Abstract: An endovascular delivery device is disclosed. The device comprises a handle assembly at a distal end thereof and a top-cap assembly at a proximal end thereof. The top-cap assembly has an open configuration and a closed configuration and comprises: a capsule comprising an inner portion and an outer tubular portion and defining a cavity within the outer tubular portion, the cavity receiving the proximal portion of the endograft in the open configuration; and a retriever assembly having a body portion arranged and constructed to fit within the cavity of the capsule in the closed configuration. The device further comprises: a guide wire catheter extending through the handle assembly, the guide wire catheter being affixed at a proximal end thereof to the top-cap assembly; and an endograft receiving portion extending distally with respect to the top-cap assembly. In the closed configuration, the cavity is closed by the body portion of the retriever assembly.

Abstract: The present invention provides, in certain aspects, medical graft products that incorporate multiple drug depots in and/or on the products. One such product is a sheet graft construct, for example for tissue support that includes a sheet graft material with a plurality of drug depots. The drug depots can be hardened deposits formed directly onto the sheet graft material and/or can be capable of eluting a drug for a minimum of 72 hours.

Abstract: Methods of reducing air within a stent graft delivery device are disclosed, utilizing various flushing techniques. A port in a manifold that includes a pusher catheter coaxially disposed about a guide wire catheter is flushed. A portion in a sheath hub that excludes a longitudinally extended outer sheath coaxially disposed about the pusher catheter is flushed with a flushing fluid and/or a blood soluble gas, such as carbon dioxide. The guide wire catheter is also flushed.

Abstract: Medical systems, devices and methods are provided for engaging tissue, e.g. for clipping tissue, closing a perforation or performing hemostasis. Generally, the medical system including a housing, first and second jaws rotatable relative to the housing, a driver, and an elongate drive wire. The elongate drive wire may be disconnected from the driver, first and second jaws, and the housing, which are left in vivo engaged with the tissue.

Abstract: A scope system is provided including an elongate tube with a distal portion and a lumen extending therethrough. The scope system also includes at least one accessory channel including a tubular structure with an accessory lumen extending therethrough, the at least one accessory channel movably disposed at least partially within the lumen of the elongate tube. The at least one accessory channel includes a distal section and a forward-viewing configuration and a side-viewing configuration. In the forward-viewing configuration, the distal section of the at least one accessory channel is substantially parallel to the distal portion of the elongate tube and in the side-viewing configuration, the distal section of the at least one accessory channel is arced at a radius greater than a radius of the distal portion of the elongate tube.

Abstract: An electrosurgical medical device may include a conductive tubular element disposed about an outer surface of an elongate tubular member at a distal portion of the tubular member. The conductive tubular member may be delivered to a treatment site of a gastrointestinal (GI) tract of a patient and electrically activated. While electrically activated, the conductive tubular element may create an opening in a wall of the GI tract and a pseudocyst. After the incision is made, the conductive tubular element may be withdrawn from the treatment site and a drainage device may be positioned in the incision for drainage of the pseudocyst.

Abstract: A sealable container for preservation of a biological sample is provided. The container includes a cap comprising a proximal open and a lumen and an elongate body that extends from a handle portion to a specimen portion. A closure portion is disposed between the handle portion and the specimen portion, wherein the closure portion is configured to make surface to surface contact with the cap when the specimen portion is fully inserted within the lumen. The closure portion comprises an outer diameter that gradually decreases in a direction from the handle portion to the specimen portion. The specimen portion comprises a scooped portion where a distance between the upper surface and the lower surface is less than distances between the upper surface and the lower surface along remaining portions of the specimen portion, wherein the scooped portion is spaced proximally from a distal tip of the specimen portion.

Abstract: Described are peritoneal dialysis systems and methods that involve the use of crossflow filtration of a used dialysate withdrawn from the peritoneal space of a patient. The filtration forms a retentate containing amounts of an osmotic agent and a permeate containing amounts of water and nitrogen-containing waste products of the patient. The retentate, or a fraction thereof, can be returned to the peritoneal space of the patient to return osmotic agent to the patient. The permeate, or a fraction thereof, can be discarded to discard nitrogen-containing waste products of the patient.

Abstract: Storage devices, loading devices, delivery systems, kits, and associated methods for implantable medical devices are described. An example embodiment of a storage device includes a storage member, a first cap, and a second cap. The storage member has a first end, a second end, and a main body that defines a first opening, a second opening, a passageway, a separating wall, and a plurality of holes. The passageway has a first portion and a second portion. The first portion extends from the first end of the storage member to the separating wall and the second portion extends from the second end of the storage member to the separating wall. Each hole of the plurality of holes extends through the separating wall and provides access between the first portion and the second portion. Each of the first and second caps is releasably attached to the storage member.

Abstract: An endovascular prosthesis delivery system comprising: a guide wire catheter; a nose cone dilator at the proximal end of the guide wire catheter; and a pusher catheter comprising a lumen configured to receive the guide wire catheter therethrough and at least one longitudinal auxiliary lumens configured to receive an auxiliary catheter. The pusher catheter may have recess in the guide wire lumen. The recess may be configured to receive a portion of the nose cone dilator when the guide wire catheter is withdrawn distally.

