Abstract: A valve for discharging a fluid, comprising: a valve body at least partially defining a fluid chamber; and a valve stem extending into the fluid chamber, the valve stem comprising an outlet port for transfer, in use, of fluid from the fluid chamber into the valve stem; the valve stem being slidably movable relative to the valve body from: i) a non-dispensing position in which the outlet port is out of communication with the fluid chamber; to ii) a dispensing position in which the outlet port is in fluid communication with the fluid chamber so as to permit transfer of the fluid from the fluid chamber into the valve stem; wherein the valve further comprises a locking member which is configured to prevent return of the valve stem into the non-dispensing position once the valve stem slides beyond a locking position.

Abstract: A dispensing apparatus (1) is provided comprising a fluid reservoir (4) and a valve (2). The fluid reservoir comprising a body which defines an internal volume which contains a fluid and the body comprising an open mouth. The valve (2) is sealingly coupled to the body of the fluid reservoir (4) to close the open mouth and the valve comprises a gasket seal (18) which engages the body of the fluid reservoir. The gasket seal (18) comprises an elastomer based on an ethylene-propylene-diene terpolymer, which terpolymer comprises from 45 to 55 wt. % ethylene, from 40 to 50 wt. % propylene, and ENB (ethylidenenorbornene) in an amount of 0.5 to 6 wt. %; and wherein the fluid comprises comprises a halogenated ether.

Abstract: A dose indicator device for a pressurized metered dose inhaler comprises an inner wheel, annular outer wheel, actuator and housing; the inner wheel comprising primary indexing teeth and a flexible drive arm; the outer wheel comprising secondary indexing teeth on an outer face of the outer wheel; the inner wheel and outer wheel located at least partially within the housing such that the inner wheel and outer wheel are rotatable about a common longitudinal axis of rotation; the actuator movable in a plane perpendicular to the axis of rotation to engage the primary indexing teeth to rotate the inner wheel; the housing being fixed relative to the axis of rotation and comprising a deflector; the deflector configured such that, on rotation of the inner wheel, the drive arm is intermittently deflected and brought into contact with the secondary indexing teeth to rotate the outer wheel about the axis of rotation.

Abstract: Fluid delivery device for discharging a fluid, having: a housing; piston pump; biasing mechanism; and trigger mechanism. The housing has a basal end and a discharge end with outlet for discharging the fluid. The piston pump has a casing defining a pump chamber for storage of fluid, a piston slidably movable relative to the pump chamber, a piston plunger, and a delivery channel. The trigger mechanism is movable from a cocked configuration wherein the trigger mechanism prevents transfer of a biasing force of the biasing mechanism to the casing to a triggered configuration with the trigger mechanism enabling transfer of the biasing force to the casing to cause movement of the casing towards the housing outlet to discharge fluid from the pump chamber, along the delivery channel and out of the outlet of the housing. The biasing mechanism has one or more flexible catch members and a manually operable trigger.

Abstract: A fluid delivery device (1) for discharging a fluid comprises a housing (2, 3), piston pump (4), biasing mechanism (5, 101), and trigger mechanism (6); the housing (2, 3) comprising a basal end (3) and discharge end (2) having an outlet (10) for discharging the fluid; the piston pump (4) comprising a casing (20) defining a pump chamber (35) for fluid storage, piston (21) slidably movable relative to the pump chamber (35), piston plunger (22), and delivery channel (59) for delivering fluid discharged from pump chamber (35) to outlet (10); the trigger mechanism (6) being movable from cocked configuration, preventing transfer of biasing mechanism (5, 101) force to the casing (20) to prevent casing (20) movement towards the outlet (10), to triggered configuration, enabling transfer of biasing mechanism (5, 101) force to the casing (20) to cause casing (20) movement towards the outlet (10) to discharge fluid from the pump chamber (35).

Abstract: A dispensing apparatus (for delivering metered doses from a pressurized dispensing container) having a housing receiving the container and a dose counter with dose indication element. The dose counter has an indexing mechanism advancing the indication element on container actuation. The dispensing apparatus has an indexing member moving within the housing in sync with the container wherein on actuation of the container in a normal mode of operation the indexing member interfaces with the indexing mechanism to apply a force to the indexing mechanism to incrementally advance the indication element. The indexing member and mechanism are configured to cooperate with one another, upon the input of a force in a second mode, such that the indexing mechanism transmits a force to the indexing member sufficient to generate a relative displacing movement between the indexing member and mechanism without incurring incremental advancement of the indication element.

