Patents Assigned to Corixa Corporation
  • Compositions and methods for the therapy and diagnosis of breast cancer
    Patent number: 7855271
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: December 21, 2010
    Assignee: Corixa Corporation
    Inventors: Yuqiu Jiang, Davin C Dillon, Jennifer L Mitcham, Jiangchun Xu, Susan L Harlocker
  • ANTIBODIES TO TREAT CANCER
    Publication number: 20100303817
    Abstract: Compositions and methods for the treatment of cancer, particularly melanoma, myeloma, small cell lung cancer, thymic lymphoma, T-cell lymphoma, B-cell lymphoma, osteosarcoma, and acute T-cell leukemia, are disclosed. Illustrative compositions include one or more anti-ganglioside antibodies and polynucleotides that encode such anti-ganglioside antibodies. These antibodies may be for example, hamster antibodies, chimeric human/hamster antibodies, or humanized antibodies. The disclosed compositions are useful, for example, in the treatment of cancer and can be used to induce apoptosis in a cancer cell.
    Type: Application
    Filed: December 8, 2009
    Publication date: December 2, 2010
    Applicants: UNIVERSITY OF MASSACHUSETTS, Corixa Corporation
    Inventors: Gary R. FANGER, Neil FANGER, David KING, Marc W. RETTER, Kenneth L. ROCK
  • Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds
    Patent number: 7829542
    Abstract: Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ cyclic AGPs for selectively stimulating immune responses in animals and plants.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: November 9, 2010
    Assignee: Corixa Corporation
    Inventors: Jory R. Baldridge, David A. Johnson, Christopher W. Cluff
  • Antibodies to treat cancer
    Patent number: 7781569
    Abstract: Compositions and methods for the treatment of cancer, particularly melanoma, myeloma, small cell lung cancer, thymic lymphoma, T-cell lymphoma, B-cell lymphoma, osteosarcoma, and acute T-cell leukemia, are disclosed. Illustrative compositions include one or more anti-ganglioside antibodies and polynucleotides that encode such anti-ganglioside antibodies. These antibodies may be for example, hamster antibodies, chimeric human/hamster antibodies, or humanized antibodies. The disclosed compositions are useful, for example, in the treatment of cancer and can be used to induce apoptosis in a cancer cell.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: August 24, 2010
    Assignees: University of Massachusetts, Corixa Corporation
    Inventors: Gary Fanger, Neil Fanger, David John King, Marc W. Retter, Kenneth L. Rock
  • FUSION PROTEINS OF MYCOBACTERIUM TUBERCULOSIS
    Publication number: 20100183657
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Application
    Filed: February 2, 2010
    Publication date: July 22, 2010
    Applicant: CORIXA CORPORATION
    Inventors: YASIR SKEIKY, JEFF GUDERIAN, STEVEN REED
  • FUSION PROTEINS OF MYCOBACTERIUM TUBERCULOSIS
    Publication number: 20100183677
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Application
    Filed: February 2, 2010
    Publication date: July 22, 2010
    Applicant: Corixa Corporation
    Inventors: Yasir Skeiky, Jeff Guderian, Steven Reed
  • Compositions and methods for the therapy and diagnosis of lung cancer
    Patent number: 7749505
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: July 6, 2010
    Assignee: Corixa Corporation
    Inventors: Tongtong Wang, Robert A. Henderson, Teresa M. Foy
  • Dna vectors
    Publication number: 20100150968
    Abstract: The present invention provides compositions and methods for expressing heterologous proteins useful in the treatment of cancer.
