Patents Assigned to Creighton University
  • Patent number: 10525027
    Abstract: The present invention is directed to novel anti-inflammatory immunomodulators including creatinine or a creatinine salt, for example, creatinine hydrochloride. The present invention is also directed to methods for treating inflammation and inducing an immunomodulatory response. In particular, the anti-inflammatory immunomodulators are useful for treating an inflammatory condition or an autoimmune disease.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: January 7, 2020
    Assignees: Vireo Systems, Inc., Creighton University
    Inventors: Thomas McDonald, Kristen Drescher
  • Patent number: 10420759
    Abstract: The present disclosure relates to pirfenidone (5-methyl-1-phenyl-2-(1H)-pyridone) and its derivatives and pharmaceutically acceptable salts thereof, use of these compounds as a medicament, and for the manufacture of a medicament for treating or delaying the onset or development of pulmonary hypertension.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: September 24, 2019
    Assignee: Creighton University
    Inventors: Yaping Tu, Yan Xie, Peter Abel
  • Patent number: 10383848
    Abstract: Provided herein are indole-2-carboxamide compounds useful for the treatment of non-tuberculosis bacterial infections. Exemplary compounds provided herein are useful for the treatment of non-tuberculosis mycobacterial infections. Methods for preparing the indole-2-carboxamide compounds are also provided.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: August 20, 2019
    Assignees: Creighton University, Colorado State University Research Foundation
    Inventors: Jeffrey North, Mary C. Jackson
  • Patent number: 10213397
    Abstract: Disclosed are methods and pharmaceutical compositions for treating cardiomyopathies. The disclosed methods and pharmaceutical compositions may be used for treating lamin A/C (LMNA)-related dilated cardiomyopathies (DCM) in a subject in need thereof. The disclosed methods may utilize and the disclosed pharmaceutical compositions may include an effective amount of a modulator of microtubule polymerization such as colchicine.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: February 26, 2019
    Assignees: Northwestern University, Creighton University
    Inventors: Jane Elizabeth Wilcox, Joshua D. Prenosil
  • Patent number: 10179134
    Abstract: An antiretroviral composition that gels upon heating and can be administered prophylactically prior to exposure to a retrovirus following sexual intercourse, and methods of using the same.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: January 15, 2019
    Assignee: Creighton University
    Inventors: Chris Destache, Abhijit Date, Annemarie Shibata
  • Publication number: 20180250255
    Abstract: The present invention is directed to novel anti-inflammatory immunomodulators including creatinine or a creatinine salt, for example, creatinine hydrochloride. The present invention is also directed to methods for treating inflammation and inducing an immunomodulatory response. In particular, the anti-inflammatory immunomodulators are useful for treating an inflammatory condition or an autoimmune disease.
    Type: Application
    Filed: May 15, 2018
    Publication date: September 6, 2018
    Applicants: Vireo Systems, Inc., Creighton University
    Inventors: Thomas McDonald, Kristen Drescher
  • Publication number: 20180169040
    Abstract: Disclosed are methods and pharmaceutical compositions for treating cardiomyopathies. The disclosed methods and pharmaceutical compositions may be used for treating lamin A/C (LMNA)-related dilated cardiomyopathies (DCM) in a subject in need thereof. The disclosed methods may utilize and the disclosed pharmaceutical compositions may include an effective amount of a modulator of microtubule polymerization such as colchicine.
