Abstract: The present invention relates to a class of novel pradimicins and analogues and derivatives thereof, including the compounds of formula A, I and 111, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof and their use to treat or prevent kinetoplastid infections and their use to manufacture a medicine to treat or prevent kinetoplastid infections, particularly infections with trypanosoma and leishmania, such as Trypanosoma brucei, Trypanosoma cruzi and Leischmania donovani. wherein Ra, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the claim 1 or as described in detail in the description of the invention. The present invention also relates to pharmaceutical compositions of said compounds and the use of said pharmaceutical compositions to treat or prevent kinetoplastid infections.

Abstract: Methods of producing transgenic photosynthetic organisms and plants overexpressing an FMO protein are disclosed. The disclosure also relates to transgenic photosynthetic organisms and plants having between 4 and 37 fold greater expression of an FMO protein compared to wild-type plants, wherein said transgenic photosynthetic organisms and plants have between 1.1 and 3.4 fold greater trimethylamine N-oxide compared to wild-type, and wherein said transgenic photosynthetic organisms plants are drought tolerant. The disclosure further relates to DNA constructs and methods of producing DNA constructs having a promoter operably linked to one or more FMO protein coding sequences. The disclosure further relates to methods of producing drought tolerant plants and photosynthetic organisms by applying an effective amount of trimethylamine N-oxide di-hydrate.

Abstract: The invention relates to a method for producing liquid fuel having a high alkane content and a low oxygenized compound content, said method comprising at least: a first step of treating 2-methylfuran with a catalyst and water in reaction conditions in order to form a mixture of products with at least ten carbon atoms; and a second step of catalytic hydrogenation and dehydration of the product or the mixture obtained in step 1, using suitable hydrogenation and dehydration catalysts.

Abstract: The invention relates to methods for increasing total lysine content in plants and plant products and related uses.

Abstract: The invention relates to a sunflower oil with high heat stability, which is characterized in that between 15% and 45% of the fatty acid total are saturated fatty acids (palmitic acid and stearic acid), between 45% and 75% of the fatty acid total is oleic acid and more than 85% of the tocopherol total corresponds to the sum of gamma-tocopherol and delta-tocopherol. The invention also relates to sunflower seeds that contain an oil with the aforementioned characteristics and sunflower plants which as a result of self-pollination produce seeds with the aforementioned characteristics. In addition, the invention relates to the use of said oil in food and animal feed and for the formulation of biolubricants and biofuels.

Abstract: The present invention relates to a family of differently substituted oxazolidinones and to the pharmaceutically acceptable salts, esters, prodrugs, tautomers, solvates and hydrates thereof, which show affinity for the alpha and gamma subtypes of the peroxisome proliferator-activated receptors (PPAR) and which, therefore, modulate the actions regulated by said receptors, such as inducing satiety, controlling ingestion and modulating metabolic effects, and thus are useful for the administration thereof as a pharmacological tool and as drugs for the treatment and/or prevention of metabolic diseases and cardiovascular diseases.

Abstract: The present invention relates to a method of identifying peptides and proteins from mass spectrometry data using multiple search engines, wherein: a) the scores calculated on each engine are modeled; b) the presence of matching parameters is included, c) the distribution of meta-scores using distribution functions is modeled, d) scores of peptide and precursor protein are built. Among the main advantages of the invention it is worth mentioning its flexibility to be applied to an arbitrary number of engines, the use of matching parameters that add additional information not available with a single engine, the increase in the number of peptides-proteins identified or its versatility to incorporate other additional sources of information, depending on the type of experiment being examined.

Abstract: The present invention relates to a negative electrode material for a sodium ion battery, and to a method for producing it. The active material of the electrode material is composed of an oxide with a structure corresponding to the layered structure of the compound Na2Ti3O7, said oxide conforming to the formula NaxTi(IV)aTi(III)bMcO7 (A), in which x denotes the number of Na+ ions inserted between the layers, per Ti3O7 structural unit, with 0<x?5; Ti(IV) and Ti(III) represent titanium in the oxidation states IV and III, respectively; M represents one or more elements selected from 3d transition metals and 4d transition metals; the values of x, a, b and c are such that the compound is electronically neutral in view of the oxidation state of the element or elements represented by M; and the ratio (a+b)/c is greater than 0.5. The electrode material is obtained by electrochemical reduction of an oxide Nax?Ti(IV)a?McO7(B).

Abstract: A device and method for the hardware detection of local edges in an image, comprised of a plurality of elemental cells for mixed signal processing, locally interconnected with each other, comprising in each cell a first switch configured to enable the pre-charging of a condenser at the supply voltage; and where once said condenser is pre-charged, it discharges via a second switch connected to a power source which varies in a monotonically increasing manner with the analog voltage representing the value of the pixel concerned; and where the value of the pixel is compared asynchronously with the neighboring pixels of the neighboring cells via two inverters, a digital NOR gate, a digital NAND gate, a third and fourth switch and a memory feature to store the result.

Abstract: The present invention relates to a method for the detection and/or quantification of Streptococcus pneumoniae, a Gram-positive bacteria that is an important human pathogen, in an isolated biological sample, through magneto-amperometric biosensors, comprising detecting fragments of lytA gene of the microorganism, amplified through PCR, preferably asymmetric PCR or direct asymmetric PCR, by hybridization thereof to a specific probe fully complementary to a region of the amplified fragment. Furthermore, the present invention also relates to the use of primers SEQ ID NO: 3 and 4 together with probes SEQ ID NO: 1 and/or SEQ ID NO: 2 to perform the detection. The biosensor developed to detect S. pneumoniae can be applied to different types of clinical samples from patients infected with this bacterium or other related bacteria. Preferably the clinical sample is an isolated biological fluid such as blood, cerebrospinal fluid, saliva or urine.

