Abstract: Autoantibodies to different proteins useful as biomarkers for the diagnosis, prognosis or monitoring of the progress of a colorectal cancer (CRC) are described.
Type:
Application
Filed:
May 25, 2010
Publication date:
April 26, 2012
Applicant:
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)
Inventors:
José Ignacio Casal Álvarez, Rodrigo Barderas Manchado, Ingrid Babel Henzieit
Abstract: The present invention relates to a preparation process of azo compounds which comprises the reaction between at least: one amine or polyamine, molecular oxygen, a catalyst formed by at least one support selected from among at least one metal oxide of one of the elements of groups 3, 4, 5, 6, 8, 9, 11 and 13, silica, anionic laminar compound of hydrotalcite type or its derivatives, active carbon or an organic polymer. In addition, said catalyst may contain gold nanoparticles.
Type:
Application
Filed:
September 10, 2009
Publication date:
December 22, 2011
Applicant:
Consejo Superior De Investigaciones Cientificas (CSIC)
Abstract: A radiation detector is disclosed. The detector has an entrance opening etched through a low-resistivity volume of silicon, a sensitive volume of high-resistivity silicon for converting the radiation particles into detectable charges, and a passivation layer between the low and high-resistivity silicon layers. The detector also has electrodes built in the form of vertical channels for collecting the charges generated in the sensitive volume, and read-out electronics for generating signals based on the collected charges.
Type:
Application
Filed:
June 4, 2010
Publication date:
April 7, 2011
Applicants:
FinPhys Oy, Consejo Superior de Investigaciones Cientificas (CSIC)
Inventors:
Francisco Garcia, Risto Orava, Manuel Lozano, Giulio Pellegrini
Abstract: The application relates to antibodies and fragments capable of binding HIV-1 gp120 protein, nucleic acids encoding such proteins, to the use of such proteins to identify active compounds, and to the use of the compounds as vaccines.
Type:
Application
Filed:
September 12, 2008
Publication date:
March 10, 2011
Applicants:
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS/ CSIC, PHARMACIA SPAIN
Inventors:
José Luis Toran Garcia, Carlos Martinez Alonso
Abstract: The invention relates to a compound according to the following general formula (I), in which: m represents an integer equal to 5, 6 or 7; n and n1 represent an integer from 1 to 5; the A groups represent, in particular, a hydrogenated atom; X represents O or S; Y represents, in particular, a group NR1, R1, representing, in particular, a hydrogenated atom; W represents CH or N; and Z represents, in particular, a hydrogenated atom.
Type:
Grant
Filed:
November 24, 2004
Date of Patent:
August 24, 2010
Assignees:
Centre National de la Recherche Scientifique, Universite Joseph Fourier, Consejo Superior de Investigaciones Cientificas (CSIC), Universidad de Sevilla
Inventors:
Jacques Defaye, Carmen Ortiz-Mellet, José Manuel Garcia-Fernandez, Juan M. Benito, Marta Gomez-Garcia, Jian-Xin Yu
Abstract: The invention relates to a cyclodextrin derivative corresponding to general formula (I) wherein n is a whole number from 1-6, m is a whole number equal to 5, 6 or 7, R1 is an OH group, all R1s are identical, Z is a thiourea group, X is a hydrogen atom, and R is a hydrogen atom or a bioidentification element.
Type:
Grant
Filed:
March 22, 2004
Date of Patent:
December 15, 2009
Assignees:
Centre National de la Recherche Scientifique, Universite Joseph Fourier, Consejo Superior de Investigaciones Cientificas (CSIC), Universidad de Sevilla
Inventors:
Jacques Defaye, Carmen Ortiz-Mellet, José Manuel Garcia-Fernandez, Maria Gomez-Garcia, Kazimierz Chmurski, Jian-Xin Yu
Abstract: Provided are DNA sequences encoding a novel type of AP2 domain-containing transcription factor as well as methods for obtaining similar sequences. Also described are methods for obtaining plants with improved growth and enhanced stress tolerance, particularly tolerance to osmotic and dehydration stress, such methods comprising expression of such DNA sequences in a plant or parts thereof. Further described are diagnostic compositions comprising the aforementioned DNA sequences and the use of such sequences in plant breeding and/or agriculture.
