Patents Assigned to CorWave SA
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Publication number: 20230338728Abstract: Systems and methods for generating blood flow with a blood pump including a membrane and an encapsulated actuator are described. The pump may be implantable and may include a stator assembly, an electromagnetic assembly supported by the stator assembly, a magnetic assembly, one or more springs attached to the stator and the magnetic assembly, and encapsulation portions that connect the magnetic assembly to the stator assembly. The magnetic assembly may further be coupled to a membrane assembly including a flexible membrane. The electromagnetic assembly may be selectively activated to cause the magnetic assembly to reciprocate, thereby causing the membrane assembly to reciprocate and inducing wavelike undulations in the flexible membrane to pump blood from an inlet to an outlet of the pump. The encapsulation portions may prevent blood from interacting with an interior moving portion of the pump thereby reducing the risk of hemolysis.Type: ApplicationFiled: April 24, 2023Publication date: October 26, 2023Applicant: CorWave SAInventors: Pierre-Yves QUELENN, Carl N. BOTTERBUSCH, Trevor SNYDER, Francois CORNAT, Francesca CONDEMI, Petrus LE BLANC, Antoine Olivé
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Publication number: 20230241371Abstract: An implantable pump system is provided, including an implantable blood pump suitable for use as a partial support assist device, the system further including an extracorporeal battery and a controller coupled to the implantable pump, and a programmer selectively periodically coupled to the controller to configure and adjust operating parameters of the implantable pump. The implantable pump includes a flexible membrane coupled to an electromagnetic actuator including a magnetic assembly and electromagnetic assembly, so that when the electromagnetic assembly is energized, the electromagnetic assembly causes wavelike undulations to propagate along the flexible membrane to propel blood through the implantable pump. The controller may be programmed by a programmer to operate at frequencies and duty cycles that mimic physiologic flow rates and pulsatility while operating in an efficient manner that avoids thrombus formation, hemolysis and/or platelet activation.Type: ApplicationFiled: April 6, 2023Publication date: August 3, 2023Applicant: CorWave SAInventors: Louis-Emmanuel LE DUC DE LILLERS, Francois CORNAT, Jean-Baptiste DREVET, Carl N. BOTTERBUSCH, Alexandra SCHMIDT
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Patent number: 11712554Abstract: An implantable cardiovascular blood pump system is provided, suitable for use as a left ventricular assist device (LVAD) system, having an implantable cardiovascular pump, an extracorporeal battery and a controller coupled to the implantable pump, and a programmer selectively periodically coupled to the controller to configure and adjust operating parameters of the implantable cardiovascular pump. The implantable cardiovascular blood pump includes a coaxial inflow cannula and outflow cannula in fluid communication with one another and with a pumping mechanism. The pumping mechanism may be a vibrating membrane pump which may include a flexible membrane coupled to an electromagnetic actuator assembly that causes wavelike undulations to propagate along the flexible membrane to propel blood through the implantable cardiovascular pump.Type: GrantFiled: August 23, 2021Date of Patent: August 1, 2023Assignee: CorWave SAInventors: Carl N. Botterbusch, Silvere Lucquin, Jean-Baptiste Drevet, Adrien Guignabert, Patrick Meneroud
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Patent number: 11623077Abstract: An implantable pump system is provided, including an implantable blood pump suitable for use as a partial support assist device, the system further including an extracorporeal battery and a controller coupled to the implantable pump, and a programmer selectively periodically coupled to the controller to configure and adjust operating parameters of the implantable pump. The implantable pump includes a flexible membrane coupled to an electromagnetic actuator including a magnetic assembly and electromagnetic assembly, so that when the electromagnetic assembly is energized, the electromagnetic assembly causes wavelike undulations to propagate along the flexible membrane to propel blood through the implantable pump. The controller may be programmed by a programmer to operate at frequencies and duty cycles that mimic physiologic flow rates and pulsatility while operating in an efficient manner that avoids thrombus formation, hemolysis and/or platelet activation.Type: GrantFiled: February 19, 2021Date of Patent: April 11, 2023Assignee: CorWave SAInventors: Louis-Emmanuel Le Duc De Lillers, Francois Cornat, Jean-Baptiste Drevet, Carl N. Botterbusch, Alexandra Schmidt
