Patents Assigned to Cornell University
  • Patent number: 10011862
    Abstract: The present invention is directed to methods for identifying the presence of one or more methylated or unmethylated target nucleotide sequences in a sample that involve a nuclease-ligation reaction. In some embodiments, the ligation products formed in the nuclease-ligation process of the present invention are subsequently amplified using a polymerase chain reaction. The ligated product sequences or extension products thereof are detected, and the presence of one or more methylated or unmethylated target nucleotide sequences in the sample is identified based on the detection.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: July 3, 2018
    Assignee: Cornell University
    Inventors: Francis Barany, Eugene Spier
  • Publication number: 20180180969
    Abstract: In one aspect, a method is provided for generating supercontinuum laser pulses within a continuous mid-infrared spectral range in a chalcogenide material. This method includes focusing an input laser beam of femtosecond pulses with a pulse energy higher than 10 microjoule along an optical path of the input laser beam; placing a chalcogenide material at a selected location along the optical path of the laser beam so that the laser intensity at the chalcogenide material is sufficiently high to cause nonlinear optical absorption that causes conversion of input optical energy into supercontinuum laser pulses of a pulse energy at or above a microjoule level at optical wavelengths within a broad continuous mid-infrared spectral range without damaging the chalcogenide material; and simultaneously moving the chalcogenide material laterally relative to the input laser beam to avoid damage to the chalcogenide material.
    Type: Application
    Filed: June 27, 2016
    Publication date: June 28, 2018
    Applicant: Cornell University
    Inventors: Poul B. Petersen, Ashley Stingel
  • Patent number: 10008248
    Abstract: Devices or circuits based on spin torque transfer (STT) and Spin Hall effect are disclosed by using a spin Hall effect (SHE) metal layer coupled to a magnetic free layer for various applications. The efficiency or strength of the STT effect based on this combination of SHE and STT can be enhanced by an interface modification between the SHE metal layer and the magnetic free layer or by modifying or engineering the SHE metal layer by doping the SHE metal with certain impurities or other means.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: June 26, 2018
    Assignee: Cornell University
    Inventors: Robert A Buhrman, Minh-hai Nguyen, Chi-feng Pai, Daniel C Ralph
  • Patent number: 9999694
    Abstract: The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer. The nanoparticle has a range of diameters including between about 0.1 nm and about 100 nm, between about 0.5 nm and about 50 nm, between about 1 nm and about 25 nm, between about 1 nm and about 15 nm, or between about 1 nm and about 8 nm. The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound. The nanoparticle also exhibits high biostability and biocompatibility. To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as poly(ethylene glycol) (PEG). The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: June 19, 2018
    Assignees: Sloan-Kettering Institute for Cancer Research, Cornell University
    Inventors: Michelle S. Bradbury, Ulrich Wiesner, Oula Penate Medina, Andrew Burns, Jason S. Lewis, Steven M. Larson
  • Publication number: 20180164432
    Abstract: Techniques, systems, and devices are described for implementing for implementing computation devices and artificial neurons based on nanoelectromechanical (NEMS) systems. In one aspect, a nanoelectromechanical system (NEMS) based computing element includes: a substrate; two electrodes configured as a first beam structure and a second beam structure positioned in close proximity with each other without contact, wherein the first beam structure is fixed to the substrate and the second beam structure is attached to the substrate while being free to bend under electrostatic force. The first beam structure is kept at a constant voltage while the other voltage varies based on an input signal applied to the NEMS based computing element.
    Type: Application
    Filed: January 25, 2018
    Publication date: June 14, 2018
    Applicant: Cornell University
    Inventors: Amit Lal, Serhan Ardanuc, Jason T. Hoople, Justin C. Kuo
  • Publication number: 20180156979
    Abstract: Optical coupling designs are disclosed to provide a photonic device, for example, that includes a substrate; an optical waveguide formed on the substrate and configured as a multimode waveguide to support light in different optical waveguide modes; and an optical fiber structured as a multimode fiber to support light in different optical fiber modes, the optical fiber located above the optical waveguide and optically coupled to the optical waveguide via evanescent coupling to allow light to be coupled between the optical fiber and the optical waveguide.
