Abstract: Presented herein is a multichannel imaging system capable of detecting and distinguishing multiple fluorescent light sources simultaneously. Also described herein are methods of using the system to image disease or cellular abnormalities, e.g., for diagnostic and/or intraoperative purposes.

Abstract: A method of determining flow speed in a low pressure environment. The method includes obtaining bi-directional acoustic data from a plurality of transducer pairs as a fluid moves relative to the plurality of transducer pairs. The method further includes measuring phase lags corresponding to the bi-directional acoustic data, and determining bi-directional flight times using the phase lags. Additionally, the method includes calculating a flow speed of the fluid corresponding to each transducer pair from the bi-directional flight times. The method includes correcting for at least one of temperature effects, pressure effects, and wake effects, using a system model. The method further includes generating a report including the flow speed of the fluid.

Abstract: The present invention provides an in vitro method, and in vitro assay, for staging, classification, screening, monitoring, stratification, selecting treatment for, ascertaining whether treatment is working in, and/or prognostication of cancer in a subject comprising determining allelic imbalance and copy number of target gene-regions in tumor DNA from a subject as set out in the application. The present invention also provides a set of oligonucleotide probes and kits for use in the method, and assay, of the present invention.

Abstract: Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.

Abstract: Exemplary methods for quantitative mapping of physical properties, systems and computer-accessible medium can be provided to generate images of tissue magnetic susceptibility, transport parameters and oxygen consumption from magnetic resonance imaging data using the Bayesian inference approach, which minimizes a data fidelity term under a constraint of a structure prior knowledge. The data fidelity term is constructed directly from the magnetic resonance imaging data. The structure prior knowledge can be characterized from known anatomic images using image feature extraction operation or artificial neural network. Thus, according to the exemplary embodiment, system, method and computer-accessible medium can be provided for determining physical properties associated with at least one structure.

Abstract: Crosslinked nucleotide polymers. A crosslinked nucleotide polymer may be formed by reaction of a biomass comprising DNA and/or RNA with one or more crosslinker(s). A crosslinked nucleotide polymers may be formed by a crosslinking reaction including an aza-Michael addition reaction. Crosslinked nucleotide polymers may be present in various forms and compositions and form various articles of manufacture. Crosslinked nucleotide polymers may be used in therapeutic methods, coating methods, and cell-free protein production methods.

Abstract: Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.

Abstract: An implant can include a flexible body made of a non-bioresorbable hydrogel material. The implant can also include a radiopaque marker located within the flexible body, where the body and the radiopaque marker can be implanted in a body cavity to mark the cavity in a radiographic image of the cavity.

Abstract: A meta-optical device, which imparts a phase delay to incident light of a wavelength band, includes: a first electrode and a second electrode spaced apart from each other; a liquid crystal layer between the first electrode and the second electrode; a meta-surface layer located within the liquid crystal layer and including a plurality of nanostructures each having a shape dimension smaller than a center wavelength of the wavelength band; and a voltage device configured to apply a voltage between the first electrode and the second electrode. The meta-optical device may exhibit an electrically controlled variable focal length.

Abstract: An integrated device for the detection of cancerous tissue including an optical fiber configured to receive at a first end modulated infrared light and to conduct the modulated infrared light from the first end to a second end; and a plasmonic metasurface, disposed on the second end of the optical fiber, configured to localize evanescent infrared light to sub-I 00 nanometer distances from the plasmonic metasurface of the optical fiber such that the localized evanescent infrared light penetrates only the membrane portion of a cell held against the second end, wherein the second end is configured to receive reflected light reflected from the membrane portion the cell, the reflected light including spectroscopic information indicative of whether the cell is noncancerous or cancerous.

Abstract: The present technology provides compounds, as well as compositions including such compounds, useful in targeted radiotherapy of cancer and/or mammalian tissue overexpressing e.g., a glypican-3 (GPC3) receptor and/or prostate specific membrane antigen, where the compounds are represented by the Formulas (I) or a pharmaceutically acceptable salt and/or solvate thereof, (II) or a pharmaceutically acceptable salt and/or solvate thereof, (III) or a pharmaceutically acceptable salt and/or solvate thereof, wherein M1 is independently at each occurrence a radionuclide. Equivalents of such compounds are also disclosed.

Abstract: Disclosed are ferroelectric devices including devices for performing a multiplication of analog input signals and resonators. In one aspect, a ferroelectric nanoelectromechanical device includes a first structural beam, a first input electrode disposed on a first top portion of the first structural beam, and an output electrode. The apparatus further includes a first ferroelectric film disposed on a second top portion of the first input electrode, and a first resistive layer disposed on a third top portion of the first ferroelectric film, wherein a first electrode is positioned at a first end of the first resistive layer and a second electrode is positioned at a second end of the first resistive layer.

