Patents Assigned to College
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Publication number: 20230367995Abstract: Systems, methods, and non-transitory computer-readable storage media for an adjustable neural network. Systems measure feature applicability for an octave of a Convolutional Neural Network (CNN) at a standard scale, resulting in (1) at least one drop-off point where the octave no longer resonates with pre-defined features; and (2) a common drop-off between the CNN and at least one other CNN trained on at least one other separate domain. The system can then measure octave resonance for a plurality of CNNs trained on large data sets with a distribution of octaves for features, and measure a pattern of octaves learned in the CNN, resulting in a measurement pattern. The system can then compare that measurement pattern to the pre-defined features, resulting in a level of adaptability of the CNN, and modify the CNN based on the level of adaptability of the CNN, resulting in a modified CNN.Type: ApplicationFiled: October 1, 2021Publication date: November 16, 2023Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Supratik MUKHOPADHYAY, Edward COLLIER, Robert DIBIANO
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Publication number: 20230365663Abstract: Provided are high affinity Mycobacterium tuberculosis capsule-specific antibodies and fragments thereof, as well as methods of use and devices employing such antibodies and/or fragments.Type: ApplicationFiled: April 28, 2023Publication date: November 16, 2023Applicant: Albert Einstein College of MedicineInventors: Jacqueline M. Achkar, Jonathan Lai, Elise Ishida, Daniel Hofmann, Tingting Chen
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Publication number: 20230365524Abstract: The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4, and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and prophylaxis of diseases, in particular hyperproliferative disorders, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: April 20, 2023Publication date: November 16, 2023Applicants: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, The Broad Institute, Inc., President and Fellows of Harvard College, The General Hospital CorporationInventors: Stefan Nikolaus GRADL, Duy NGUYEN, Knut EIS, Judith GÜNTHER, Timo STELLFELD, Andreas JANZER, Sven CHRISTIAN, Thomas MÜLLER, Sherif El SHEIKH, Han Jie ZHOU, Changjia ZHAO, David B. SYKES, Steven James FERRARA, Kery LIU, Michael KRÖBER, Claudia MERZ, Michael NIEHUES, Martina SCHÄFER, Katja ZIMMERMANN, Carl Friedrich NISING
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Publication number: 20230365912Abstract: The present disclosure is generally directed to systems and methods for retrieving cells from a continuous culture microfluidic device. In some aspects, a system that allows for selective extraction of one or more cells of interest from an arbitrary population of cells using a high-throughput negative cell selection technique is disclosed herein. For example, the system may comprise a microfluidic device comprising a plurality of cell growth trenches configured to contain cells and a patterned light source capable of selectively killing unwanted cells contained within the device. Coupled with time-lapse imaging, one or more cells of interest within the device may, in some aspects, be identified and extracted with a relatively high extraction efficiency, e.g., at least 99.9% of cells of interest may be extracted from the plurality of cells. In addition, some aspects of the disclosure are directed to methods for using such a system.Type: ApplicationFiled: April 27, 2023Publication date: November 16, 2023Applicant: President and Fellows of Harvard CollegeInventors: Johan Paulsson, Scott Luro
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Publication number: 20230364226Abstract: The invention relates to RNA constructs, and particularly, although not exclusively, to mRNA constructs and saRNA replicons and to nucleic acids and expression vectors encoding such RNA constructs. The invention extends to the use of such RNA constructs in therapy, for example in treating diseases and/or in vaccine delivery. The invention extends to pharmaceutical compositions comprising such RNA constructs, and methods and uses thereof.Type: ApplicationFiled: December 17, 2021Publication date: November 16, 2023Applicants: Imperial College Innovations Limited, VaxEquity LtdInventors: Robin Shattock, Paul McKay, Michael Watson, Elaine Harper
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Publication number: 20230366011Abstract: Provided herein, in some aspects, are methods of imaging molecules without a microscope or other specialized equipment, referred to herein as “microscope-free imaging (MFI).” Herein, “molecular instruments” (e.g., DNA-based and protein-based molecules) are used, instead of microscopes, in a “bottom-up” approach for inspecting molecular targets.Type: ApplicationFiled: March 28, 2023Publication date: November 16, 2023Applicant: President and Fellows of Harvard CollegeInventors: Thomas E. Schaus, Xi Chen, Peng Yin
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Patent number: 11815745Abstract: Certain embodiments of the present invention are directed to therapeutic intervention in patients with eye-length-related disorders to prevent, ameliorate, or reverse the effects of the eye-length-related disorders. Embodiments of the present invention include methods for early recognition of patients with eye-length-related disorders, therapeutic methods for inhibiting further degradation of vision in patients with eye-length-related disorders, reversing, when possible, eye-length-related disorders, and preventing eye-length-related disorders. Additional embodiments of the present invention are directed to particular devices used in therapeutic intervention in patients with eye-length-related disorders.Type: GrantFiled: October 20, 2022Date of Patent: November 14, 2023Assignee: The Medical College of Wisconsin, Inc.Inventors: Jay Neitz, Maureen Neitz
