Patents Assigned to Cornell University
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Publication number: 20240082221Abstract: The present disclosure provides compositions and methods for treating eye diseases (e.g., retinopathies), and more particularly, eye diseases associated with cytotoxic lipofuscin-associated cytotoxicity in retinal cells.Type: ApplicationFiled: January 21, 2022Publication date: March 14, 2024Applicant: Cornell UniversityInventor: Marcelo M. Nociari
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Patent number: 11926644Abstract: Disclosed is a compound of formula (I): wherein R1, R2, R3, and are as defined herein. Also disclosed are methods for increasing mammalian cell NAD+ production and improving mitochondrial cell densities comprising administering to a cell the compound or a salt thereof.Type: GrantFiled: July 27, 2021Date of Patent: March 12, 2024Assignee: Cornell UniversityInventors: Anthony Sauve, Farheen Sultana Mohammed, Yue Yang
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Patent number: 11922250Abstract: The present disclosure provides collaborative radiofrequency identification (RFID) readers that employ code division multiple access (CDMA) encoding to simultaneously broadcast to and read responses from tags in an overlapping reading zone with improved data synchronization and read yield rates. In some embodiments, a harmonic backscattering scheme is used to enable the system to have a much higher signal-to-noise ratio (SNR) and sensitivity, while the reader CDMA protocol can be integrated with an initial TDMA polling process or alternative tag CDMA scheme.Type: GrantFiled: June 13, 2022Date of Patent: March 5, 2024Assignee: Cornell UniversityInventors: Edwin C. Kan, Xiaonan Hui
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Patent number: 11918319Abstract: Systems and method to measure pressure are described herein. The system can include a force sensor can that be implanted into a patient to measure, for example, cardiac pressure. The force sensor can include first and second film layers that can define a plurality of pressure cells. An external pressure can deform the pressure cells and change their resonant frequency. When exposed to an acoustic signal, the pressure cells can resonant at a pressure-dependent resonant frequency. The system can detect reflected acoustic waves generated by the resonance of the pressure cells. The system can convert the frequency readings into pressure values.Type: GrantFiled: February 1, 2019Date of Patent: March 5, 2024Assignee: CORNELL UNIVERSITYInventors: Seyedhamidreza Alaie, Amir Ali Amiri Moghadam, Subhi Al'Aref, James K. Min, Bobak Mosadegh, Simon Dunham
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Patent number: 11920930Abstract: Disclosed are devices and techniques based on optical coherence tomography (OCT) technology in combination with optical actuation. A system for providing optical actuation and optical sensing can include an optical coherence tomography (OCT) device that performs optical imaging of a sample based on optical interferometry from an optical sampling beam interacting with an optical sample and an optical reference beam; an OCT light source to provide an OCT imaging beam into the OCT device which splits the OCT imaging beam into the optical sampling beam and the optical reference beam; and a light source that produces an optical actuation beam that is coupled along with the optical sampling beam to be directed to the sample to actuate particles or structures in the sample so that the optical imaging captures information of the sample under the optical actuation.Type: GrantFiled: February 1, 2021Date of Patent: March 5, 2024Assignee: Cornell UniversityInventors: Steven G Adie, Yuechuan Lin, Nichaluk Leartprapun
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Patent number: 11921321Abstract: Provided are three dimensional, stretchable, optical sensor networks that can localize deformations. The devices described herein are suitable for uses in soft robots to determine the position of external contact, such as touching, and possibly internal deformations that may be caused by actuation. Sensor networks of the present disclosure contain a substrate, such as a 3D lattice, and cores having a cladding, such as air. Light passes through the cores and upon deformation of the substrate, cores may come into contact, allowing light to couple between cores due to frustrated total internal reflection. The resulting changes in intensity in the cores can be used to determine the placement and magnitude of deformation.Type: GrantFiled: September 12, 2022Date of Patent: March 5, 2024Assignee: Cornell UniversityInventors: Patricia Xu, Robert F. Shepherd
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Patent number: 11913164Abstract: The disclosure provides a composition comprising a modified cellulosic surface having aliphatic fatty acid molecules and amine-silica particles that are covalently bonded to cellulose fibers of the cellulosic surface. Also disclosed is a composition comprising a modified cellulosic surface including low surface energy molecules and amine functionalized nanotubes decorated with silica nanoparticles that are covalently bonded to cellulose fibers of the cellulosic surface. Also disclosed is a process for increasing hydrophobicity of a cellulosic surface. Also disclosed is a process for increasing hydrophobicity and surface roughness of a cellulosic surface. Also disclosed are products comprising the compositions and modified cellulosic surfaces of the present invention.Type: GrantFiled: May 9, 2022Date of Patent: February 27, 2024Assignee: CORNELL UNIVERSITYInventors: Anil N. Netravali, Yidong Zhong, Namrata V. Patil
