Patents Assigned to Cornell University
  • Publication number: 20250025605
    Abstract: Disclosed herein are tissue scaffold materials with microspheres of one density embedded in hydrogel of a different density. The disclosed materials have improved ability to facilitate cellular invasion and vascularization for wound healing and tissue regeneration. The inventors have found that materials having components with different densities promotes invasion of cells, including desirable cells such as fibroblasts and endothelial precursor cells, into the scaffold.
    Type: Application
    Filed: May 24, 2024
    Publication date: January 23, 2025
    Applicant: CORNELL UNIVERSITY
    Inventors: Jason SPECTOR, Abraham D. STROOCK, John MORGAN
  • Patent number: 12201136
    Abstract: The present invention relates to a process for preparing an edible foodstuff from food industry waste stream byproducts. This process involves the steps of: (i) combining, in an extruder, an extrusion formulation comprising a first food byproduct and at least one additional ingredient; (ii) introducing supercritical carbon dioxide (SC-CO2) into the extruder to mix with the first food byproduct and the at least one additional ingredient; and (iii) producing an edible foodstuff containing the first food byproduct and the at least one additional ingredient, where the edible foodstuff comprises an extrudate prepared under supercritical fluid extrusion (SCFX) conditions. The present invention also relates to a process for preparing an edible foodstuff from a protein concentrate. The present invention further relates to edible foodstuffs produced by the various processes disclosed herein.
    Type: Grant
    Filed: August 23, 2023
    Date of Patent: January 21, 2025
    Assignee: CORNELL UNIVERSITY
    Inventors: Syed S. H. Rizvi, Ilankovan Paraman
  • Patent number: 12194675
    Abstract: Systems and methods are provided for incremental 3D printing, wherein wireframes are generated and printed (scheduled for print) during the design process. In another aspect, systems and methods are provided for printing arbitrary meshes. A 3D printer system is described having, for example, five degree-of-freedom (5DOF). The 5DOF printer may be used to perform any of the methods described herein and combinations of the methods.
    Type: Grant
    Filed: November 1, 2021
    Date of Patent: January 14, 2025
    Assignee: Cornell University
    Inventors: Francois Guimbretiere, Huaishu Peng, Stephen Robert Marschner, Rundong Wu
  • Patent number: 12186288
    Abstract: The present technology is directed to compounds, compositions, medicaments, and methods related to the treatment of cancers expressing PSMA. The compounds are of Formulas I & II or pharmaceutically acceptable salts thereof. The present technology is especially well-suited for use in treating prostate cancer.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: January 7, 2025
    Assignee: Cornell University
    Inventors: John W. Babich, James M. Kelly, Alejandro Amor-Coarasa, Shashikanth Ponnala
  • Patent number: 12188015
    Abstract: Provided are compositions, methods, and kits for CRISPR-based editing of DNA targets by Type I CRISPR-associated (Cas) enzymes.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: January 7, 2025
    Assignees: Cornell University, The Regents of the University of Michigan
    Inventors: Ailong Ke, Adam Dolan, Yan Zhang, Zhonggang Hou
  • Patent number: 12188939
    Abstract: Methods of obtaining and kits that can be used to obtain an optical super-resolution image of a sample or a portion thereof or an individual or a portion thereof. In various examples, the individual is an individual with cancer. In various examples, a method includes contacting a sample or individual with one or more aluminosilicate nanoparticle(s) that have at least one organic fluorophore molecule covalently bonded to the aluminosilicate network of the nanoparticle(s), or a composition including the aluminosilicate nanoparticle(s); irradiating the sample or the individual, thereby exciting at least one of the fluorophore molecules of an individual aluminosilicate nanoparticle; and obtaining a fluorescence image or a sequence of fluorescence images, which can be processed to obtain a super-resolution image of the sample or the individual. In various examples, the sample is a biological sample, living or fixed tissues and/or cells, or a biopsy obtained from an individual.
    Type: Grant
    Filed: October 14, 2021
    Date of Patent: January 7, 2025
    Assignee: Cornell University
    Inventors: Jacob Erstling, Joshua A. Hinckley, Nirmalya Bag, Ulrich B. Wiesner
  • Patent number: 12188072
    Abstract: Disclosed are methods, systems, components, and compositions for cell-free synthesis of glycosylated carrier proteins. The glycosylated carrier proteins may be utilized in vaccines, including anti-bacterial vaccines. The glycosylated carrier proteins may include a bacterial polysaccharide conjugated to a carrier, which may be utilized to generate an immune response in an immunized host against the polysaccharide conjugated to the carrier. The glycosylated carrier proteins may be synthesized in cell-free glycoprotein synthesis (CFGpS) systems using prokaryote cell lysates that are enriched in components for glycoprotein synthesis such as oligosaccharyltransferases (OSTs) and lipid-linked oligosaccharides (LLOs) including OSTs and LLOs associated with synthesis of bacterial O antigens.