    Type: Application
    Filed: June 9, 2004
    Publication date: June 17, 2010
    Applicant: CORIXA CORPORATION
    Inventors: Gregory A. Spies, Lynda Misher
  • Fusion proteins of
    Patent number: 7691993
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: April 6, 2010
    Assignee: Corixa Corporation
    Inventors: Yasir Skeiky, Jeff Guderian, Steven Reed
  • Fusion proteins of
    Patent number: 7678375
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Grant
    Filed: January 26, 2006
    Date of Patent: March 16, 2010
    Assignee: Corixa Corporation
    Inventors: Yasir Skeiky, Jeff Guderian, Steven Reed
  • Compositions and methods for WT1 specific immunotherapy
    Patent number: 7662386
    Abstract: Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
    Type: Grant
    Filed: December 13, 2007
    Date of Patent: February 16, 2010
    Assignees: Corixa Corporation, University of Washington
    Inventors: Alexander Gaiger, Martin A. Cheever
  • Compositions and methods for WT1 specific immunotherapy
    Patent number: 7655249
    Abstract: Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
    Type: Grant
    Filed: July 12, 2002
    Date of Patent: February 2, 2010
    Assignee: Corixa Corporation
    Inventors: Alexander Gaiger, Patricia D. McNeill
  • Fusion Proteins of Mycobacterium Tuberculosis
    Publication number: 20100015096
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Application
    Filed: June 23, 2009
    Publication date: January 21, 2010
    Applicant: Corixa Corporation
    Inventors: Yasir Skeiky, Steven Reed, Mark Alderson
  • COMPOUNDS AND METHODS FOR IMMUNOTHERAPY AND DIAGNOSIS OF TUBERCULOSIS
    Publication number: 20090312244
    Abstract: Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.
    Type: Application
    Filed: October 29, 2007
    Publication date: December 17, 2009
    Applicant: Corixa Corporation
    Inventors: Steven G. Reed, Yasir A.W. Skeiky, Davin C. Dillon, Antonio Campos-Neto, Raymond Houghton, Thomas S. Vedvick, Daniel R. Twardzik, Michael J. Lodes, Ronald C. Hendrickson
  • Fusion Proteins of Mycobacterium Tuberculosis
    Publication number: 20090306195
    Abstract: The present invention relates to fusion proteins containing at least two Mycobacterium species antigens. In particular, it relates to nucleic acids encoding fusion proteins that include two or more individual M. tuberculosis antigens, which increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Application
    Filed: June 24, 2009
    Publication date: December 10, 2009
    Applicant: Corixa Corporation
    Inventors: Yasir Skeiky, Steven Reed, Raymond L. Houghton, Patricia D. McNeill, Davin C. Dillon, Michael J. Lodes
  • Fusion proteins of mycobacterium tuberculosis antigens and their uses
    Publication number: 20090281168
    Abstract: The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M. tuberculosis antigens, tri-fusion proteins which contain three M. tuberculosis antigens, tetra-fusion proteins which contain four M. tuberculosis antigens, and penta-fusion proteins which contain five M. tuberculosis antigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.
    Type: Application
    Filed: October 29, 2007
    Publication date: November 12, 2009
    Applicant: Corixa Corporation
    Inventors: Steven G. Reed, Yasir A. Skeiky, Davin C. Dillon, Mark Alderson, Antonio Campos-Nero
  • Compositions and methods for the therapy and diagnosis of breast cancer
    Patent number: 7598226
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: October 6, 2009
    Assignee: Corixa Corporation
    Inventors: Yuqiu Jiang, Davin C. Dillon, Jennifer L. Mitcham, Jiangchun Xu, Susan L. Harlocker
  • Compositions and methods for the therapy and diagnosis of ovarian cancer
    Patent number: 7598051
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: October 6, 2009
    Assignee: Corixa Corporation
    Inventors: Gary R Fanger, Steven P Fling
  • Compositions and methods for the therapy and diagnosis of lung cancer
    Patent number: 7585506
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
    Type: Grant
    Filed: November 22, 2006
    Date of Patent: September 8, 2009
    Assignee: Corixa Corporation
    Inventors: Tongtong Wang, Robert A. Henderson, Teresa M. Foy
  • Methods for the detection of cervical cancer
    Patent number: 7579160
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
    Type: Grant
    Filed: August 19, 2004
    Date of Patent: August 25, 2009
    Assignee: Corixa Corporation
    Inventors: Chaitanya S. Bangur, Barbara K. Zehentner-Wilkinson