    Type: Application
    Filed: August 28, 2017
    Publication date: June 7, 2018
    Applicant: Cornell University
    Inventors: Brian Stern, Michal Lipson, Aseema Mohanty, Felippe Barbosa, Jaime Cardenas
  • Patent number: 9988667
    Abstract: Provided herein are methods and devices for single object detection. The methods and devices can be used to identify a plurality of epigenetic markers on a genetic material, or a chromatin, encompassing fragments thereof. The invention provides for the characterization of the genetic material flowing through a channel in a continuous body of fluid based on detection of one or more properties of the genetic material. The methods and systems provided herein allow genome-wide, high-throughput epigenetic analysis and overcome a variety of limitations common to bulk analysis techniques.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: June 5, 2018
    Assignee: Cornell University
    Inventors: Harold G. Craighead, Benjamin R. Cipriany, Stephen Levy, Paul Soloway
  • Patent number: 9988421
    Abstract: The compounds of the present invention are represented by the following compounds having Formula (I) where the substituents R1-R10, X, Y, k, m, n, q, and s are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders or for providing immunosuppression for transplanted organs or tissues.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: June 5, 2018
    Assignee: Cornell University
    Inventors: Gang Lin, Carl Nathan, Aihao Ding, Xiaojing Ma
  • Patent number: 9986738
    Abstract: The invention features a method of improving the growth of a plant, involving applying to a seed or locus thereof a composition comprising an active ingredient and a pH-dependent film-forming polymer, followed by exposing the composition to an appropriate pH to release said active ingredient. The invention further features a seed including a composition having a) an active ingredient; and b) a pH-dependent film-forming polymer. Additionally, the invention features a seed treatment composition that includes a) an agrochemical; b) a pH-dependent film-forming polymer; and c) a seed coating agent.
    Type: Grant
    Filed: April 21, 2011
    Date of Patent: June 5, 2018
    Assignee: Cornell University
    Inventors: Alan Taylor, Alexandr Bolotin, Sarah Pollicove, Ryan Taylor
  • Patent number: 9986893
    Abstract: Apparatus comprising: a sleeve adapted to be slid over the exterior of an endoscope; a proximal balloon secured to the sleeve; an inflation/deflation tube carried by the sleeve and in fluid communication with the interior of the proximal balloon; a push tube slidably mounted to the sleeve; and a distal balloon secured to the distal end of the push tube, the interior of the distal balloon being in fluid communication with the push tube, wherein the distal balloon is capable of assuming a deflated condition and an inflated condition, and further wherein when the distal balloon is in its deflated condition, an axial opening extends therethrough, the axial opening being sized to receive the endoscope therein, and when the distal balloon is in its inflated condition, the axial opening is closed down.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: June 5, 2018
    Assignee: Cornell University
    Inventors: John Frederick Cornhill, Jeffrey Milsom, Sameer Sharma, Tuan Anh Nguyen, Christopher Dillon, Gabriel Greeley, Rahul Sathe, Matthew DeNardo, Ashley Whitney, Jeremy Van Hill, Anthony Z. Assal
  • Patent number: 9985774
    Abstract: A synchronization solution is described, which, in one aspect, allowed finer grained segmentation of clock domains on a chip. This solution incorporates computation into the synchronization overhead time and is called Gradual Synchronization. With Gradual Synchronization as a synchronization method, the design space of a chip could easily mix both asynchronous and synchronous blocks of logic, paving the way for wider use of asynchronous logic design.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: May 29, 2018
    Assignee: Cornell University
    Inventors: Rajit Manohar, Sandra J. Jackson
  • Patent number: 9982301
    Abstract: Non-invasive methods for detecting, predicting, and/or monitoring differential diagnosis of kidney transplant dysfunction in kidney transplant patients are described.
    Type: Grant
    Filed: January 7, 2015
    Date of Patent: May 29, 2018
    Assignee: Cornell University
    Inventors: Thangamani Muthukumar, Manikkam Suthanthiran, Ruchuang Ding
  • Patent number: 9981032
    Abstract: Provided are compositions and methods for use in prophylaxis of puerperal metritis and improving reproductive function of ruminants. The methods and compositions are for subcutaneous administration and are provided as veterinary compositions and as articles of manufacture. The veterinary composition can contain whole cells selected from whole cells of Escherichia coli (E. coli), Trueperella pyogenes (T. pyogenes), Fusobacterium necrophorum (F. necrophorum) and combinations thereof; and/or proteins selected from F. necrophorum leukotoxin (LKT), E. coli type 1 fimbrial adhesin (FimH), T. pyogenes pyolysin (PLO), and all combinations of the whole cells and the proteins.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: May 29, 2018
    Assignee: Cornell University
    Inventors: Rodrigo Carvalho Bicalho, Robert Owen Gilbert, Vinicius Machado, Marcela Bicalho
  • Publication number: 20180133346
    Abstract: An aqueous synthesis methodology for the preparation of silica nanoparticles (SNPs), core-shell SNPs having, for example, a size of 2 to 15 nm and narrow size-dispersion with size control below 1 nm, i.e. at the level of a single atomic layer. Different types of dyes, including near infrared (NIR) emitters, can be covalently encapsulated within and brightness can be enhanced via addition of extra silica shells. The surface may be functionalized with polyethylene glycol (PEG) groups and, optionally, specific surface ligands. This aqueous synthesis methodology also enables synthesis of 2 to 15 nm sized fluorescent core and core-shell aluminosilicate nanoparticles (ASNPs) which may also be surface functionalized. Encapsulation efficiency and brightness of highly negatively charged NIR fluorophores is enhanced relative to the corresponding SNPs without aluminum.