Type:
Grant
Filed:
March 28, 2002
Date of Patent:
August 19, 2008
Assignee:
Consejo Superior de Investigaciones Cientificas (CSIC)
Inventors:
Montserrat Pages, Dimosthenis Kizis, Ana Isabel Sanz Molinero
Abstract: The invention relates to a method and a device for the early detection of the presence of micro-organisms in food, particularly in milk and derivatives thereof. One of the main advantages of the invention lies in the fact that the aforementioned detection method can be performed inside the commercial packaging thereof without the need for said packaging to be opened. The presence of micro-organism is detected, before they can produce drastic changes in the physical properties of the product, according to changes in the propagation of elastic waves (velocity, attenuation and harmonic distortion) through the product and, moreover, different types of micro-organisms can be distinguished. The inventive detection method is performed under dry conditions and requires an environment with controlled humidity and temperature.
Type:
Grant
Filed:
December 13, 2004
Date of Patent:
July 10, 2007
Assignees:
Consejo Superior De Investigaciones Cientificas (CSIC), Corporacion Alimentaria Penasanta, S. A.
Inventors:
Luis Elvira Segura, Francisco Montero de Espinosa Freijo, Pablo Resa López, Yago Gomez-Ullate Ricon
Abstract: Meal from sunflower plants that produce seeds with an extractable oil having an oleic acid content of more than 40% by weight and a stearic acid content of more than 12% by weight is disclosed.
Type:
Grant
Filed:
June 26, 2003
Date of Patent:
November 28, 2006
Assignee:
Consejo Superior de Investigaciones Cientificas (CSIC)
Inventors:
Enrique Martinez Force, Juan Munoz-Ruz, Jose M. Fernandez Martinez, Rafael Garces
Abstract: The invention relates to a method and a device for the early detection of the presence of micro-organisms in food, particularly in milk and derivatives thereof. One of the main advantages of the invention lies in the fact that the aforementioned detection method can be performed inside the commercial packaging thereof without the need for said packaging to be opened. The presence of micro-organism is detected, before they can produce drastic changes in the physical properties of the product, according to changes in the propagation of elastic waves (velocity, attenuation and harmonic distortion) through the product and, moreover, different types of micro-organisms can be distinguished. The inventive detection method is performed under dry conditions and requires an environment with controlled humidity and temperature.
Type:
Application
Filed:
December 13, 2004
Publication date:
June 2, 2005
Applicants:
Consejo Superior de Investigaciones Cientificas (CSIC), Corporation Alimentaria Penasanta, S.A.
Inventors:
Luis Segura, Francisco de Espinosa Freijo, Pablo Lopez, Yago Ricon
Abstract: Sunflower plants that produce seeds with an extractable oil having an oleic acid content of more than 40% by weight and a stearic acid content of more than 12% by weight are disclosed, together with products containing the oil and methods for selecting plants containing the oil.
Type:
Grant
Filed:
December 13, 2001
Date of Patent:
August 3, 2004
Assignee:
Consejo Superior de Investigaciones Cientificas (CSIC)
Inventors:
Enrique Martinez Force, Juan Munoz-Ruz, Jose M. Fernandez Martinez, Rafael Garces
Abstract: Meal from sunflower plants that produce seeds with an extractable oil having an oleic acid content of more than 40% by weight and a stearic acid content of more than 12% by weight is disclosed.
Type:
Application
Filed:
June 26, 2003
Publication date:
May 6, 2004
Applicant:
Consejo Superior de Investigaciones Cientificas (CSIC)
Inventors:
Enrique Martinez Force, Juan Munoz-Ruz, Jose M. Fernandez Martinez, Rafael Garces
Abstract: Sunflower seeds having an oleic acid content of more than 5% and less than 65%, a palmitic acid content of more than 20% and less than 40%, a stearic acid content of more than 3% and less than 15%, and a palmitoleic acid content less than 4%, all based on the total fatty acid weight, are disclosed, together with methods of obtaining the sunflower seeds.
