Patents Assigned to Creighton University
-
Publication number: 20080275473Abstract: A surgical system for performing gastrointestinal procedures is disclosed. The system includes an elongated body defining an endoscope lumen. The body is adapted to be inserted into the esophagus with a proximal end extending from a body orifice. A working member includes at least one side disposed suction cavity and a cutting device configured to excise a surface layer from the tissue that is captured in the suction cavity. One or more needles are also provided in the working portion, which can be used to apply suture to the captured tissue and/or to inject fluid into the captured tissue prior to excision. Particular applications may be to treat Barrett's esophagus, to treat GERD, or for performing gastroplasty in the stomach.Type: ApplicationFiled: June 6, 2008Publication date: November 6, 2008Applicant: CREIGHTON UNIVERSITYInventors: Charles J. Filipi, Jason L. Addink, Scott D. Klopfenstein, Aaron B. Moncur, Timothy B. Hunt
-
Patent number: 7387797Abstract: Disclosed are compositions which include an isolated soft tissue from Modiolus modiolus (“MM”) and compositions which include an oil isolated from MM or a portion thereof. Also disclosed are methods of treating adenocarcinoma in a subject; methods of decreasing proliferation of adenocarcinoma cells, or of inducing apoptosis of adenocarcinoma cells, or of inducing differentiation of adenocarcinoma cells into non-cancerous cells; methods of inhibiting the activity of 5-lipoxygenase or 12-lipoxygenase or both in cells; and methods of treating a subject suffering from a disease or condition associated with excessive 5-lipoxygenase activity or 12-lipoxygenase activity or both. A process for preparing an MM extract by contacting MM or a portion thereof with a solvent under conditions effective to extract one or more materials from the MM or portion thereof is also described.Type: GrantFiled: March 22, 2001Date of Patent: June 17, 2008Assignee: Creighton UniversityInventors: Peter D. Collin, Thomas E. Adrian
-
Publication number: 20080125119Abstract: A method and system for registering for a course of an educational institution with a telecommunication device via a mobile registration system being executed on a server is disclosed. The server sends registration notifications to the telecommunication devices of a student eligible to participate the mobile registration system. A student operates their telecommunication device to send a registration request to the server to receive registration data. The mobile registration system then retrieves the requested registration data, and based on an infinite number of business rules, performs a smart interpretation convenient when accessing the information via a mobile telecommunications device.Type: ApplicationFiled: November 16, 2007Publication date: May 29, 2008Applicant: CREIGHTON UNIVERSITYInventors: Cindy Corritore, Nate Rempe
-
Publication number: 20080091261Abstract: An implantable valve prosthesis (10) having a deformable body (12) defining an upstream opening in fluid communication with a downstream opening wherein the deformable body (12) has a first configuration that permits fluid flow in one direction only and a second configuration that prevents retrograde fluid flow in the opposite direction is disclosed.Type: ApplicationFiled: October 15, 2007Publication date: April 17, 2008Applicant: CREIGHTON UNIVERSITYInventors: Andrew Long, Attila Csordas
-
Patent number: 7335485Abstract: The present invention provides a method of determining the antibiotic susceptibility of a microorganism comprising the following steps. First, a culture of the microorganism whose susceptibility is to be determined is admixed with an antibiotic to which susceptibility is to be assayed, and a permeabilizing agent for the microorganism present in a non-growth-inhibiting microorganism-permeabilizing effective amount to form an assay culture. Next, the assay culture is incubated under appropriate culture conditions and for a time sufficient to determine the susceptibility of the microorganism to the antibiotic.Type: GrantFiled: December 8, 2006Date of Patent: February 26, 2008Assignee: Creighton UniversityInventors: Jennifer A. Black, Ellen S. Moland, Kenneth Thomson
-
Publication number: 20070248954Abstract: Oliognucleotide primers are provided that are specific for nucleic acid characteristic of certain ?-lactamase genes. The primers can be employed in methods to identify nucleic acid characteristic of family-specific (and even group-specific) ?-lactamase enzymes in samples, and particularly, in clinical isolates of Gram-negative bacteria.Type: ApplicationFiled: September 10, 2004Publication date: October 25, 2007Applicant: Creighton UniversityInventor: Nancy Hanson
-
Patent number: 7285400Abstract: The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof. The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.Type: GrantFiled: December 10, 2003Date of Patent: October 23, 2007Assignees: Genome Therapeutics Corporation, Creighton UniversityInventors: John P. Carulli, Randall D. Little, Robert R. Recker, Mark L. Johnson
-
