputted data pertaining to symptoms of the user. The remote server device receives and processes the head motion and positional data, the user inputted symptoms data and communicates a set of updated therapeutic configuration data to the user device based on the processed data for use in a next training session.
Type:
Application
Filed:
December 24, 2021
Publication date:
February 15, 2024
Applicants:
The Provost, Fellows, Foundation Scholars and the other members of Board, of the College of the Holy, Royal College of Surgeons in Ireland
Abstract: The disclosure generally relates to the artificial intelligence (AI) automatic methods, computer program product, and systems and methodology for dietary and medical treatment planning, food waste estimation, analyzing three-dimensional food image construction, measurement, nutrient estimation, nutritional assessment, evaluation, prediction and management. More particularly, the embodiments described herein relate to utilizing an AI-based algorithm that can automatically, detect food items from images acquired by cameras for dietary assessment, dietary planning, and for estimating food waste. In one aspect, the method may include food calorie estimation techniques using machine learning and computer vision techniques for dietary assessment. In another aspect, the tools may apply to personalized nutrition. The method may also include the automation of nutrition planning.
Type:
Application
Filed:
December 17, 2021
Publication date:
February 15, 2024
Applicants:
Trustees of Tufts College, Research Foundation of the City University of New York
Inventors:
Karen A. Panetta, Shishir Paramathma Rao, Shreyas Kamath Kalasa Mohandas, Rahul Rajendran, Srijith Rajeev, Erin Hennessy, Christina Economos, Eleanor Tate Shonkoff, Sos S. Agaian
Abstract: The present invention provides mito-honokiol or mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-honokiol or mito-magnolol compounds in the treatment of cancer.
Type:
Grant
Filed:
November 16, 2020
Date of Patent:
February 13, 2024
Assignees:
The Medical College of Wisconsin, Inc., Aix-Marseille Universite
Inventors:
Balaraman Kalyanaraman, Jacek Michal Zielonka, Gang Cheng, Micael J. Hardy, Olivier Ouari, Ming You
Abstract: Provided herein are systems, compositions, kits, and methods for the suppression of pain (e.g., chronic pain). Genes encoding ion channels (e.g., SCN9A) responsible for the propagation pain signals in neurons (e.g., DRG neurons) may be edited using a genome editing agent (e.g., a nucleobase editor). In some embodiments, loss-of-function ion channel mutants are generated, leading to pain suppression. In some embodiments, the genome editing agent is administered locally to the site of pain or to the nerves responsible for propagation of the pain signal.
Type:
Grant
Filed:
March 9, 2018
Date of Patent:
February 13, 2024
Assignee:
President and Fellows of Harvard College
Abstract: Disclosed is a method of preparing a filtration membrane. The method includes providing a copolymer solution by dissolving a statistical copolymer in a mixture of a co-solvent and a first organic solvent, coating the copolymer solution onto a porous support layer to form a polymeric layer thereon, coagulating the polymeric layer on top of the support layer to form a thin film composite membrane, and immersing the thin film composite membrane into a water bath to obtain a filtration membrane. Also disclosed are a filtration membrane prepared by the method, and a process of filtering a liquid using the filtration membrane thus prepared.
Abstract: Certain embodiments of the present invention are directed to therapeutic intervention in patients with eye-length-related disorders to prevent, ameliorate, or reverse the effects of the eye-length-related disorders. Embodiments of the present invention include methods for early recognition of patients with eye-length-related disorders, therapeutic methods for inhibiting further degradation of vision in patients with eye-length-related disorders, reversing, when possible, eye-length-related disorders, and preventing eye-length-related disorders. Additional embodiments of the present invention are directed to particular devices used in therapeutic intervention in patients with eye-length-related disorders.