Type:
Application
Filed:
February 14, 2002
Publication date:
December 5, 2002
Applicant:
Consejo Superior de Investigaciones Cientificas (CSIC)
Inventors:
Enrique Martinez Force, Begona Perez Vich, Jose M. Fernandez Martinez, Rafael Garces
Abstract: Sun flower plants that produce seeds with an extractable oil having an oleic acid content of more than 40% by weight and a stearic acid content of more than 12% by weight are disclosed, together with products containing the oil and methods for selecting plants containing the oil.
Type:
Application
Filed:
December 13, 2001
Publication date:
July 25, 2002
Applicant:
Consejo Superior de Investigaciones Cientificas (CSIC)
Inventors:
Enrique Martinez Force, Juan Munoz-Ruz, Jose M. Fernandez Martinez, Rafael Garces
Abstract: The present invention relates to transgenic and non-transgenic plants that produce oil having high levels of saturated fatty acids and medium to high levels of olecic acid. More specifially, the invention relates to a sunflower plant, seed, and the extractable oil having increased stearic acid content and increased oleic acid content relative to the normal sunflower oil level of stearic acid and oleic acid.
Type:
Grant
Filed:
June 4, 1999
Date of Patent:
May 14, 2002
Assignee:
Consejo Superior de Investigaciones Cientificas (
CSIC)
Inventors:
Enrique Martinez Force, Juan Munoz-Ruz, Jose M. Fernandez Martinez, Rafael Garces
Abstract: The invention relates to plant seeds that contain an oil having an oleic acid content of more than 5% and less than 65% by weight based upon the total fatty acid content, a linoleic acid content of more than 1% and less than 65% by weight based upon the total fatty acid content, a palmitic acid content of more than 20% and less than 40% by weight based upon the total fatty acid content, a stearic acid content of more than 3% and less than 15% based upon the total fatty acid content, and wherein the palmitoleic acid content is less than 4% based upon the total fatty acid content, and the asclepic acid content is less than 4% based upon the total fatty acid content.
The invention further relates to the oil that can be obtained from the seeds, the use of that oil and to plants grown from the seeds or producing the seeds.
Type:
Grant
Filed:
June 4, 1999
Date of Patent:
February 19, 2002
Assignee:
Consejo Superior de Investigaciones Cientificas (CSIC)
Inventors:
Enrique Martinez Force, Begona Perez Vich, Jose Fernandez Martinez, Rafael Garces
Abstract: A corrosion detecting probe is to be used in combination with an electrochemical corrosion-rate meter for performing on-site diagnosis of the corrosion rate of metallic reinforcement systems in concrete structures. After the probe is brought into surface contact with a concrete member, voltage/current signals are applied thereto and a series of calculations are performed to determine the polarization resistance directly about a confined concrete portion. The probe consists essentially of an external counterelectrode, a central counterelectrode, a central reference electrode and a pair of extra reference electrodes (sensors). A current applied from the external counterelectrode serves to repel the lines of current (resulting from a voltage signal first applied at the central counterelectrode) below the probe and within the confined concrete portion which is between the central counterelectrode and the external one.
Type:
Grant
Filed:
March 1, 1993
Date of Patent:
November 9, 1993
Assignees:
Geotecnia Y Cimientos, S.A.-Geocisa, Consejo Superior De Investigaciones Cientificas (CSIC)
Inventors:
Sebastian Feliu, Jose A. Gonzalez, Vicente Feliu, Sebastian Feliu, Jr., M. Lorenza Escudero, Isabel A. Rodriguez-Maribona, Vicente Ausin, M. Carmen Andrade, Jose A. Bolano, Francisco Jimenez