Abstract: Disclosed herein are methods for providing a molecular efficacy of a ligand, especially when utilizing single-molecule fluorescence resonance energy transfer (“smFRET”) imaging, as well as compounds useful in such methods.

Abstract: An apparatus in one embodiment comprises a processing platform having at least one processing device. The processing platform implements a trusted bridge configured for at least temporary coupling between one or more data sources and a smart contract program of a blockchain. The trusted bridge comprises a secure enclave component and a relay component. Data obtained from a given one of the data sources via the relay component of the trusted bridge is authenticated in the secure enclave component of the trusted bridge. Information based at least in part on the data authenticated in the secure enclave component of the trusted bridge is provided to the smart contract program of the blockchain via the relay component of the trusted bridge. The secure enclave component illustratively receives a request for authenticated data from the blockchain smart contract program via the relay component, and responds to the request via the relay component.

Abstract: The present technology provides compounds as well as compositions including such compounds useful for the treatment of cancers where the compounds are represented by the following formula or a pharmaceutically acceptable salt thereof, wherein M is an alpha-emitting radionuclide.

Abstract: The epitaxial growth of ScxAl1-xN—GaN heterostructures and the observation of robust room temperature ferroelectric behavior are disclosed. A semiconductor device, which, for having one or more ScxAl1-xN layers of thicknesses in which ferroelectricity can be observed in the one or more ScxAl1-xN layers, is a nitride ferroelectric transistor (FeFET), which is also disclosed.

Abstract: As described herein, chromosomal missegregations, chromosomal micronuclei, cytosolic DNA, and combinations thereof are indicative of metastatic cancer. Methods and compositions are described herein that are useful for detection and treatment of patients with chromosomal instabilities such as chromosomal missegregations, chromosomal micronuclei, cytosolic DNA, and combinations thereof. For example, some of the methods and compositions include use of kinesin-13 proteins such as Kif2b, MCAK/Kif2c, or KIF13A. The methods and compositions can also include inhibitors of STING, ENPP1, cGAS, NF-kB transcription factor p52, NF-kB transcription factor RelB, or any combination thereof. Methods are also described for identifying compounds that are effective for treatment of cancer, including metastatic cancer.

Abstract: Modified AAV vectors and uses thereof are provided.

Abstract: Disclosed are approaches that may provide image-guidance to interventionalists by providing true 3D visualization and quantitative feedback in real-time. A guidance system may allow a physician to manipulate a medical device and see a 3D rendering with quantitative feedback floating in mixed reality, next to standard monitors. Image tracking may detect and co-register the medical device's 3D position using, for example, bi-plane C-arm X-ray fluoroscopy and provide a 3D trajectory as quantitative feedback. Patterns in a fluoroscopic image may be used to accurately determine an object's z-position from a single angle projection.

Abstract: Provided are cortical interneurons and other neuronal cells and in vitro methods for producing such cortical interneurons and other neuronal cells by the directed differentiation of stem cells and neuronal progenitor cells. The present disclosure relates to novel methods of in vitro differentiation of stem cells and neural progenitor cells to produce several type neuronal cells and their precursor cells, including cortical interneurons, hypothalamic neurons and pre-optic cholinergic neurons. The present disclosure describes the derivation of these cells via inhibiting SMAD and Wnt signaling pathways and activating SHH signaling pathway. The present disclosure relates to the novel discovery that the timing and duration of SHH activation can be harnessed to direct controlled differentiation of neural progenitor cells into either cortical interneurons, hypothalamic neurons or pre-optic cholinergic neurons.

Abstract: Described herein are nanofibers and methods for making nanofibers that include any one or more of (a) a non-homogeneous charge density; (b) a plurality of regions of high charge density; and/or (c) charged nanoparticles or chargeable nanoparticles. In one aspect, the present invention fulfills a need for filtration media that are capable of both high performance (e.g., removal of particle sizes between 0.1 and 0.5 ?m) with a low pressure drop, however the invention is not limited in this regard.

Abstract: A device comprising a housing including a palm portion, a sheath portion extending from one end of the palm portion, and a slot comprising an adjustable platform capable of receiving a syringe and a needle connected to the syringe with the needle resting in the sheath portion. A trigger mechanism is connected to the adjustable platform. Adjustment of the trigger mechanism in a first direction moves the platform along the slot toward the sheath portion and adjustment of the bidirectional trigger mechanism in a second direction moves the platform away from the sheath. A light element is connected to the housing and is capable of directing light along the sheath portion away from the palm portion. A power source is electrically coupled to the light element to provide electrical power to the light element. Also disclosed is a system comprising the device, as well as methods of using the device.

Abstract: The present invention is directed to a curable polymer comprising: a base acrylic monomer (monomer A); a monomer with bioactive functionality (monomer B); a monomer containing a cross-linker (monomer C). The present invention also relates to a method of making a polymer coating on a solid support. The present invention also relates to a method of preserving a product.