Abstract: The present invention provides an improved percutaneous dilation tracheostomy device. The device is configured to include all of the required components to perform a percutaneous tracheotomy. The device includes a retractable needle and an extendable j-wire rather than having separate components as in typical percutaneous tracheostomy devices. The device includes a dilator section to expand the diameter of a patient's stoma. The device is further configured to allow an operator to perform a bubble test to alert the user that the tube is in the trachea. In addition, the device is generally more compact than typical emergency tracheostomy devices.
Type:
Grant
Filed:
November 15, 2022
Date of Patent:
February 13, 2024
Assignees:
University of Maryland, Baltimore, University of Maryland, College Park
Inventors:
Joseph Rabin, Conor Bloomer, Paige Chan, Scott Kivitz, Peter Chen, Torrance Wang
Abstract: Aspects and embodiments relate to a plasmonic metamaterial structure, applications and devices including that plasmonic metamaterial structure, and a method of forming that plasmonic metamaterial structure. Aspects and embodiments provide a plasmonic metamaterial structure which comprises: a plurality of optical antenna elements. The plurality of optical antenna elements comprise: a first electrode, a second electrode and a plasmonic nanostructure element located between the first and second electrode to form an electron tunnelling junction between the first and second electrodes. The plurality of optical antenna elements are configured such that the electromagnetic field of one optical antenna element spatially overlaps that of adjacent optical antenna elements and adjacent optical antenna elements are electromagnetically coupled to allow the plurality of optical antenna elements to act as a plasmonic metamaterial.
Type:
Grant
Filed:
January 18, 2018
Date of Patent:
February 13, 2024
Assignee:
King's College London
Inventors:
Anatoly Zayats, Pan Wang, Mazhar Nasir, Wayne Dickson, Alexey Krasavin
Abstract: An ophthalmic imaging system comprises a first imaging subsystem, a sensor array and a second imaging subsystem. The first imaging subsystem forms a primary image of the interior of an eye through the diameter of the eye pupil. The second imaging subsystem comprises a lens array to form an array of secondary images on the sensor array. The lens array is composed of a plurality of types of lenses, each type having a different optical power.
Abstract: A high-efficiency visible-light catalytic material, a preparation method and an application thereof are provided by the present application, relating to the technical field of photocatalytic materials. The present application prepares photocatalytic material Ag@AgCl/CA by compounding Ag@AgCl and calcium alginate gel, and the prepared photocatalytic material is shaped as small particles. The photocatalytic material Ag@AgCl/CA is used to degrade tetracycline antibiotics.
Type:
Grant
Filed:
July 17, 2023
Date of Patent:
February 13, 2024
Assignees:
Jiangsu Vocational College of Agriculture and Forestry, Huayu Automotive Electric Drive System Co., Ltd.
Inventors:
Daxiang Gao, Zhong Gao, Lin Wang, Hetong Yang, Jun Shi, Gangjun Xi
Abstract: Acyclic CB[n]-type compounds, methods of making such compounds, and uses of the compounds. For example, these compounds can be used as nanocontainers to solubilize pharmaceutical agents. Also provided are compositions and methods of using them for therapy or prophylaxis of a wide variety of conditions for which therapy or prophylaxis is desirable.
Type:
Grant
Filed:
December 14, 2020
Date of Patent:
February 13, 2024
Assignee:
University of Maryland, College Park
Inventors:
Lyle David Isaacs, Volker Briken, Gaya Hettiarachchi, Da Ma, Duc M. Nguyen
Abstract: The present disclosure concerns combination therapy for cancer that utilizes (i) an oncolytic virus; (ii) a virus comprising nucleic acid encoding an immunomodulatory factor; and (iii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen. In particular embodiments, the virus comprises nucleic acid encoding an immunomodulatory factor comprises nucleic acid encoding IL-12 and/or antagonist anti-PD-L1 antibody.
Abstract: The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect both DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA.
Type:
Grant
Filed:
September 7, 2018
Date of Patent:
February 13, 2024
Assignees:
The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows Harvard College
Inventors:
Feng Zhang, Jonathan Gootenberg, Omar Abudayyeh