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Publication number: 20230001179Abstract: An implantable pump system is provided, suitable for use as a left ventricular assist device (LVAD) system, having an implantable pump, a battery, a controller, and a programmer. The implantable pump includes a flexible membrane coupled to an actuator assembly via a skirt that extends toward the inlet of the pump and curves to guide blood toward the outlet. The actuator assembly is magnetically engageable with electromagnetic coils, so that when the electromagnetic coils are energized, the actuator assembly causes wavelike undulations to propagate along the flexible membrane to propel blood from the inlet, across the skirt, and through the outlet of the implantable pump. The controller may be programmed by a programmer to operate at frequencies and duty cycles that mimic physiologic flow rates and pulsatility while operating in an efficient manner that avoids thrombus formation, hemolysis and/or platelet activation.Type: ApplicationFiled: September 7, 2022Publication date: January 5, 2023Applicant: CorWave SAInventors: Luc POLVERELLI, Leopold MAINE, Carl N. BOTTERBUSCH, Silvere LUCQUIN, Jean-Baptiste DREVET, Adrien GUIGNABERT, Patrick MENEROUD, Alexandra SCHMIDT, Pier-Paolo MONTICONE
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Patent number: 11512689Abstract: The present invention relates to an undulating-membrane fluid circulator having an intake port (3), a pump housing (4) delimiting a propulsion chamber (5), a discharge port (6), and an undulating membrane (2) paired with a drive means permitting an undulating movement of the membrane (2) between the upstream (8) and downstream (9) edges thereof, the undulating membrane (2) being capable of moving a fluid towards the discharge port (6). According to the invention, the circulator further comprises at least one means (7) for guiding the fluid, said means being disposed in the fluid propulsion chamber (5) near one of the edges (8, 9) of the undulating membrane (2) and making it possible to channel the fluid flow in a direction substantially parallel to the displacement of the wave along the membrane (2).Type: GrantFiled: November 9, 2018Date of Patent: November 29, 2022Assignee: CorWave SAInventors: Jean-Baptiste Drevet, Harold Guillemin
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Patent number: 11446480Abstract: An implantable pump system is provided, suitable for use as a left ventricular assist device (LVAD) system, having an implantable pump, a battery, a controller, and a programmer. The implantable pump includes a flexible membrane coupled to an actuator assembly via a skirt that extends toward the inlet of the pump and curves to guide blood toward the outlet. The actuator assembly is magnetically engagable with electromagnetic coils, so that when the electromagnetic coils are energized, the actuator assembly causes wavelike undulations to propagate along the flexible membrane to propel blood from the inlet, across the skirt, and through the outlet of the implantable pump. The controller may be programmed by a programmer to operate at frequencies and duty cycles that mimic physiologic flow rates and pulsatility while operating in an efficient manner that avoids thrombus formation, hemolysis and/or platelet activation.Type: GrantFiled: November 22, 2018Date of Patent: September 20, 2022Assignee: CorWave SAInventors: Luc Polverelli, Leopold Maine, Carl N. Botterbusch, Silvere Lucquin, Jean-Baptiste Drevet, Adrien Guignabert, Patrick Meneroud, Alexandra Schmidt, Pier-Paolo Monticone
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Publication number: 20220226633Abstract: An implantable pump system is provided, suitable for use as a left ventricular assist device (LVAD) system, having an implantable pump, an extracorporeal battery and a controller coupled to the implantable pump, and a programmer selectively periodically coupled to the controller to configure and adjust operating parameters of the implantable pump. The implantable pump includes a flexible membrane coupled to an actuator assembly that is magnetically engagable with electromagnetic coils, so that when the electromagnetic coils are energized, the actuator assembly causes wavelike undulations to propagate along the flexible membrane to propel blood from through the implantable pump. The controller may be programmed by a programmer to operate at frequencies and duty cycles that mimic physiologic flow rates and pulsatility while operating in an efficient manner that avoids thrombus formation, hemolysis and/or platelet activation.Type: ApplicationFiled: April 5, 2022Publication date: July 21, 2022Applicant: CorWave SAInventors: Carl N. BOTTERBUSCH, Silvere LUCQUIN, Piere-Paolo MONTICONE, Jean-Baptiste DREVET, Adrien GUIGNABERT, Patrick MENEROUD
