Abstract: The current disclosure current disclosure is directed to methods of diagnosing, triaging, and treating tuberculosis. Another aspect of the current disclosure is directed to methods of establishing a panel of biomarkers that correlates with tuberculosis disease status.

Abstract: A delivery device, such as a feeding tube, may have one or more pullout resistors that can anchor the delivery device to a patient's abdomen. When implanted, the pullout resistors can lie between the small intestine and intraabdominal wall. The pullout resistors can prevent inadvertent retrograde displacement of the delivery device without obstructing the lumen of the intestine. The pullout resistors can be flexible to enable a healthcare professional to apply an external retraction force to remove the delivery device.

Abstract: The present invention relates to compositions of aqueous humor and/or vitreous humor derived extracellular vesicles and their use for the delivery of therapeutic agents to ocular tissues for the treatment of ophthalmic diseases. Further disclosed are methods of making the compositions. Methods of treating and diagnosing an ocular condition are also disclosed.

Abstract: Provided are compositions and methods that include a K. pneumoniae yidR protein or an antigenic segment of the protein, and homologous of the protein, and antigenic segments of the homologs. The compositions can be provided as vaccine formulations for use with humans and non-human animals, including but not limited to dairy cows. The compositions and methods are useful for prophylaxis and/or therapy of conditions associated with Gram negative bacteria that include K. pneumonia, E. coli, and other pathogenic Gram negative bacteria. The conditions include such bacterial infections generally, and include specifically mastitis and metritis. The compositions and methods can also improve fertility and milk production. Administration of the compositions can improve the likelihood of a first service conception.

Abstract: Provided are compositions and methods related to improved mucins, methods of making the improved mucins, and cells and cell cultures that express glycosylated mucins. The compositions and methods provide improved cell cultures, and improved methods of producing co-expressed proteins that are distinct from the mucins.

Abstract: Silica nanorings, methods of making silica nanorings, and uses of silica nanorings. The silica nanorings may be PEGylated. The silica nanorings may be surface functionalized, which may be surface selective functionalization, with one or more polyethylene glycol (PEG) group(s), one or more display group(s), one or more functional group(s), or a combination thereof. The silica nanorings may have a size of 5 to 20 nm. The silica nanorings may be made using micelles. The absence or presence of the micelles during PEGylation and/or functionalization allows for surface selective functionalization. The silica nanorings may be used in various diagnostic and/or treatment methods.

Abstract: The present disclosure provides systems and methods for characterizing and predicting an anatomical feature, and predicting the progression of a condition of the anatomical feature, based on a signal from an ultrasonic transducer. For example, the systems and methods disclosed herein can be utilized to characterize and predict a condition such as myopia based on an elasticity of an anterior sclera.

Abstract: The present disclosure is directed to novel nucleoside analog compounds and methods for treating diseases characterized by high expression levels of adenosine kinase (ADK).

Abstract: Provided are methods for the capture of energy critical high value metals and an apparatus or system for an electrochemical approach to produce Ca- and Mg-hydroxides, silica, and leach metals into the solution phase that can be sequentially recovered. The methods entail: providing a functionalized sorbent for metal capture; recovering the metal from the metal-containing solution by contacting the functionalized sorbent with the metal-containing solution, thereby adsorbing metal ions from the metal-containing solution onto the functionalized sorbent; and desorbing the metal ions from the functionalized sorbent by contacting the functionalized sorbent with a stripping agent, thereby forming a stripped solution containing the metal ions.

Abstract: A land-based ungulate recovery support and stabilization system includes at least one fall control unit mounted in a recovery space and coupled to a harness via at least one rope. The at least one fall control unit provides means for applying brake force(s) to a land-based hoofed animal, such as a horse, fitted in the harness to manage motion of the animal. By managing motion, an uncontrolled fall, a stagger, and other jerking motions can be avoided to prevent injury.

Abstract: Controlled release coacervate formulations for slow, extended release of C-X-C chemokine receptor 3 (CXCR3) activating peptides are described. The controlled release compositions are designed for ophthalmic administration, such as by topical administration to the eye or by injection into the conjunctiva. Methods of treating dry eye disease and enhancing goblet cell density in the conjunctiva are also described.

Abstract: The present technology is directed to compounds, intermediates thereof, compositions thereof, medicaments thereof, and methods related to the imaging of mammalian tissue overexpressing PSMA. The compounds are of Formula I or a pharmaceutically acceptable salt thereof, wherein one of R1, R2, and R3 is and of Formula IV or a pharmaceutically acceptable salt thereof.

