Abstract: A land-based ungulate recovery support and stabilization system includes at least one fall control unit mounted in a recovery space and coupled to a harness via at least one rope. The at least one fall control unit provides means for applying brake force(s) to a land-based hoofed animal, such as a horse, fitted in the harness to manage motion of the animal. By managing motion, an uncontrolled fall, a stagger, and other jerking motions can be avoided to prevent injury.

Abstract: Controlled release coacervate formulations for slow, extended release of C-X-C chemokine receptor 3 (CXCR3) activating peptides are described. The controlled release compositions are designed for ophthalmic administration, such as by topical administration to the eye or by injection into the conjunctiva. Methods of treating dry eye disease and enhancing goblet cell density in the conjunctiva are also described.

Abstract: The present technology is directed to compounds, intermediates thereof, compositions thereof, medicaments thereof, and methods related to the imaging of mammalian tissue overexpressing PSMA. The compounds are of Formula I or a pharmaceutically acceptable salt thereof, wherein one of R1, R2, and R3 is and of Formula IV or a pharmaceutically acceptable salt thereof.

Abstract: The technology disclosed in this patent document can be used to construct devices with opto-electronic circuitry for sensing and identification applications, to provide untethered devices for deployment in living objects and other applications, and to provide fabrication techniques for making such devices for commercial production. As illustrated by specific examples disclosed herein, the disclosed technology can be implemented to provide fabrication methods, substrates, and devices that enable wireless, inorganic cell-scaled sensor and identification systems that are optically-powered and optically-readout.

Abstract: The present disclosure includes a method of producing solid inorganic carbonate compounds by capturing, converting, and storing carbon dioxide comprising providing one or more precursor compound; providing one or more carbon dioxide capture solvent or capture additive; and reacting said one or more precursor compound with said one or more carbon dioxide capture solvent or capture additive under conditions effective to produce one or more solid inorganic carbonate compound. Also disclosed is a method of producing solid inorganic bicarbonate compounds by capturing, converting, and storing carbon dioxide comprising providing one or more precursor compound; providing one or more carbon dioxide capture solvent or capture additive; and reacting said one or more precursor compound with said one or more carbon dioxide capture solvent or capture additive under conditions effective to produce one or more solid inorganic bicarbonate compound.

Abstract: A computer-implemented method of training a neural network to recognize sensory patterns includes obtaining input data, preprocessing the input data in one or more preprocessors of the neural network, and applying the preprocessed input data to a core portion of the neural network. The core portion of the neural network includes a plurality of principal neurons and a plurality of interneurons, and is configured to implement a feedback loop from the interneurons to the principal neurons that supports persistent unsupervised differentiation of multiple learned sensory patterns over time. The method further includes obtaining an output from the core portion, and performing at least one automated action based at least in part on the output obtained from the core portion. The neural network may be adaptively expanded to facilitate the persistent unsupervised differentiation of multiple learned sensory patterns over time by incorporating additional interneurons into at least the core portion.

Abstract: The present technology provides compounds, as well as compositions including such compounds, useful for imaging and/or treatment of a glioma, a breast cancer, an adrenal cortical cancer, a cervical carcinoma, a vulvar carcinoma, an endometrial carcinoma, a primary ovarian carcinoma, a metastatic ovarian carcinoma, a non-small cell lung cancer, a small cell lung cancer, a bladder cancer, a colon cancer, a primary, gastric adenocarcinoma, a primary colorectal adenocarcinoma, a renal cell carcinoma, and/or a prostate cancer. The compounds are represented by the following formula or a pharmaceutically acceptable salt thereof.

Abstract: A single or multiple self-tuning coil element for an MR imaging system is provided. The element is flexible and stretchable and may conform to various body parts and patient sizes. The element may be worn by the patient during the MR imaging session. Each coil may have one or more interdigital capacitors formed of flexible conductive traces. The capacitance of the interdigital capacitor(s) changes under stretching which provides the self-tuning. The traces may be made of liquid metal. The liquid metal may be doped with a contrast agent such that the coil is substantially invisible on an MR image. The coil(s) in a multiple coil element may be arranged in a single or a dual layer.

Abstract: Disclosed herein are plant-based, molecular and diagnostic tools that can be used to block aphid transmission of poleroviruses, including stabilized proteins for expression in transgenic plants and/or in formulations for direct plant delivery. Further disclosed are proteins that can kill aphids and methods to produce these proteins. Antibodies and useful for diagnostic and therapeutic uses against poleroviruses.

