Abstract: A wire lock assembly for an access port of an elongate medical tube includes a body having an exterior surface, an interior surface, and a central opening disposed therethrough, an attachment mechanism disposed through the exterior surface of the body, the attachment mechanism having an open end and a closed end, at least one notch arranged on the body and positioned proximate to the central opening and at least one seal supported within the interior surface of the body in communication with the central opening, the seal comprising a passageway therethrough, where the interior surface of the body defines a non-linear pathway for securing one or more medical devices.

Abstract: A prosthesis is provided for a variety of medical treatments. The prosthesis may include an expandable tubular frame structure and a covering disposed along the frame structure. A proximal liner may be situated along a proximal end of the frame, a distal liner may be situated along a distal end of the frame, and an intermediate liner may be between the proximal liner and the distal liner along the frame. The intermediate liner comprises an extended layer that meets and bonds to the proximal liner and the distal liner at their respective ends. A method of manufacturing the prosthesis is also provided.

Abstract: A stent delivery system includes an elongate shaft including a proximal portion, a distal portion, at least one lumen extending at least partially therethrough, and a stent receiving portion on the distal portion of the elongate shaft. A stent is positioned on the stent receiving portion of the elongate shaft, the stent having a first configuration and a second configuration. A proximal constraining arrangement is engaged with a proximal end of the stent and a distal constraining arrangement is engaged with a distal end of the stent, the distal constraining arrangement including a first distal constraining member engaged with a first distal portion of the stent and a second distal constraining member engaged with a second distal portion of the stent. When the stent is in the first configuration, the proximal restraining assembly and the distal restraining assembly applies an axial mechanical force to the distal constraining member.

Abstract: The present invention relates to a long-lasting medical product for protecting or treating a lesion in the gastrointestinal tract. The medical product includes a protective covering, wherein the medical product upon application at and about the site of the lesion adheres to the gastrointestinal tissue and is capable of remaining at and about the site of the lesion for a time sufficient to allow the lesion to heal or be treated.

Abstract: A method of crosslinking a protein or peptide for use as a biomaterial, the method comprising the step of irradiating a photoactivatable metal-ligand complex and an electron acceptor in the presence of the protein or peptide, thereby initiating a cross-linking reaction to form a 3-dimensional matrix of the biomaterial.

Abstract: An endoluminal prosthesis system for a branched body lumen comprises a branch vessel prosthesis. The branch vessel prosthesis is deployable within a branch vessel body lumen and comprises a stent having a generally tubular body portion, a flareable proximal end portion, and a coupling portion disposed intermediate the body portion and the flareable portion. The coupling portion is more crush-resistant than the body portion. The flareable proximal end may be disposed within a fenestrated stent graft with coupling portion disposed in the fenestration of the fenestrated stent graft.

Abstract: Disclosed herein is a die assembly comprising a first attachment block having a passage, an inlet port and an exit port; where the passage is operative to transport a molten material from the inlet port to the outlet port; a die; and a conduit; where the conduit comprises a passage that is operative to transport the molten material from the first attachment block to an entry port of the die; where the die comprises a first outer tube; and an extrusion pin that comprises a post and fins; where the extrusion pin is located in the first outer tube using the fins and where the post extends from the fins in a direction away from the entry port of the die; and where the post comprises one or more passages; where at least of these passages open to the atmosphere to provide for pressure equalization; and a travelling template; the template being operative to contact an extrudate that emanates from the die and to transfer a texture to a surface of the extrudate by virtue of pressure applied by a guide tube to the extr

Abstract: Various aspects of the present disclosure provide compositions including a water-insoluble therapeutic agent and a gallate-containing compound. Other aspects provide methods of using such compositions.

Abstract: The disclosure is directed to a system, device and method for data storage on implantable magnetizable fabric. The system includes implantable magnetizable fabric coupled to a graft segment of a prosthesis for being delivered into a body of a subject. The system includes information written on the implantable magnetizable fabric. The system further includes a magnetic detection device capable of, after the prosthesis is delivered into the body of the subject, detecting the implantable magnetizable fabric and accessing at least a portion of the information.

Abstract: An electrosurgical system may include a medical delivery device and an electrosurgical device to perform an electrosurgical procedure. The electrosurgical device may have a monopolar configuration. An outer surface of the medical delivery device may include a conductive portion that is part of a return path for a bipolar configuration. Current may be supplied through an active member of the electrosurgical device to perform the procedure. After passing through tissue, the current may be drawn to the electrode portion of the medical delivery device to complete the circuit.

