Patents Assigned to Consejo Superior De Investigaciones Cientificas
  • Publication number: 20230358758
    Abstract: In the present invention, we herein generally provide an in vitro method for detecting in at least one biological sample an antibody that binds to at least one epitope of the SARS-CoV-2 virus, comprising contacting said at least one biological sample with at least one isolated SARS-CoV-2 Mpro protein, or at least one fragment of said isolated SARS-CoV-2 Mpro protein comprising at least one epitope of the SARS-CoV-2 virus, and detecting the formation of an antigen-antibody complex between said virus protein or said fragment and an antibody present in said biological sample.
    Type: Application
    Filed: June 8, 2021
    Publication date: November 9, 2023
    Applicant: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)
    Inventors: Hugh Thomson REYBURN, María Del Mar VALÉS GÓMEZ, José Miguel RODRÍGUEZ FRADE, José María CASASNOVAS SUELVES
  • Patent number: 11808673
    Abstract: Disclosed are apparatus and methods for sampling air-borne particles. According to one embodiment a nozzle is used to generate a jet of fog that includes a gas and liquid droplets of different sizes. The jet of fog is formed by the nozzle in a way to cause particles in the air surrounding the jet of fog to be drawn into the jet of fog and to further cause the particles to aggregate with the liquid droplets inside the jet of fog. A sample collecting surface is located opposite and spaced apart from an outlet of the nozzle. The sample collecting surface is preferably sloped so that the liquid sample can be forced by gravity off the collecting surface and into a vial or other liquid sample container. Inside the jet of fog and on the sample collection surface the liquid droplets merge with one another to form larger sized droplets that are collectable in the liquid sample container.
    Type: Grant
    Filed: March 4, 2022
    Date of Patent: November 7, 2023
    Assignees: COUNTERFOG CORPORATION, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS
    Inventors: José Luis Pérez Díaz, Antonio Alcamí Pertejo
  • Patent number: 11796579
    Abstract: An electromagnetic sensor for use in a variety of applications requiring extremely high sensitivity, such as measuring power and characteristics of incident electromagnetic radiation includes a superconducting layer that carries an exchange field for providing a spin splitting effect of charge carriers in the superconducting layer, a metal electrode, and an insulating layer arranged between the superconducting layer and metal electrode to form a spin filter junction therebetween. The electromagnetic sensor provides an antenna including a wave collecting element, in contact with the superconducting layer to convey thereinto external electromagnetic waves that are generated by an external source.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: October 24, 2023
    Assignees: UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA, AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS, UNIVERSITY OF JYVÄSKYLÄ
    Inventors: Fernando Sebastian Bergeret Sbarbaro, Francesco Giazotto, Tero Heikkilä, Ilari Maasilta
  • Patent number: 11796689
    Abstract: A device for detecting photons and charged particles includes a first photon-detecting panel, which causes a Compton scattering of incident radiation with charged particles, such that the wavelength thereof increases, losing part of their energy, generating a signal. A central charged particle-detecting panel, following the first photon-detecting panel on a side opposite that of the incident radiation, identifies charged particles generated in the first photon-detecting panel, generating a signal. A second photon-detecting panel, follows the central charged particle-detecting panel on a side opposite that of the first photon-detecting panel. Scattered photons and/or charged particles are generated in the first photon-detecting panel interact, generating a signal.
    Type: Grant
    Filed: November 4, 2020
    Date of Patent: October 24, 2023
    Assignees: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS, UNIVERSITAT DE VALENCIA
    Inventors: Gabriela Dolores Llosá Llácer, Carlos Lacasta Llácer, John Barrio Toala
  • Patent number: 11747194
    Abstract: The photomultiplier includes a set of macrocells, each comprising at least two microcells, each being connected to an output node according to an OR diagram, and achieving great energy efficiency upon deactivating each of the microcells when these are activated almost simultaneously, and that otherwise would have been masked by the OR diagram. To this end, each of the microcells comprises an active quenching and recharge circuit; an avalanche diode; a first deactivation transistor with its gate connected to an external processor, and its drain and source associated with the active quenching and recharge circuit; a second deactivation transistor with its gate connected to an external processor, and its source associated with the active quenching and recharge circuit.
