Patents Assigned to Cornell University
  • Publication number: 20210221715
    Abstract: Metal-chelating compositions having the structure (1a) wherein: R1, R2, R3, and R4 are independently selected from the following groups: (i) hydrogen atom, (ii) hydrocarbon groups (R) containing 1-12 carbon atoms; (iii) halogen atoms; (iv) —P(R5)(?O)OH groups; (v) —C(?O)OH groups; (vi) —S(?O)2OH groups; and (vii) —OH groups, wherein R5 is selected from hydrocarbon groups (R) and —OH; R1 and R2 may optionally interconnect to form Ring A fused to the ring on which R1 and R2 are present; R3 and R4 may optionally interconnect to form Ring B fused to the ring on which R3 and R4 are present; wherein Ring A and Ring B are optionally and independently substituted with one or more of groups (ii)-(vii). Methods of using the above-described compositions for chelating metal ions having an atomic number of at least 56 (e.g., Ba or Ra) are also described.
    Type: Application
    Filed: May 31, 2019
    Publication date: July 22, 2021
    Applicant: CORNELL UNIVERSITY
    Inventors: Justin WILSON, Nikki THIELE
  • Patent number: 11066397
    Abstract: The compounds of the present invention are represented by the following compounds having Formula (I) where the substituents R, R1-R5, k, m, n, and q are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders, infectious disease, or for providing immunosuppression for transplanted organs or tissues.
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: July 20, 2021
    Assignee: CORNELL UNIVERSITY
    Inventors: Gang Lin, Carl Nathan, Pradeep K. Singh, Lei Shi, Laura Kirkman
  • Patent number: 11069822
    Abstract: Provided are van der Waals (VDW) films comprising one or more transition metal chalcogenide (TMD) films. Also provided are methods of making VDW films. The methods are based on transfer of monolayer TMD films under vacuum, for example, using a handle layer. Also provided are apparatuses and devices comprising one or more VDW film.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: July 20, 2021
    Assignee: CORNELL UNIVERSITY
    Inventors: Jiwoong Park, Kibum Kang, Hui Gao, Saien Xie, Kan-Heng Lee
  • Publication number: 20210214386
    Abstract: The invention provides a compound of formula (I): wherein R is as described herein. The invention also provides a process for the preparation of the compound.
    Type: Application
    Filed: March 29, 2021
    Publication date: July 15, 2021
    Applicant: Cornell University
    Inventor: Anthony A. Sauve
  • Patent number: 11059800
    Abstract: The present invention provides dehydroleucodine derivatives. In particular, the present invention provides amine derivatives of dehydroleucodine and methods of using dehydroleucodine and the amine derivatives of dehydroleucodine to inhibit the growth of cancer cells.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: July 13, 2021
    Assignees: Universidad Tecnica Particular De Loja, Cornell University, BioVentures, LLC
    Inventors: Cesar M. Compadre, Paola E. Ordonez, Monica L. Guzman, Darin E. Jones, Omar Malagon, Giovanni Vidari, Peter Crooks
  • Publication number: 20210196860
    Abstract: The present invention relates to a peripheral nerve-specific hydrogel material, which is deliverable in a minimally invasive fashion, sustains the growth of neurons, and speeds recovery following surgical reconstruction.
    Type: Application
    Filed: August 13, 2020
    Publication date: July 1, 2021
    Applicants: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, CORNELL UNIVERSITY
    Inventors: Bryan Nicklaus Brown, Jonathan Cheetham
  • Patent number: 11050118
    Abstract: Lithium ion batteries, electrodes, nanofibers, and methods for producing same are disclosed herein. Provided herein are batteries having (a) increased energy density; (b) decreased pulverization (structural disruption due to volume expansion during lithiation/de-lithiation processes); and/or (c) increased lifetime. In some embodiments described herein, using high throughput, water-based electrospinning process produces nanofibers of high energy capacity materials (e.g., ceramic) with nanostructures such as discrete crystal domains, mesopores, hollow cores, and the like; and such nanofibers providing reduced pulverization and increased charging rates when they are used in anodic or cathodic materials.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: June 29, 2021
    Assignee: Cornell University
    Inventors: Yong Lak Joo, Nathaniel S. Hansen, Daehwan Cho, Kyoung Woo Kim
  • Patent number: 11046945
    Abstract: The present invention relates to a labeled glutaminase (GLS) protein comprising a GLS protein and a fluorescent reporter group attached to the GLS protein, wherein the fluorescent reporter group is attached to the GLS protein within the glutaminase domain pfam04960 of GLS. The present invention also relates to isolated glutaminase protein mutants. Also disclosed is a method of screening for compounds that allosterically bind to a glutaminase protein. The present invention also relates to a method of identifying compounds that inhibit or stabilize tetramer formation of glutaminase protein. The present invention further relates to a screening kit for compounds that inhibit or stabilize tetramer formation.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: June 29, 2021
