Patents Assigned to Consejo Superior De Investigaciones Cientificas
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Patent number: 11696537Abstract: The present invention relates to a composition comprising methyl jasmonate and a polysiloxane polyether for increasing the content of glucosinolates in adult plants of the genus Brassica, for example, broccoli. By means of foliar application of the composition on adult plants having a developed cuticle, a significant increase is achieved in the concentrations of glucosinolates (mainly glucoraphanin and neoglucobrassicin), in the floret of the plants, without degrading the organoleptic properties thereof.Type: GrantFiled: June 28, 2019Date of Patent: July 11, 2023Assignees: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), SAKATA SEED IBERICA, S.L.U.Inventors: Micaela Carvajal Alcaraz, Diego A. Moreno Fernandez, Juan Jose Rios Ruiz, Javier Bernabeu Durá, Agatha Agudelo Sanchez
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Patent number: 11672244Abstract: Disclosed is an insect repulsion and/or barrier system (10) and a method for repelling insects (2) and/or for preventing insects (2) from passing through a defined opening (12) or surface (9). The barrier system (10) is equipped with devices (16) for preventing insects from passing through an opening (12) or for repelling insects when approaching the opening (12) and/or the devices (16). The devices (16) have at least two electrodes (18), whereby different electrical potentials are applied to or can be applied to the at least two electrodes (18). The at least two electrodes (18) are arranged within or on the edge of or outside the opening such that an electrical field (28) is formed between the at least two electrodes (18). The electrical field (28) rejects and/or repels insects approaching the electrical field (28) or prevents insects approaching the electrical field (28) from passing through the opening (12).Type: GrantFiled: October 18, 2018Date of Patent: June 13, 2023Assignees: Biogents AG, Agencia Consejo Superior de Investigaciones Científicas (CSIC), Instituto de Salud Global Barcelona (ISGlobal)Inventors: Andreas Rose, Farooq Tanveer, Elies Molins, Krijn Paaijmans, Berta Domènech Garcia
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Patent number: 11644612Abstract: The invention relates to a waveguide and a polarisation splitter based on said waveguide, in which a rotation of an angle greater than zero is applied to a plurality of sections of a core material and a plurality of sections of a covering material, thereby achieving an independent control of the refractive indices of a zero-order transverse electric mode and a zero-order transverse magnetic mode. This document also describes a manufacturing method of said waveguide which allows the birefringence of the light that passes through the waveguide.Type: GrantFiled: June 27, 2019Date of Patent: May 9, 2023Assignees: UNIVERSIDAD DE MALAGA, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICASInventors: Robert Halir, Jose Manuel Luque Gonzalez, Alaine Herrero Bermello, Alejandro Ortega Monux, Inigo Molina Fernandez, Juan Gonzalo Wanguemert Perez, Aitor Villafranca Velasco
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Publication number: 20230116496Abstract: A modular artificial neural sensing system includes a hierarchical network of neural sensing units including a neuromimetic sensor array of artificial sensory synapses and sensory neurons for receiving physicochemical sensed signals and for outputting sensor output signals. An artificial neural network processor is adapted for processing the sensor output signals and includes processor neurons interconnected by processor synapses forming first connections and second connections. The processor outputs processor output signals. A first sensor interface feeds processed or unprocessed sensed signals into the processor. A second sensor interface receives output predicted signals from other neural sensing units and feeds processed or unprocessed output predicted signals into the processor. A signal decoder decodes the processor output signals and outputs decoder output signals.Type: ApplicationFiled: January 21, 2021Publication date: April 13, 2023Applicants: UNIVERSITÄT ZÜRICH, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICASInventors: Josep Maria MARGARIT TAULÉ, Shih-Chii LIU, Cecilia JIMÉNEZ JORQUERA
