Patents Assigned to Colorado State University Research Foundation
  • PAPER-BASED ASSAY FOR ANTIMICROBIAL RESISTANCE
    Publication number: 20200131558
    Abstract: Antimicrobial resistance (AMR), the ability of a bacterial species to resist the action of an antimicrobial drug, has been on the rise due to the widespread use of antimicrobial agents, and one of the many ways AMR can spread is through contaminated water sources. To monitor these water sources, we have developed an inexpensive, fast assay using a paper-based analytical device (PAD) that can test for the presence of ?-lactamase-mediated resistance as one major form of AMR that has reliably detected resistance in sewage water.
    Type: Application
    Filed: April 20, 2018
    Publication date: April 30, 2020
    Applicant: Colorado State University Research Foundation
    Inventors: Charles S. HENRY, Katherine BOEHLE, Brian J. GEISS
  • Synthetic polymeric materials and devices thereof
    Patent number: 10626267
    Abstract: Provided herein is a polymeric material comprising a polymer host; and a guest molecule comprising a glycosaminoglycan; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. In some embodiments, the polymer host comprises a silicone-based polymer. In other embodiments, the glycosaminoglycan is chosen from hyaluronic acid and derivatives thereof.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: April 21, 2020
    Assignee: Colorado State University Research Foundation
    Inventors: Susan P. James, David A. Prawel, Richard L. Koch
  • DEVICES AND METHODS FOR MEASURING TEMPERATURE, OXIDATION REDUCTION POTENTIAL, AND WATER-LEVEL WITHIN A SUBSURFACE FORMATION
    Publication number: 20200116894
    Abstract: A subsurface monitoring system and method is provided that includes a sensor array and a monitoring system in communication with the array. The sensor array may include several sensors, such as subsurface temperature sensors, water-level sensors, and oxidation reduction potential sensors may be disposed in a vertical and/or horizontal fence through the subsurface of the monitored site. The sensor array may measure, collect, and analyze the subsurface conditions and provide the measurements to a monitoring system. The monitoring system may provide access the measurements via a user interface for analysis of the measurements. In addition, the monitoring system may process the measurements to generate one or more graphs of information for better understanding of the conditions of the subsurface of the monitored site.
    Type: Application
    Filed: October 14, 2019
    Publication date: April 16, 2020
    Applicant: Colorado State University Research Foundation
    Inventors: Thomas C. Sale, Jay M. Ham, William Samuel Gallo, Kayvan Karimi Askarani, Zachary Scott Ferrie, Joseph Scalia, IV
  • WEDGE OSTEOTOMY DEVICE AND METHOD OF USE
    Publication number: 20200113581
    Abstract: A wedge osteotomy device including a cutting guide coupled to a base plate via a joint. The cutting guide configured to pivot relative to the base plate about a pivot axis extending through the joint. The cutting guide including a guide body including a cutting slot extending through the guide body, an arcuate slot extending through the guide body and defining a radius to the joint, and a plurality of markers on the guide body identifying a position of the cutting guide relative to the base plate. The base plate including planar top and bottom surfaces.
    Type: Application
    Filed: October 8, 2019
    Publication date: April 16, 2020
    Applicant: Colorado State University Research Foundation
    Inventor: Felix Duerr
  • ANTI-HIV PEPTIDES
    Publication number: 20200115418
    Abstract: Simple ?-hairpin peptides in linear and cyclic form that specifically bind to HIV-1 Trans-Activation Response element (HIV-1 TAR), as well as compositions and use thereof are described.
    Type: Application
    Filed: December 20, 2019
    Publication date: April 16, 2020
    Applicants: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION, University of Rochester
    Inventors: Brian R. McNaughton, David W. Crawford, Joseph E. Wedekind, Ivan A. Belashov
  • SCFV'S FOR LIVE CELL IMAGING AND OTHER USES
    Publication number: 20200102373
    Abstract: Disclosed herein are methods to engineer single chain variable fragments (scFv's) that specifically bind a plurality of antigens in vivo, as well as novel scFv's produced therefrom. The disclosed novel scFV's can be used a variety of applications.
    Type: Application
    Filed: September 27, 2019
    Publication date: April 2, 2020
    Applicants: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION, TOKYO INSTITUTE OF TECHNOLOGY
    Inventors: Timothy Stasevich, Ning Zhao, Hiroshi Kimura, Yuko Sato
  • Compositions comprising resurfaced cell-penetrating nanobodies and methods of use thereof
    Patent number: 10604558
    Abstract: The disclosure encompasses resurfaced cell-penetrating nanobodies and their methods of use. The resurfacing of nanobodies with positively-charged amino acids facilitates their penetration into a cell and allows targeting of a specific intracellular protein.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: March 31, 2020
    Assignee: Colorado State University Research Foundation
    Inventors: Brian R. McNaughton, Virginia J. Bruce
  • Systems and Methods for Determining Engine Start Time During Predicted Acceleration Events
    Publication number: 20200094809
    Abstract: A method may include predicting an acceleration event of a vehicle. The method may further include predicting a maximum speed of the predicted acceleration event. The method may also include determining an engine start time based on the predicted maximum speed. The method may still further include starting an engine of the vehicle at the engine start time.