    Type: Application
    Filed: December 21, 2017
    Publication date: June 21, 2018
    Applicants: Northwestern University, Creighton University
    Inventors: Jane Elizabeth Wilcox, Joshua D. Prenosil
  • Patent number: 9993452
    Abstract: The present invention is directed to novel anti-inflammatory immunomodulators including creatinine or a creatinine salt, for example, creatinine hydrochloride. The present invention is also directed to methods for treating inflammation and inducing an immunomodulatory response. In particular, the anti-inflammatory immunomodulators are useful for treating an inflammatory condition or an autoimmune disease.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: June 12, 2018
    Assignees: Vireo Systems, Inc., Creighton University
    Inventors: Thomas McDonald, Kristen Drescher
  • Patent number: 9925185
    Abstract: The present disclosure relates to methods of treating acquired sensorineural hearing loss and/or ototoxicity in mammals by administering quinoxaline or a pharmaceutically acceptable derivative thereof. In implementations, quinoxaline and its derivatives can decrease cochlear hair cell damage and/or stimulate cochlear hair cell proliferation. In some implementations, quinoxaline can be administered as a pre-treatment prior to, or in conjunction with, exposure to ototoxic pharmaceutical agent(s) and/or acoustic trauma to prevent or decrease cochlear hair cell cytotoxicity and/or stimulate cochlear hair cell proliferation. In other implementations, quinoxaline can be administered as a treatment following exposure to ototoxic pharmaceutical agent(s) and/or acoustic trauma to stimulate cochlear hair cell proliferation.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: March 27, 2018
    Assignee: Creighton University
    Inventor: Sonia M. Rocha-Sanchez
  • Patent number: 9700541
    Abstract: A method and a composition are utilized to affect mitochondrial functions on a seizure-genic brain region. In one aspect, the disclosure comprises methods of treating seizures. Seizures are a transient symptom of abnormal excessive or synchronous neuronal activity in the brain. Seizures may manifest as a wild thrashing movement, a brief loss of awareness, an alteration in mental state, tonic or clonic movements, convulsions, a full body slump, and various other psychic symptoms such as déjà vu or jamais vu. Recurrent, unprovoked seizures are medically known as epilepsy. In one implementation, the method of treating a seizure includes administering a composition that restores mitochondrial function to a seizure-genic brain region. In some embodiments, the composition can include ascorbic acid, vitamin E, and pyruvate.
    Type: Grant
    Filed: June 12, 2013
    Date of Patent: July 11, 2017
    Assignee: Creighton University
    Inventors: Kristina A. Simeone, Timothy A. Simeone
  • Publication number: 20160175272
    Abstract: The present invention is directed to novel anti-inflammatory immunomodulators including creatinine or a creatinine salt, for example, creatinine hydrochloride. The present invention is also directed to methods for treating inflammation and inducing an immunomodulatory response. In particular, the anti-inflammatory immunomodulators are useful for treating an inflammatory condition or an autoimmune disease.
    Type: Application
    Filed: December 7, 2015
    Publication date: June 23, 2016
    Applicants: Vireo Systems, Inc., Creighton University
    Inventors: Thomas McDonald, Kristen Drescher
  • Patent number: 8977517
    Abstract: System and methods to evaluate and administer drugs. The present invention instantaneously identifies the effects that drugs, including appetite-affecting agents, have on animals. Data is collected automatically and analyzed and further organized to identify feeding patterns and the effect an appetite-affecting agent has on those feeding patterns. The present invention includes a system for data management, including a program with a data acquisition phase and a data analyzing phase to determine the feeding patterns of animals to aid in the evaluation of appetite-affecting drug efficacy.
    Type: Grant
    Filed: June 4, 2007
    Date of Patent: March 10, 2015
    Assignee: Creighton University
    Inventor: Roger D. Reidelberger
  • Patent number: 8973573
    Abstract: A bite block 20 for use during transoral medical procedures has a main lumen 42 and a side mount 110 for receiving a separately inserted airway 160. The airway 110 may be a commercially available nasopharangeal airway which is inserted in mount 110 and extends into the oral cavity so as to effectively function as oral pharangeal airway.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: March 10, 2015
    Assignee: Creighton University
    Inventor: Charles J. Filipi
  • Patent number: 8906040
    Abstract: A surgical system for performing gastrointestinal procedures is disclosed. The system includes an elongated body defining an endoscope lumen. The body is adapted to be inserted into the esophagus with a proximal end extending from a body orifice. A working member includes at least one side disposed suction cavity and a cutting device configured to excise a surface layer from the tissue that is captured in the suction cavity. One or more needles are also provided in the working portion, which can be used to apply suture to the captured tissue and/or to inject fluid into the captured tissue prior to excision. Particular applications may be to treat Barrett's esophagus, to treat GERD, or for performing gastroplasty in the stomach.