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Patent number: 11813618Abstract: The invention provides a monolithic integrated mesh device for atomization or pumping of a fluid or liquid comprising a plurality of apertures and a piezoelectric material. The piezoelectric material is bonded to the mesh device at an atomic scale. In one embodiment the monolithic micro-fabricated device of the invention includes piezoelectric material that eliminates the need for expensive assembly process and improves reliability. This also has advantage of requiring lower operating voltage and less complicated circuitry.Type: GrantFiled: March 6, 2017Date of Patent: November 14, 2023Assignee: University College Cork—National University of IrelandInventors: Nathan Jackson, Alan Mathewson, Zbigniew Olszewski
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Patent number: 11814527Abstract: The invention provides a supramolecular polymer composition capable of co-assembly to maintain a three dimensional (3-D) macrostructural form after 3-D printing, made of a solvent, a template molecule; and a reactive component. The reactive component can be at least one monomer that is capable of hydrogen bonding with the template molecule to form a 1D supramolecular structure. The template may be an amphiphilic polymer. The monomer has at least two pendant groups capable of covalent crosslinking. The invention also includes a 3-D structure formed by crosslinking a 3-D printed supramolecular polymer composition, which optionally has a mesoporous structure. Also included is a method of manufacturing a 3-D structure by delivering a supramolecular polymer composition onto a surface of a substrate to form the 3-D structure.Type: GrantFiled: April 27, 2018Date of Patent: November 14, 2023Assignee: Trustees of Dartmouth CollegeInventors: Chenfeng Ke, Pengfei Zhang, Longyu Li, Qianming Lin
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Patent number: 11813100Abstract: An apparatus and method for medical imaging uses a first and second contrast agent, the second agent targeted to a particular tissue type. First images are obtained using the first agent, and second images using the second agent using medical imaging systems. An image processing system is adapted to process the first and second medical images by fitting parameters of a pharmacokinetic model to the first medical images, identifying a nontargeted tissue type, scaling the fitted parameters to best match the nontargeted tissue in the second medical images, executing the pharmacokinetic model to prepare a correction image, and generating corrected medical images by subtracting the correction image from the second medical images.Type: GrantFiled: January 9, 2017Date of Patent: November 14, 2023Assignee: The Trustees of Dartmouth CollegeInventors: Kenneth M. Tichauer, Scott C. Davis, Brian William Pogue
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Patent number: 11814398Abstract: The present invention provides novel compounds (e.g., compounds of Formulae (I), (II), (III), (IV)) having tumor vascular remodeling effect and/or anti-CAF (Cancer Associated Fibroblasts) activity, or pharmaceutically acceptable salts thereof, optionally in a pharmaceutically acceptable carrier, and a medical uses thereof.Type: GrantFiled: June 23, 2022Date of Patent: November 14, 2023Assignees: President and Fellows of Harvard College, Eisai R&D Management Co., LTD.Inventors: Yoshito Kishi, Kazunobu Kira, Ken Ito
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Patent number: 11814687Abstract: The present invention features methods for characterizing mutational profiles in patients with bladder cancer.Type: GrantFiled: August 7, 2020Date of Patent: November 14, 2023Assignees: The Broad Institute, Inc., The General Hospital Corporation, Baylor College of Medicine, The Brigham and Women's Hospital, Inc., Northwestern University, The Johns Hopkins University, United States Government as represented by the U.S. Department of Veterans AffairsInventors: Jaegil Kim, Gad Getz, Seth Paul Lerner, David Kwiatkowski, Joshua Meeks, Joaquim Bellmunt, David McConkey
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Patent number: 11817589Abstract: In various embodiments, a solid oxide fuel cell features a functional layer for reducing interfacial resistance between the cathode and the solid electrolyte.Type: GrantFiled: November 2, 2021Date of Patent: November 14, 2023Assignees: Redox Power Systems, LLC, University of Maryland, College ParkInventors: Ke-Ji Pan, Mohammed Hussain Abdul Jabbar, Dong Ding, Eric Wachsman
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Patent number: 11813268Abstract: Activators of mitofusins and their uses in treatment of diseases and disorders are disclosed.Type: GrantFiled: October 16, 2018Date of Patent: November 14, 2023Assignee: Albert Einstein College of MedicineInventors: Evripidis Gavathiotis, Richard N. Kitsis, Nikolaos Biris, Emmanouil Zacharioudakis
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Patent number: 11815528Abstract: A sensing probe may be formed of a diamond material comprising one or more spin defects that are configured to emit fluorescent light and are located no more than 50 nm from a sensing surface of the sensing probe. The sensing probe may include an optical outcoupling structure formed by the diamond material and configured to optically guide the fluorescent light toward an output end of the optical outcoupling structure. An optical detector may detect the fluorescent light that is emitted from the spin defects and that exits through the output end of the optical outcoupling structure after being optically guided therethrough. A mounting system may hold the sensing probe and control a distance between the sensing surface of the sensing probe and a surface of a sample while permitting relative motion between the sensing surface and the sample surface.Type: GrantFiled: February 18, 2022Date of Patent: November 14, 2023Assignee: President and Fellows of Harvard CollegeInventors: Michael S. Grinolds, Sungkun Hong, Patrick Maletinsky, Amir Yacoby