    Assignee: CORNELL UNIVERSITY
    Inventors: Clint A. Stalnecker, Jon W. Erickson, Sekar Ramachandran, Rick Cerione
  • Patent number: 11046748
    Abstract: The present invention relates to chimeric antigen receptors (CARs) specific to ICAM-1 comprising I domain of the ?L subunit of human lymphocyte function-associated antigen 1 (LFA-1). The invention particularly relates to CARs comprising human I domains having different affinities (1 mM to 1 nM Kd) to ICAM-1. CAR T cells comprising human I domain having a low affinity (1 to 200 ?M Kd) to ICAM-1 can avoid targeting healthy tissues with basal ICAM-1 expression while simultaneously exhibiting increased potency and long-term efficacy against tumor tissues with high ICAM-1 expression. The present invention also relates to an adoptive cell therapy method for treating cancer by administering the CAR-T cells comprising human I domain to a subject suffering from cancer, whereby the CAR T cells bind to the cancer cells overexpressing ICAM-1 and kill the cancer cells.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: June 29, 2021
    Assignee: Cornell University
    Inventor: Moonsoo Jin
  • Publication number: 20210194004
    Abstract: A titanium disulfide-sulfur (TiS2—S) composite particle contains a titanium disulfide (TiS2) substrate having solid elemental sulfur (S) disposed directly on a surface of the TiS2. The TiS2 substrate has a layered crystalline hexagonal structure of space group P-3 ml and includes at least 100 distinct layers. The TiS2 and S are present in the composite in a weight ratio (TiS2:S) of 20:80 to 50:50. Cathodes and batteries containing the composite particle, as well as related methods, are also disclosed.
    Type: Application
    Filed: December 20, 2018
    Publication date: June 24, 2021
    Applicants: CORNELL UNIVERSITY, WUHAN UNIVERSITY
    Inventors: Héctor D. ABRUÑA, Yao YANG, Fu-Sheng KE, Xiao-Chen LIU
  • Publication number: 20210187329
    Abstract: An integrated GHz ultrasonic neuro-cognitive system including a chip-cyborg having a network of biological neurons that forms a biological information processor, which can be controlled by electronics, optics, and GHz ultrasonic beams. In one example, the chip-scale microsystem includes a CMOS chip with RF CMOS and piezoelectric thin film transducers that can generate GHz ultrasonic waves, which can be phased to form narrow beams, achieving significant ultrasonic intensity to affect neurons. With a sufficient number of ultrasonic pixels, the focal point of the beam can be narrow enough to focus effect specific section of a neuron to enhance or decrease synaptic weights owing to ultrasonic radiation forces and acoustic streaming.
    Type: Application
    Filed: May 23, 2019
    Publication date: June 24, 2021
    Applicant: CORNELL UNIVERSITY
    Inventors: Amit Lal, Chris Xu, Ankur Singh
  • Publication number: 20210193466
    Abstract: The present invention provides a method for removing re-sputtered material on a substrate. A process chamber having a plasma source and a substrate support is provided along with the substrate having an upper surface and a lower surface. A masking material having a patterned sidewall is patterned onto the upper surface of the substrate along with a sacrificial layer between the upper surface of the substrate and the masking material. The lower surface of the substrate is placed onto the substrate support. A plasma is generated using the plasma source. The substrate is processed on the substrate support using the generated plasma. The sacrificial layer is removed after the processing of the substrate.
    Type: Application
    Filed: December 2, 2020
    Publication date: June 24, 2021
    Applicant: Cornell University
    Inventors: David G. Lishan, Kyle Dorsey, Vincent J. Genova
  • Publication number: 20210189381
    Abstract: The present invention relates to a microfluidic device for extracting and isolating DNA from cells. The device includes a support having an inlet port for receiving a sample containing a cell, an outlet port for dispensing DNA isolated from the cell, and a microfluidic channel disposed within the support and extending from the inlet port to the outlet port. The microfluidic channel includes a micropillar array, an inflow channel disposed between the inlet port and the micropillar array, and an outflow channel disposed between the micropillar array and the outlet port. The micropillar array includes micropillars spatially configured to entrap, by size exclusion, the cell, to immobilize DNA released from the cell, and to maintain the immobilized DNA in elongated or non-elongated form when hydrodynamic force is applied to the microfluidic channel. Systems and methods of making and using the device are also provided herein.
