Patents Assigned to Cornell University
  • Patent number: 11397182
    Abstract: The present invention is directed to a method for identifying an individual who is at risk for developing metastatic liver disease that involves measuring, in a sample isolated from the individual, exosomal levels of one or more markers of metastatic liver disease. Kits for carrying out this method are also disclosed. The present invention also relates to a method of preventing metastatic liver disease in an individual who are at risk for developing the disease that involves administering one or more inhibitors of liver pre-metastatic niche formation.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: July 26, 2022
    Assignee: CORNELL UNIVERSITY
    Inventors: David C. Lyden, Bruno Costa Da Silva
  • Publication number: 20220229140
    Abstract: Exemplary methods for quantitative mapping of physical properties, systems and computer-accessible medium can be provided to generate images of tissue magnetic susceptibility, transport parameters and oxygen consumption from magnetic resonance imaging data using the Bayesian inference approach, which minimizes a data fidelity term under a constraint of a structure prior knowledge. The data fidelity term is constructed directly from the magnetic resonance imaging data. The structure prior knowledge can be characterized from known anatomic images using image feature extraction operation or artificial neural network. Thus, according to the exemplary embodiment, system, method and computer-accessible medium can be provided for determining physical properties associated with at least one structure.
    Type: Application
    Filed: May 28, 2020
    Publication date: July 21, 2022
    Applicant: Cornell University Center for Technology Licensing (CTL)
    Inventors: Yi WANG, Zhe LIU, Jinwei ZHANG, Qihao ZHANG, Junghun CHO, Pascal SPINCEMAILLE
  • Patent number: 11392782
    Abstract: The present disclosure provides collaborative radiofrequency identification (RFID) readers that employ code division multiple access (CDMA) encoding to simultaneously broadcast to and read responses from tags in an overlapping reading zone with improved data synchronization and read yield rates. In some embodiments, a harmonic backscattering scheme is used to enable the system to have a much higher signal-to-noise ratio (SNR) and sensitivity, while the reader CDMA protocol can be integrated with an initial TDMA polling process or alternative tag CDMA scheme.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: July 19, 2022
    Assignee: CORNELL UNIVERSITY
    Inventors: Edwin C. Kan, Xiaonan Hui
  • Patent number: 11394033
    Abstract: Provided is an apparatus containing, as a cathode catalyst, a metal oxide/carbon catalyst composition. The metal oxide/carbon catalyst composition includes 40 to 95 wt % porous Mn—Co spinel oxide nanoparticles of the formula MnxCo3-xO4. The nanoparticles have an octahedral morphology, an average particle size of 5-100 nm, and average pore sizes of 1-5 nm (where x is the atomic fraction of manganese and 3-x is the atomic fraction of cobalt). The metal oxide nanoparticles are supported on a carbon substrate that contains at least 96 atomic % carbon.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: July 19, 2022
    Assignees: CORNELL UNIVERSITY, WUHAN UNIVERSITY
    Inventors: Yao Yang, Héctor D. Abruña, Lin Zhuang, Hanging Peng, Li Xiao
  • Patent number: 11382368
    Abstract: An embodiment of a robotic fabric has a first fabric layer and an actuator that is configured to have a first state and a second state. A property of the first fabric layer is different when the actuator is in the first state as compared to the property of the first fabric layer when the actuator is in the second state.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: July 12, 2022
    Assignee: Cornell University
    Inventors: Jintu Fan, Dahua Shou, Yan Cui
  • Patent number: 11384205
    Abstract: Methods of making sequence-defined polymers and sequence-defined polymers. The methods are based on the orthogonal reactivity of monomers having at least two different functional groups. The sequence-defined polymers can be used in various applications. For example, the SDPs (e.g., pH sensitive SDPs) are used in cell lysis methods or as molecular vehicles to transport drug cargo into cells.
    Type: Grant
    Filed: December 10, 2019
    Date of Patent: July 12, 2022
    Assignee: CORNELL UNIVERSITY
    Inventors: Christopher Akinleye Alabi, Mintu Porel
  • Patent number: 11383252
    Abstract: Provided in certain embodiments herein are gas controlled electrospray systems and processes for manufacturing depositions, such as thin layer films. In some embodiments, processes and systems provided herein are suitable for and configured to manufacture uniform depositions, such as having uniform thickness.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: July 12, 2022
    Assignee: CORNELL UNIVERSITY
    Inventors: Yong Lak Joo, Yevgen Zhmayev
  • Patent number: 11383240
    Abstract: The present invention relates to, inter alia, a microfluidic device for performing single cell genomic DNA isolation and amplification under flow. The microfluidic device comprises a solid substrate having one or more microfluidic channel system formed therein. Each microfluidic channel system of the microfluidic device comprises: (a) an intake region comprising a single microchannel; (b) a plurality of cell segregation microchannels; (c) a cell capture site located downstream of each cell segregation microchannel; and (d) a DNA capture array positioned downstream of the cell capture site and comprising a plurality of micropillars. Also disclosed is a whole genome amplification system that includes the microfluidic device of the present disclosure, as well as a method for conducting single cell DNA analysis via on-chip whole genome amplification while under flow, and a method for multiple displacement amplification (MDA) reactions of one or more nucleic acid sequence isolated single cells.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: July 12, 2022
    Assignee: CORNELL UNIVERSITY
    Inventors: Harold G. Craighead, Harvey C. Tian
  • Publication number: 20220211800
    Abstract: This invention relates to methods and compositions for detecting, identifying and treating glaucoma diseases. In addition, this invention discloses compositions and methods for affecting intraocular pressure and increasing ocular outflows in glaucoma. Compositions are provided for treating a glaucoma disease, reducing intraocular pressure, and/or reducing ocular extracellular vesicle complexes in a subject.