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Patent number: 11911784Abstract: Provided in certain embodiments herein are alternating current electrospray systems and processes for manufacturing depositions, such as thin layer depositions. In some embodiments, processes and systems provided herein are suitable for and configured to manufacture uniform depositions, such as having uniform thickness.Type: GrantFiled: October 29, 2021Date of Patent: February 27, 2024Assignee: CORNELL UNIVERSITYInventors: Yong Lak Joo, Yevgen Zhmayev
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Patent number: 11912894Abstract: The present application discloses a method of forming a hydrogel-coated substrate, wherein the hydrogel has antifouling and antimicrobial properties. The method comprises applying an aqueous pre-hydrogel solution to a substrate, polymerizing the aqueous pre-hydrogel solution, thereby forming a coated substrate having a conformal hydrogel coating and a non-conformal hydrogel coating, contacting the coated substrate with a swelling agent, and removing the non-conformal hydrogel coating from the coated substrate, thereby leaving the conformal hydrogel coating on the substrate to form the hydrogel-coated substrate. The aqueous pre-hydrogel solution comprises a monomer with antimicrobial activity, a monomer with antifouling activity, and either a polymer, oligomer, or macromer which, when polymerized together, form a hydrogel. Also disclosed is a coated substrate and a hydrogel coating.Type: GrantFiled: November 26, 2019Date of Patent: February 27, 2024Assignee: CORNELL UNIVERSITYInventors: Minglin Ma, You Yong, Mingyu Qiao, Qingsheng Liu
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Patent number: 11914018Abstract: A radio-frequency method for range finding includes modulating a reference signal having an intermediate frequency to a downlink signal having a carrier frequency using a clock signal. The downlink signal is transmitted to a tag using a transceiver. An uplink signal backscattered front the tag is received and demodulated using the clock signal. The uplink signal has a frequency that is a harmonic of the carrier frequency. A distance between the tag and the transceiver is calculated based on a phase of the demodulated uplink signal. A system for range finding includes a transceiver and a processor. The transceiver modulates a reference signal to downlink signal and transmits the downlink signal. The transceiver receives and demodulates an uplink signal. The processor is configured to receive the demodulated uplink signal and calculate a distance between the tag and the transceiver using a phase of the demodulated uplink signal.Type: GrantFiled: August 31, 2022Date of Patent: February 27, 2024Assignee: Cornell UniversityInventors: Xiaonan Hui, Edwin C. Kan
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Patent number: 11903843Abstract: The present disclosure describes an intervertebral disk replacement system. The system can include a tissue-engineered intervertebral disc that is combined with a bioresorbable stabilization system for structural guidance. The system can prevent or reduce intervertebral disk implant displacement and can increase the stiffness when compared to the implantation of the intervertebral disk implant without the stabilization system.Type: GrantFiled: November 3, 2022Date of Patent: February 20, 2024Assignee: CORNELL UNIVERSITYInventors: Roger Hartl, Lawrence Bonassar, Yu Moriguchi, Gernot Lang, Rodrigo Navarro-Ramirez
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Patent number: 11903976Abstract: Disclosed are an implantable therapeutic delivery system and methods of treatment utilizing the implantable therapeutic delivery system. The implantable therapeutic delivery system includes a nanofibrous core substrate including one or more internal spaces wherein one or more therapeutic agents is positioned in the one or more internal spaces; and an outer biocompatible polymeric coating surrounding said nanofibrous core substrate.Type: GrantFiled: October 29, 2019Date of Patent: February 20, 2024Assignee: CORNELL UNIVERSITYInventors: Minglin Ma, James A. Flanders, Duo An
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Publication number: 20240050599Abstract: The present technology provides compounds, as well as compositions including such compounds, useful for imaging and/or treatment of a glioma, a breast cancer, an adrenal cortical cancer, a cervical carcinoma, a vulvar carcinoma, an endometrial carcinoma, a primary ovarian carcinoma, a metastatic ovarian carcinoma, a non-small cell lung cancer, a small cell lung cancer, a bladder cancer, a colon cancer, a primary, gastric adenocarcinoma, a primary colorectal adenocarcinoma, a renal cell carcinoma, and/or a prostate cancer.Type: ApplicationFiled: February 23, 2023Publication date: February 15, 2024Applicant: Cornell UniversityInventors: John W. Babich, James M. Kelly, Alejandro Amor-Coarasa, Shashikanth Ponnala
