Abstract: Methods, systems, and devices are disclosed for implementing electro-optical modulators in which a resonating cavity structure is coupled to a transmission waveguide. In one example, the resonating structure includes a ring resonator whose coupling strength is controlled via an electrical control signal. The ring resonator is made of a capacitor comprising monolayer graphene sheets separated by a thick layer of dielectric material.

Abstract: The present invention provides compositions and methods to treat Alzheimer's disease and other neurodegenerative diseases and conditions by expressing exogenous prohibitin in the neurons of the brain of the subject.

Abstract: The present disclosure provides methods and systems for managing power in a processor having multiple cores. In one implementation, a microarchitecture of a core within a general-purpose processor may include configurable lanes (horizontal slices through the pipeline) which can be powered on and off independently from each other within the core. An online optimization algorithm may determine within a reasonably small fraction of a time slice a combination of lanes within different cores of the processor to be powered on that optimizes performance under a power constraint budget for the workload running on the general-purpose processor. The online optimization algorithm may use an objective function based on response surface models constructed to fit to a set of sampled data obtained by running the workload on the general-purpose processor with multiple cores, without running the full workload. In other implementations, the power supply to lanes can be gated.

Abstract: A nucleophilic substitution reaction to crosslink cyclodextrin (CD) polymer with rigid aromatic groups, providing a high surface area, mesoporous CD-containing polymers (P-CDPs). The P-CDPs can be used for removing organic contaminants from water. By encapsulating pollutants to form well-defined host-guest complexes with complementary selectivities to activated carbon (AC) sorbents. The P-CDPs can rapidly sequester pharmaceuticals, pesticides, and other organic micropollutants, achieving equilibrium binding capacity in seconds with adsorption rate constants 15-200 times greater than ACs and nonporous CD sorbents. The CD polymer can be regenerated several times, through a room temperature washing procedure, with no loss in performance.

Abstract: Techniques, systems, and devices are disclosed to provide on-chip integrated gas sensor based on photonic sensing. For example, a sensing device is provided to include an optical comb generator that produces an optical comb of different optical comb frequencies in a mid-infrared (MIR) spectral range to interact with a sample under detection, the optical comb generator including a substrate, an optical resonator formed on the substrate and an optical waveguide formed on the substrate and coupled to the optical resonator, and an optical detector that detects light from the sample at the different optical comb frequencies.

Abstract: Recombinant cells and methods are provided that relate to the use of isolated, engineered recombinant cells to directly or indirectly treat diseases or disorders in a mammalian host such as endocrine, gastrointestinal or autoimmune disorders. A recombinant cell is provided that comprises a signal sequence and a promoter, wherein: the signal sequence is capable of regulating signal-dependent expression of a target nucleic acid in a host or is capable of regulating signal-dependent expression of a target nucleic acid in response to an environmental stimulus, the cell is derived from an enteric or a commensal bacterium, and the target nucleic acid encodes a mammalian factor that promotes normal functioning of a physiological process in the host or is effective in preventing onset, establishment, or spread of a non-infectious disease in the host. The recombinant cell is administered to the host to treat the disease or disorder.

Abstract: Disclosed are devices and techniques based on optical coherence tomography (OCT) technology in combination with optical actuation. A system for providing optical actuation and optical sensing can include an optical coherence tomography (OCT) device that performs optical imaging of a sample based on optical interferometry from an optical sampling beam interacting with an optical sample and an optical reference beam; an OCT light source to provide an OCT imaging beam into the OCT device which splits the OCT imaging beam into the optical sampling beam and the optical reference beam; and a light source that produces an optical actuation beam that is coupled along with the optical sampling beam to be directed to the sample to actuate particles or structures in the sample so that the optical imaging captures information of the sample under the optical actuation.

Abstract: Method for identifying a modulator of Sirt6, PfSir2a, or Sirt7 deacylase activity, wherein a fatty-acylated substrate containing an acyl-lysine moiety and an indicator moiety is contacted with Sirt6, PfSir2a, or Sirt7 in the presence of a candidate compound under conditions for Sirt6, PfSir2a, or Sirt7 to deacylate the substrate, wherein the acyl is a hydrophobic fatty acyl group containing a hydrocarbon group having at least three carbon atoms connected by carbon-carbon bonds; contacting the deacylated substrate with a cleavage agent that cleaves the linkage between the lysine and indicator moiety to generate a detectable signal; and correlating a quantified Sirt6, PfSir2a, or Sirt7 deacylase activity therefrom. Modulating compounds of Sirt6, PfSir2a, or Sirt7 deacylase activity are also described, as are pharmaceutical compositions thereof, methods of treatment by administration of the modulating compounds, and kits for practicing the method.

Abstract: Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof, which may be useful as MALT1 inhibitors. Also provided are for the treatment of proliferative disorders (e.g., cancer (e.g., non-Hodgkin's lymphoma, diffuse large B-cell lymphoma, MALT, lymphoma), benign neoplasm, a disease associated with angiogenesis, an autoimmune disease, an inflammatory disease, an autoinflammatory disease) by administering a compound of Formula (I).