    Type: Grant
    Filed: February 11, 2021
    Date of Patent: September 5, 2023
    Assignees: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), UNIVERSIDAD DE SEVILLA
    Inventors: Ion Vornicu, Ricardo Carmona Galán, Ángel Rodríguez Vázquez
  • Publication number: 20230274451
    Abstract: A method estimates a full shape of a crystalline lens from measurements of the lens taken in-vivo by optical imaging techniques and include visible portions of the lens. The method includes receiving the in-vivo measurements of the lens, determining non-visible portions of the lens parting from the in-vivo measurements. Determining non-visible portions of the lens includes establishing a location of points which define an initial full shape of a crystalline lens, displacing these points by lengths following a directions to a location of a second set of points, which are estimated points of the full shape of the lens. The initial full shape of a crystalline lens is obtained from ex-vivo measurements and the lengths is estimated from the in-vivo measurements. A further method selects an intraocular lens implantable in an eye. Yet further, a data-processing system configured to determines a full shape of a crystalline lens.
    Type: Application
    Filed: May 10, 2021
    Publication date: August 31, 2023
    Applicant: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS
    Inventors: Eduardo MARTÍNEZ ENRÍQUEZ, Susana MARCOS CELESTINO
  • Patent number: 11730707
    Abstract: The invention relates to the use of a selective ?2 adrenergic receptor antagonist for treating and preventing a tumor in a patient with von Hippel-Lindau syndrome. In particular, the invention relates to the use of an alkanolamine derivative or a pharmaceutically acceptable acid-addition salt thereof for treating and preventing a hemangioblastoma in VHL syndrome patients.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: August 22, 2023
    Assignees: ALIANZA ESPAÑOLA DE FAMILIAS DE VON HIPPEL-LINDAU-VHL, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS
    Inventors: Luisa María Botella Cubells, Virginia Albiñana Díaz, Karina Villar Gomez-De Las Heras
  • Publication number: 20230241365
    Abstract: A wearable device for transdermal product supply comprises a head, which houses two ultrasonic resonators in resonance, with an outer cavity. A first, more distal resonator emits towards the skin at a first frequency and a second, more proximal resonator surrounds the cavity and emits parallel to the skin at a second frequency. One frequency is high-frequency sonophoresis (HFS) and the other is low-frequency sonophoresis (LFS). The second resonator comprises a hole in order to enable the waves from the first resonator to pass through. The waves from the second resonator pass through the head, the hole and the cavity, bouncing off an opposite area of the head and interfering with the waves from the first resonator. The interference between the waves creates a stationary field which increases the permeability of the skin, enabling a device with a reduced size to be incorporated into a wearable.
    Type: Application
    Filed: April 12, 2021
    Publication date: August 3, 2023
    Applicants: Medicsensors Limited, Agencia Estatal Consejo Superior de Investigaciones Cientificas, M.P.
    Inventors: Eduardo Walther Jorgensen de Vizacarrondo, Jose Carlos Montesinos Perez, Juan Cesar de Mercado Santamarta, Francisco Ramon Montero de Espinosa Freijo
  • Patent number: 11707515
    Abstract: The present application provides a modified Brucella strain, its use as a medicament, and its use as a medicament for the treatment and/or prevention of brucellosis. The Brucella strain has been modified through an inactivation of the wzm gene. Further, the present application provides a pharmaceutical composition which comprises the modified Brucella strain, its use as a medicament, and its use as a medicament for the treatment and/or prevention of brucellosis. The present application also provides a kit which comprises the modified Brucella strain and a pharmaceutically acceptable carrier or diluent and its use for the treatment and/or prevention of brucellosis.
    Type: Grant
    Filed: March 4, 2022
    Date of Patent: July 25, 2023
    Assignees: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC), UNIVERSIDAD PÚBLICA DE NAVARRA
    Inventors: María Jesús Grilló Dolset, Beatriz San Román Aberasturi, Leyre Palacios Chaves, Sara Mena Bueno, Ana Zabalza Baranguá
  • Patent number: 11696537
    Abstract: The present invention relates to a composition comprising methyl jasmonate and a polysiloxane polyether for increasing the content of glucosinolates in adult plants of the genus Brassica, for example, broccoli. By means of foliar application of the composition on adult plants having a developed cuticle, a significant increase is achieved in the concentrations of glucosinolates (mainly glucoraphanin and neoglucobrassicin), in the floret of the plants, without degrading the organoleptic properties thereof.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: July 11, 2023
    Assignees: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), SAKATA SEED IBERICA, S.L.U.