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Patent number: 11298522Abstract: An implantable pump system is provided, suitable for use as a left ventricular assist device (LVAD) system, having an implantable pump, an extracorporeal battery and a controller coupled to the implantable pump, and a programmer selectively periodically coupled to the controller to configure and adjust operating parameters of the implantable pump. The implantable pump includes a flexible membrane coupled to an actuator assembly that is magnetically engagable with electromagnetic coils, so that when the electromagnetic coils are energized, the actuator assembly causes wavelike undulations to propagate along the flexible membrane to propel blood from through the implantable pump. The controller may be programmed by a programmer to operate at frequencies and duty cycles that mimic physiologic flow rates and pulsatility while operating in an efficient manner that avoids thrombus formation, hemolysis and/or platelet activation.Type: GrantFiled: August 30, 2019Date of Patent: April 12, 2022Assignee: CorWave SAInventors: Carl N. Botterbusch, Silvere Lucquin, Pier-Paolo Monticone, Jean-Baptiste Drevet, Adrien Guignabert, Patrick Meneroud
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Publication number: 20220062618Abstract: Systems and methods for controlling an implantable pump are provided. For example, the exemplary controller for controlling the implantable pump may only rely on the actuator's current measurement. The controller is robust to pressure and flow changes inside the pump head, and allows fast change of pump's operation point. For example, the controller includes, a two stage, nonlinear position observer module based on a reduced order model of the electromagnetic actuator. The controller includes an algorithm that estimates the position of the moving component of the implantable pump based on the actuator's current measurement and adjusts operation of the pump accordingly. Alternatively, the controller may rely on position measurements and/or velocity estimations.Type: ApplicationFiled: September 14, 2021Publication date: March 3, 2022Applicant: CorWave SAInventors: Mattias SCHEFFLER, Nicolas BARABINO, Marc REBILLAT, Eric MONTEIRO, Nazih MECHBAL
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Publication number: 20220016412Abstract: An apparatus for coupling a blood pump to a patients heart is provided. The apparatus includes a sewing ring designed to be sutured to the patients heart, wherein the sewing ring has an opening sized and shaped to receive an inflow cannula of the blood pump. The apparatus further includes a locking element coupled to a housing of the blood pump and transitionable between a closed state and an open state. The locking element is structured to receive the sewing ring in the open state and engage the sewing ring in the closed state to prevent translational and rotational movement of the locking element relative to the sewing ring. In addition, the apparatus includes a biased structure designed to bias the locking element in the closed state.Type: ApplicationFiled: November 26, 2019Publication date: January 20, 2022Applicant: CorWave SAInventors: Amelie BOURQUIN, Antoine RABARDEL, Antoine RUDELLE, Pierre-Yves QUELENN
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Publication number: 20210379353Abstract: An implantable cardiovascular blood pump system is provided, suitable for use as a left ventricular assist device (LVAD) system, having an implantable cardiovascular pump, an extracorporeal battery and a controller coupled to the implantable pump, and a programmer selectively periodically coupled to the controller to configure and adjust operating parameters of the implantable cardiovascular pump. The implantable cardiovascular blood pump includes a coaxial inflow cannula and outflow cannula in fluid communication with one another and with a pumping mechanism. The pumping mechanism may be a vibrating membrane pump which may include a flexible membrane coupled to an electromagnetic actuator assembly that causes wavelike undulations to propagate along the flexible membrane to propel blood through the implantable cardiovascular pump.Type: ApplicationFiled: August 23, 2021Publication date: December 9, 2021Applicant: CorWave SAInventors: Carl N. BOTTERBUSCH, Silvere LUCQUIN, Jean-Baptiste DREVET, Adrien GUIGNABERT, Patrick MENEROUD