Abstract: The technology disclosed in this patent document can be used to construct devices with opto-electronic circuitry for sensing and identification applications, to provide untethered devices for deployment in living objects and other applications, and to provide fabrication techniques for making such devices for commercial production. As illustrated by specific examples disclosed herein, the disclosed technology can be implemented to provide fabrication methods, substrates, and devices that enable wireless, inorganic cell-scaled sensor and identification systems that are optically-powered and optically-readout.

Abstract: The present disclosure includes a method of producing solid inorganic carbonate compounds by capturing, converting, and storing carbon dioxide comprising providing one or more precursor compound; providing one or more carbon dioxide capture solvent or capture additive; and reacting said one or more precursor compound with said one or more carbon dioxide capture solvent or capture additive under conditions effective to produce one or more solid inorganic carbonate compound. Also disclosed is a method of producing solid inorganic bicarbonate compounds by capturing, converting, and storing carbon dioxide comprising providing one or more precursor compound; providing one or more carbon dioxide capture solvent or capture additive; and reacting said one or more precursor compound with said one or more carbon dioxide capture solvent or capture additive under conditions effective to produce one or more solid inorganic bicarbonate compound.

Abstract: A computer-implemented method of training a neural network to recognize sensory patterns includes obtaining input data, preprocessing the input data in one or more preprocessors of the neural network, and applying the preprocessed input data to a core portion of the neural network. The core portion of the neural network includes a plurality of principal neurons and a plurality of interneurons, and is configured to implement a feedback loop from the interneurons to the principal neurons that supports persistent unsupervised differentiation of multiple learned sensory patterns over time. The method further includes obtaining an output from the core portion, and performing at least one automated action based at least in part on the output obtained from the core portion. The neural network may be adaptively expanded to facilitate the persistent unsupervised differentiation of multiple learned sensory patterns over time by incorporating additional interneurons into at least the core portion.

Abstract: The present technology provides compounds, as well as compositions including such compounds, useful for imaging and/or treatment of a glioma, a breast cancer, an adrenal cortical cancer, a cervical carcinoma, a vulvar carcinoma, an endometrial carcinoma, a primary ovarian carcinoma, a metastatic ovarian carcinoma, a non-small cell lung cancer, a small cell lung cancer, a bladder cancer, a colon cancer, a primary, gastric adenocarcinoma, a primary colorectal adenocarcinoma, a renal cell carcinoma, and/or a prostate cancer. The compounds are represented by the following formula or a pharmaceutically acceptable salt thereof.

Abstract: A single or multiple self-tuning coil element for an MR imaging system is provided. The element is flexible and stretchable and may conform to various body parts and patient sizes. The element may be worn by the patient during the MR imaging session. Each coil may have one or more interdigital capacitors formed of flexible conductive traces. The capacitance of the interdigital capacitor(s) changes under stretching which provides the self-tuning. The traces may be made of liquid metal. The liquid metal may be doped with a contrast agent such that the coil is substantially invisible on an MR image. The coil(s) in a multiple coil element may be arranged in a single or a dual layer.

Abstract: Disclosed herein are plant-based, molecular and diagnostic tools that can be used to block aphid transmission of poleroviruses, including stabilized proteins for expression in transgenic plants and/or in formulations for direct plant delivery. Further disclosed are proteins that can kill aphids and methods to produce these proteins. Antibodies and useful for diagnostic and therapeutic uses against poleroviruses.

Abstract: Technologies for radiomyography gesture recognition include a computing device coupled to a radio near-field sensor device including multiple transmitting and receiving antennas. The computing device transmits multiple radio frequency signals with the sensor device, which is positioned near the muscle area of interest for a user. The sensor device may include a cuff or armband that surrounds the forearm of the user. The computing device receives multiple time-domain signals with the receiving antennas and classifies the signals with a trained machine learning model to generate one or more distinct states, such as a gesture or posture classification. The computing device may transform each time-domain signal to a two-dimensional spectrogram and classify the two-dimensional spectrogram with a vision-based model such as a vision transformer model. Other embodiments are described and claimed.

Abstract: This invention relates to a new and distinct primocane bearing red raspberry plant designated as ‘Crimson Beauty’ primarily adapted to growing conditions of west central New York and other regions of similar climate. The new plant is primarily characterized by branched and self-supporting canes, conical fruit that is longer than broad, an early primocane season production period, a long production season and light red colored fruit with uniform drupelets.