Abstract: Provided herein are soluble adenylyl cyclase (sAC) inhibitors and uses thereof. In one aspect, provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof, and pharmaceutical compositions thereof. The compounds provided herein are soluble adenylyl cyclase (sAC) inhibitors and are therefore useful for the treatment and/or prevention of various diseases and conditions (e.g., ocular conditions (e.g., ocular hypotony), liver diseases (e.g., non-alcoholic steatohepatitis (NASH)), inflammatory diseases, autoimmune diseases (e.g., psoriasis)). Compounds provided herein are also useful as contraceptive agents (e.g., for male and female contraception).

Abstract: Absorbable 3D printed implants can be used to reconstruct the nipple with regenerated tissue resulting in improved aesthetic satisfaction. The implants are formed from parallel planes of filaments that are offset and bonded to each other to form macroporous networks (130) with open cell structures comprising cylindrical shapes. The macroporous network (130) may be enclosed by a shell (120) or coating, or may be at least partly filled with a hydrogel. The implants are particularly suitable for use in plastic surgery procedures, for example, to reconstruct the nipple following total mastectomy and breast reconstruction.

Abstract: The technology disclosed in this patent document can be used to construct devices with opto-electronic circuitry for sensing and identification applications, to provide untethered devices for deployment in living objects and other applications, and to provide fabrication techniques for making such devices for commercial production. As illustrated by specific examples disclosed herein, the disclosed technology can be implemented to provide fabrication methods, substrates, and devices that enable wireless, inorganic cell-scaled sensor and identification systems that are optically-powered and optically-readout.

Abstract: A method for fabricating a molded piece includes filling a mold with a slurry, curing the slurry in the mold to create a cured piece, and heating the mold, with the cured piece therein, to burn off the mold and a binder of the slurry. The mold is fabricated from a material that vaporizes at a temperature lower than the melting temperature of the molded piece, thereby ensuring that the molded piece maintains its shape while the mold and binder burns off. The mold may be fabricated from a resin or polymer using three-dimensional (3D) printing. The molded piece may be a porous ceramic electrospray emitter. To create this emitter with a sharp tip, at least part of the mold may be fabricated using 3D printing based on two-photon polymerization, which has a higher spatial resolution than other types of 3D printing.

Abstract: Disclosed herein are tissue scaffold materials with microspheres of one density embedded in hydrogel of a different density. The disclosed materials have improved ability to facilitate cellular invasion and vascularization for wound healing and tissue regeneration. The inventors have found that materials having components with different densities promotes invasion of cells, including desirable cells such as fibroblasts and endothelial precursor cells, into the scaffold.

Abstract: Systems and methods are disclosed for optimizing a sub-sampling pattern for efficient capture of a sub-sampled image to be reconstructed to form a high-resolution image, in a data-driven fashion. For example, Magnetic Resonance Imaging (MRI) scans can be accelerated by under-sampling in k-space (i.e., the Fourier domain). Since the reconstruction model's success depends on the sub-sampling pattern, optimization of the sub-sampling pattern can be combined with optimization of the model, for a given sparsity constraint, using an end-to-end learning operation. A machine-learning model may be trained using full-resolution training data that are under-sampled retrospectively, yielding a sub-sampling pattern and reconstruction model that are customized to the type of images represented in the training data.

Abstract: A gene therapy treatment for alpha 1-antitrypsin (AAT) deficiency is provided comprising a plasmid or viral, e.g., an AAV, vector coding for an elastase- or cathepsin G-inhibiting, oxidation-resistant human AAT with a substitution at, for example, Met358 and/or Met351.

Abstract: A method performed by at least one processing device in an illustrative embodiment comprises applying a first image and a message to an encoder of a steganographic encoder-decoder neural network, generating in the encoder, based at least in part on the first image and the message, a perturbed image containing the message, decoding the perturbed image in a decoder of the steganographic encoder-decoder neural network, and providing information characterizing the decoded perturbed image to the encoder. The generating, decoding and providing are iteratively repeated, with different perturbations being determined in the encoder as a function of respective different instances of the provided information, until the decoded perturbed image meets one or more specified criteria relative to the message. The perturbed image corresponding to the decoded perturbed image that meets the one or more specified criteria relative to the message is output as a steganographic image containing the message.