Patents Assigned to Cook Biotech Incorporated
  • Patent number: 10512463
    Abstract: Described are medical devices useful for applying a bolster material to a surgical fastening device such as a stapler, and related methods of manufacture and use. The devices include an applicator element for receipt between arms of the stapler, and a bolster material, desirably a remodelable extracellular matrix material, coupled to the applicator element. In certain embodiments, the bolster material is held by the applicator element, for example having at least a portion looped around or received through or over a portion of the applicator element. Also described are unique implantable materials including coatings of dried, reversible adhesive.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: December 24, 2019
    Assignee: Cook Biotech Incorporated
    Inventors: Michael C. Hiles, Umesh H. Patel, Bhavin Shah, Chad S. McAlexander
  • Patent number: 10500309
    Abstract: Described are medical products including an adhesive containing a polypeptide component such as gelatin and a tackiness-providing polyhydroxy compound, such as at least one compound selected from the group consisting of glycerin and fructose. Such medical products can find use as a bolster material for use in conjunction with a surgical fastening device such as a stapler. Other medical applications utilizing a medical product of the invention include tissue repair and pharmaceutical delivery to a desired location. Related methods of manufacture and use are also described.
    Type: Grant
    Filed: September 24, 2008
    Date of Patent: December 10, 2019
    Assignee: Cook Biotech Incorporated
    Inventors: Bhavin Shah, Paul J. Hall
  • Publication number: 20190351241
    Abstract: Described are implantable pouch products having a segmental lamination structure that provides an interior pocket for receiving a medical device, for example an electronic medical device such as a cardiac pacemaker or defibrillator. Also described are methods for making and using such products.
    Type: Application
    Filed: January 18, 2019
    Publication date: November 21, 2019
    Applicant: Cook Biotech Incorporated
    Inventor: Tyler Novak
  • Patent number: 10471182
    Abstract: Described are packaged, sterile medical graft products containing controlled levels of a growth factor such as Fibroblast Growth Factor-2 (FGF-2). Also described are methods of manufacturing medical graft products wherein processing, including sterilization, is controlled and monitored to provide medical graft products having modulated, known levels of a extracellular matrix factor, such as a growth factor, e.g. FGF-2. Preferred graft materials are extracellular matrix materials isolated from human or animal donors, particularly submucosa-containing extracellular matrix materials. Further described are ECM compositions that are or are useful for preparing gels, and related methods for preparation and use.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: November 12, 2019
    Assignee: Cook Biotech Incorporated
    Inventors: Michael C. Hiles, Jason P. Hodde, David M.J. Ernst, Lal Ninan
  • Patent number: 10470749
    Abstract: Described are medical graft products, systems, and methods useful for treating fistulae, particularly enterocutaneous fistulae. Certain products of the invention are configured to have portions residing in and around a primary fistula opening in a wall of the alimentary canal. One such product includes a biocompatible graft body which is configured to block at least the primary opening. The graft body includes a capping member connected to an elongate plug member. The capping member is configured to contact portions of the alimentary canal wall adjacent to the primary opening, and the elongate plug member is configured to extend into at least a portion of the fistula. A graft product of this sort may be particularly adapted to allow a portion of the capping member to be positioned alongside an exterior, lateral surface of the plug member, e.g., when placed in a delivery device lumen. Such a capping member may be hingedly or non-hingedly coupled to the elongate plug member.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: November 12, 2019
    Assignee: Cook Biotech Incorporated
    Inventors: F. Joseph Obermiller, Steve Chen
  • Publication number: 20190336650
    Abstract: Described are packaged, sterile medical graft products containing controlled levels of a growth factor such as Fibroblast Growth Factor-2 (FGF-2). Also described are methods of manufacturing medical graft products wherein processing, including sterilization, is controlled and monitored to provide medical graft products having modulated, known levels of a extracellular matrix factor, such as a growth factor, e.g. FGF-2. Preferred graft materials are extracellular matrix materials isolated from human or animal donors, particularly submucosa-containing extracellular matrix materials. Further described are ECM compositions that are or are useful for preparing gels, and related methods for preparation and use.