Abstract: Dose indicator device for metered dose inhalers having a base, inner wheel, outer wheel, drive, transmission cog and flexible cover. The drive, inner wheel and outer wheel are concentrically, rotatably mounted about a first rotation axis. The cog rotates about a second axis parallel to the first. The inner wheel has inner annular surface primary indexing teeth and one or more outer annular surface secondary indexing teeth. The outer wheel has indexing teeth on an inner annular surface. The cog has gear teeth engageable with outer wheel indexing teeth and engageable by one or more inner wheel secondary indexing teeth. The drive has one or more arms engageable with primary indexing teeth. The flexible cover being flexible downwardly wherein, in use, downward drive movement is accompanied by drive rotation about the first axis, the rotation causing inner wheel rotation by interengagement of the drive and the primary indexing teeth.

Abstract: A dose indicator device for a pressurised metered dose inhaler comprises an inner wheel, annular outer wheel, actuator and housing; the inner wheel comprising primary indexing teeth and a flexible drive arm; the outer wheel comprising secondary indexing teeth on an outer face of the outer wheel; the inner wheel and outer wheel located at least partially within the housing such that the inner wheel and outer wheel are rotatable about a common longitudinal axis of rotation; the actuator movable in a plane perpendicular to the axis of rotation to engage the primary indexing teeth to rotate the inner wheel; the housing being fixed relative to the axis of rotation and comprising a deflector; the deflector configured such that, on rotation of the inner wheel, the drive arm is intermittently deflected and brought into contact with the secondary indexing teeth to rotate the outer wheel about the axis of rotation.

Abstract: A metering valve (10) for dispensing metered doses of a pressurized product derived from a bulk supply of a pressurized product, the metering valve comprising a valve body (14), a valve stem (11), and sealing means (17,18), the valve stem (11) comprising an outlet for the pressurized product, the valve body (14) defining an internal volume (33), the metering valve further comprising a metering chamber (12), the valve stem being movable between a non-dispensing position in which the metering chamber is, in use, in fluid communication with the bulk supply of pressurized product and a dispensing position in which the metering chamber is in fluid communication with the outlet, characterized in that, in use, the bulk supply of pressurized product is wholly contained within the internal volume (33) of the valve body (14).

Abstract: A valve for discharging a fluid, comprising: a valve body at least partially defining a fluid chamber; and a valve stem extending into the fluid chamber, the valve stem comprising an outlet port for transfer, in use, of fluid from the fluid chamber into the valve stem; the valve stem being slidably movable relative to the valve body from: i) a non-dispensing position in which the outlet port is out of communication with the fluid chamber; to ii) a dispensing position in which the outlet port is in fluid communication with the fluid chamber so as to permit transfer of the fluid from the fluid chamber into the valve stem; wherein the valve further comprises a locking member which is configured to prevent return of the valve stem into the non-dispensing position once the valve stem slides beyond a locking position.

Abstract: A valved container assembly which has a container for containing a fluid, the container extending in an axial direction and having an open front end and a valve disposed in the container. The valved container assembly is configured so that forward axial movement of the valve relative to the container is inhibited. A plunger element is disposed axially rearward of the valve and is axially moveable in the container. The plunger element is configured to increase the pressure of a fluid in a first volume of the container upon forward axial movement relative to the valve. The valve includes a channel bypassing the permanent seal, the channel having a first opening in fluid communication with the atmosphere outside of the valved container assembly and a second opening selectively sealed from the first volume by a resilient seal.

Abstract: A syringe assembly which has a barrel for containing one or more medicaments and a stopper disposed in the barrel defining and separating a first volume and a second volume within the syringe assembly. The stopper includes a permanent seal fluidly sealing the stopper to the barrel about the entire perimeter of the stopper intermediate the first volume and second volume, and a channel bypassing the permanent seal, the channel having a first opening in fluid communication with the second volume and a second opening selectively sealed from the first volume by a resilient seal. The resilient seal is moveable between a sealing configuration and an open configuration to selectively seal the channel from the first volume and is moveable from the sealing configuration to the open configuration upon fluid pressure in the first volume or second volume exceeding a first pressure threshold.

