Abstract: The present invention relates to a method for the detection and/or quantification of Streptococcus pneumoniae, a Gram-positive bacteria that is an important human pathogen, in an isolated biological sample, through magneto-amperometric biosensors, comprising detecting fragments of lytA gene of the microorganism, amplified through PCR, preferably asymmetric PCR or direct asymmetric PCR, by hybridization thereof to a specific probe fully complementary to a region of the amplified fragment. Furthermore, the present invention also relates to the use of primers SEQ ID NO: 3 and 4 together with probes SEQ ID NO: 1 and/or SEQ ID NO: 2 to perform the detection. The biosensor developed to detect S. pneumoniae can be applied to different types of clinical samples from patients infected with this bacterium or other related bacteria. Preferably the clinical sample is an isolated biological fluid such as blood, cerebrospinal fluid, saliva or urine.

Abstract: The present invention relates to a compound material consisting of a natural zeolite having calcium as an exchangeable cation, in which hydroxyapatite on a nanometric scale is grown in a controlled manner on the surface thereof; to the method by which said compound material is obtained; and to the use thereof for removing fluoride from water in order to make same drinkable. As a result of the aforementioned special characteristics of hydroxyapatite crystals, said material has a very high intrinsic capacity (based on the weight of hydroxyapatite) for removing fluoride. This capacity, combined with the low cost and ease of access to the materials used for preparing same, and with the straightforward nature of the method, means that said material is the perfect candidate for removing fluoride from water having high levels of this contaminant.

Abstract: The invention relates to the use of the insulin-like growth factor (IGF-1) as a reagent for the early diagnosis and/or prognosis of Alzheimer disease, to a kit comprising IGF-1 and a sedative, and to the use thereof in the early diagnosis and/or prognosis of Alzheimer disease.

Abstract: The invention relates to a family of differently substituted benzothiazoles having inhibitory activity against casein kinase 1 (CK-1) enzyme, as a result of which they are suitable for use in the treatment or prevention of diseases caused by this enzyme, particularly diseases associated with circadian rhythm and inflammatory, autoimmune, psychiatric, neurodegenerative, neurological or ophthalmic diseases, as well as for inducing cell regeneration

Abstract: The present invention describes a refractive multifocal intraocular lens with aspheric geometry on both surfaces in such a way that the map of local optical strength of the lens, combined with the cornea, has a central region of intermediate optical strength surrounded by a ring of maximum optica! strength, with a smooth transition between the two, after which it alternates smoothly between rings of varying strengths.

Abstract: The invention concerns a method for producing a field effect transistor having a trench gate comprising:—the forming (110) of at least one trench (11, 12, 13) in a semi-conductive substrate (1) having a first type of conductivity, said substrate comprising two opposing faces called front face and rear face,—the primary implantation (120) of ions having a second type of conducitivity so as to implant each trench of the substrate to form an active gate area,—the depositing (160) of a layer of polycrystalline silicon having the second type of conductivity on the implanted active gate area,—the oxidation (160) of the layer of polycrystalline silicon, and—the metallisation (180) of the substrate on the front and rear faces of same in order to form active source and drain areas.

Abstract: The invention concerns an aerosol charger having electrical discharge comprising: •—a body (2); •—an ion source (3) comprising two electrodes (31, 32); the charger being characterised in that •—the body (2) and at least a first electrode (32) of the ion source (3) are aligned along a same axis of longitudinal symmetry (AA?) of the charger, the body (2) surrounding the first electrode (32) in such a way as to define an area (5) for an aerosol to flow between a space defined between the body (2) and the first electrode (32); and in that •—the first electrode (32) comprises a hole (321) in communication with the area (5) for the aerosol (Ae) to flow, the hole (321) being designed to allow ions formed at the ion source (3) to pass therethrough in order for them to mix with an aerosol (Ae) flowing in the area (5) for the aerosol (Ae) to flow.

Abstract: The present invention describes a procedure for the production of liquid fuel having a content high in alkanes and low in oxygenated compounds, comprising as a minimum: a first step of alkylation of 2-methylfuran (commonly denominated Sylvan) with a furan alcohol 2 having the formula: (2), wherein R1 is H or an aliphatic or aromatic or heteroaromatic moiety, R2 is H or an aliphatic or aromatic or heteroaromatic moiety, and R3 is H, hydroxymethyl or an aliphatic or aromatic or heteroaromatic moiety, in the presence of a catalyst, a second step of hydrogenation and dehydration of the compound obtained in step 1 in the presence of hydrogen, utilizing suitable hydrogenation and dehydration catalysts.

Abstract: A method for increasing drought tolerance in a plant or photosynthetic organism is provided, where the tolerance is increased by applying an effective amount of trimethylamine N-oxide (TMAO) or trimethylamine N-oxide di-hydrate, or a TMAO chemical derivative, or a TMAO chemical analog and thereof to a plant, seed or photosynthetic organism that has been exposed to or to be exposed to water stress conditions. Water stress tolerant plants or photosynthetic organisms produced through the application of trimethylamine N-oxide (TMAO) or trimethylamine N-oxide di-hydrate, or a TMAO chemical derivative, or a TMAO chemical analog to a plant or photosynthetic organism are also disclosed.