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Patent number: 11191946Abstract: Systems and methods for generating blood flow with a pump incorporating linear bearing technology are provided. The pump may include an actuator assembly, a moving assembly, and a linear hydrodynamic or thin-film bearing positioned within a housing. The moving assembly may include at least one magnet and the actuator assembly may include a magnetic assembly for selectively generating a magnetic field to cause linear reciprocating movement of the moving assembly with respect to the actuator assembly. The linear hydrodynamic or thin-film bearing may include a bearing portion on the moving assembly that is in fluid communication with a bearing portion on the actuator assembly or pump housing. The system may involve an implantable pump, an extracorporeal battery and a controller coupled to the implantable pump. The implantable pump may be suitable for use as a left ventricular assist device (LVAD).Type: GrantFiled: March 5, 2021Date of Patent: December 7, 2021Assignee: CorWave SAInventors: Trevor Snyder, Carl N. Botterbusch, Petrus Le Blanc, Bastien Wittig
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Publication number: 20210275797Abstract: Systems and methods for generating blood flow with a pump incorporating linear bearing technology are provided. The pump may include an actuator assembly, a moving assembly, and a linear hydrodynamic or thin-film bearing positioned within a housing. The moving assembly may include at least one magnet and the actuator assembly may include a magnetic assembly for selectively generating a magnetic field to cause linear reciprocating movement of the moving assembly with respect to the actuator assembly. The linear hydrodynamic or thin-film bearing may include a bearing portion on the moving assembly that is in fluid communication with a bearing portion on the actuator assembly or pump housing. The system may involve an implantable pump, an extracorporeal battery and a controller coupled to the implantable pump. The implantable pump may be suitable for use as a left ventricular assist device (LVAD).Type: ApplicationFiled: March 5, 2021Publication date: September 9, 2021Applicant: CorWave SAInventors: Trevor SNYDER, Carl N. BOTTERBUSCH, Petrus LE BLANC, Bastien WITTIG
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Patent number: 11097091Abstract: An implantable cardiovascular blood pump system is provided, suitable for use as a left ventricular assist device (LVAD) system, having an implantable cardiovascular pump, an extracorporeal battery and a controller coupled to the implantable pump, and a programmer selectively periodically coupled to the controller to configure and adjust operating parameters of the implantable cardiovascular pump. The implantable cardiovascular blood pump includes a coaxial inflow cannula and outflow cannula in fluid communication with one another and with a pumping mechanism. The pumping mechanism may be a vibrating membrane pump which may include a flexible membrane coupled to an electromagnetic actuator assembly that causes wavelike undulations to propagate along the flexible membrane to propel blood through the implantable cardiovascular pump.Type: GrantFiled: December 27, 2018Date of Patent: August 24, 2021Assignee: CorWave SAInventors: Carl N. Botterbusch, Silvere Lucquin, Jean-Baptiste Drevet, Adrien Guignabert, Patrick Meneroud
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Publication number: 20210172429Abstract: The present invention relates to an undulating-membrane fluid circulator having an intake port (3), a pump housing (4) delimiting a propulsion chamber (5), a discharge port (6), and an undulating membrane (2) paired with a drive means permitting an undulating movement of the membrane (2) between the upstream (8) and downstream (9) edges thereof, the undulating membrane (2) being capable of moving a fluid towards the discharge port (6). According to the invention, the circulator further comprises at least one means (7) for guiding the fluid, said means being disposed in the fluid propulsion chamber (5) near one of the edges (8, 9) of the QI undulating membrane (2) and making it possible to channel the fluid flow in a direction substantially parallel to the displacement of the wave along the membrane (2).Type: ApplicationFiled: November 9, 2018Publication date: June 10, 2021Applicant: CorWave SAInventors: Jean-Baptiste DREVET, Harold GUILLEMIN