Abstract: An apparatus comprises a first processing node configured to participate in a consensus protocol with a plurality of additional processing nodes. The first processing node is further configured in conjunction with its participation in the consensus protocol to implement repeated polling of respective selected subsets of the additional processing nodes, to resolve a state for a given transaction to a particular one of a plurality of possible states for the given transaction responsive to results of the repeated polling; and to initiate at least one automated action based at least in part on the resolved state for the given transaction. In some embodiments, the first processing node utilizes the results of the repeated polling to maintain a directed acyclic graph or other data structure of transactions that characterizes relationships between the given transaction and a plurality of other transactions.

Abstract: Atomic force microscopy apparatus and method that enable observing charge generation transients with nanometer spatial resolution and nanosecond to picosecond time resolution, the timescale relevant for studying photo-generated charges in the world's highest efficiency photovoltaic films. The AFM apparatus includes an AFM, a light source for illumination of a sample operatively coupled to the AFM, a voltage source operatively coupled to the AFM, and a control circuitry operatively coupled to the light source and the voltage source. The AFM apparatus improves the time resolution and enables rapid acquisition of photocapacitance transients in a wide array of solar-energy-harvesting materials.

Abstract: The methods and systems described herein enable the accurate diagnosis of novel biotypes of depression that transcend current diagnostic boundaries and may be useful for identifying individuals who are most likely to benefit from antidepressant treatment. Functional magnetic resonance imaging is used to characterize the architecture of functional connectivity across the brain to show that patients with depression can be subdivided into four neurophysiological biotypes based solely on unique patterns of abnormal connectivity in resting state brain networks. Clustering subjects on this basis reduces diagnostic heterogeneity, enabling the development of depression biotype classifiers for diagnosing biotypes of depresion in individual patients, These biotypes also predict differing responses to antidepressant treatment, and abnormal connectivity patterns can be used to track changes in depression severity over time.

Abstract: Provided herein are positive electrodes for lithium batteries, particularly lithium sulfur batteries, and the manufacture thereof. Particularly, such electrodes have good performance characteristics, such as capacity and capacity retention, even at very high loading of sulfur (e.g., >5 mg/cm2), as well as flexibility. Exemplary manufacturing techniques include the electrospraying of sulfur (e.g., electrode active sulfur compounds), and an optional additive (e.g., a nanostructured conductive additive), onto a porous, conductive substrate (e.g., a porous carbon substrate, such as comprising multiple layers and/or domains).

Abstract: The present technology relates generally to methods for treating, preventing, and/or ameliorating metastasis in a subject in need thereof comprising administering to the subject a therapeutically effective amount of low dose carbon monoxide.

Abstract: Implanted medical devices need a mechanism of immobilization to surrounding tissues, which minimizes tissue damage while providing reliable long-term anchoring. This disclosure relates to techniques for patterning arbitrarily shaped 3D objects and to patterned balloon devices having micro- or nano-patterning on an outer surface of an inflatable balloon. The external pattern can provide enhanced friction and anchoring in an aqueous environment. Examples of these types of patterns are hexagonal arrays inspired by tree frogs, corrugated patterns, and microneedle patterns. The patterned balloon devices can be disposed between an implant and surrounding tissues to facilitate anchoring of the implant.

Abstract: Quantitative susceptibility mapping methods, systems and computer-accessible medium include generating images of tissue magnetism property from complex magnetic resonance imaging data using the Bayesian inference approach. The tissue magnetism images is then used to monitor remyelination, such as remyelination in multiple sclerosis patients in response to therapy. Multiple sclerosis lesions defined on magnetic resonance imaging are further characterized on tissue magnetism images into hyperintense, isointense and hypointense parts for measuring remyelination. Thus, magnetic susceptibility information and other tissue properties associated with at least one structure are determined.

Abstract: An integrated device for the detection of cancerous tissue including an optical fiber configured to receive at a first end modulated infrared light and to conduct the modulated infrared light from the first end to a second end; and a plasmonic metasurface, disposed on the second end of the optical fiber, configured to localize evanescent infrared light to sub-I 00 nanometer distances from the plasmonic metasurface of the optical fiber such that the localized evanescent infrared light penetrates only the membrane portion of a cell held against the second end, wherein the second end is configured to receive reflected light reflected from the membrane portion the cell, the reflected light including spectroscopic information indicative of whether the cell is noncancerous or cancerous.

Abstract: Systems and methods herein provide for data deduplication in memory. In one embodiment, an Input/Output (I/O) module is operable to process a write I/O request to the memory, and to extract data of the write I/O request. A data deduplication module is operable to access a table to identify a first portion of the data of the write I/O request that is stored at a first address of the memory, to assign a pointer to the first portion of the data in the table, to identify a second portion of the data of the write I/O request that is not stored in memory, and to direct the second portion of the data of the write I/O request to be written to a second address of the memory.