    Type: Application
    Filed: March 6, 2021
    Publication date: June 24, 2021
    Applicant: CORNELL UNIVERSITY
    Inventors: Harold G. CRAIGHEAD, Juraj TOPOLANCIK, Harvey TIAN, Christopher WALLIN
  • Patent number: 11043612
    Abstract: A DUV-LED including a bottom substrate, a n-contact/injection layer formed on the bottom substrate, a p-contact region, and an emitting active region between the n-contact/injection layer and the contact region. The emitting active region includes at least one GaN quantum heterostructure. The at least one GaN quantum heterostructures is sized and shaped to determine a certain emission wavelength. Preferably, the certain emission wavelength is in a range of approximately 219-280 nm. In one embodiment, the size is controlled by precisely controlling parameters selected from the group consisting of: an epitaxial deposition time; a Ga/N ratio; a thermal annealing time; a temperature during deposition; and combinations thereof.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: June 22, 2021
    Assignee: Cornell University
    Inventors: SM Islam, Vladimir Protasenko, Huili Grace Xing, Debdeep Jena, Jai Verma
  • Publication number: 20210178393
    Abstract: The present invention relates to, inter alia, a microfluidic device for capturing target cells and analyzing genomic DNA isolated from the target cells while under flow conditions. The microfluidic device includes a cell microchannel and a nucleic acid microchannel that intersect in an orthogonal manner, thereby forming a cell capture intersection region. The microfluidic device also includes a cell capture array and a nucleic acid entanglement array. The cell capture array includes a plurality of cell capturing micropillars and is located in the cell capture intersection region. The nucleic acid entanglement array includes a plurality of nucleic acid entanglement micropillars that function to physically entangle and maintain thereon genomic DNA isolated from the one or more target cell, and is located in a portion of the nucleic acid microchannel that is adjacent to and downstream of the cell capture intersection region. Methods of using the microfluidic device are also disclosed.
    Type: Application
    Filed: May 22, 2017
    Publication date: June 17, 2021
    Applicant: CORNELL UNIVERSITY
    Inventors: Harold G. CRAIGHEAD, Sarah J. REINHOLT
  • Publication number: 20210181627
    Abstract: A pattern-forming method includes: applying directly or indirectly on a substrate a radiation-sensitive composition containing a complex and an organic solvent to form a film; exposing the film to an ultraviolet ray, a far ultraviolet ray, an extreme ultraviolet ray, or an electron beam; and developing the film exposed, wherein the complex is represented by formula (1). [MmLnQp]??(1) In the formula (1), M represents a zinc atom, a cobalt atom, a nickel atom, a hafnium atom, a zirconium atom, a titanium atom, an iron atom, a chromium atom, a manganese atom, or an indium atom; and L represents a ligand derived from a compound represented by formula (2). R1—CHR3—R2 ??(2) In the formula (2), R1 and R2 each independently represent —C(?O)—RA, —C(?O)—ORB, or —CN.
    Type: Application
    Filed: February 16, 2021
    Publication date: June 17, 2021
    Applicants: JSR CORPORATION, CORNELL UNIVERSITY
    Inventors: Kazunori SAKAI, Vasiliki KOSMA, Christopher K. OBER, Emmanuel P. GIANNELIS
  • Patent number: 11034796
    Abstract: Provided are poly(arylamine)s. The polymers can be redox active. The polymers can be used as electrode materials in, for example, electrochemical energy storage systems. The polymers can be made by electropolymerization on a conducting substrate (e.g., a current collector).
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: June 15, 2021
    Assignee: CORNELL UNIVERSITY
    Inventors: Thanh-Tam Truong, Hector D. Abruna, Geoffrey W. Coates, Brett P. Fors
  • Patent number: 11038240
    Abstract: Provided herein are ceramic nanofibers and processes for preparing the same. In specific examples, provided herein are ceramic nanofiber mats for use as separators in batteries, particularly lithium ion batteries. Provided herein is battery separator comprising a nanofiber mat, the nanofiber mat comprising at least one nanofiber, the at least one nanofiber comprising a continuous matrix of ceramic, the continuous matrix of ceramic being continuous along at least 10% of the length of the nanofiber.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: June 15, 2021
    Assignee: CORNELL UNIVERSITY
    Inventors: Yong Lak Joo, Daehwan Cho, Yong Seok Kim
  • Patent number: 11028118
    Abstract: The invention provides a process for the preparation of nicotinamide mononucleotide having formula (I): The method involves the protection of nicotinamide riboside by ketalization, followed by phosphorylation and then deprotection to provide nicotinamide mononucleotide.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: June 8, 2021
    Assignee: Cornell University
    Inventors: Anthony Sauve, Farheen Sultana Yang Mohammed
  • Publication number: 20210165965
    Abstract: Privacy, protection, and de-anonymization are issues of societal importance that are implicitly at the core of several key information systems, from electronic health records to online reviews. The system and method herein allows for an identification of an author of anonymous writing based on the text and structured data, subject to practical constraints on the intruder's amount of training data and effort using Shapley values.
    Type: Application
    Filed: November 20, 2020
    Publication date: June 3, 2021
    Applicants: Drexel University, Cornell University
    Inventors: Matthew John Schneider, Shawn Mankad