Patents Assigned to Creighton University
  • Patent number: 12246058
    Abstract: The disclosure provides polypeptides and pharmaceutical compositions thereof. Such polypeptides can be useful, for example, in treating pain in a subject. In some embodiments, the polypeptides are useful for treating neuropathic and/or inflammatory pain.
    Type: Grant
    Filed: January 20, 2021
    Date of Patent: March 11, 2025
    Assignee: Creighton University
    Inventor: Shashank Dravid
  • Patent number: 12146191
    Abstract: Systems and methods for detection and classification of IMP carbapenemases are described. In an aspect, sets of PCR primers associated with specific probes can be used to identify specific families of IMP ?-lactamases and utilize multiple primer sets to identify all IMP variants via real-time PCR assays. The sets of PCR primers can also be coupled with a fluorescent dye to detect a broad range of the IMP variants.
    Type: Grant
    Filed: May 3, 2023
    Date of Patent: November 19, 2024
    Assignee: Creighton University
    Inventors: Nancy D. Hanson, Hayden Smith, Stacey Morrow
  • Patent number: 11685766
    Abstract: Systems and methods for treatment of squamous cell carcinoma or other cancer utilizing targeting peptides are described. The targeting peptides interact with SCC cells or other cancerous cells to block or interfere with 14-3-3? heterodimerization or CDC25A binding to 14-3-3?. A peptide composition embodiment includes, but is not limited to, at least one of a first targeting peptide comprising a structure of Ac-Gln-Arg-Gln-Asn-Ser-(PO32?)-Ala-Pro-Ala-Arg-NH2 (SEQ ID NO: 4) and a second targeting peptide comprising a structure of Ac-Arg-Thr-Lys-Ser-Arg-Thr(PO32?)-Trp-Ala-Gly-NH2 (SEQ ID NO: 5), and a third targeting peptide comprising a modification of or a substituted derivative of the peptide of SEQ ID NO: 4 or SEQ ID NO: 5.
    Type: Grant
    Filed: May 7, 2021
    Date of Patent: June 27, 2023
    Assignees: Creighton University, Nutech Ventures
    Inventors: Laura Hansen, Sandor Lovas, Nicholas Palermo
  • Patent number: 11608328
    Abstract: The present application provides detectable compounds useful for identifying compounds that bind (e.g., inhibit) MmpL3. Methods of identifying compounds that bind and/or inhibit MmpL3 are also provided.
    Type: Grant
    Filed: February 21, 2020
    Date of Patent: March 21, 2023
    Assignees: Creighton University, Colorado State University Research Foundation
    Inventors: E. Jeffrey North, Amitkumar Navinchandra Pandya, Mary C. Jackson, Wei Li, Mercedes Gonzalez-Juarrero
  • Patent number: 11154619
    Abstract: Provided herein is a small molecule delivery system with illumination-induced small molecule release based on the binary combination of charged liposomes containing small molecules and oppositely charged conjugates of a peptide with a photosensitizer attached to one end of peptide chain, providing binding to liposomes and their permeabilization upon light illumination.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: October 26, 2021
    Assignee: Creighton University
    Inventors: Igor Meerovich, Alekha Dash, Michael Nichols, David Smith
  • Patent number: 11058655
    Abstract: The present invention is directed to novel anti-inflammatory immunomodulators including creatinine or a creatinine salt, for example, creatinine hydrochloride. The present invention is also directed to methods for treating inflammation and inducing an immunomodulatory response. In particular, the anti-inflammatory immunomodulators are useful for treating an inflammatory condition or an autoimmune disease.