    Type: Application
    Filed: March 16, 2022
    Publication date: July 7, 2022
    Applicants: CORNELL UNIVERSITY, AUFBAU MEDICAL INNOVATIONS LIMITED
    Inventors: John T. G. PENA, James Murray MITCHELL, Harmon Lawrence REMMEL
  • Publication number: 20220213464
    Abstract: A hierarchical catalyst composition comprising a continuous or particulate macroporous scaffold in which is incorporated mesoporous aggregates of magnetic nanoparticles, wherein an enzyme is embedded in mesopores of the mesoporous aggregates of magnetic nanoparticles. Methods for synthesizing the hierarchical catalyst composition are also described. Also described are processes that use the recoverable hierarchical catalyst composition for depolymerizing lignin, remediation of water contaminated with aromatic substances, polymerizing monomers by a free-radical mechanism, epoxidation of alkenes, halogenation of phenols, inhibiting growth and function of microorganisms in a solution, and carbon dioxide conversion to methanol.
    Type: Application
    Filed: January 28, 2022
    Publication date: July 7, 2022
    Applicant: CORNELL UNIVERSITY
    Inventors: Stephane C. CORGIE, Xiaonan DUAN, Emmanuel GIANNELIS, Daniel ANESHANSLEY, Larry P. WALKER
  • Publication number: 20220211318
    Abstract: Systems, methods and programs for processing EEG data for display and/or automatically detecting a seizure in a patient based on one or more spectrograms created from the EEG data. EEG data from a patient may be paired into channels based on electrode locations. Spectrograms are generated from EEG data from channels, respectively. The spectrograms of different channels are grouped and a median power spectrogram (MPS) is calculated for the group. The MPS may be used to automatically determine whether the patient had a seizure by applying a machined learned model (ML) model. The ML model is trained and tested using historical EEG data from a plurality of patients. The MPS or a relationship between a plurality of MPS of different groups may be displayed on a bedside monitor in real-time for viewing by a bedside clinician.
    Type: Application
    Filed: April 29, 2020
    Publication date: July 7, 2022
    Applicant: CORNELL UNIVERSITY
    Inventors: Peter YAN, Zachary GRINSPAN
  • Patent number: 11376276
    Abstract: The invention relates to methods of lubricating biological tissue, such as joints, bone, ocular tissue, nasal tissue, tendons, tendon capsule, and vaginal tissue, by contacting the biological tissue with an effective amount of a block copolymer lubricating composition which functions at least or better than lubricin. In particular embodiments, the method is used to treat osteoarthritis. In specific embodiments, the block copolymer has an ammonium-containing polymer block and a non-ionic hydrophilic polymer block, or the copolymer has a carboxylic acid-containing polymer block and a non-acid non-ionic hydrophilic polymer block.
    Type: Grant
    Filed: October 4, 2017
    Date of Patent: July 5, 2022
    Assignee: CORNELL UNIVERSITY
    Inventors: David Putnam, Lawrence Bonassar, Zhexun Sun
  • Patent number: 11381159
    Abstract: The present disclosure provides a high-power-density power converter topology with a common neutral between its input and output AC ports while having a single DC bus. The topology may also be embodied as an online uninterruptible power supply (UPS). The presently-disclosed topology enables high power density by utilizing half-bridge switch structures suitable for MHz-frequency operation.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: July 5, 2022
    Assignees: Cornell University, The Regents of the University of Colorado, a body corporate
    Inventors: Khurram Afridi, Nauman Zaffar, Danish Shahzad
  • Publication number: 20220202061
    Abstract: The present invention relates to a process for preparing an edible foodstuff from food industry waste stream byproducts. This process involves the steps of: (i) combining, in an extruder, an extrusion formulation comprising a first food byproduct and at least one additional ingredient; (ii) introducing supercritical carbon dioxide (SC-CO2) into the extruder to mix with the first food byproduct and the at least one additional ingredient; and (iii) producing an edible foodstuff containing the first food byproduct and the at least one additional ingredient, where the edible foodstuff comprises an extrudate prepared under supercritical fluid extrusion (SCFX) conditions. The present invention also relates to a process for preparing an edible foodstuff from a protein concentrate. The present invention further relates to edible foodstuffs produced by the various processes disclosed herein.
