Abstract: An apparatus and a method using no switching elements for multiplexing and reading arrays of sensors whose electrical resistance is modulated by the signals to be measured are proposed. Sensor elements are arranged in groups and columns where each column is fed with a continuous voltage waveform of different amplitude, frequency and phase characteristics which then produce current signals that are modulated by the variable resistance signals to be measured. Modulated currents are summed row-wise and collected at the read-out circuits, either by applying a constant voltage to each row of the array or by connecting a capacitor and converting these current summations into output voltage signals. The read-out circuits de-multiplex each individual sensor signal to be measured by lock-in demodulation according to the frequencies and phases employed for the stimulation of each column.

Abstract: A method for controlled production of an array of planar microparticles with the multiplexing of molecules on the surface thereof, intended to function as molecular sensors and/or actuators and a matrix (array) of microparticles, the surface thereof being printed with all of the molecular components required to provide the surface with functionality. Different molecular elements are multiplexed on the surface of each particle while they are supported on a substrate by means of a structural foot engraved below the particle. These microparticles can be released mechanically from the support on which they are produced using a controlled mechanical rupture method which is not chemically aggressive and therefore does not affect the molecules previously printed on the surface. The array and the particles contained therein offer great versatility in both chemical and/or biological applications.

Abstract: The present invention relates to a series of compounds having a structural benzothiazole-benzamide core with capacity to inhibit the LRRK2 enzyme, due to which the invention also relates to the use of these compounds for treating neurodegenerative diseases in which this enzyme is involved, such as Parkinson's Disease or Alzheimer's Disease.

Abstract: The present invention relates to a dynamic chemical network that mimics the transfer of information and ultimately produces a chemical response, for example a readable signal. More specifically, the invention discloses a dynamic system able to selectively sense a biologically-relevant analyte, such as cysteine, in its reduced or its oxidized form (cystine) in aqueous media and in a biofluid (such as urine) for diagnostic application. Due to this property, said dynamic system is useful for the detection of cysteine or its derivatives in biological fluids such as urine.

Abstract: A chemiresistive sensor has a low limit for detecting NO2 at ambient temperature. An active layer of the sensor includes a few-layer graphene material. The response of the sensor is not altered by relative humidity, and the sensor also demonstrates very low interference with ammonia, allowing this interference to be disregarded in the measurements.

Abstract: The invention relates to methods and compositions for treatment of IL13R?2-overexpressing cancer, wherein the treatment comprises administering a protein tyrosine phosphatase-1B (PTP1B) inhibitor.

Abstract: The present invention relates to methods for producing wheat lines that are low gliadin, low-gluten and transgene-free using genome editing. Also described are nucleic acid constructs and sgRNA molecules for use in genome editing, as well as genetically altered plants obtained by these methods.

Abstract: In a method of preparing an immobilized selenium system or body, a selenium-carbon-oxygen mixture is formed. The mixture is then heated to a temperature above the melting temperature of selenium and the heated mixture is then cooled to ambient or room temperature, thereby forming the immobilized selenium system or body.

Abstract: The present invention relates to a method for producing mixtures of hydrocarbons and aromatic compounds, for use as fuel components (preferably in the range C5-C16), by means of catalytic conversion of the oxygenated organic compounds contained in aqueous fractions derived from biomass treatments, wherein said method can comprise at least the following steps: (i) bringing the aqueous mixture containing the oxygenated organic compounds derived from biomass in contact with a catalyst comprising at least Sn and Nb, Sn and Ti, and combinations of Sn, Ti and Nb; (ii) reacting the mixture with the catalyst in a catalytic reactor at temperatures between 100 and 350° C. and under pressures from 1 to 80 bar in the absence of hydrogen; and (iii) recovering the products obtained by means of the liquid/liquid separation of the aqueous and organic phases.

Abstract: In the present invention, we herein generally provide an in vitro method for detecting in at least one biological sample an antibody that binds to at least one epitope of the SARS-CoV-2 virus, comprising contacting said at least one biological sample with at least one isolated SARS-CoV-2 Mpro protein, or at least one fragment of said isolated SARS-CoV-2 Mpro protein comprising at least one epitope of the SARS-CoV-2 virus, and detecting the formation of an antigen-antibody complex between said virus protein or said fragment and an antibody present in said biological sample.

Abstract: Disclosed are apparatus and methods for sampling air-borne particles. According to one embodiment a nozzle is used to generate a jet of fog that includes a gas and liquid droplets of different sizes. The jet of fog is formed by the nozzle in a way to cause particles in the air surrounding the jet of fog to be drawn into the jet of fog and to further cause the particles to aggregate with the liquid droplets inside the jet of fog. A sample collecting surface is located opposite and spaced apart from an outlet of the nozzle. The sample collecting surface is preferably sloped so that the liquid sample can be forced by gravity off the collecting surface and into a vial or other liquid sample container. Inside the jet of fog and on the sample collection surface the liquid droplets merge with one another to form larger sized droplets that are collectable in the liquid sample container.