Abstract: A method for controlling a first node transmitting a transmission message to a plurality of second nodes may be provided. The method includes dividing the transmission message into at least one sub-message, encoding the at least one sub-message to a data stream, determining a first transmission direction of the data stream toward at least one of the plurality of second nodes, based on a polynomial of a channel gain between the first node and the at least one of the plurality of second nodes, and transmitting the data stream to the at least one of the plurality of second nodes, based on the determined first transmission direction.

Abstract: A multi-tip nano-probe apparatus and a method for probing a sample while using the multi-tip nano-probe apparatus each employ located over a substrate: (1) an immovable probe tip with respect to the substrate; (2) a movable probe tip with respect to the substrate; and (3) a motion sensor that is coupled with the movable probe tip. The multi-tip nano-probe apparatus and related method provide for improved sample probing due to close coupling of the motion sensor with the movable probe tip, and also retractability of the movable probe tip with respect to the immovable probe tip.

Abstract: The present invention relates to carbon-based fluorescent nano-agent tracers for analysis of oil reservoirs. The carbon-based fluorescent nano-agents may be used in the analysis of the porosity of a formation. The nanoagents are suitable for injection into a petroleum reservoir and may be recovered from the reservoir for the determination of hydrocarbon flow rates and retention times.

Abstract: A clock synchronization system and methods including an algorithm, or protocol, that synchronizes to any source of time without the need of estimating frequency errors and only performing frequency adaptions. Specifically, a clock synchronization protocol synchronizes networked nodes without explicit estimation of the clock skews and steep corrections on the time. The algorithm is guaranteed to converge even in the presence of timing loops which allow different clients to share timing information and even collectively outperform individual clients when the time source has large jitter.

Abstract: Disclosed is a compound of formula (I): wherein R1, R2, R3, and are as defined herein. Also disclosed are methods for increasing mammalian cell NAD+ production and improving mitochondrial cell densities comprising administering to a cell the compound or a salt thereof.

Abstract: Methods, systems, and devices are disclosed for using optical modes in optical waveguides to carry different optical communication signals. In one aspect, an optical device for optical MDM in optical communications includes an optical waveguide configured to support multiple optical waveguide modes and to carry light of different optical communication channels in different optical waveguide modes, respectively, of the multiple optical waveguide modes. The optical device includes an optical resonator configured to be capable of carrying an optical communication channel in one optical resonator mode and optically coupled to the optical waveguide to selectively couple the optical communication channel in the optical resonator into the optical waveguide to add a channel into the optical waveguide via optical mode division multiplexing. In another aspect, an optical mode division demultiplexing can be performed by coupling an optical waveguide and an optical resonator.

Abstract: A non-aqueous Na-oxygen battery utilizes a gas mixture of CO2 and O2 as fuel. The battery exhibits a comparatively high specific energy of 6500-7000 Whkg?1 over a range of CO2 feed compositions. The energy density achieved is higher, by 200% to 300%, than obtained with pure oxygen feed. Ex-situ FTIR and XRD analysis confirm Na2O2, Na2C2O4 and Na2CO3 as discharge products. The Na—O2/CO2 battery provides a promising approach for CO2 capture and conversion into electrical energy. The Na—O2/CO2 battery may be extended to other metals. In addition, operation of a metal battery fueled at least in-part by carbon dioxide within an optimal temperature range is considered.

Abstract: Optical sensing techniques and devices based on detection of fluorescent emissions at different optical wavelengths by nonlinear optical absorption of different excitation beams at different excitation wavelengths that interact with fluorescently-labeled structures within the sample to cause nonlinear optical absorption of two or more photons at each excitation wavelength. The fluorescent light at different fluorescent emission wavelengths by nonlinear optical absorption of excitation light at a particular excitation wavelength is spectrally separated into different optical channel output beams along different optical channel optical paths at different designated fluorescent imaging wavelength bands and the fluorescent light at different fluorescent imaging wavelengths within each designated fluorescent imaging wavelength is detected.

Abstract: A method for preparing a material composition comprising a hollow transition metal oxide nanoparticle supported upon a carbon material support includes a solution impregnation process step, followed by a thermal reduction process step and finally a thermal oxidation process step. The material composition, an electrode and an electrical component such as but not limited to a battery are all predicated at least in-part upon the material composition prepared in accord with the foregoing method. The foregoing material composition, electrode, battery and method may ultimately provide a LIB with enhanced performance.

Abstract: A compressed sensing method based on non-uniform wavelet bandpass sampling. A K-sparse signal of interest is projected onto a sequence of waveforms succeeding one another at the bandpass sampling rate, the waveforms belonging to an overcomplete dictionary, the parameters of the waveforms depending on the characteristics of the bands of the signal. The correlation values are then non-uniformly sampled to provide a compressed representation of the signal.

Abstract: Methods, systems, and devices are disclosed for implementing a fiber-waveguide evanescent coupling. In one aspect, a device having integrated photonic components includes a substrate, a waveguide formed on the substrate to include a terminal waveguide portion that terminates at one side of the substrate, and a fiber including a fiber core and fiber cladding surrounding the fiber core, in which at least a portion of the fiber cladding is removed at or near a fiber terminal end to enable optical evanescent coupling via a side surface of the fiber core at the or near the fiber terminal end, the fiber core at the or near the fiber terminal end is placed over the one side of the substrate to be above and to overlap with the terminal waveguide portion of the waveguide to enable optical evanescent coupling via side surfaces of the fiber core and the waveguide.