Abstract: The present invention relates to the use of non deactivable security markers comprising the combination of at least two types of nanoparticles of materials presenting Raman effect, wherein said nanoparticles are in a dispersed state or is forming agglomerates of between 2 and 500 nanoparticles. The invention also relates to security documents, articles or elements incorporating these markers, as well as to a method and system for the detection thereof.

Abstract: The present invention relates to heterocyclic substituted quinoline derivatives as allosteric inhibitors of the glycogen synthase kinase-3 (GSK-3) enzyme. Therefore, these compounds are useful for the manufacturing of a medicament designed for the treatment and/or prevention of diseases wherein GSK-3 is involved, such as neurodegenerative diseases, inflammatory diseases, cancer, diabetes, and to promote various regenerative processes.

Abstract: The present invention relates to the use of a series of quinazoline-derived compounds to produce a medicament for the treatment and/or prevention of neurological and/or neurodegenerative diseases, such as Parkinson's disease or Alzheimer's disease. The present invention also relates to a method for the treatment and/prevention of neurological and/neurodegenerative diseases comprising the administration of a therapeutically effective amount of said compounds.

Abstract: The subject of the present disclosure is a multilayer nanoparticular, mesoporous structure that has properties of a Bragg reflector or of a unidimensional photonic crystal in the ultraviolet, visible and infrared ranges close to the electromagnetic spectrum. The unidimensional photonic crystal is formed by laminae with different indices of refraction and of a controlled size, made up of nanoparticles, which can be deposited on different types of substrates using a simple and reliable method. The periodic alternating of laminae with different indices of refraction gives rise to a high reflection factor which can easily be observed with the naked eye and can be measured with a spectrophotometer. In contrast to other, dense, reflective structures, the mesoporous structure of this reflector allows the passage of liquids.

Abstract: The invention discloses a system for the simultaneous detection and/or quantification of various analytes in a sample or for the simultaneous detection and/or quantification of an analyte in various samples, comprising: a multi-electrode chip (10) comprising an array of microelectrodes (11a, 11b, 11c, 11d); a single-duct cell (20), comprising a groove (21) which accommodates the multi-electrode chip (10) and a duct (22) through which a fluid sample can sequentially flow through each of the microelectrodes (11a, 11b, 11c, 11d) of a multi-electrode chip (10) when the latter is inserted into the groove (21); and a multi-duct cell (30), comprising a groove (31) housing the multi-electrode chip (10) and several independent ducts (32a, 32b, 32c, 32d) through which several samples can pass independently through each electrode (11a, 11b, 11c, 11d) of the multi-electrode chip (10).

Abstract: Method for generating piecewise-affine multivariate functions, wherein the online computation of the search tree is performed in order to locate the input value in the polytopes of the partition, and the subsequent generation of the corresponding affine function. It also proposes a configurable and programmable device for generating piecewise-affine multivariate functions composed of an architecture with four functional blocks namely: a control unit block (1), a tree memory block, a parameter memory block and an arithmetic unit block; and it has at least three operating modes which can be selected using different values of a bus (config): writing of the tree memory, writing of the parameter memory and evaluating the affine function. It may include a fourth operating mode, which is the test mode.

Abstract: The invention relates to a method for obtaining membrane vesicles enriched in membrane transport proteins of plant origin, for cosmetic or therapeutic use, which can contain other substances, such as natural bioactive compounds. Preferably, said vesicles are obtained from plants of the Brassicaceae (cruciferae) family. In addition, the invention relates to a method for increasing these proteins of plant origin.

Abstract: Derivates of chromene of formula I, where the meanings for the various substituents are as indicated in the description. These compounds are useful as inhibitors of TCR-Nck interaction in T lymphocytes.

Abstract: An optical pulse generator and a method for using the same, where the optical pulse generator includes a source to deliver a chirped pulse and a chirped pulse compressor, and a first manipulation device and a second manipulation device capable of wavelength dependent manipulating the propagation direction of the chirped pulse and a focusing device having a predetermined focus point. The second manipulation device is arranged after the first manipulation device in propagation direction of the chirped pulse and the first and the second manipulation device are capable of manipulating the propagation direction of the chirped pulse such that the chirped pulse is transformed, after passing the second manipulation device, into a pulse, wherein different chromatic parts of the pulse are spatially spread and temporarily fully aligned.

Abstract: The invention relates to novel molecules that can modulate one of the mechanisms leading to the massive deposition of cholesterol in the cardiomyocytes and/or in the smooth muscle cells of the vascular wall, during acute myocardial infarction or other clinical situations involving ischaemia. The invention also shows that the blockage of LRP1 by means of certain agents, including a recombinant expression vector, an RNAi, an antibody, a siRNA etc., prevents the overaccumulation of esterified cholesterol in the cardiomyocytes and/or in the smooth muscle cells of the vascular wall exposed to ischaemia. The invention also relates to the use of said molecules in the treatment and/or prevention of the changes in the metabolism of calcium and cardiac remodeling associated with ischaemia.

Abstract: The invention relates to therapeutic compositions for the treatment of dry eye, more specifically to compositions comprising a TRPM8 receptor agonist ligand. Furthermore, the invention relates to therapeutic compositions for the treatment of epiphora, more specifically to compositions comprising a TRPM8 receptor antagonist.