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Publication number: 20240051832Abstract: The present disclosure includes a method of producing solid inorganic carbonate compounds by capturing, converting, and storing carbon dioxide comprising providing one or more precursor compound; providing one or more carbon dioxide capture solvent or capture additive; and reacting said one or more precursor compound with said one or more carbon dioxide capture solvent or capture additive under conditions effective to produce one or more solid inorganic carbonate compound. Also disclosed is a method of producing solid inorganic bicarbonate compounds by capturing, converting, and storing carbon dioxide comprising providing one or more precursor compound; providing one or more carbon dioxide capture solvent or capture additive; and reacting said one or more precursor compound with said one or more carbon dioxide capture solvent or capture additive under conditions effective to produce one or more solid inorganic bicarbonate compound.Type: ApplicationFiled: September 3, 2021Publication date: February 15, 2024Applicant: CORNELL UNIVERSITYInventor: Greeshma GADIKOTA
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Patent number: 11898992Abstract: Disclosed are devices, systems and methods for touch, force and/or thermal sensing by an ultrasonic transceiver chip. In some aspects, an ultrasonic transceiver sensor device includes a semiconductor substrate; a CMOS layer attached to the substrate; an array of piezoelectric transducers coupled to the CMOS layer to generate ultrasonic pulses; and a contact layer attached to the substrate on a side opposite the substrate for providing a surface for contact with an object, where an ultrasonic pulse generated by a piezoelectric transducer propagates through the substrate and the contact layer, such that when the object is in contact with the surface of the contact layer, a reflected ultrasonic pulse is produced and propagates through the contact layer and the substrate to be received at the array of piezoelectric transducers, and the CMOS layer receive and process outputs from the piezoelectric transducers produced in response to the received reflected ultrasonic pulses.Type: GrantFiled: September 21, 2022Date of Patent: February 13, 2024Assignee: Cornell UniversityInventors: Amit Lal, Mamdouh Abdelmejeed, Justin Kuo
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Patent number: 11898844Abstract: A rotation sensor, including: (i) a substrate having a top surface and an interior bottom surface; (ii) an electrode module positioned on the top surface of the substrate and including a first set of electrodes configured to generate a bulk acoustic wave directly into the substrate, wherein at least a portion of the bulk acoustic wave is transduced into a shear wave upon reflection on the interior bottom surface of the substrate without use of a reflector, and a second set of electrodes configured to detect the shear wave; and (iii) a controller in communication with the first set and second set of electrodes and configured to determine, based on the detected shear wave, an effect of Coriolis force on the sensor.Type: GrantFiled: October 5, 2020Date of Patent: February 13, 2024Assignee: Cornell UniversityInventors: Amit Lal, Benyamin Davaji, Visarute Pinrod
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Publication number: 20240041088Abstract: The present invention relates to a process for preparing an edible foodstuff from food industry waste stream byproducts. This process involves the steps of: (i) combining, in an extruder, an extrusion formulation comprising a first food byproduct and at least one additional ingredient; (ii) introducing supercritical carbon dioxide (SC-CO2) into the extruder to mix with the first food byproduct and the at least one additional ingredient; and (iii) producing an edible foodstuff containing the first food byproduct and the at least one additional ingredient, where the edible foodstuff comprises an extrudate prepared under supercritical fluid extrusion (SCFX) conditions. The present invention also relates to a process for preparing an edible foodstuff from a protein concentrate. The present invention further relates to edible foodstuffs produced by the various processes disclosed herein.Type: ApplicationFiled: August 23, 2023Publication date: February 8, 2024Applicant: CORNELL UNIVERSITYInventors: Syed S.H. RIZVI, Ilankovan PARAMAN
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Patent number: 11894468Abstract: Described herein are the design and fabrication of Group III trioxides, such as ?-Ga2O3, trench-MOS barrier Schottky (TMBS) structures with high voltage (>1 kV), low leakage capabilities, while addressing on the necessary methods to meet the requirements unique to Group III trioxides, such as ?-Ga2O3.Type: GrantFiled: October 30, 2019Date of Patent: February 6, 2024Assignee: Cornell UniversityInventors: Wenshen Li, Zongyang Hu, Kazuki Nomoto, Debdeep Jena, Huili Grace Xing
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Patent number: 11892344Abstract: A device configured for low-energy ultrasonic 2D Fourier transform analysis, comprising: (i) a first layer comprising an array of piezoelectric pixels; (ii) a second layer comprising an array of piezoelectric pixels; (iii) a third layer, positioned between the first and second layers, comprising a bulk ultrasonic transmission medium; wherein the second layer of array of piezoelectric pixels is in the Fourier plane of an input signal of the first layer array of piezoelectric pixels.Type: GrantFiled: April 15, 2022Date of Patent: February 6, 2024Assignee: Cornell UniversityInventor: Amit Lal
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Patent number: D1017765Type: GrantFiled: April 3, 2021Date of Patent: March 12, 2024Assignee: CORNELL UNIVERSITYInventors: Syed S. H. Rizvi, Richard Hebb