Abstract: A method of crosslinking a protein or peptide for use as a biomaterial, the method comprising the step of irradiating a photoactivatable metal-ligand complex and an electron acceptor in the presence of the protein or peptide, thereby initiating a cross-linking reaction to form a 3-dimensional matrix of the biomaterial.

Abstract: A handle for an implant deployment device converts rotational movement into longitudinal movement in order to provide controlled release of one or more trigger wires. The handle also allows the trigger wire to be withdrawn into the device so that it does not need to be separately removed. A preferred handle includes a rotatable portion and a slidable portion. Releasable locks ensure that the handle is used to carry out implant deployment steps in a specific order.

Abstract: A device for permeation of a biological material may include a lower portion and an upper portion configured to be releasably coupled to the lower portion. The lower portion may include a groove configured to receivingly support a biological material. The lower portion and the upper portion may be coupled such that a first reservoir and a second reservoir are formed collectively by the lower portion and the upper portion. The first reservoir, the second reservoir, and the groove may be in fluid communication with each other.

Abstract: A device includes a medusa wire group with at least three separate wires slidably received in a vascular catheter. The multiple wires of the medusa wire group maximize the chances of at least one wire entering a target branch vessel during an attempt to achieve access. Entry into the branch vessel may then be gained by advancing the vascular catheter over the at least one wire that successfully entered the branch passageway.

Abstract: A device for culturing specimens may include a housing and a conveyor disposed within the housing, where the conveyor is translatable in vertical directions. The device may further include a plurality of plate holders disposed along a length of the conveyor, such that each plate holder of the plurality of plate holders can be moved to different positions along the length of the conveyor by a translation of the conveyor in the vertical directions. The device may further include an isolation chamber movable between a first position and a second position. The isolation chamber may include an opening and a door. The isolation chamber may be configured such that when the isolation chamber is in the second position, a first plate holder of the plurality of plate holders is isolated from a rest of the housing by the isolation chamber.

Abstract: An endovascular delivery device comprises an outer handle with a track; an inner handle moveable relative to the outer handle; a tip assembly slider mounted on the track; the tip assembly having a top cap and a retriever, the top cap comprising a mouth receiving a proximal portion of the endograft and closable by the retriever; a connector extending from the tip to the inner handle and including a distal portion slidably engaging the inner handle; a pusher catheter extending from the outer handle assembly; a guidewire catheter; a distal trigger wire operable to release the distal end of the endograft; a proximal trigger wire release slider mounted on the track and movable from an initial to a triggered position, wherein the tip assembly slider engages the trigger wire release slider to prevent distal movement until the trigger wire release slider is moved distally.

Abstract: The present embodiments provide apparatus and methods suitable for delivering a therapeutic agent to a target site. The apparatus generally comprises at least one container for holding a therapeutic agent, and a pressure source for facilitating delivery of the therapeutic agent. In one embodiment, the pressure source may be placed in selective fluid communication with a proximal region of the container and fluid from the pressure source may flow through at least a portion of the container to urge the therapeutic agent through container towards the target site. In an alternative embodiment, the container and the pressure source may be coupled to first and second inlet ports of a connecting member, respectively, such that the therapeutic agent flows through an outlet port of the connecting member and towards the target site.

Abstract: A stent graft (2) for placement in the thoracic arch of a patient has a first tubular body portion (6) with a first lumen therein for placement in the ascending aorta of a patient and a second tubular body portion (8) to extend along the thoracic arch and down the descending aorta. The second tubular body portion is of a lesser diameter than the first tubular body portion. There is a step portion (10) between the first body portion and the second body portion. The step portion is joined to and continuous with the first portion and the second portion. A first side of each of the first body portion, the step portion and the second body portion are substantially aligned so that there is a step (18) defined on a second side opposite to the first side of the body portion. There is an aperture (30) in the step portion and an internal tube (32) extending from the aperture towards the first body portion.

Abstract: The present invention provides, in certain aspects, medical graft products that incorporate multiple drug depots in and/or on the products. One such product is a sheet graft construct, for example for tissue support that includes a sheet graft material with a plurality of drug depots. The drug depots can be hardened deposits formed directly onto the sheet graft material and/or can be capable of eluting a drug for a minimum of 72 hours.

Abstract: A medical retrieval device for retrieving stones, calculi, and the like from various organs and passages may comprising an elongated member, and a first wire and a second wire that forms a retrieval basket. The wires forming the basket and the elongated member may be secured by a crimp joint and a second joint. Processing of the device may include placing all ends of the first wire and the second wire into an elongated member through a distal end of the elongated member, moving said elongated member to a position where the first loop and the second loop start their curvatures, placing said first and second wires and said elongated member through a crimping fixture having thru cuts configured for the interlocked wires, aligning said elongated member in a desired position, and crimping said first and second wires and said elongated member.