Abstract: A device for detecting photons and charged particles includes a first photon-detecting panel, which causes a Compton scattering of incident radiation with charged particles, such that the wavelength thereof increases, losing part of their energy, generating a signal. A central charged particle-detecting panel, following the first photon-detecting panel on a side opposite that of the incident radiation, identifies charged particles generated in the first photon-detecting panel, generating a signal. A second photon-detecting panel, follows the central charged particle-detecting panel on a side opposite that of the first photon-detecting panel. Scattered photons and/or charged particles are generated in the first photon-detecting panel interact, generating a signal.

Abstract: An electromagnetic sensor for use in a variety of applications requiring extremely high sensitivity, such as measuring power and characteristics of incident electromagnetic radiation includes a superconducting layer that carries an exchange field for providing a spin splitting effect of charge carriers in the superconducting layer, a metal electrode, and an insulating layer arranged between the superconducting layer and metal electrode to form a spin filter junction therebetween. The electromagnetic sensor provides an antenna including a wave collecting element, in contact with the superconducting layer to convey thereinto external electromagnetic waves that are generated by an external source.

Abstract: The photomultiplier includes a set of macrocells, each comprising at least two microcells, each being connected to an output node according to an OR diagram, and achieving great energy efficiency upon deactivating each of the microcells when these are activated almost simultaneously, and that otherwise would have been masked by the OR diagram. To this end, each of the microcells comprises an active quenching and recharge circuit; an avalanche diode; a first deactivation transistor with its gate connected to an external processor, and its drain and source associated with the active quenching and recharge circuit; a second deactivation transistor with its gate connected to an external processor, and its source associated with the active quenching and recharge circuit.

Abstract: A method estimates a full shape of a crystalline lens from measurements of the lens taken in-vivo by optical imaging techniques and include visible portions of the lens. The method includes receiving the in-vivo measurements of the lens, determining non-visible portions of the lens parting from the in-vivo measurements. Determining non-visible portions of the lens includes establishing a location of points which define an initial full shape of a crystalline lens, displacing these points by lengths following a directions to a location of a second set of points, which are estimated points of the full shape of the lens. The initial full shape of a crystalline lens is obtained from ex-vivo measurements and the lengths is estimated from the in-vivo measurements. A further method selects an intraocular lens implantable in an eye. Yet further, a data-processing system configured to determines a full shape of a crystalline lens.

Abstract: The invention relates to the use of a selective ?2 adrenergic receptor antagonist for treating and preventing a tumor in a patient with von Hippel-Lindau syndrome. In particular, the invention relates to the use of an alkanolamine derivative or a pharmaceutically acceptable acid-addition salt thereof for treating and preventing a hemangioblastoma in VHL syndrome patients.

Abstract: The invention relates to a waveguide and a polarisation splitter based on said waveguide, in which a rotation of an angle greater than zero is applied to a plurality of sections of a core material and a plurality of sections of a covering material, thereby achieving an independent control of the refractive indices of a zero-order transverse electric mode and a zero-order transverse magnetic mode. This document also describes a manufacturing method of said waveguide which allows the birefringence of the light that passes through the waveguide.

Abstract: A wearable device for transdermal product supply comprises a head, which houses two ultrasonic resonators in resonance, with an outer cavity. A first, more distal resonator emits towards the skin at a first frequency and a second, more proximal resonator surrounds the cavity and emits parallel to the skin at a second frequency. One frequency is high-frequency sonophoresis (HFS) and the other is low-frequency sonophoresis (LFS). The second resonator comprises a hole in order to enable the waves from the first resonator to pass through. The waves from the second resonator pass through the head, the hole and the cavity, bouncing off an opposite area of the head and interfering with the waves from the first resonator. The interference between the waves creates a stationary field which increases the permeability of the skin, enabling a device with a reduced size to be incorporated into a wearable.

Abstract: The present application provides a modified Brucella strain, its use as a medicament, and its use as a medicament for the treatment and/or prevention of brucellosis. The Brucella strain has been modified through an inactivation of the wzm gene. Further, the present application provides a pharmaceutical composition which comprises the modified Brucella strain, its use as a medicament, and its use as a medicament for the treatment and/or prevention of brucellosis. The present application also provides a kit which comprises the modified Brucella strain and a pharmaceutically acceptable carrier or diluent and its use for the treatment and/or prevention of brucellosis.

Abstract: The present invention relates to a composition comprising methyl jasmonate and a polysiloxane polyether for increasing the content of glucosinolates in adult plants of the genus Brassica, for example, broccoli. By means of foliar application of the composition on adult plants having a developed cuticle, a significant increase is achieved in the concentrations of glucosinolates (mainly glucoraphanin and neoglucobrassicin), in the floret of the plants, without degrading the organoleptic properties thereof.