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Publication number: 20210170160Abstract: An implantable pump system is provided, including an implantable blood pump suitable for use as a partial support assist device, the system further including an extracorporeal battery and a controller coupled to the implantable pump, and a programmer selectively periodically coupled to the controller to configure and adjust operating parameters of the implantable pump. The implantable pump includes a flexible membrane coupled to an electromagnetic actuator including a magnetic assembly and electromagnetic assembly, so that when the electromagnetic assembly is energized, the electromagnetic assembly causes wavelike undulations to propagate along the flexible membrane to propel blood through the implantable pump. The controller may be programmed by a programmer to operate at frequencies and duty cycles that mimic physiologic flow rates and pulsatility while operating in an efficient manner that avoids thrombus formation, hemolysis and/or platelet activation.Type: ApplicationFiled: February 19, 2021Publication date: June 10, 2021Applicant: CorWave SAInventors: Louis-Emmanuel LE DUC DE LILLERS, Francois CORNAT, Jean-Baptiste DREVET, Carl N. BOTTERBUSCH, Alexandra SCHMIDT
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Patent number: 10933181Abstract: An implantable pump system is provided, including an implantable blood pump suitable for use as a partial support assist device, the system further including an extracorporeal battery and a controller coupled to the implantable pump, and a programmer selectively periodically coupled to the controller to configure and adjust operating parameters of the implantable pump. The implantable pump includes a flexible membrane coupled to an electromagnetic actuator including a magnetic assembly and electromagnetic assembly, so that when the electromagnetic assembly is energized, the electromagnetic assembly causes wavelike undulations to propagate along the flexible membrane to propel blood through the implantable pump. The controller may be programmed by a programmer to operate at frequencies and duty cycles that mimic physiologic flow rates and pulsatility while operating in an efficient manner that avoids thrombus formation, hemolysis and/or platelet activation.Type: GrantFiled: March 29, 2018Date of Patent: March 2, 2021Assignee: CorWave SAInventors: Louis-Emmanuel Le Duc De Lillers, Francois Cornat, Jean-Baptiste Drevet, Carl N. Botterbusch, Alexandra Schmidt
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Publication number: 20200368417Abstract: An implantable pump system is provided, suitable for use as a left ventricular assist device (LVAD) system, having an implantable pump, a battery, a controller, and a programmer. The implantable pump includes a flexible membrane coupled to an actuator assembly via a skirt that extends toward the inlet of the pump and curves to guide blood toward the outlet. The actuator assembly is magnetically engagable with electromagnetic coils, so that when the electromagnetic coils are energized, the actuator assembly causes wavelike undulations to propagate along the flexible membrane to propel blood from the inlet, across the skirt, and through the outlet of the implantable pump. The controller may be programmed by a programmer to operate at frequencies and duty cycles that mimic physiologic flow rates and pulsatility while operating in an efficient manner that avoids thrombus formation, hemolysis and/or platelet activation.Type: ApplicationFiled: November 22, 2018Publication date: November 26, 2020Applicant: CorWave SAInventors: Luc POLVERELLI, Leopold MAINE, Carl N. BOTTERBUSCH, Silvere LUCQUIN, Jean-Baptiste DREVET, Adrien GUIGNABERT, Patrick MENEROUD, Alexandra SCHMIDT, Pier-Paolo MONTICONE
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Patent number: 10799625Abstract: Systems and methods for controlling an implantable pump are provided. For example, the exemplary controller for controlling the implantable pump may only rely on the actuator's current measurement. The controller is robust to pressure and flow changes inside the pump head, and allows fast change of pump's operation point. For example, the controller includes, a two stage, nonlinear position observer module based on a reduced order model of the electromagnetic actuator. The controller includes an algorithm that estimates the position of the moving component of the implantable pump based on the actuator's current measurement and adjusts operation of the pump accordingly. Alternatively, the controller may rely on position measurements and/or velocity estimations.Type: GrantFiled: March 13, 2020Date of Patent: October 13, 2020Assignee: CorWave SAInventors: Mattias Scheffler, Nicolas Barabino, Marc Rebillat, Eric Monteiro, Nazih Mechbal