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Patent number: 11603810Abstract: The invention relates to an internal combustion engine that comprises a first Brayton cycle comprising a mixed ionic-electronic conducting (MIEC) membrane that separates the O2 from the air such that the suctioned air current is free from N2; a second Brayton cycle combined in a binary manner with the first Brayton cycle and nested with a cycle selected from an Otto cycle and a diesel cycle performed by means of oxy-combustion. The second Brayton cycle transmits mechanical energy and thermal energy from exhaust gases to the first Brayton cycle. The first Brayton cycle provides to the second Brayton cycle compressed O2 from the MIEC membrane. By means of the present engine, the NOx emission into the atmosphere is prevented by the separation of N2 in the MIEC membrane.Type: GrantFiled: March 21, 2020Date of Patent: March 14, 2023Assignees: UNIVERSITAT POLITÉCNICA DE VALÉNCIA, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC)Inventors: Francisco José Arnau Martínez, Jesús Vicente Benajes Calvo, David Catalán Martínez, José María Desantes Fernández, Luis Miguel García-Cuevas González, José Manuel Serra Alfaro, José Ramón Serrano Cruz
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Patent number: 11588149Abstract: In a method of preparing an immobilized selenium system or body, a selenium-carbon-oxygen mixture is formed. The mixture is then heated to a temperature above the melting temperature of selenium and the heated mixture is then cooled to ambient or room temperature, thereby forming the immobilized selenium system or body.Type: GrantFiled: June 26, 2020Date of Patent: February 21, 2023Assignees: II-VI DELAWARE, INC., CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CISC)Inventors: Wen-Qing Xu, Xiaoming Li, Shailesh Patkar, Elgin E. Eissler, Marta Sevilla Solis, Antonio Benito Fuertes Arias
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Publication number: 20230035094Abstract: Procedure for the generation of a reflex tear secretion, which comprises the chemical stimulation of the cornea of the eye of a subject by applying a controlled jet of a gas with a high CO2 content, of at least 80% of CO2. Compact device (1,1?) for the generation of a reflex tear secretion, comprising a gas source (7) in the form of a disposable type cartridge containing a pressurized gas with a composition of at least 80% of CO2; and a pneumatic circuit connecting an outlet mouth of said gas source (7) with a gas outlet nozzle (3) of the device (1,1?), the circuit comprising pressure regulation means (8) and flow rate (17) regulation means suitable for ejecting puffs of gas through the outlet nozzle (3) at a predetermined pressure and flow rates.Type: ApplicationFiled: December 30, 2020Publication date: February 2, 2023Applicants: UNIVERSIDAD MIGUEL HERNÁNDEZ DE ELCHE (UNH), CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICASInventors: Carlos BELMONTE MARTÍNEZ, Juana GALLAR MARTÍNEZ, Maria Carmen ACOSTA BOJ, Maria Luisa MERINO SUÁREZ
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Publication number: 20230009041Abstract: The disclosure relates to recombinant vectors and methods for using the same. In certain embodiments, the recombinant vectors are immunogenic.Type: ApplicationFiled: April 28, 2022Publication date: January 12, 2023Applicants: Arizona Board of Regents, a body corporate of the State of Arizona acting for and on behalf of, Consejo Superior De Investigaciones Cientificas, IPPOX FoundationInventors: Giuseppe Pantaleo, Thierry Calandra, Alexandre Harari, Thierry Roger, Mariano Esteban, Bertram Jacobs, Karen Kibler, Cornelius Melief, Rafick-Pierre Sekaly, Elias Haddad, James Tartaglia
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Patent number: 11518802Abstract: The invention relates to monoclonal antibodies, in particular against a peptide of the BAMBI protein, as well as the uses thereof and methods comprising same. Preferably, the antibodies are used for the treatment of autoimmune diseases.Type: GrantFiled: November 30, 2016Date of Patent: December 6, 2022Assignees: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), UNIVERSIDAD DE CANTABRIAInventors: Jesús Merino Pérez, Ramón Merino Pérez