Abstract: The present embodiments provide systems and methods for improved retention of stents on a delivery system. In one embodiment, a delivery system comprises a catheter and a balloon. A proximal end of the balloon is secured to an exterior surface of the catheter at a first location, and a distal end of the balloon is secured to the exterior surface of the catheter at a second location. A plurality of bands are disposed in a circumferential space situated between the exterior surface of the catheter and an interior surface of the balloon. The plurality of bands may comprise at least four bands that are discretely spaced-apart in an axial direction from one another along a length of the catheter. At least one stent is secured to the exterior surface of the balloon in a compressed delivery state.

Abstract: An implantable medical device includes an elongate support member including an internal wall forming an internal lumen and an elongate flexible tubular valve member having a length, a proximal end, and a closable distal end. The proximal end of the valve member is secured to the support member and is configured to be held open thereby in a deployed condition of the device. The valve member is at least partially unstented along its length. In a deployed condition of the device, flow in a proximal direction causes the distal end of the valve member to be closed.

Abstract: An introduction arrangement for a fenestrated or branched stent graft intended for deployment into the lumen of a vessel having a blind vessel extending from it. The introducer has a distal end intended to remain outside a patient in use and a proximal end with a nose cone dilator and an arrangement to retain the branched stent graft distally of the nose cone dilator. A sheath on the introducer extends over the branched stent graft to the nose cone dilator. An indwelling catheter extends from the distal end of the introducer and enters the fenestration or side arm and through to the nose cone dilator, the indwelling catheter has a guide wire extending through it. The guide wire can be extended beyond the nose cone dilator in use before the sheath is withdrawn from the branched stent graft so that it can be snared from the contra-lateral artery.

Abstract: A delivery system is provided for self-expanding medical devices, such as stents. The delivery system has a restraining sheath that maintains the stent in a compressed state prior to deployment. The restraining sheath terminates distally from the deployment handle, and a wire connects the restraining sheath to the deployment handle. The restraining sheath is withdrawn from the stent to deploy the stent by pulling the wires proximally at the deployment handle.

Abstract: A method of making a self-expanding stent entails applying a bend stress sufficient to over-bend a portion of a wire by an amount in a range from about 85% to about 105%, where the wire comprises a Ni—Ti alloy and includes from about 40% to about 46% cold work. The bend stress is then released, thereby forming a bend having a predetermined bend angle in the wire. The application and release of the bend stress are repeated on successive portions of the wire in order to create a series of bends along a length of the wire in a predetermined bend pattern. The wire comprising the predetermined bend pattern is then positioned about a mandrel in an expanded stent geometry and heat set. Thus, a self-expanding stent is formed.

Abstract: Differential pressure material processing systems, apparatus, methods, and products are described. An example embodiment of a differential pressure material processing system includes a tank, a holding member, and a sheet of tissue disposed within the holding member. The holding member defines a first holding member chamber and a second holding member chamber. The first holding member chamber has a first pressure when a fluid is disposed within the first holding member chamber. The second holding member chamber has a second pressure when a fluid is disposed within the second holding member chamber. The second pressure is different than the first pressure.

Abstract: The present invention relates generally to expandable medical devices including a light-activated shape-memory polymer. In certain embodiments, the devices include, for example, balloon catheters, used to treat narrowed or obstructed portions of a body vessel, and retrieval devices, used to remove obstructions from a body vessel. Certain aspects of the invention relate to methods of manufacturing and using such devices.

Abstract: Endoscope systems with bending sections that can bend in four directions independent of the rotatable viewing configuration of the endoscope systems are provided. Methods of using the endoscope systems in a patient's body are further provided.

Abstract: The disclosure relates to medical devices and methods of assembling medical devices, such as MRI-compatible interventional wireguides. An example of a wireguide includes a series of individual segments, a plurality of connectors, and a plurality of spacers. Each segment in the series of individual segments has a first end and a second end. Each connector of the plurality of connectors joins adjacent segments in the series of individual segments to one another such that a first end of a first segment and a second end of a second segment in the series of individual segments are attached to a connector of the plurality of connectors. A spacer of the plurality of spacers is disposed between each pair of adjacent segments in the series of individual segments. Each of the segments in the series of individual segments is electrically insulated from an adjacent segment in the series of individual segments.

Abstract: Various aspects of the present invention provide compositions and implantable devices including a water-insoluble therapeutic agent solubilized in a matrix of a gallate-containing compound. Other aspects provide methods of manufacturing and using such compositions and devices.