    Type: Application
    Filed: September 26, 2018
    Publication date: March 26, 2020
    Applicants: Toyota Motor Engineering & Manufacturing North America, Inc., Colorado State University Research Foundation
    Inventors: Joshua Payne, Heraldo Stefanon, Benjamin Geller, Takanori Aoki, Thomas Bradley, Zachary Asher, David Trinko
  • REVERSIBLE METALLOPOLYMER NETWORK
    Publication number: 20200087463
    Abstract: The invention provides a metallopolymer coordination network comprising one or more coinage or similar metals and a glyme or glyme-equivalent. The composition has an amorphous polymer network that is significantly stronger than previously reported supramolecular hydrogels synthesized without glyme. Glyme chain length and water content strongly influence the mechanical, electronic, and optical behavior of the network.
    Type: Application
    Filed: November 21, 2019
    Publication date: March 19, 2020
    Applicant: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: William Scott Compel, Christopher J. Ackerson, O. Andrea Wong
  • Engineered programmable molecular scaffolds from porous protein crystals
    Patent number: 10590176
    Abstract: The present disclosure provides compositions and methods for preparing engineered porous protein crystals comprising at least one guest molecule.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: March 17, 2020
    Assignee: Colorado State University Research Foundation
    Inventors: Christopher D. Snow, Thaddaus R. Huber
  • METHODS FOR PREPARING A DECELLULARIZED MUSCLE SCAFFOLD
    Publication number: 20200069843
    Abstract: The present disclosure provides a method for preparing a decellularized muscle scaffold, decellularized muscle scaffolds produced therefrom, and uses thereof to treat a subject with damaged or lost muscle.
    Type: Application
    Filed: May 18, 2018
    Publication date: March 5, 2020
    Applicant: Colorado State University Research Foundation
    Inventors: Ruth J. Rose, Nicole P. Ehrhart, Matthew E. Randolph, Laura Chubb
  • Tongue stimulation for communication of information to a user
    Patent number: 10576270
    Abstract: Example devices and methods of tongue stimulation for communication of information to a user are disclosed herein. In an example, a tongue stimulation device may include a body configured to be placed entirely within a mouth of the user and atop the tongue of the user. An array of electro-tactile elements may be distributed on the body, wherein each of the electro-tactile elements is configured to stimulate an area of the tongue adjacent the electro-tactile element. A wireless receiver coupled to the body may be configured to receive stimulation information wirelessly from outside the mouth of the user. At least one processing unit coupled to the body may be configured to transform the received stimulation information into a stimulation signal for each of the electro-tactile elements, and to provide the stimulation signals to the electro-tactile elements.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: March 3, 2020
    Assignee: Colorado State University Research Foundation
    Inventors: John D. Williams, Joel A. Moritz, Leslie M. Stone-Roy
  • SYSTEMS AND METHODS FOR ANIMAL PATIENT HEALTH MANAGEMENT DURING VETERINARY PROCEDURES
    Publication number: 20200060616
    Abstract: Implementations described and claimed herein provide systems and methods for managing animal patient during a veterinary procedure. In one implementation, a base has an interior surface, an exterior surface, and an opening. An electrode is disposed in the opening. The electrode is configured to communicate with medical device(s) for monitoring vital(s) of the patient during the procedure. A thermal insulator extends from the base. The thermal insulator forms a housing. An internal cavity is defined within the housing. The foot of the patient is receivable into the internal cavity. The thermal insulator regulates the body temperature of the animal patient during the veterinary procedure by retaining heat within the internal cavity.
    Type: Application
    Filed: August 21, 2019
    Publication date: February 27, 2020
    Applicant: Colorado State University Research Foundation
    Inventor: Natalie M. Malkut
  • ROTARY MANIFOLD FOR PAPER-BASED IMMUNOASSAYS
    Publication number: 20200038866
    Abstract: A system for and methods of analyzing a test sample through the use of a rotary apparatus that includes a microfluidic paper-based apparatus (mPAD). The apparatus includes two or more layers that are rotatable with respect to one another. A middle layer may comprise a microfluidic apparatus having one or more reagent channels. Each of the reagent channels may include reagent dried on the surface of the channel, and, together with an adsorption pad, may be aligned vertically with a sample chamber. Male and female engagement surfaces on each of the middle layer, the top layer, and the bottom layer interlock to secure each layers in vertical alignment so that fluid flows through the apparatus to contact a test sample with a reagent and facilitate detection of a target analyte in the test sample in the sample chamber.