    Type: Application
    Filed: June 26, 2019
    Publication date: November 7, 2019
    Applicant: Cook Biotech Incorporated
    Inventors: Michael C. Hiles, Jason P. Hodde, David M.J. Ernst, Lal Ninan
  • Patent number: 10441256
    Abstract: Among other things, there are disclosed apparatuses and methods for medically sealing an opening in a vessel or wall. For example, in medical applications, a delivery tube is provided for insertion through a sheath into a vessel (e.g. a blood vessel). A dome-shaped seal fixed to a filament, an absorbent and/or compressible buffer, and a locking member are provided in the delivery tube. The delivery tube is configured so that it can be inserted into the vessel through a sheath. Tension is maintained on the filament to hold the seal against the tube or sheath. The sheath is pulled out, which pulls out the tube at the same time, leaving the seal over the opening in the vessel wall. The locking member compresses the buffer against the outside of the vessel and with the filament holds the seal in place against the inside of a vessel.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: October 15, 2019
    Assignees: Cook Medical Technologies LLC, Cook Biotech Incorporated
    Inventors: Ram H. Paul, Jr., Cleon Stanley, Brian L. Bates, F. Joseph Obermiller, Thomas A. Osborne, Sean D. Chambers
  • Patent number: 10342523
    Abstract: Described are medical graft products, systems, and methods useful for treating fistulae, particularly enterocutaneous fistulae. Certain products of the invention are configured to have portions residing in and around a primary fistula opening in a wall of the alimentary canal. One such product includes a biocompatible graft body which is configured to block at least the primary opening. The graft body includes a capping member connected to an elongate plug member. The capping member is configured to contact portions of the alimentary canal wall adjacent to the primary opening, and the elongate plug member is configured to extend into at least a portion of the fistula. A graft product of this sort may be particularly adapted to allow a portion of the capping member to be positioned alongside an exterior, lateral surface of the plug member, e.g., when placed in a delivery device lumen. Such a capping member may be hingedly or non-hingedly coupled to the elongate plug member.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: July 9, 2019
    Assignee: Cook Biotech Incorporated
    Inventors: F. Joseph Obermiller, Steve Chen
  • Publication number: 20190141987
    Abstract: Disclosed are products having animal tissue packed within the lumen of a device such as a needle cannula and being therein impregnated with a cryopreservation medium. The needle cannula or other device can be received in a capsule and/or other container, which in some forms can contain additional amounts of the cryopreservation medium occurring external of the lumen. Methods of use of the products are also described and can include ejecting the animal tissue from the lumen of device using pressurized liquid passed through the lumen, potentially to deliver the animal tissue directly into a patient. Methods of manufacture of the products are also described.
    Type: Application
    Filed: November 14, 2018
    Publication date: May 16, 2019
    Applicant: Cook Biotech Incorporated
    Inventors: Umesh H. Patel, Michael L. Taylor, Claus Sondergaard, Cara McCammon, Rae Ritchie
  • Publication number: 20190117825
    Abstract: Various compositions of matter, methods of making compositions of matter, and methods of using compositions of matter, e.g. for inducing hemostasis, are disclosed. In some embodiments, a starting fibrin material is subjected to controlled hydrolysis, desirably base-catalyzed, to prepare a fibrin hydrolysate material with increased water sorption capacity. Such fibrin hydrolysate materials, alone or combined with one or more additional substances, can be used in the preparation of hemostasis promoting foams, powders or gels. In some embodiments, a starting dialdehyde starch material is subjected to controlled hydrolysis to prepare a dialdehyde starch hydrolysate material. Such dialdehyde starch hydrolysate materials, alone or combined with one or more additional substances, in some cases combined with a fibrin hydrolysate material, can be used in the preparation of hemostasis promoting foams, powders or gels.
    Type: Application
    Filed: October 10, 2018
    Publication date: April 25, 2019
    Applicant: Cook Biotech Incorporated
    Inventors: Niraj Ramachandran, Brooke Lynn Davisson
  • Publication number: 20190117843
    Abstract: Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.
    Type: Application
    Filed: September 11, 2018
    Publication date: April 25, 2019
    Applicants: Muffin Incorporated, Cook Biotech Incorporated
    Inventors: Michael C. Hiles, Chad E. Johnson, Neal E. Fearnot, Thomas Payne, Ronald Jankowski
  • Patent number: 10226256
    Abstract: This invention relates in one aspect to the treatment of a vascular vessel with a biomaterial. The biomaterial can be a remodelable material that strengthens and/or supports the vessel walls. Additionally the biomaterial can include a variety of naturally occurring or added bioactive agents and/or viable cellular populations.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: March 12, 2019
    Assignees: Cook Medical Technologies LLC, Cook Biotech Incorporated
    Inventors: Brian C. Case, Jacob A. Flagle, Michael C. Hiles, Umesh H. Patel, F. Joseph Obermiller
  • Publication number: 20190046211
    Abstract: A filamentous graft has an elongate filament body including one or more intact segments of a decellularized collagenous tissue membrane. The graft can have a length of at least about 20 cm. The graft can be cut from a laminate of two or more decellularized collagenous tissue membranes. The graft can have a generally rectangular cross-section and can have substantially uniform dimensions and tensile strength along at least a substantial portion of its length. Methods for preparing and using filamentous grafts are also described.
