Patents Assigned to Corvas International, Inc.
  • Asp-Pro-Arg .alpha.-keto-amide enzyme inhibitors
    Patent number: 5371072
    Abstract: Asp-Pro-Arg alpha-keto-amide derivatives, and their pharmaceutically acceptable salts and compositions, for use as antithrombotic agents in mammals are disclosed. The method of use of these inhibitor compounds for treatment or prevention of conditions of abnormal thrombus formation in mammals is also disclosed. Further disclosed are alpha-hydroxy amide compounds used as intermediates in the preparation of the keto-amide compounds.
    Type: Grant
    Filed: October 16, 1992
    Date of Patent: December 6, 1994
    Assignee: Corvas International, Inc.
    Inventors: Thomas R. Webb, Todd A. Miller, George P. Vlasuk
  • Reagents for automated synthesis of peptide analogs
    Patent number: 5367072
    Abstract: Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.
    Type: Grant
    Filed: December 13, 1991
    Date of Patent: November 22, 1994
    Assignee: Corvas International, Inc.
    Inventor: Thomas R. Webb
  • Tissue factor based prothrombin time reagent
    Patent number: 5314695
    Abstract: Prothrombin time reagents are provided which comprise novel liposome compositions in which tissue factor is associated with an inserted into the phospholipid bilayer of the liposomes. Methods for their preparation are also provided. The liposome compositions may be adjusted to allow maximum coagulant activity and sensitivity to extrinsic coagulation factors.
    Type: Grant
    Filed: October 29, 1991
    Date of Patent: May 24, 1994
    Assignee: Corvas International, Inc.
    Inventor: Scott M. Brown