    Inventors: Micaela Carvajal Alcaraz, Diego A. Moreno Fernandez, Juan Jose Rios Ruiz, Javier Bernabeu Durá, Agatha Agudelo Sanchez
  • Patent number: 11672244
    Abstract: Disclosed is an insect repulsion and/or barrier system (10) and a method for repelling insects (2) and/or for preventing insects (2) from passing through a defined opening (12) or surface (9). The barrier system (10) is equipped with devices (16) for preventing insects from passing through an opening (12) or for repelling insects when approaching the opening (12) and/or the devices (16). The devices (16) have at least two electrodes (18), whereby different electrical potentials are applied to or can be applied to the at least two electrodes (18). The at least two electrodes (18) are arranged within or on the edge of or outside the opening such that an electrical field (28) is formed between the at least two electrodes (18). The electrical field (28) rejects and/or repels insects approaching the electrical field (28) or prevents insects approaching the electrical field (28) from passing through the opening (12).
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: June 13, 2023
    Assignees: Biogents AG, Agencia Consejo Superior de Investigaciones Científicas (CSIC), Instituto de Salud Global Barcelona (ISGlobal)
    Inventors: Andreas Rose, Farooq Tanveer, Elies Molins, Krijn Paaijmans, Berta Domènech Garcia
  • Patent number: 11644612
    Abstract: The invention relates to a waveguide and a polarisation splitter based on said waveguide, in which a rotation of an angle greater than zero is applied to a plurality of sections of a core material and a plurality of sections of a covering material, thereby achieving an independent control of the refractive indices of a zero-order transverse electric mode and a zero-order transverse magnetic mode. This document also describes a manufacturing method of said waveguide which allows the birefringence of the light that passes through the waveguide.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: May 9, 2023
    Assignees: UNIVERSIDAD DE MALAGA, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
    Inventors: Robert Halir, Jose Manuel Luque Gonzalez, Alaine Herrero Bermello, Alejandro Ortega Monux, Inigo Molina Fernandez, Juan Gonzalo Wanguemert Perez, Aitor Villafranca Velasco
  • Publication number: 20230116496
    Abstract: A modular artificial neural sensing system includes a hierarchical network of neural sensing units including a neuromimetic sensor array of artificial sensory synapses and sensory neurons for receiving physicochemical sensed signals and for outputting sensor output signals. An artificial neural network processor is adapted for processing the sensor output signals and includes processor neurons interconnected by processor synapses forming first connections and second connections. The processor outputs processor output signals. A first sensor interface feeds processed or unprocessed sensed signals into the processor. A second sensor interface receives output predicted signals from other neural sensing units and feeds processed or unprocessed output predicted signals into the processor. A signal decoder decodes the processor output signals and outputs decoder output signals.
    Type: Application
    Filed: January 21, 2021
    Publication date: April 13, 2023
    Applicants: UNIVERSITÄT ZÜRICH, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS
    Inventors: Josep Maria MARGARIT TAULÉ, Shih-Chii LIU, Cecilia JIMÉNEZ JORQUERA
  • Patent number: 11603810
    Abstract: The invention relates to an internal combustion engine that comprises a first Brayton cycle comprising a mixed ionic-electronic conducting (MIEC) membrane that separates the O2 from the air such that the suctioned air current is free from N2; a second Brayton cycle combined in a binary manner with the first Brayton cycle and nested with a cycle selected from an Otto cycle and a diesel cycle performed by means of oxy-combustion. The second Brayton cycle transmits mechanical energy and thermal energy from exhaust gases to the first Brayton cycle. The first Brayton cycle provides to the second Brayton cycle compressed O2 from the MIEC membrane. By means of the present engine, the NOx emission into the atmosphere is prevented by the separation of N2 in the MIEC membrane.