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Patent number: 11489157Abstract: The present invention relates to a calcium-based secondary cell containing: an electrolyte arranged between the negative electrode and the positive electrode and comprising a calcium salt of a fluorine-containing anion of formula (XFn)m? wherein n is a positive integer of at most 6 and m is a positive integer of at least 1 and m<n, a positive-electrode active material at the positive electrode which is a one-dimensional structure accommodating Ca2+ ions and has the formula (1): Can+2Me1(n+1)?y?zMe2yMe3zO3n+3??(1) wherein: Me1, Me2, Me3 are different transition metals; 1?n and n is not necessarily an integer; 0?y and y is not necessarily an integer; 0?z and z is not necessarily an integer.Type: GrantFiled: January 8, 2018Date of Patent: November 1, 2022Assignees: TOYOTA MOTOR EUROPE, AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICASInventors: Fanny Barde, Maria Rosa Palacin, Deyana Stoytcheva, Alexandre Ponrouch, Carlos Frontera
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Patent number: 11486823Abstract: An interchangeable sensor device for a functional near-infrared spectroscopy system (fNIRS) is a non-invasive device intended to detect changes in the concentration of hemoglobin species on any body surface area. The device includes a plurality of measurement units having different elastic configurations, each intended to be adapted to a specific area of the body, and a control unit for controlling any of the measurement units. Each of the measurement units is equipped with a first connector and the control unit is equipped with a second connector, which connectors allow the control unit to be interchangeably connected to any of the measurement units.Type: GrantFiled: May 24, 2017Date of Patent: November 1, 2022Assignees: UNIVERSIDAD MIGUEL HERNANDEZ, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICASInventors: Joaquin Ibanez Ballesteros, Carlos Belmonte Martinez
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Patent number: 11486884Abstract: The invention relates to methods for the diagnosis of ischemia or ischemic tissue damage, methods for predicting the progression of ischemia in a patient having suffered an ischemic event, for determining the prognosis of a patient having suffered an ischemic event and for determining the risk that a patient suffering from stable coronary disease suffers a recurrent ischemic event based on the detection of the levels of glycosylated Apo J. The invention relates as well to a method for the determination of glycosylated Apo J in a sample.Type: GrantFiled: April 12, 2017Date of Patent: November 1, 2022Assignees: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS, FUNDACIÓ INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SAINT PAUInventors: Lina Badimon Maestro, Judit Cubedo Ràfols, Teresa Padró Capmany
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Patent number: 11472862Abstract: The invention relates to a peptide comprising the amino acid sequence SEQ ID NO: 1 or a variant thereof capable of inhibiting IL13/IL13R?2 signalling. The invention also relates to a fusion protein, nanoparticle, virus-like particle and pharmaceutical composition comprising said peptide, and to their use for treating a cancer characterized by having increased expression of IL13R?2, or for treating asthma, atopic dermatitis or fibrosis, or for preventing the metastatic progression of a cancer characterized by having increased expression of IL13R?2.Type: GrantFiled: November 5, 2018Date of Patent: October 18, 2022Assignee: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICASInventors: Jose Ignacio Casal Alvarez, Rubén Álvaro Bartolomé Conde
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Patent number: 11472755Abstract: Method of making BTX compounds including benzene, toluene, and xylene, including feeding heavy reformate to a reactor containing a composite zeolite catalyst. The composite zeolite catalyst includes a mixture of layered mordenite (MOR-L) comprising a layered or rod-type morphology with a layer thickness less than 30 nm and ZSM-5. The MOR-L, the ZSM-5, or both include one or more impregnated metals. The method further includes producing the BTX compounds by simultaneously performing transalkylation and dealkylation of the heavy reformate in the reactor. The composite zeolite catalyst is able to simultaneously catalyze both the transalkylation and dealkylation reactions.Type: GrantFiled: July 13, 2021Date of Patent: October 18, 2022Assignees: SAUDI ARABIAN OIL COMPANY, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS, UNIVERSITAT POLITECNICA DE VALENCIAInventors: Raed Hasan Abudawoud, Avelino Corma Canos, M. Teresa Portilla Ovejero, Vicente J. Margarit Benavent, M. Teresa Navarro Villalba, M. Cristina Martinez Sanchez, Ibrahim M. Al-Zahrani