    Type: Grant
    Filed: December 19, 2022
    Date of Patent: January 7, 2025
    Assignees: Northwestern University, Cornell University
    Inventors: Michael Christopher Jewett, Jessica Carol Stark, Matthew P. DeLisa, Thapakorn Jaroentomeechai
  • Publication number: 20250000829
    Abstract: The present disclosure relates generally to methods for determining whether a patient suffering from or at risk for STXBP1- or SYNGAP1-encephalopathy will benefit from treatment with phenylbutyrate compositions comprising screening the patient for mutations in STXBP1 or SYNGAP1. Also disclosed herein are methods for selecting patients at risk for developmental and epileptic encephalopathy (DEE) for treatment with compositions including phenylbutyrate.
    Type: Application
    Filed: June 5, 2024
    Publication date: January 2, 2025
    Applicant: CORNELL UNIVERSITY
    Inventors: Zachary Grinspan, Jacqueline Burré
  • Publication number: 20250006297
    Abstract: The present disclosure encompasses systems and methods for predicting embryo ploidy. Specific embodiments encompass methods of non-invasively predicting ploidy status of an embryo, by receiving a dataset with video including a plurality of image frames of the embryo, analyzing the plurality of image frames by one or more machine and/or deep learning model via one or more classification task applied to the dataset; and generating an output prediction of the ploidy status of the embryo. Particular methods relate to methods wherein the dataset additionally includes one or more clinical and/or morphological features for the embryo, such as maternal age at the time of oocyte retrieval. Embodiments also relate to predicting embryo viability and/or improving embryo selection, such as during in vitro fertilization, and uses thereof.
    Type: Application
    Filed: February 8, 2024
    Publication date: January 2, 2025
    Applicant: CORNELL UNIVERSITY
    Inventors: Iman HAJIRASOULIHA, Nikica ZANINOVIC, Josue BARNES, Zev ROSENWAKS, Olivier ELEMENTO, Jonas MALMSTEN, Suraj RAJENDRAN
  • Publication number: 20240424726
    Abstract: Implanted medical devices need a mechanism of immobilization to surrounding tissues, which minimizes tissue damage while providing reliable long-term anchoring. This disclosure relates to techniques for patterning arbitrarily shaped 3D objects and to patterned balloon devices having micro-or nano-patterning on an outer surface of an inflatable balloon. The external pattern can provide enhanced friction and anchoring in an aqueous environment. Examples of these types of patterns are hexagonal arrays inspired by tree frogs, corrugated patterns, and microneedle patterns. The patterned balloon devices can be disposed between an implant and surrounding tissues to facilitate anchoring of the implant.
    Type: Application
    Filed: July 9, 2024
    Publication date: December 26, 2024
    Applicant: Cornell University
    Inventors: Seyedhamidreza Alaie, Simon Dunham, Bobak Mosadegh, James K. Min, Amir Ali Amiri Moghadam
  • Publication number: 20240423258
    Abstract: The present invention relates to a process for preparing an edible foodstuff from food industry waste stream byproducts. This process involves the steps of: (i) combining, in an extruder, an extrusion formulation comprising a first food byproduct and at least one additional ingredient; (ii) introducing supercritical carbon dioxide (SC-CO2) into the extruder to mix with the first food byproduct and the at least one additional ingredient; and (iii) producing an edible foodstuff containing the first food byproduct and the at least one additional ingredient, where the edible foodstuff comprises an extrudate prepared under supercritical fluid extrusion (SCFX) conditions. The present invention also relates to a process for preparing an edible foodstuff from a protein concentrate. The present invention further relates to edible foodstuffs produced by the various processes disclosed herein.
    Type: Application
    Filed: September 4, 2024
    Publication date: December 26, 2024
    Applicant: CORNELL UNIVERSITY
    Inventors: Syed S.H. RIZVI, Ilankovan PARAMAN
  • Patent number: 12174176
    Abstract: The present invention is directed to kits for identifying the presence of one or more target nucleotide sequences in a sample that involve a ligation and/or polymerase reaction. In some embodiments, the ligation products formed in the ligation process of the present invention are subsequently amplified using a polymerase chain reaction. The ligated product sequences or extension products thereof are detected, and the presence of one or more target nucleotide sequences in the sample is identified based on the detection.
    Type: Grant
    Filed: December 16, 2021
    Date of Patent: December 24, 2024
    Assignee: CORNELL UNIVERSITY
    Inventors: Francis Barany, Eugene Spier, Alain Mir
  • Patent number: 12176572
    Abstract: Provided are compositions including one or more cyclic ether(s), one or more salt(s), which may be one or more lithium salt(s), one or more sodium salt(s), or a combination thereof, and, optionally, one or more ring-opening polymerization initiator(s). The compositions may be used to form solid-state electrolytes. Also provided are methods for forming solid-state electrolytes using the compositions and devices comprising one or more composition(s) or one or more solid-state electrolyte(s) using the compositions.
