Abstract: Provided herein are methods of determining sensitivity to dose intense chemotherapy regimens based upon an index of estrogen receptor (ER)- and progesterone receptor (PR)-related genes, referred to as the sensitivity to endocrine therapy index (SETER/PR index). Further provided are methods of treating cancer patients determined to be sensitive to dose intense chemotherapy therapy by the SETER/PR index. Also provided herein are methods for determining prognosis based on the SET2,3 index.

Abstract: The present invention relates to, inter alia, a microfluidic device for capturing target cells and analyzing genomic DNA isolated from the target cells while under flow conditions. The microfluidic device includes a cell microchannel and a nucleic acid microchannel that intersect in an orthogonal manner, thereby forming a cell capture intersection region. The microfluidic device also includes a cell capture array and a nucleic acid entanglement array. The cell capture array includes a plurality of cell capturing micropillars and is located in the cell capture intersection region. The nucleic acid entanglement array includes a plurality of nucleic acid entanglement micropillars that function to physically entangle and maintain thereon genomic DNA isolated from the one or more target cell, and is located in a portion of the nucleic acid microchannel that is adjacent to and downstream of the cell capture intersection region. Methods of using the microfluidic device are also disclosed.

Abstract: Near-field coherent sensing (NCS) methods and systems are described herein. The techniques may be used to monitor vital signs is introduced herein. Multiple-input, multiple output near-field techniques may be used to characterize motion. In some embodiments, the methods and systems are used to measure cardiac motion. In some embodiments, the disclosed system is integrated into a seat, such as, for example, a car seat. The system be configured to monitor the vital signs of a seat occupant with multiple sensing points. The sensor can be integrated into the cushion and hence “invisible” to the user.

Abstract: The present application relates to method of vaccinating a subject against infection by an enveloped virus. The method includes providing a compound of the Formula (I) as described herein, and contacting the compound of Formula (I) with an isolated enveloped virus, having a membrane, to inactivate the membrane of the isolated enveloped virus. The subject is then treated with the enveloped virus having an inactivated membrane to vaccinate the subject against the enveloped virus. Further disclosed is an ex vivo vaccine composition including the compound of Formula (I) and an enveloped virus.

Abstract: A system for measuring synchrony between two or more regions, or within a single region, of a subject's brain. The system can include a signal conditioning module in communication with a phase extraction module. The signal conditioning module can receive an oscillating signal, bandpass filter the signal, and convert the signal to its real and imaginary components. The phase extraction module can receive the real and imaginary components, determine the quadrant of the oscillating signal on the complex plane based on the real and imaginary components, and determine the phase of the oscillating signal using a linear arctangent approximation based on the determined quadrant. The system can calculate synchrony metrics based on the determined phase.

Abstract: Solid-polymer electrolytes, methods of making solid-polymer electrolytes, and uses of solid-polymer electrolytes. A solid-polymer electrolyte comprises a cross-linked polymer network. A cross-linked polymer network may comprise a plurality of groups, which may be cross-linked groups, such as, for example, cross-linked difunctional polyether groups, cross-linked difunctional ionic groups, non-crosslinked groups, which may be referred to as “dangling” groups, or a combination thereof, and a plurality of cross-linked multifunctional crosslinker groups. A solid polymer electrolyte can be formed by polymerization. A solid polymer electrolyte can be formed in situ in a device. A solid polymer electrolyte can be used in devices such as, for example, batteries, supercapacitors, fuel cells, and the like.

Abstract: A method for controlling connectivity between two or more brain regions of a subject includes receiving signals corresponding to a connectivity between two or more regions of a subject's brain, measuring a connectivity level from the signals, and delivering at least one stimulation pulse to at least one target region of the subject's brain if the measured connectivity level is outside of a predetermined range.

Abstract: The present invention relates to a method of fixing extracellular vesicles. The method includes providing a sample containing extracellular vesicles and contacting the sample with a non-reversible cross-linking agent and, optionally, an aldehyde-containing fixative. Preferably the non-reversible cross-linking agent is 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide. The method also includes imaging the fixed extracellular vesicles for the determination or exclusion of disease or disorder in a clinical sample. The present invention also relates to a kit for fixing extracellular vesicles in a biological sample.