    Type: Grant
    Filed: June 6, 2008
    Date of Patent: December 9, 2014
    Assignee: Creighton University
    Inventors: Charles J. Filipi, Jason L. Addink, Scott D. Klopfenstein, Aaron B. Moncur, Timothy B. Hunt
  • Patent number: 8846096
    Abstract: Provided herein are nanoparticles and methods for using nanoparticles. The nanoparticles include at least three antiretroviral agents. When introduced to cells the nanoparticles cause an increase in the intracellular concentration of the antiretroviral agents to a level that is at least the IC50 against HIV-I or HIV-2. This concentration may be maintained for at least 21 days after the cells are contacted with the nanoparticle. When administered to a subject the nanoparticles cause the concentration of the antiretroviral agents to increase to at least 100 ng/ml in the serum of the subject, at least 0.5 ?g/gram tissue in an organ of the subject, or a combination thereof. Such a concentration may be maintained for at least 21 days after the administration.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: September 30, 2014
    Assignee: Creighton University
    Inventor: Christopher J. Destache
  • Patent number: 8820320
    Abstract: Bite blocks providing an instrument lumen 62 for use during transoral medical procedures may be made from a material having a Shore D hardness less than 60 for improved patient comfort. An air way lumen 64 may be provide in side by side arrangement to the instrument lumen 62 for maintaining the patient's airway. The air way 70 may have a concave guiding channel 72 for helping to guide the instruments down the esophagus.
    Type: Grant
    Filed: November 23, 2009
    Date of Patent: September 2, 2014
    Assignee: Creighton University
    Inventors: Charles J. Filipi, Michael L. Hadley
  • Patent number: 8753306
    Abstract: Among other things, embodiments of devices (and parts thereof) are disclosed that can be used in treating Barrett's esophagus. Embodiments may have a suction cavity or window portion having elongated planar floor and ramped end surfaces with suction holes on one or both end surfaces. Examples include one or more fluid injection needles and parts for controlling fluid injection rate based on the rate of needle withdrawal. Embodiments can include one or more injection needles and receiving holes, with the ability to allow injectate to flow into tissue before withdrawing the needle(s), and/or lockout mechanism to prevent resection of tissue by a cutting mechanism prior to injection of fluid. Methods for treatment are also disclosed, and can include inserting a needle completely through tissue, and injecting fluid into tissue while withdrawing the needle back through the tissue, and/or injecting fluid into tissue while moving the needle forward through tissue.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: June 17, 2014
    Assignee: Creighton University
    Inventors: Charles J. Filipi, Timothy B. Hunt
  • Patent number: 8735463
    Abstract: Dental restorative composites having self-healing capabilities to repair discontinuities in the composite are provided. Dental restorative composites according to the present invention include a microsphere that encapsulates a monomer. When a fracture occurs, the microsphere is ruptured and the monomer fills the fracture. Depending on the monomer present in the microsphere, it is polymerized by a polymerization initiator or by an olefin metathesis catalyst present in the dental restorative composite. Self-healing dental restorative composites provide increased resistance to fracturing, and thus remain substantially intact for a longer period of time, preserving the remedial integrity of the dental repair or reconstruction.
    Type: Grant
    Filed: May 31, 2007
    Date of Patent: May 27, 2014
    Assignee: Creighton University
    Inventors: Stephen M. Gross, Mark A. Latta
  • Publication number: 20140050669
    Abstract: The present invention provides methods of imaging dental tissue. More particularly, the invention relates to a method of imaging dental caries by administering a topical intra-oral composition that provides enhanced radiographic imaging.
    Type: Application
    Filed: May 4, 2012
    Publication date: February 20, 2014
    Applicant: CREIGHTON UNIVERSITY
    Inventor: Douglas K. Benn
  • Patent number: 8641729
    Abstract: A surgical system for performing gastroplasty is disclosed. The system includes an elongated body adapted to be inserted into the esophagus with a proximal end extending from a body orifice. A working member includes a pair of elongated suction cavities that capture and excise portions of the anterior and posterior stomach walls and apply sutures to the captured tissue, which, when drawn tight, serve to create a modified lumen in the stomach.
    Type: Grant
    Filed: July 13, 2006
    Date of Patent: February 4, 2014
    Assignee: Creighton University
    Inventors: Charles J. Filipi, Scott D. Klopfenstein, Jason L. Addink