Abstract: Technologies for radiomyography gesture recognition include a computing device coupled to a radio near-field sensor device including multiple transmitting and receiving antennas. The computing device transmits multiple radio frequency signals with the sensor device, which is positioned near the muscle area of interest for a user. The sensor device may include a cuff or armband that surrounds the forearm of the user. The computing device receives multiple time-domain signals with the receiving antennas and classifies the signals with a trained machine learning model to generate one or more distinct states, such as a gesture or posture classification. The computing device may transform each time-domain signal to a two-dimensional spectrogram and classify the two-dimensional spectrogram with a vision-based model such as a vision transformer model. Other embodiments are described and claimed.

Abstract: The disclosure provides a method of treating fibrosis of an organ comprising administering a c-P4H inhibitor to a patient suffering from fibrosis in an organ, to counteract pathological fibrosis. c-P4H inhibitors can be administered via various routes, including in an aerosolized state using a nebulizer, intravenous, intraperitoneal or subcutaneous injection.

Abstract: The invention provides compositions and methods for providing a cardioprotective effect in a subject. Specifically, the invention provides compositions and methods for treating cardiovascular ailments, for example, ischemia/reperfusion (I/R) injury, cardiac arrhythmias, oxidative stress, or cardiac failure by administering a retinoic acid receptor-beta (RAR?) agonist.

Abstract: The disclosed subject matter provides methods of synthesizing a helical graphene nanoribbon (hGNR), and electrode arrays and transistors based thereon. The method includes polymerizing a perylene tetraester precursor with an alkyne monomer to form a polymer backbone; inducing the polymer backbone to visible-light-mediated photocyclization to generate a helical nanoribbon precursor; and post-functionalizing the helical nanoribbon precursor with imide groups having oligoethylene glycol substituents, thereby forming a substantially defect-free helical graphene nanoribbon adapted for mixed ionic and electronic conduction.

Abstract: A plasmonic nanostructure includes a dielectric substrate, a periodic array of dielectric pillars on the dielectric substrate; and, on each dielectric pillar of the periodic array, a respective conductive layer. Each dielectric pillar of the periodic array of dielectric pillars is between the respective conductive layer and the dielectric substrate. A method for imaging a cell includes reflecting an optical beam off the plasmonic nanostructure. The plasmonic nanostructure has biological cells adhered thereto. The method also includes collecting the reflected optical beam with an optical detector.

Abstract: As described herein ingestion of high amounts of sugar, especially fructose, can increase the growth of intestinal tumors. Such cancer growth can be inhibited or prevented by limiting the amounts of sugar and amino acids ingested, by inhibiting ketohexokinase (KHK), fructose transport (via GLUT5), fatty acid synthesis (via FASN), phosphoinositide 3-kinases (PI3K), or by limiting amounts of sugar and amino acids ingested while also receiving KHK inhibitors, GLUT5 inhibitors, FASN inhibitors, PI3K inhibitors, or a combination of such inhibitors.

Abstract: A method in an illustrative embodiment comprises obtaining an acoustic signal for a given individual, generating an image representation of at least a portion of the acoustic signal, processing the image representation in at least one neural network of an acoustics classifier to generate a classification for the acoustic signal, and executing at least one automated action based at least in part on the generated classification. The acoustic signal illustratively comprises, for example, at least one of a heart sound signal, a blood flow sound signal, a lung sound signal, a bowel sound signal, a cough sound signal, or other physiological sound signal of the given individual. Generating the image representation illustratively comprises generating at least one spectrogram. Additionally or alternatively, generating the image representation may comprise generating one or more recurrence plots, Markov transition field image representations and/or Gramian angular field image representations.

Abstract: The disclosure provides a method of altering a DNA sequence, which method comprises the use of a type I-C CRISPR-Cas system based on Neisseria lactamica. The system involves a combination of two or more Neisseria lactamica proteins selected from Cas3, Cas5, Cas8c, and Cas7 and a synthetic guide RNA sequence.

Abstract: The invention relates to methods of lubricating biological tissue, such as joints, bone, ocular tissue, nasal tissue, tendons, tendon capsule, and vaginal tissue, by contacting the biological tissue with an effective amount of a block copolymer lubricating composition which functions at least or better than lubricin. In particular embodiments, the method is used to treat osteoarthritis. In specific embodiments, the block copolymer has an ammonium-containing polymer block and a non-ionic hydrophilic polymer block, or the copolymer has a carboxylic acid-containing polymer block and a non-acid non-ionic hydrophilic polymer block.

Abstract: Disclosed herein is the selective functionalization of one or more hydrocarbons ranging from the longest macromolecules to methane as the smallest. Functionalization is achieved through C—H activation of the one or more hydrocarbons and is carried out by the catalytic complex described herein. Also disclosed is the compound of formula (I) and the compound of formula (II).

Abstract: Provided are methods of increasing a response to a chemotherapeutic agent or an immunotherapeutic agent in a patient in need thereof, and methods of treating cancer in a patient in need thereof, comprising administering to the patient a chemotherapeutic agent or an immunotherapeutic agent and a metastasis inhibiting compound, as described in this disclosure.