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Patent number: 11448780Abstract: The invention relates to a device for the detection of gamma rays coming from a source without image truncation and without image overlapping, comprising, at least, two detection cells and each of said cells comprising a detection space adapted to receive the gamma rays that penetrate through an opening, wherein said detection space comprises one or more detection assemblies, with some of said assemblies being positioned such that they stand in the way of the gamma rays coming into the overlap volume thereof.Type: GrantFiled: October 30, 2019Date of Patent: September 20, 2022Assignees: UNIVERSITAT POLITECNICA DE VALENCIA, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)Inventors: Victor Ilisie, Jose Maria Benlloch Baviera, Filomeno Sanchez Martinez
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Patent number: 11446304Abstract: The present invention relates to a series of substituted purine derivatives capable of inhibiting CDC7 kinase activity and, as such, suitable for use in the treatment of neurological diseases such as, inter alia, Alzheimer's disease, amyotrophic lateral sclerosis or frontotemporal dementia, involving hyperphosphorylation of TDP-43 and the subsequent formation of aggregates, induced by CDC7.Type: GrantFiled: March 21, 2018Date of Patent: September 20, 2022Assignee: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC)Inventors: Ana Martinez Gil, Daniel I. Perez, Carmen Gil Ayuso-Gontán, Angeles Martin-Requero, Elisa Rojas Prats, Loreto Martinez-Gonzalez, Concepción Perez
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Publication number: 20220287824Abstract: The invention relates to an intraocular lens with extended depth of focus including aspheric anterior and posterior optical surfaces.Type: ApplicationFiled: September 10, 2020Publication date: September 15, 2022Applicants: PHYSIOL SA, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC)Inventors: Susana Marcos Celestino, Carlos Dorronsoro Diaz, Suad Redzovic, Christophe Pagnoulle
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Publication number: 20220273754Abstract: The present invention relates to SS-31 or composition comprising SS-31 for use in the treatment and/or prevention of aneurysm.Type: ApplicationFiled: July 28, 2020Publication date: September 1, 2022Applicants: FUNDACIÓ INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC)Inventors: María GALÁN ARROYO, Miquel NAVAS MADROÑAL, M. Cristina RODRIGUEZ SINOVAS, José MARTÍNEZ GONZÁLEZ
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Patent number: 11426371Abstract: The present application provides novel compositions and methods for treating acute myeloid leukemia (AML). Compounds of the invention are acid ceramidase inhibitors, reduce AML cell viability, inhibit AML cell proliferation, increase cell death of AML cells, and induce apoptosis in AML cells. A primary compound of the invention is SACLAC: 2-chloro-N-((2S,3R)-1,3-dihydroxyoctadecan-2-yl)acetamide. The bromine analog of SACLAC (SABRAC: 2-bromo-N-((2S,3R)-1,3-dihydroxyoctadecan-2-yl)acetamide) is also useful for treating AML. SACLAC has much better activity than other know drugs used to treat AML.Type: GrantFiled: April 27, 2018Date of Patent: August 30, 2022Assignees: University of Virginia Patent Foundation, Universität de Barcelona, Consejo Superior de Investigaciones Cientificas (CSIC)Inventors: Thomas P. Loughran, Jr., Gemma Fabrias, Jose Luis Abad, Josefina Casas, David J. Feith, Su-Fern Tan, Jennifer M. Pearson, Antonio Delgado Cirilo
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Patent number: 11407642Abstract: The present invention refers to a method for exfoliating and transferring graphene from a doped silicon carbide substrate to another substrate, the method being based on exfoliation induced by hydrogen bubbles produced in the electrolysis of water.Type: GrantFiled: December 27, 2017Date of Patent: August 9, 2022Assignees: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC), CENTRO DE INVESTIGACIÓN BIOMEDICA EN RED (CIBER)Inventors: Gemma Rius Suñé, Philippe Godignon, Rosa Villa Sanz, Elisabet Prats Alfonso