Abstract: A fluid delivery device (1) for discharging a fluid comprises a housing (2, 3), piston pump (4), biasing mechanism (5, 101), and trigger mechanism (6); the housing (2, 3) comprising a basal end (3) and discharge end (2) having an outlet (10) for discharging the fluid; the piston pump (4) comprising a casing (20) defining a pump chamber (35) for fluid storage, piston (21) slidably movable relative to the pump chamber (35), piston plunger (22), and delivery channel (59) for delivering fluid discharged from pump chamber (35) to outlet (10); the trigger mechanism (6) being movable from cocked configuration, preventing transfer of biasing mechanism (5, 101) force to the casing (20) to prevent casing (20) movement towards the outlet (10), to triggered configuration, enabling transfer of biasing mechanism (5, 101) force to the casing (20) to cause casing (20) movement towards the outlet (10) to discharge fluid from the pump chamber (35).

Abstract: The present invention provides dispensing apparatus for delivering metered doses of product from a pressurized dispensing container comprising: a housing for receiving a pressurized dispensing container; a dose counting mechanism comprising indication means for displaying to a user an indication associated with the number or quantity of doses dispensed from, or the number or quantity of doses remaining in, the received pressurized dispensing container; the dose counting mechanism further comprising an indexing mechanism for advancing the indication means on actuation of the received pressurized dispensing container; wherein the dispensing apparatus comprises an indexing member capable of moving within the housing in sync with the received pressurized dispensing container; wherein on actuation of the received pressurized dispensing container in a normal mode of operation the indexing member is able to interface with the indexing mechanism to apply a force to the indexing mechanism sufficient to incrementally a

Abstract: A dose counter system, and a dispensing apparatus having such a dose counter system, for counting activations of a pressurised dispensing container including: a hydraulic system; and a counter; the hydraulic system having a hydraulic cylinder with a primary piston, a secondary piston and a working fluid, wherein the secondary piston is coupled to, or otherwise operates the counter and the primary piston is engaged by, fixed to, coupled to, or otherwise moved by, a pressurised dispensing container.

Abstract: A fluid delivery device for discharging a fluid having a housing, a piston pump, a biasing mechanism, and a trigger mechanism. The housing has a fluid discharge outlet. The pump has a pump chamber casing for fluid storage, a piston sliding in the pump chamber, a piston plunger, and a delivery channel leading to the housing outlet. The biasing mechanism biases the piston pump casing towards the housing outlet. The trigger mechanism has a catch member and a restraining member movable by a manually actuatable trigger from a cocked to a triggered configuration. The cocked restraining member engages the catch member to prevent movement and fluid discharge. A triggered restraining member disengages from the catch member for movement of the casing towards the housing outlet to discharge fluid from housing outlet.

Abstract: Dispensing apparatus for delivering metered doses of product from a pressurized dispensing container, having a housing for receiving, in use, the pressurized dispensing container, and an outlet through which, in use, metered doses of product from the pressurized dispensing container can be dispensed. The housing has an aperture via which the pressurized dispensing container can be inserted into the housing. The dispensing apparatus is at least partially enclosed by a shrink wrapped film, the shrink wrapped film including an opening which is: (a) at least partly aligned with the aperture of the housing; and (b) dimensioned so as to allow, in use, said pressurized dispensing container to pass through the opening in order to be inserted into the housing via the aperture.

Abstract: Dose indicator device for metered dose inhalers having a base, inner wheel, outer wheel, drive, transmission cog and flexible cover. The drive, inner wheel and outer wheel are concentrically, rotatably mounted about a first rotation axis. The cog rotates about a second axis parallel to the first. The inner wheel has inner annular surface primary indexing teeth and one or more outer annular surface secondary indexing teeth. The outer wheel has indexing teeth on an inner annular surface. The cog has gear teeth engageable with outer wheel indexing teeth and engageable by one or more inner wheel secondary indexing teeth. The drive has one or more arms engageable with primary indexing teeth. The flexible cover being flexible downwardly wherein, in use, downward drive movement is accompanied by drive rotation about the first axis, the rotation causing inner wheel rotation by interengagement of the drive and the primary indexing teeth.

Abstract: The present invention relates to a seal for a valve for use in a pharmaceutical dispensing device, which seal is formed from an elastomeric composition comprising: (a) one or more elastomers; and (b) a cross-linking agent comprising an aliphatic dialkyl peroxide and/or an aliphatic perketal peroxide.