    Type: Application
    Filed: August 2, 2019
    Publication date: February 6, 2020
    Applicants: Colorado State University Research Foundation, United States Department of Agriculture
    Inventors: Charles S. HENRY, Rachel FEENY, Alan B. FRANKLIN, Cody CARRELL
  • Synthesis and utility of new capgroup largazole analogs
    Patent number: 10538534
    Abstract: Analogs of largazole are described herein. Methods of treating cancer, blood disorders, autoimmune disease, and Alzheimer's Disease using largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: January 21, 2020
    Assignees: Colorado State University Research Foundation, Dana-Farber Cancer Institute, Inc., University of Notre Dame du Lac
    Inventors: Robert M. Williams, James E. Bradner, Dane Clausen, Olaf G. Wiest, Le Zhao, Christine Elizabeth Dunne
  • Anti-HIV peptides
    Patent number: 10538556
    Abstract: Simple ?-hairpin peptides in linear and cyclic form that specifically bind to HIV-1 Trans-Activation Response element (HIV-1 TAR), as well as compositions and use thereof are described.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: January 21, 2020
    Assignees: Colorado State University Research Foundation, University of Rochester
    Inventors: Brian R. McNaughton, David W. Crawford, Joseph E. Wedekind, Ivan A. Belashov
  • Soft tissue mimetics and thermoplastic elastomer hydrogels
    Patent number: 10532130
    Abstract: Provided herein is a soft tissue mimetic formed from a block copolymer hydrogel and methods of making such. The hydrogel comprises a glass formed from a dry blend of polystyrene-poly(ethylene oxide) diblock copolymer (SO) and polystyrene-poly(ethylene oxide)-polystyrene triblock copolymer (SOS) in a molar ratio from between 95:5 and 1:99 SO/SOS and a liquid medium at a concentration between about 32:1 and about 2:1 liquid medium/SO-SOS by weight. The soft tissue mimetic has a fatigue resistance to at least 500,000 compression cycles.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: January 14, 2020
    Assignee: Colorado State University Research Foundation
    Inventors: Travis S. Bailey, Kristine Fischenich, Jackson T. Lewis, Tammy Haut Donahue, Chen Guo
  • ADAPTIVE COUPLER FOR CALIBRATION OF ARBITRARILY SHAPED MICROPHONES
    Publication number: 20190394550
    Abstract: Accurate measurements of the sound pressure level require regular calibration of the microphone. Closed-coupler calibration devices are designed to work with laboratory and working standard microphones, but there are numerous microphones with dimensions that do not fit a standard coupler. For example, micro-electro-mechanical system microphones are very small and widely used due to their size, performance, and cost. Described herein is an acoustical coupler that can accommodate microphones of arbitrary cross-sectional shape. The coupler utilizes a flexible membrane that adapts to the shape of the microphone. In contrast to a rigid enclosure, the permeability of the membrane creates an open system that reduces the sensitivity to fit. The precision and accuracy of the device is demonstrated by calibrating a small, oddly shaped microphone using the substitution method.
    Type: Application
    Filed: April 22, 2019
    Publication date: December 26, 2019
    Applicant: Colorado State University Research Foundation
    Inventor: Daniel J. Mennitt
  • Compositions and methods for enhanced innate immunity
    Patent number: 10512687
    Abstract: The disclosed compositions and methods relate to an immunogenic composition that, in certain aspects, comprise cationic liposomes; a mixture of toll like receptor 3 (TLR3) and toll like receptor 9 (TLR9) ligands; and a cellular adhesion agent, and methods of using such compositions. In certain aspects, disclosed compositions are administered to a mammal to induce a non-specific innate immune response at mucosal surfaces. In further aspects, disclosed compositions are administered to a mammal in conjunction with an antigen to enhance the immune response of the mammal to the antigen.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: December 24, 2019
    Assignees: Colorado State University Research Foundation, The Regents of the University of Colorado, a body corporate
    Inventors: Steven Dow, Michael R. Lappin, William H. Wheat, Lyndah Chow, Daniel P. Regan, Thomas J. Anchordoquy
  • Use of peptide-based inhibitors of the stat3-IL10 pathway for treating bacterial infection and granulomatous disease
    Patent number: 10512673
    Abstract: The invention provides a method of treating pathogenic bacterial infection (e.g., tuberculosis infection) in an animal comprising administering a peptide-based inhibitor of the STAT3-IL10 pathway or a nucleic acid encoding the peptide-based inhibitor to the animal. The invention also provides methods of treating chronic granulomatous disease and Wegener's granulomatosis in an animal comprising administering a peptide-based inhibitor of the STAT3-IL10 pathway or a nucleic acid encoding the peptide-based inhibitor to the animal.
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: December 24, 2019
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Colorado State University Research Foundation
    Inventors: Nadya I. Tarasova, Mercedes Gonzalez-Juarrero