    Type: Application
    Filed: December 2, 2016
    Publication date: February 14, 2019
    Applicant: COOK BIOTECH INCORPORATED
    Inventors: Christine Bronikowski, F Joseph Obermiller, Wade Colburn
  • Patent number: 10143457
    Abstract: The present invention provides, in certain aspects, medical devices deliverable into passageways and other open spaces in the body. In one embodiment, the invention provides a fistula plug for delivery into a fistula tract. This fistula plug includes an elongate plug body, and a removable core material that is received in the plug body and effective to increase the column strength of the plug body. The plug body may be formed with one or more of a variety of biocompatible materials including some that are naturally derived and some that are non-naturally derived. The present invention also provides apparatuses and methods for delivering these and other medical devices into the body. One such apparatus includes a fistula plug having a plug body, and a removable delivery device received in the plug body, wherein the delivery device is effective to deliver the plug body into a fistula tract when advanced therethrough.
    Type: Grant
    Filed: April 7, 2008
    Date of Patent: December 4, 2018
    Assignee: Cook Biotech Incorporated
    Inventor: Charles W. Agnew
  • Patent number: 10123900
    Abstract: Devices, kits, and methods useful in the treatment of Obstructive Sleep Apnea (OSA) are described. Example devices include a jig, a first needle, a second needle, and a third needle. An example jig comprises a drill guide and a tongue depressor. A first needle comprises an elongate shaft that defines a bend and a curve. A second needle comprises an elongate shaft that defines a curve. A third needle comprises an elongate shaft that defines a curve.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: November 13, 2018
    Assignees: COOK MEDICAL TECHNOLOGIES LLC, COOK BIOTECH INCORPORATED
    Inventors: Arun Mohan, Darin Schaeffer, Christopher Nelson, Patrick Melder, Dan Dalenberg
  • Publication number: 20180296223
    Abstract: There are disclosed various dispensing mechanisms for dispensing filamentary material through a catheter into a treatment site of a patient, for example into an aneurysm sack in a patient's vessel. In one embodiment the assembly includes a conical material carrier which is substantially aligned with the dispensing direction, thereby avoiding the need to have a rotating carrier. Another embodiment has a carrier which is at least partially cylindrical. The carrier provides for efficient dispensation of filamentary material at substantial dispensing speeds.
    Type: Application
    Filed: June 7, 2018
    Publication date: October 18, 2018
    Applicants: Cook Medical Technologies LLC, Cook Biotech Incorporated
    Inventors: Aidan Furey, Steen Aggerholm, Palle Munk Hansen, Anders Ginge Jensen, Kirsten Asser Larsen, Ryan Bernstein
  • Publication number: 20180272136
    Abstract: Certain aspects of this disclosure relate to uniquely constructed medical implants that incorporate an electronic or other medical device. Some illustrative pocket-like implants provide an interior space for receipt of an electronic medical device, and are implantable in a patient with the electronic medical device positioned in the interior space. In one form, an inventive construct includes a remodelable material component that is effective upon implantation to promote cellular invasion and ingrowth into the remodelable material so that it becomes replaced by new patient tissue and so that the electronic medical device becomes surrounded by a new pocket structure comprised of newly generated, functional patient tissue. The electronic medical device will be a pacing device or other cardiac rhythm management (CRM) device in select embodiments.
    Type: Application
    Filed: May 30, 2018
    Publication date: September 27, 2018
    Applicants: Cook Biotech Incorporated, Cook Medical Technologies LLC
    Inventors: Joseph B. Horn, Michael C. Hiles
  • Patent number: 10071187
    Abstract: Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: September 11, 2018
    Assignees: Cook Biotech Incorporated, Muffin Incorporated
    Inventors: Michael C. Hiles, Chad E. Johnson, Neal E. Fearnot, Thomas Payne, Ronald Jankowski
  • Publication number: 20180228939
    Abstract: Described are packaged, sterile medical graft products containing controlled levels of a growth factor such as Fibroblast Growth Factor-2 (FGF-2). Also described are methods of manufacturing medical graft products wherein processing, including sterilization, is controlled and monitored to provide medical graft products having modulated, known levels of a extracellular matrix factor, such as a growth factor, e.g. FGF-2. Preferred graft materials are extracellular matrix materials isolated from human or animal donors, particularly submucosa-containing extracellular matrix materials. Further described are ECM compositions that are or are useful for preparing gels, and related methods for preparation and use.
    Type: Application
    Filed: December 15, 2017
    Publication date: August 16, 2018
    Applicant: Cook Biotech Incorporated
    Inventors: Michael C. Hiles, Jason P. Hodde, David M.J. Ernst, Lal Ninan
  • Publication number: 20180195798
    Abstract: The present embodiments generally relate to containers having utility in the lypohilization of fluids to form powers and to methods of using such containers. One embodiment provides a side-ported syringe. Another embodiment provides a two-part container.
    Type: Application
    Filed: January 9, 2018
    Publication date: July 12, 2018
    Applicant: COOK BIOTECH INCORPORATED
    Inventors: Michael L. Taylor, Christopher Nelson