Abstract: The present invention relates to a compound material consisting of a natural zeolite having calcium as an exchangeable cation, in which hydroxyapatite on a nanometric scale is grown in a controlled manner on the surface thereof; to the method by which said compound material is obtained; and to the use thereof for removing fluoride from water in order to make same drinkable. As a result of the aforementioned special characteristics of hydroxyapatite crystals, said material has a very high intrinsic capacity (based on the weight of hydroxyapatite) for removing fluoride. This capacity, combined with the low cost and ease of access to the materials used for preparing same, and with the straightforward nature of the method, means that said material is the perfect candidate for removing fluoride from water having high levels of this contaminant.

Abstract: The invention relates to the use of the insulin-like growth factor (IGF-1) as a reagent for the early diagnosis and/or prognosis of Alzheimer disease, to a kit comprising IGF-1 and a sedative, and to the use thereof in the early diagnosis and/or prognosis of Alzheimer disease.

Abstract: The invention relates to a family of differently substituted benzothiazoles having inhibitory activity against casein kinase 1 (CK-1) enzyme, as a result of which they are suitable for use in the treatment or prevention of diseases caused by this enzyme, particularly diseases associated with circadian rhythm and inflammatory, autoimmune, psychiatric, neurodegenerative, neurological or ophthalmic diseases, as well as for inducing cell regeneration

Abstract: The present invention describes a refractive multifocal intraocular lens with aspheric geometry on both surfaces in such a way that the map of local optical strength of the lens, combined with the cornea, has a central region of intermediate optical strength surrounded by a ring of maximum optica! strength, with a smooth transition between the two, after which it alternates smoothly between rings of varying strengths.

Abstract: The invention concerns a method for producing a field effect transistor having a trench gate comprising:—the forming (110) of at least one trench (11, 12, 13) in a semi-conductive substrate (1) having a first type of conductivity, said substrate comprising two opposing faces called front face and rear face,—the primary implantation (120) of ions having a second type of conducitivity so as to implant each trench of the substrate to form an active gate area,—the depositing (160) of a layer of polycrystalline silicon having the second type of conductivity on the implanted active gate area,—the oxidation (160) of the layer of polycrystalline silicon, and—the metallisation (180) of the substrate on the front and rear faces of same in order to form active source and drain areas.

Abstract: The invention concerns an aerosol charger having electrical discharge comprising: •—a body (2); •—an ion source (3) comprising two electrodes (31, 32); the charger being characterised in that •—the body (2) and at least a first electrode (32) of the ion source (3) are aligned along a same axis of longitudinal symmetry (AA?) of the charger, the body (2) surrounding the first electrode (32) in such a way as to define an area (5) for an aerosol to flow between a space defined between the body (2) and the first electrode (32); and in that •—the first electrode (32) comprises a hole (321) in communication with the area (5) for the aerosol (Ae) to flow, the hole (321) being designed to allow ions formed at the ion source (3) to pass therethrough in order for them to mix with an aerosol (Ae) flowing in the area (5) for the aerosol (Ae) to flow.

Abstract: The present invention describes a procedure for the production of liquid fuel having a content high in alkanes and low in oxygenated compounds, comprising as a minimum: a first step of alkylation of 2-methylfuran (commonly denominated Sylvan) with a furan alcohol 2 having the formula: (2), wherein R1 is H or an aliphatic or aromatic or heteroaromatic moiety, R2 is H or an aliphatic or aromatic or heteroaromatic moiety, and R3 is H, hydroxymethyl or an aliphatic or aromatic or heteroaromatic moiety, in the presence of a catalyst, a second step of hydrogenation and dehydration of the compound obtained in step 1 in the presence of hydrogen, utilizing suitable hydrogenation and dehydration catalysts.

Abstract: A method for increasing drought tolerance in a plant or photosynthetic organism is provided, where the tolerance is increased by applying an effective amount of trimethylamine N-oxide (TMAO) or trimethylamine N-oxide di-hydrate, or a TMAO chemical derivative, or a TMAO chemical analog and thereof to a plant, seed or photosynthetic organism that has been exposed to or to be exposed to water stress conditions. Water stress tolerant plants or photosynthetic organisms produced through the application of trimethylamine N-oxide (TMAO) or trimethylamine N-oxide di-hydrate, or a TMAO chemical derivative, or a TMAO chemical analog to a plant or photosynthetic organism are also disclosed.

Abstract: The present invention relates to heterocyclic substituted quinoline derivatives as allosteric inhibitors of the glycogen synthase kinase-3 (GSK-3) enzyme. Therefore, these compounds are useful for the manufacturing of a medicament designed for the treatment and/or prevention of diseases wherein GSK-3 is involved, such as neurodegenerative diseases, inflammatory diseases, cancer, diabetes, and to promote various regenerative processes.

Abstract: The present invention relates to the use of non deactivable security markers comprising the combination of at least two types of nanoparticles of materials presenting Raman effect, wherein said nanoparticles are in a dispersed state or is forming agglomerates of between 2 and 500 nanoparticles. The invention also relates to security documents, articles or elements incorporating these markers, as well as to a method and system for the detection thereof.