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: July 13, 2021
    Assignees: Vireo Systems, Inc., Creighton University
    Inventors: Thomas McDonald, Kristen Drescher
  • Patent number: 10907217
    Abstract: Methods for differentiating E. coli sequence type 131 are described. In one implementation, a method that employs example techniques in accordance with the present disclosure for determining E. coli sequence type 131 includes amplifying a gene target in the presence of a fluorescent reporter dye; exposing the gene target and the fluorescent reporter dye to an increasing temperature gradient to denature and reduce the helicity of a double-stranded oligo of the gene target; recording fluctuations in fluorescence using a High Resolution Melting analysis (HRM)-capable thermocycler; and producing a melt curve unique to the gene target.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: February 2, 2021
    Assignee: Creighton University
    Inventors: Nancy D. Hanson, Lucas Harrison
  • Publication number: 20200331897
    Abstract: The present application provides detectable compounds useful for identifying compounds that bind (e.g., inhibit) MmpL3. Methods of identifying compounds that bind and/or inhibit MmpL3 are also provided.
    Type: Application
    Filed: February 21, 2020
    Publication date: October 22, 2020
    Applicants: Creighton University, Colorado State University Research Foundation
    Inventors: Jeffrey North, Amitkumar Navinchandra Pandya, Mary Jackson, Wei Li, Mercedes Gonzalez-Juarrero
  • Publication number: 20200197343
    Abstract: The present invention is directed to novel anti-inflammatory immunomodulators including creatinine or a creatinine salt, for example, creatinine hydrochloride. The present invention is also directed to methods for treating inflammation and inducing an immunomodulatory response. In particular, the anti-inflammatory immunomodulators are useful for treating an inflammatory condition or an autoimmune disease.
    Type: Application
    Filed: January 6, 2020
    Publication date: June 25, 2020
    Applicants: Vireo Systems, Inc., Creighton University
    Inventors: Thomas McDonald, Kristen Drescher
  • Patent number: 10613011
    Abstract: A method of performing a diffusion test includes clamping a membrane to a body such that a first surface of the membrane is in fluid communication with an interior chamber of the body and a second surface of the membrane is exposed to ambient air, flowing a substance through the ambient air such that at least a portion of the substance lands on the second surface while the membrane is vertically oriented, and determining a concentration of the substance in the interior chamber after some of the substance has diffused through the membrane.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: April 7, 2020
    Assignee: Creighton University
    Inventors: Daniel Munt, Alekha Dash
  • Patent number: 10525027
    Abstract: The present invention is directed to novel anti-inflammatory immunomodulators including creatinine or a creatinine salt, for example, creatinine hydrochloride. The present invention is also directed to methods for treating inflammation and inducing an immunomodulatory response. In particular, the anti-inflammatory immunomodulators are useful for treating an inflammatory condition or an autoimmune disease.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: January 7, 2020
    Assignees: Vireo Systems, Inc., Creighton University
    Inventors: Thomas McDonald, Kristen Drescher
  • Patent number: 10420759
    Abstract: The present disclosure relates to pirfenidone (5-methyl-1-phenyl-2-(1H)-pyridone) and its derivatives and pharmaceutically acceptable salts thereof, use of these compounds as a medicament, and for the manufacture of a medicament for treating or delaying the onset or development of pulmonary hypertension.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: September 24, 2019
    Assignee: Creighton University
    Inventors: Yaping Tu, Yan Xie, Peter Abel
  • Patent number: 10383848
    Abstract: Provided herein are indole-2-carboxamide compounds useful for the treatment of non-tuberculosis bacterial infections. Exemplary compounds provided herein are useful for the treatment of non-tuberculosis mycobacterial infections. Methods for preparing the indole-2-carboxamide compounds are also provided.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: August 20, 2019
    Assignees: Creighton University, Colorado State University Research Foundation
    Inventors: Jeffrey North, Mary C. Jackson
  • Patent number: 10213397
    Abstract: Disclosed are methods and pharmaceutical compositions for treating cardiomyopathies. The disclosed methods and pharmaceutical compositions may be used for treating lamin A/C (LMNA)-related dilated cardiomyopathies (DCM) in a subject in need thereof. The disclosed methods may utilize and the disclosed pharmaceutical compositions may include an effective amount of a modulator of microtubule polymerization such as colchicine.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: February 26, 2019
    Assignees: Northwestern University, Creighton University
    Inventors: Jane Elizabeth Wilcox, Joshua D. Prenosil
  • Patent number: 10179134
    Abstract: An antiretroviral composition that gels upon heating and can be administered prophylactically prior to exposure to a retrovirus following sexual intercourse, and methods of using the same.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: January 15, 2019
    Assignee: Creighton University
    Inventors: Chris Destache, Abhijit Date, Annemarie Shibata
  • Publication number: 20180250255
    Abstract: The present invention is directed to novel anti-inflammatory immunomodulators including creatinine or a creatinine salt, for example, creatinine hydrochloride. The present invention is also directed to methods for treating inflammation and inducing an immunomodulatory response. In particular, the anti-inflammatory immunomodulators are useful for treating an inflammatory condition or an autoimmune disease.