Abstract: The present disclosure provides systems and methods capable of determining a roll angle of a medical instrument in real time based on one or more medical images that include the medical instrument. In different versions, the images may be, for example, fluoroscopic, ultrasound, and/or video. The roll angle may be determined using one or more machine learning models. Other degrees of freedom may also be determined. The roll angle (and potentially other degrees of freedom) may be used in visualizations that guide a user of the medical instrument. The visualization may employ various displays and/or headsets, and may be used with an augmented reality (AR) system, a mixed reality (MR) system, a virtual reality (VR) system, an extended reality (XR) system, and/or a spatial computing system.

Abstract: A third-harmonic generation method includes frequency-quadrupling a fundamental optical beam via cascaded second-harmonic generation to yield a fourth-harmonic optical beam. The method also includes down-converting the fourth-harmonic optical beam to yield a third-harmonic optical beam. A third harmonic generator includes a monolithic optical element having nonzero quadratic electric susceptibility to (i) frequency-quadruple a fundamental optical beam via cascaded second-harmonic generation, and (ii) down-convert a fourth-harmonic optical beam to yield a third-harmonic optical beam.

Abstract: Engineered phospholipase D mutants are described herein. Also described herein are methods of making engineered phospholipase D mutants. Additionally, methods of using engineered phospholipase D mutants are described.

Abstract: The current disclosure current disclosure is directed to methods of diagnosing, triaging, and treating tuberculosis. Another aspect of the current disclosure is directed to methods of establishing a panel of biomarkers that correlates with tuberculosis disease status.

Abstract: A delivery device, such as a feeding tube, may have one or more pullout resistors that can anchor the delivery device to a patient's abdomen. When implanted, the pullout resistors can lie between the small intestine and intraabdominal wall. The pullout resistors can prevent inadvertent retrograde displacement of the delivery device without obstructing the lumen of the intestine. The pullout resistors can be flexible to enable a healthcare professional to apply an external retraction force to remove the delivery device.

Abstract: The present invention relates to compositions of aqueous humor and/or vitreous humor derived extracellular vesicles and their use for the delivery of therapeutic agents to ocular tissues for the treatment of ophthalmic diseases. Further disclosed are methods of making the compositions. Methods of treating and diagnosing an ocular condition are also disclosed.

Abstract: Provided are compositions and methods that include a K. pneumoniae yidR protein or an antigenic segment of the protein, and homologous of the protein, and antigenic segments of the homologs. The compositions can be provided as vaccine formulations for use with humans and non-human animals, including but not limited to dairy cows. The compositions and methods are useful for prophylaxis and/or therapy of conditions associated with Gram negative bacteria that include K. pneumonia, E. coli, and other pathogenic Gram negative bacteria. The conditions include such bacterial infections generally, and include specifically mastitis and metritis. The compositions and methods can also improve fertility and milk production. Administration of the compositions can improve the likelihood of a first service conception.

Abstract: Provided are compositions and methods related to improved mucins, methods of making the improved mucins, and cells and cell cultures that express glycosylated mucins. The compositions and methods provide improved cell cultures, and improved methods of producing co-expressed proteins that are distinct from the mucins.

Abstract: Silica nanorings, methods of making silica nanorings, and uses of silica nanorings. The silica nanorings may be PEGylated. The silica nanorings may be surface functionalized, which may be surface selective functionalization, with one or more polyethylene glycol (PEG) group(s), one or more display group(s), one or more functional group(s), or a combination thereof. The silica nanorings may have a size of 5 to 20 nm. The silica nanorings may be made using micelles. The absence or presence of the micelles during PEGylation and/or functionalization allows for surface selective functionalization. The silica nanorings may be used in various diagnostic and/or treatment methods.

Abstract: The present disclosure provides systems and methods for characterizing and predicting an anatomical feature, and predicting the progression of a condition of the anatomical feature, based on a signal from an ultrasonic transducer. For example, the systems and methods disclosed herein can be utilized to characterize and predict a condition such as myopia based on an elasticity of an anterior sclera.

Abstract: The present disclosure is directed to novel nucleoside analog compounds and methods for treating diseases characterized by high expression levels of adenosine kinase (ADK).

Abstract: This invention relates to a new and distinct primocane bearing red raspberry plant designated as ‘Crimson Beauty’ primarily adapted to growing conditions of west central New York and other regions of similar climate. The new plant is primarily characterized by branched and self-supporting canes, conical fruit that is longer than broad, an early primocane season production period, a long production season and light red colored fruit with uniform drupelets.