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Publication number: 20230357766Abstract: The disclosure provides modified pegRNAs comprising one or more appended nucleotide structural motifs which increase the editing efficiency during prime editing, increase half-life in vivo, and increase lifespan in a cell. Modifications include, but are not limited to, an aptamer (e.g., prequeosim-1 riboswitch aptamer or “evopreQi-1”) or a variant thereof, a pseudoknot (the MMLV viral genome pseudoknot or “Mpknot-1”) or a variant thereof, a tRNA (e.g., the modified tRNA used by MMLV as a primer for reverse transcription) or a variant thereof, or a G-quadruplex or a variant thereof. The disclosure further provides prime editor complexes comprising the modified pegRNAs and having improved characteristics and/or performance, including stability, improved cellular lifespan, and improved editing efficiency.Type: ApplicationFiled: September 24, 2021Publication date: November 9, 2023Applicants: The Broad Institute, Inc., President and Fellows of Harvard CollegeInventors: David R. Liu, James William Nelson, Peyton Barksdale Randolph, Andrew Vito Anzalone, Simon Shen, Kelcee Everette, Peter J. Chen
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Publication number: 20230357286Abstract: Provided are new nickel./zirconium-mediated coupling reactions useful in the synthesis of ketone-containing compounds, e.g., halichondrin natural products and related molecules. A feature of the present disclosure is the use of a nickel(I) catalyst in tandem with a nickel (II) catalyst in the Ni/Zr-mediated coupling reactions. Without wishing to be bound by any particular theory, the nickel (I) catalyst selectively activates the electrophilic coupling partner (i.e., the compound of Formula (A)), and the nickel(ll) catalyst selectively activates the nucleophilic coupling partner (i.e., a thioester of Formula (B)). This dual catalyst system leads to improved coupling efficiency and eliminates the need for a large excess of one of the coupling partners (i.e., a compound of Formula (A) or (B)).Type: ApplicationFiled: July 24, 2020Publication date: November 9, 2023Applicant: President and Fellows of Harvard CollegeInventors: Yoshito Kishi, Atsushi Umehara
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Publication number: 20230355161Abstract: An apparatus, computer program and method is described comprising: separating neuron discharge patterns obtained from electromyography signals into one or more frequency band signals based on bandpass filter configuration parameters and converting one or more of said one or more frequency band signals into a one or more control signals, wherein said one or more control signals include one or more first control signals, wherein the or each first control signal is an independent augmented control signal.Type: ApplicationFiled: September 14, 2021Publication date: November 9, 2023Applicant: Imperial College Innovations LimitedInventors: Dario FARINA, Mario BRÄCKLEIN, Deren Yusuf BARSAKCIOGLU, Jaime IBANEZ PEREDA
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Publication number: 20230357690Abstract: The present disclosure relates to a microfluidic devices and methods for culturing bone marrow cells. Aspects include methods of preparing microfluidic devices and culturing bone marrow cells with the microfluidic devices. In some aspects, a method includes providing a microfluidic device having an upper chamber, a lower chamber, and a porous membrane separating the upper chamber from the lower chamber. The method further includes seeding walls of the lower chamber and a bottom surface of the membrane with endothelial cells. The method further includes providing a matrix within the upper chamber. The matrix includes fibrin gel and bone marrow cells. The method further includes filling or perfusing the upper chamber with a media.Type: ApplicationFiled: June 28, 2023Publication date: November 9, 2023Applicants: President and Fellows of Harvard College, The General Hospital CorporationInventors: David Benson Chou, Liliana S. Teixeira Moreira Leijten, Arianna Rech, Richard Novak, Donald E. Ingber, Yuka Milton, Viktoras Frismantas, Oren Levy
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Publication number: 20230360162Abstract: Serious gaming for interrelated critical infrastructure (CI) resilience improvement includes receiving from a serious gaming participant a selection of an anomalous event for a geographic region for which a hierarchy of CI elements has been modeled, and a specified change in allocation of at least one resource in a corresponding one of the CI elements. A previously determined cascading impact upon the CI elements resulting from the anomalous event is then retrieved and compared to a hypothetical cascading impact produced by a simulation of the model with the specified change. A visualization of the comparison is transmitted to the serious gaming participant so as to show the result of the hypothetical change in resources upon the cascading impact of the event in the hierarchy of CI elements.Type: ApplicationFiled: May 4, 2022Publication date: November 9, 2023Applicants: University College Dublin, Nurogames GmbHInventors: Páraic James Carroll, Daniel Patrick McCrum, Yash Shekhawat