    Type: Application
    Filed: March 19, 2022
    Publication date: June 30, 2022
    Applicant: CORNELL UNIVERSITY
    Inventors: Syed S.H. RIZVI, Ilankovan PARAMAN
  • Publication number: 20220206020
    Abstract: The response of biological cells to applied stress is central to the functioning of living systems. The present disclosure is directed to systems, compositions and methods for rapidly reporting biomechanical properties of cells or cellular organelles at a single cell or population level.
    Type: Application
    Filed: April 24, 2020
    Publication date: June 30, 2022
    Applicant: CORNELL UNIVERSITY
    Inventors: Nicholas ABBOTT, Karthik NAYANI
  • Publication number: 20220208194
    Abstract: The present disclosure describes approaches to voice restoration using personal devices that detect surface electromyographic (sEMG) signals from articulatory muscles for the recognition of silent speech in a patient (such as a patient with total laryngectomy, on voice rest, etc.). A personal device may comprise a cutaneous sensor unit and a control module that wirelessly transmits signals to a computing device capable of, for example, applying a predictive model to signals to generate text or synthesize speech. Methods and systems for training and applying predictive models, and fabricating personal devices, are disclosed.
    Type: Application
    Filed: May 28, 2020
    Publication date: June 30, 2022
    Applicant: Cornell University
    Inventors: Anais Rameau, Simon Dunham, Fei Wang
  • Patent number: 11370896
    Abstract: An ionic nanocomposite comprising a nanomaterial comprising charged groups disposed on at least a portion of a surface of the nanomaterial and a polymer material comprising charged pendant group and/or end functionalized charged groups, where the charged groups of the nanomaterial and the charged pendant groups of the polymer material have opposite charges and the nanomaterial and polymer material are connected by one or more ionic bonds. A nanomaterial can be nanoparticles comprising sulfate groups disposed on at least a portion of the surface of the nanoparticles. The polymer material can be a polymer with pendant imidazolium groups. An ionic nanocomposite can be present as a film (e.g., a thin film). An ionic nanocomposite can be used in devices. A nanocomposite can be used in various coating application.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: June 28, 2022
    Assignees: CORNELL UNIVERSITY, UNIVERSITÉ DE MONS
    Inventors: Jérémy Odent, Emmanuel P. Giannelis, Jean-Marie Raquez, Philippe Dubois
  • Publication number: 20220199782
    Abstract: Gallium nitride high-electron-mobility transistors (GaN HEMTs) are at a point of rapid growth in defense (radar, SATCOM) and commercial (5G and beyond) industries. This growth also comes at a point at which the standard GaN heterostructures remain unoptimized for maximum performance. For this reason, the shift to the aluminum nitride (AlN) platform is disclosed. AlN allows for smarter, highly-scaled heterostructure design that improves the output power and thermal management of GaN amplifiers. Beyond improvements over the incumbent amplifier technology, AlN allows for a level of integration previously unachievable with GaN electronics. State-of-the-art high-current p-channel FETs, mature filter technology, and advanced waveguides, all monolithically integrated with an AlN/GaN/AlN HEMT, is made possible with aluminum nitride. It is on this AlN platform that nitride electronics may maximize their full high-power, highspeed potential for mm-wave communication and high-power logic applications.
    Type: Application
    Filed: December 17, 2021
    Publication date: June 23, 2022
    Applicant: Cornell University
    Inventors: Austin Hickman, Reet Chaudhuri, James C. M. Hwang, Huili Grace Xing, Debdeep Jena
  • Publication number: 20220194904
    Abstract: The present technology is directed to compounds, intermediates thereof, compositions thereof, medicaments thereof, and methods related to the imaging of mammalian tissue overexpressing PSMA. The compounds are of Formula I or a pharmaceutically acceptable salt thereof, wherein one of R1, R2, and R3 is and of Formula IV or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: July 30, 2021
    Publication date: June 23, 2022
    Applicant: Cornell University
    Inventors: John W. Babich, Jasmes M. Kelly, Alejandro Amor-Coarasa, Shashikanth Ponnala
  • Publication number: 20220186403
    Abstract: Described herein are nanofibers and methods for making nanofibers that include any one or more of (a) a non-homogeneous charge density; (b) a plurality of regions of high charge density; and/or (c) charged nanoparticles or chargeable nanoparticles. In one aspect, the present invention fulfills a need for filtration media that are capable of both high performance (e.g., removal of particle sizes between 0.1 and 0.5 ?m) with a low pressure drop, however the invention is not limited in this regard.
    Type: Application
    Filed: November 4, 2021
    Publication date: June 16, 2022
    Applicant: CORNELL UNIVERSITY
    Inventors: Yong Lak Joo, Daehwan Cho, Alexander Naydich