    Type: Application
    Filed: May 15, 2018
    Publication date: September 6, 2018
    Applicants: Vireo Systems, Inc., Creighton University
    Inventors: Thomas McDonald, Kristen Drescher
  • Publication number: 20180169040
    Abstract: Disclosed are methods and pharmaceutical compositions for treating cardiomyopathies. The disclosed methods and pharmaceutical compositions may be used for treating lamin A/C (LMNA)-related dilated cardiomyopathies (DCM) in a subject in need thereof. The disclosed methods may utilize and the disclosed pharmaceutical compositions may include an effective amount of a modulator of microtubule polymerization such as colchicine.
    Type: Application
    Filed: December 21, 2017
    Publication date: June 21, 2018
    Applicants: Northwestern University, Creighton University
    Inventors: Jane Elizabeth Wilcox, Joshua D. Prenosil
  • Patent number: 9993452
    Abstract: The present invention is directed to novel anti-inflammatory immunomodulators including creatinine or a creatinine salt, for example, creatinine hydrochloride. The present invention is also directed to methods for treating inflammation and inducing an immunomodulatory response. In particular, the anti-inflammatory immunomodulators are useful for treating an inflammatory condition or an autoimmune disease.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: June 12, 2018
    Assignees: Vireo Systems, Inc., Creighton University
    Inventors: Thomas McDonald, Kristen Drescher
  • Patent number: 9925185
    Abstract: The present disclosure relates to methods of treating acquired sensorineural hearing loss and/or ototoxicity in mammals by administering quinoxaline or a pharmaceutically acceptable derivative thereof. In implementations, quinoxaline and its derivatives can decrease cochlear hair cell damage and/or stimulate cochlear hair cell proliferation. In some implementations, quinoxaline can be administered as a pre-treatment prior to, or in conjunction with, exposure to ototoxic pharmaceutical agent(s) and/or acoustic trauma to prevent or decrease cochlear hair cell cytotoxicity and/or stimulate cochlear hair cell proliferation. In other implementations, quinoxaline can be administered as a treatment following exposure to ototoxic pharmaceutical agent(s) and/or acoustic trauma to stimulate cochlear hair cell proliferation.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: March 27, 2018
    Assignee: Creighton University
    Inventor: Sonia M. Rocha-Sanchez
  • Patent number: 9700541
    Abstract: A method and a composition are utilized to affect mitochondrial functions on a seizure-genic brain region. In one aspect, the disclosure comprises methods of treating seizures. Seizures are a transient symptom of abnormal excessive or synchronous neuronal activity in the brain. Seizures may manifest as a wild thrashing movement, a brief loss of awareness, an alteration in mental state, tonic or clonic movements, convulsions, a full body slump, and various other psychic symptoms such as déjà vu or jamais vu. Recurrent, unprovoked seizures are medically known as epilepsy. In one implementation, the method of treating a seizure includes administering a composition that restores mitochondrial function to a seizure-genic brain region. In some embodiments, the composition can include ascorbic acid, vitamin E, and pyruvate.
    Type: Grant
    Filed: June 12, 2013
    Date of Patent: July 11, 2017
    Assignee: Creighton University
    Inventors: Kristina A. Simeone, Timothy A. Simeone