    Type: Grant
    Filed: March 21, 2020
    Date of Patent: March 14, 2023
    Assignees: UNIVERSITAT POLITÉCNICA DE VALÉNCIA, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC)
    Inventors: Francisco José Arnau Martínez, Jesús Vicente Benajes Calvo, David Catalán Martínez, José María Desantes Fernández, Luis Miguel García-Cuevas González, José Manuel Serra Alfaro, José Ramón Serrano Cruz
  • Patent number: 11588149
    Abstract: In a method of preparing an immobilized selenium system or body, a selenium-carbon-oxygen mixture is formed. The mixture is then heated to a temperature above the melting temperature of selenium and the heated mixture is then cooled to ambient or room temperature, thereby forming the immobilized selenium system or body.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: February 21, 2023
    Assignees: II-VI DELAWARE, INC., CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CISC)
    Inventors: Wen-Qing Xu, Xiaoming Li, Shailesh Patkar, Elgin E. Eissler, Marta Sevilla Solis, Antonio Benito Fuertes Arias
  • Publication number: 20230035094
    Abstract: Procedure for the generation of a reflex tear secretion, which comprises the chemical stimulation of the cornea of the eye of a subject by applying a controlled jet of a gas with a high CO2 content, of at least 80% of CO2. Compact device (1,1?) for the generation of a reflex tear secretion, comprising a gas source (7) in the form of a disposable type cartridge containing a pressurized gas with a composition of at least 80% of CO2; and a pneumatic circuit connecting an outlet mouth of said gas source (7) with a gas outlet nozzle (3) of the device (1,1?), the circuit comprising pressure regulation means (8) and flow rate (17) regulation means suitable for ejecting puffs of gas through the outlet nozzle (3) at a predetermined pressure and flow rates.
    Type: Application
    Filed: December 30, 2020
    Publication date: February 2, 2023
    Applicants: UNIVERSIDAD MIGUEL HERNÁNDEZ DE ELCHE (UNH), CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS
    Inventors: Carlos BELMONTE MARTÍNEZ, Juana GALLAR MARTÍNEZ, Maria Carmen ACOSTA BOJ, Maria Luisa MERINO SUÁREZ
  • Publication number: 20230009041
    Abstract: The disclosure relates to recombinant vectors and methods for using the same. In certain embodiments, the recombinant vectors are immunogenic.
    Type: Application
    Filed: April 28, 2022
    Publication date: January 12, 2023
    Applicants: Arizona Board of Regents, a body corporate of the State of Arizona acting for and on behalf of, Consejo Superior De Investigaciones Cientificas, IPPOX Foundation
    Inventors: Giuseppe Pantaleo, Thierry Calandra, Alexandre Harari, Thierry Roger, Mariano Esteban, Bertram Jacobs, Karen Kibler, Cornelius Melief, Rafick-Pierre Sekaly, Elias Haddad, James Tartaglia
  • Patent number: 11518802
    Abstract: The invention relates to monoclonal antibodies, in particular against a peptide of the BAMBI protein, as well as the uses thereof and methods comprising same. Preferably, the antibodies are used for the treatment of autoimmune diseases.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: December 6, 2022
    Assignees: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), UNIVERSIDAD DE CANTABRIA
    Inventors: Jesús Merino Pérez, Ramón Merino Pérez
  • Patent number: 11489157
    Abstract: The present invention relates to a calcium-based secondary cell containing: an electrolyte arranged between the negative electrode and the positive electrode and comprising a calcium salt of a fluorine-containing anion of formula (XFn)m? wherein n is a positive integer of at most 6 and m is a positive integer of at least 1 and m<n, a positive-electrode active material at the positive electrode which is a one-dimensional structure accommodating Ca2+ ions and has the formula (1): Can+2Me1(n+1)?y?zMe2yMe3zO3n+3??(1) wherein: Me1, Me2, Me3 are different transition metals; 1?n and n is not necessarily an integer; 0?y and y is not necessarily an integer; 0?z and z is not necessarily an integer.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: November 1, 2022
    Assignees: TOYOTA MOTOR EUROPE, AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
    Inventors: Fanny Barde, Maria Rosa Palacin, Deyana Stoytcheva, Alexandre Ponrouch, Carlos Frontera
  • Patent number: 11486884
    Abstract: The invention relates to methods for the diagnosis of ischemia or ischemic tissue damage, methods for predicting the progression of ischemia in a patient having suffered an ischemic event, for determining the prognosis of a patient having suffered an ischemic event and for determining the risk that a patient suffering from stable coronary disease suffers a recurrent ischemic event based on the detection of the levels of glycosylated Apo J. The invention relates as well to a method for the determination of glycosylated Apo J in a sample.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: November 1, 2022
    Assignees: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS, FUNDACIÓ INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SAINT PAU
    Inventors: Lina Badimon Maestro, Judit Cubedo Ràfols, Teresa Padró Capmany