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: December 24, 2024
    Assignee: Cornell University
    Inventors: Lynden A. Archer, Qing Zhao, Kasim Khan, Xiaotun Liu
  • Patent number: 12168658
    Abstract: Provided are compounds, compositions and methods for inhibiting fascin activity or treating a condition or disorder mediated by fascin activity in a subject in need thereof.
    Type: Grant
    Filed: December 21, 2023
    Date of Patent: December 17, 2024
    Assignees: NOVITA PHARMACEUTICALS, INC., CORNELL UNIVERSITY
    Inventors: Xin-Yun Huang, Christy Young Shue
  • Patent number: 12161734
    Abstract: The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer. The nanoparticle has a range of diameters including between about 0.1 nm and about 100 nm, between about 0.5 nm and about 50 nm, between about 1 nm and about 25 nm, between about 1 nm and about 15 nm, or between about 1 nm and about 8 nm. The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound. The nanoparticle also exhibits high biostability and biocompatibility. To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as poly(ethylene glycol) (PEG). The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo.
    Type: Grant
    Filed: July 5, 2022
    Date of Patent: December 10, 2024
    Assignees: Sloan-Kettering Institute for Cancer Research, Cornell University
    Inventors: Michelle S. Bradbury, Ulrich Wiesner, Oula Penate Medina, Andrew Burns, Jason S. Lewis, Steven M. Larson
  • Publication number: 20240402173
    Abstract: Methods of detecting IgE+ plasmablasts in a mammal are described herein. Also described herein are methods of predicting clinical allergy in a mammal. Additionally, methods of monitoring progression of an allergy along with methods of monitoring efficacy of treatment of an allergy are described.
    Type: Application
    Filed: October 14, 2022
    Publication date: December 5, 2024
    Applicant: CORNELL UNIVERSITY
    Inventors: Bettina WAGNER, Elisabeth SIMONIN, Susanna BABASYAN
  • Patent number: 12157895
    Abstract: Embodiments of the disclosure are directed to compositions and methods for enhancing disease resistance in plants. One aspect of embodiments of the disclosure relates to a nucleic acid construct comprising a nucleic acid molecule comprising a Pseudomonas tomato race 1 (Ptr1) polynucleotide, a 5? heterologous DNA promoter sequence, and a 3? terminator sequence, wherein the nucleic acid molecule, the DNA promoter sequence, and the terminator sequence are operatively coupled to permit transcription of the nucleic acid molecule. Methods of imparting disease resistance to a plant and methods of identifying a candidate plant suitable for breeding that displays enhanced disease resistance are also disclosed. Embodiments of the disclosure also include plant cells, plants, and plant seeds including a heterologous Pseudomonas tomato race 1 (Ptr1) polynucleotide.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: December 3, 2024
    Assignees: BOYCE THOMPSON INSTITUTE FOR PLANT RESEARCH, INC., CORNELL UNIVERSITY
    Inventors: Gregory B. Martin, Ari Feder, Samantha Mainiero, Sarah Hind, Diana Carolina Mazo Molina
  • Patent number: 12161052
    Abstract: Solid-state devices including a layer of a superconductor material epitaxially grown on a crystalline high thermal conductivity substrate, the superconductor material being one of TiNx, ZrNx, HfNx, VNx, NbNx, TaNx, MoNx, WNx, or alloys thereof, and one or more layers of a semiconducting or insulating or metallic material epitaxially grown on the layer of superconductor material, the semiconducting or insulating material being one of a Group III N material or alloys thereof or a Group 4b N material or SiC or ScN or alloys thereof.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: December 3, 2024
    Assignees: Cornell University, Govmt. of U.S.—Navy
    Inventors: Rusen Yan, Guru Bahadur Singh Khalsa, John Wright, H. Grace Xing, Debdeep Jena, D. Scott Katzer, Neeraj Nepal, Brian P. Downey, David J. Meyer
  • Patent number: RE50268
    Abstract: The present invention relates to an exceptionally broad and potent neutralizing antibody which may comprise cross-clade neutralizing coverage of 83% at a median IC50 of 0.003 ?g/ml, compositions containing the same and uses thereof.
    Type: Grant
    Filed: April 8, 2022
    Date of Patent: January 14, 2025
    Assignees: International AIDS Vaccine Initiative, The Scripps Research Institute, Cornell University
    Inventors: Dennis R. Burton, Marit J. Van Gils, Wayne Koff, Pascal R. G. Poignard, Rogier W. Sanders, Melissa D. J. S. Simek-Lemos, Devin Sok
  • Patent number: PP36404
    Abstract: An Alstroemeria plant particularly distinguished with vibrant coral colored flowers. The flowers on this plant have coral tepals with intense yellow highlights and little flecks of brown on the base of the inner tepals. Has a good longevity as a cut flower, continuous flowering from summer through fall, and winter-hardy from USDA zone 5 as described.
    Type: Grant
    Filed: January 24, 2024
    Date of Patent: January 21, 2025
    Assignee: Cornell University
    Inventors: Mark P. Bridgen, Ockert F. Greyvenstein, Elizabeth K. Bresky