    Type: Application
    Filed: May 4, 2016
    Publication date: May 17, 2018
    Applicant: Cornell University
    Inventors: Ulrich B. WIESNER, Kai MA, Carlie MENDOZA
  • Publication number: 20180133342
    Abstract: Disclosed herein are nanoparticle immunoconjugates useful for therapeutics and/or diagnostics. The immunoconjugates have diameter (e.g., average diameter) no greater than 20 nanometers (e.g., as measured by dynamic light scattering (DLS) in aqueous solution, e.g., saline solution). In certain embodiments, the conjugates are silica-based nanoparticles with single chain antibody fragments attached thereto.
    Type: Application
    Filed: April 7, 2016
    Publication date: May 17, 2018
    Applicants: Memorial Sloan Kettering Cancer Center, The Curators of the University of Missouri, Cornell University, The Curators of the University of Missouri
    Inventors: Barney Yoo, Thomas P. Quinn, Michelle S. Bradbury, Ulrich Wiesner, Jason Lewis, Kai Ma, Feng Chen
  • Patent number: 9970853
    Abstract: An ultrasonic or acoustic viscosity sensor or viscometer is provided that can be used to accurately measure viscosity for fluid samples of less than 1 ?l in volume. Methods for measuring viscosity for fluid samples of less than 1 ?l in volume are also provided. The viscosity sensor and methods based thereon enable simultaneous measurement of bulk and dynamic (shear-rate dependent) viscosity of a non-Newtonian fluid. Bulk and dynamic viscosity of the non-Newtonian fluid can be measured simultaneously without separating constituents of the fluid, and thus distinguishing the effect of constituents on the viscosity. Dynamic viscosity of the non-Newtonian fluid can be estimated at varying shear rates, to study the deformability of the constituents of the fluid as a function of shear rate.
    Type: Grant
    Filed: July 14, 2011
    Date of Patent: May 15, 2018
    Assignee: Cornell University
    Inventors: Amit Lal, Ramkumar Abhishek
  • Patent number: 9971164
    Abstract: An optical system particularly suited for non-linear fluorescence collecting includes a front lens system, a rear lens system, and a bulk, dichroic beam splitting component intermediate the front lens system and the rear lens system to direct the fluorescent emission from a target object to a photodetector. A lens housing may have a reflective coating on an interior surface thereof. The objective optical system is particularly advantageous for use in cases where large fields of view and high collection efficiencies are desirable.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: May 15, 2018
    Assignee: Cornell University
    Inventors: Jesse McMullen, Warren Zipfel
  • Publication number: 20180131504
    Abstract: A compressed sensing method based on non-uniform wavelet bandpass sampling. A K-sparse signal of interest is projected onto a sequence of waveforms succeeding one another at the bandpass sampling rate, the waveforms belonging to an overcomplete dictionary, the parameters of the waveforms depending on the characteristics of the bands of the signal. The correlation values are then non-uniformly sampled to provide a compressed representation of the signal.
    Type: Application
    Filed: November 4, 2016
    Publication date: May 10, 2018
    Applicants: Commissariat A L'Energie Atomique et aux Energies Alternatives, Cornell University
    Inventors: Michael PELISSIER, Christoph Emanuel STUDER
  • Patent number: 9958549
    Abstract: Methods and systems that can detect GNSS spoofing attacks and that do not require explicit or implicit knowledge of exact position or attitude and that provide hypothesis test statistics, threshold values, and probabilities of false alarm and missed detection.
    Type: Grant
    Filed: September 20, 2013
    Date of Patent: May 1, 2018
    Assignee: Cornell University
    Inventors: Mark L. Psiaki, Steven P. Powell, Brady W. O'Hanlon
  • Patent number: 9956236
    Abstract: The invention provides, e.g., compositions and methods for increasing activation of immune cells.
    Type: Grant
    Filed: February 7, 2012
    Date of Patent: May 1, 2018
    Assignee: Cornell University
    Inventors: Laurie H. Glimcher, Sarah Bettigole, Fabio Martinon