Patents Assigned to Corixa Corporation
  • Patent number: 10981978
    Abstract: Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: April 20, 2021
    Assignee: CORIXA CORPORATION
    Inventors: Robert Hershberg, Nancy Ann Hosken, Michael J. Lodes, Raodoh Mohamath
  • Patent number: 10457722
    Abstract: Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: October 29, 2019
    Assignee: Corixa Corporation
    Inventors: Robert Hershberg, Nancy Ann Hosken, Michael J. Lodes, Raodoh Mohamath
  • Publication number: 20180362622
    Abstract: Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.
    Type: Application
    Filed: June 22, 2018
    Publication date: December 20, 2018
    Applicant: Corixa Corporation
    Inventors: Robert Hershberg, Nancy Ann Hosken, Michael J. Lodes, Raodoh Mohamath
  • Patent number: 10011650
    Abstract: Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: July 3, 2018
    Assignee: Corixa Corporation
    Inventors: Robert Hershberg, Nancy Ann Hosken, Michael J. Lodes, Raodoh Mohamath
  • Publication number: 20180142001
    Abstract: Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.
    Type: Application
    Filed: January 11, 2018
    Publication date: May 24, 2018
    Applicant: CORIXA CORPORATION
    Inventors: ROBERT HERSHBERG, NANCY ANN HOSKEN, MICHAEL J. LODES, RAODOH MOHAMATH
  • Patent number: 9868779
    Abstract: Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: January 16, 2018
    Assignee: Corixa Corporation
    Inventors: Robert Hershberg, Nancy Ann Hosken, Michael J. Lodes, Raodoh Mohamath
  • Publication number: 20160362481
    Abstract: Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.
    Type: Application
    Filed: February 18, 2016
    Publication date: December 15, 2016
    Applicant: CORIXA CORPORATION
    Inventors: Robert Hershberg, Nancy Ann Hosken, Michael J. Lodes, Raodoh Mohamath, Stephan R. Targan
  • Patent number: 9512159
    Abstract: The invention relates to a method for extracting lipopolysaccharide (LPS) from rough trough mutant bacteria cells by extracting the cells with an aqueous aliphatic alcohol having from 1 to 4 carbon atoms at a temperature between 35 and 65 degrees C. to produce cells having a reduced phospholipid content. The resultant cells are then extracted with chloroform/methanol to yield LPS.
    Type: Grant
    Filed: May 6, 2014
    Date of Patent: December 6, 2016
    Assignee: CORIXA Corporation
    Inventors: Kent R. Myers, D. Scott Snyder
  • Patent number: 9290543
    Abstract: Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.
    Type: Grant
    Filed: February 25, 2008
    Date of Patent: March 22, 2016
    Assignee: CORIXA CORPORATION
    Inventors: Nancy Ann Hosken, Michael J. Lodes, Raodoh Mohamath, Stephan R. Targan
  • Patent number: 9175046
    Abstract: Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: November 3, 2015
    Assignee: Corixa Corporation
    Inventors: Robert Hershberg, Nancy Ann Hosken, Michael J. Lodes, Raodoh Mohamath
  • Patent number: 8920776
    Abstract: Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias, lymphomas and multiple myelomas. Disclosed are compositions, methods and kits for eliciting immune and T cell responses to specific malignancy-related antigenic polypeptides and antigenic polypeptide fragments thereof in an animal. Also disclosed are compositions and methods for use in the identification of cells and biological samples containing one or more hematological malignancy-related compositions, and methods for the detection and diagnosis of such diseases and affected cell types. Also disclosed are diagnostic and therapeutic kits, as well as methods for the diagnosis, therapy and/or prevention of variety of leukemias and lymphomas.
    Type: Grant
    Filed: January 22, 2003
    Date of Patent: December 30, 2014
    Assignee: Corixa Corporation
    Inventors: Alexander Gaiger, Paul A. Algate, Jane Mannion, Jonathan David Clapper, Aijun Wang, Nadia Ordonez, Lauren Carter, Patricia Dianne McNeill
  • Publication number: 20140056967
    Abstract: The present invention relates to compositions comprising proteins or polynucleotides of Chlamydia sp., in particular combinations of proteins or polynucleotides encoding them, and methods for the use of the proteins or polynucleotides in the treatment, prevention and diagnosis of Chlamydia infection.
    Type: Application
    Filed: August 13, 2013
    Publication date: February 27, 2014
    Applicants: GlaxoSmithKline Biologicals S.A., Corixa Corporation
    Inventors: Brenda Barth, India Ajay, Mark Alderson, Jean-Francois L. Maisonneuve, Yves Lobert, Florence Bernadette Nozay, Martine Marchand, Pascal Mettens, Yasir A. Skeiky, Peter Probst
  • Patent number: 8541007
    Abstract: The present invention relates to compositions comprising proteins or polynucleotides of Chlamydia sp., in particular combinations of proteins or polynucleotides encoding them, and methods for the use of the proteins or polynucleotides in the treatment, prevention and diagnosis of Chlamydia infection.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: September 24, 2013
    Assignees: GlaxoSmithKline Biologicals S.A., Corixa Corporation
    Inventors: Mark Alderson, Ajay Bhatia, Yves Lobet, Brenda Maisonneuve, Jean-Francois L Maisonneuve, Martine Marchand, Pascal Mettens, Florence Bernadette Nozay, Peter Probst, Samira H Skeiky
  • Publication number: 20130231293
    Abstract: Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.
    Type: Application
    Filed: November 21, 2012
    Publication date: September 5, 2013
    Applicant: Corixa Corporation
    Inventors: Robert Hershberg, Nancy Ann Hosken, Michael J. Lodes, Raodoh Mohamath
  • Publication number: 20120301492
    Abstract: Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
    Type: Application
    Filed: May 25, 2012
    Publication date: November 29, 2012
    Applicants: CORIXA CORPORATION, UNIVERSITY OF WASHINGTON
    Inventors: Alexander Gaiger, Martin A. Cheever
  • Patent number: 8318901
    Abstract: Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.
    Type: Grant
    Filed: April 22, 2011
    Date of Patent: November 27, 2012
    Assignee: Corixa Corporation
    Inventors: Robert Hershberg, Nancy Ann Hosken, Michael J. Lodes, Raodoh Mohamath
  • Patent number: 8318697
    Abstract: Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ mono- and disaccharide-based compounds for selectively stimulating immune responses in animals and plants.
    Type: Grant
    Filed: March 7, 2011
    Date of Patent: November 27, 2012
    Assignee: Corixa Corporation
    Inventors: David H. Persing, Richard Thomas Crane, Gary T. Elliott, J. Terry Ulrich, Michael J. Lacy, David A. Johnson, Jory R. Baldridge, Rong Wang
  • Patent number: 8263089
    Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: September 11, 2012
    Assignee: Corixa Corporation
    Inventors: Ajay Bhatia, Yasir A. W. Skeiky, Peter Probst
  • Publication number: 20120171248
    Abstract: Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.
    Type: Application
    Filed: October 29, 2007
    Publication date: July 5, 2012
    Applicant: CORIXA CORPORATION
    Inventors: Steven G. Reed, Yasir A.W. Skeiky, Davin C. Dillon, Antonio Campos-Neto, Raymond Houghton, Thomas S. Vedvick, Daniel R. Twardzik, Michael J. Lodes, Ronald C. Hendrickson
  • Patent number: 8182823
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: May 22, 2012
    Assignee: Corixa Corporation
    Inventors: Yuqiu Jiang, Davin C. Dillon, Jennifer L. Mitcham, Jiangchun Xu