Patent number: 7267962Abstract: The present invention provides a method of determining the antibiotic susceptibility of a microorganism comprising the following steps. First, a culture of the microorganism whose susceptibility is to be determined is admixed with an antibiotic to which susceptibility is to be assayed, and a permeabilizing agent for the microorganism present in a non-growth-inhibiting microorganism-permeabilizing effective amount to form an assay culture. Next, the assay culture is incubated under appropriate culture conditions and for a time sufficient to determine the susceptibility of the microorganism to the antibiotic.Type: GrantFiled: July 7, 2005Date of Patent: September 11, 2007Assignee: Creighton UniversityInventors: Jennifer A. Black, Ellen S. Moland, Kenneth S. Thomson
-
Patent number: 7166442Abstract: The present invention provides a method of determining the antibiotic susceptibility of a microorganism comprising the following steps. First, a culture of the microorganism whose susceptibility is to be determined is admixed with an antibiotic to which susceptibility is to be assayed, and a permeabilizing agent for the microorganism present in a non-growth-inhibiting microorganism-permeabilizing effective amount to form an assay culture. Next, the assay culture is incubated under appropriate culture conditions and for a time sufficient to determine the susceptibility of the microorganism to the antibiotic.Type: GrantFiled: July 8, 2005Date of Patent: January 23, 2007Assignee: Creighton UniversityInventors: Jennifer A. Black, Ellen S. Moland, Kenneth Thomson
-
Publication number: 20060240494Abstract: A method for identifying a compound that has a biocidal effect against a selected organism involves screening from among known or unknown peptide or non-peptide molecules, a test molecule that binds selectively to a target sequence of a multi-helical lid of a heat shock protein of the organism. The binding of the test compound inhibits the protein folding activity of the protein. A specific embodiment of such a method is useful for identifying or designing a pharmaceutical or veterinary biocidal or antibiotic compound, preferably a pathogen and/or strain-specific compound. For this purpose, the compound does not bind to a heat shock protein that is homologous to the mammalian subject to be treated with the compound. Screening methods can encompass direct binding or competitive assays. Molecules or compounds identified by these methods are employed as biocides for pharmaceutical, veterinary, pesticide, insecticide and rodenticide uses, among others.Type: ApplicationFiled: June 28, 2006Publication date: October 26, 2006Applicants: The Wistar Institute of Anatomy and Biology, Creighton UniversityInventors: Laszlo Otvos, Magdalena Blaszczyk-Thurin, Mark Rogers, Sandor Lovas
-
Patent number: 7045291Abstract: Oliognucleotide primers are provided that are specific for nucleic acid characteristic of certain AmpC beta-lactamases. The primers can be employed in methods to detect the presence or absence of an AmpC beta-lactamase gene in samples, and to identify nucleic acid characteristic of AmpC beta-lactamase genes in samples, particularly, in clinical isolates of Gram-negative bacteria.Type: GrantFiled: May 17, 2002Date of Patent: May 16, 2006Assignee: Creighton UniversityInventors: Nancy Jo Dohse Hanson, Francisco-Javier Perez Perez
-
Publication number: 20050260633Abstract: Oliognucleotide primers are provided that are specific for nucleic acid characteristic of certain beta-lactamases. The primers can be employed in methods to identify nucleic acid characteristic of family-specific beta-lactamase enzymes in samples, and particularly, in clinical isolates of Gram-negative bacteria.Type: ApplicationFiled: March 21, 2005Publication date: November 24, 2005Applicant: Creighton UniversityInventors: Nancy Hanson, Christine Sanders, Anton Ehrhardt
-
Publication number: 20050142617Abstract: The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof. The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.Type: ApplicationFiled: April 29, 2004Publication date: June 30, 2005Applicants: Genome Therapeutics Corporation, Creighton University School of MedicineInventors: John Carulli, Randall Little, Robert Recker, Mark Johnson
-
Patent number: 6905848Abstract: Oliognucleotide primers are provided that are specific for nucleic acid characteristic of certain beta-lactamases. The primers can be employed in methods to identify nucleic acid characteristic of family-specific beta-lactamase enzymes in samples, and particularly, in clinical isolates of Gram-negative bacteria.Type: GrantFiled: March 21, 2001Date of Patent: June 14, 2005Assignee: Creighton UniversityInventors: Nancy D. Hanson, Christine C. Sanders, Anton F. Ehrhardt
-
Patent number: 6893846Abstract: Oliognucleotide primers are provided that are specific for nucleic acid characteristic of certain beta-lactamases. The primers can be employed in methods to identify nucleic acid characteristic of family-specific beta-lactamase enzymes in samples, and particularly, in clinical isolates of Gram-negative bacteria.Type: GrantFiled: March 21, 2001Date of Patent: May 17, 2005Assignee: Creighton UniversityInventors: Nancy D. Hanson, Christine C. Sanders, Anton F. Ehrhardt
-
Publication number: 20040176582Abstract: The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof. The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.Type: ApplicationFiled: December 10, 2003Publication date: September 9, 2004Applicants: Genome Therapeutics Corporation, Creighton UniversityInventors: John P. Carulli, Randall D. Little, Robert R. Recker, Mark L. Johnson
-
Patent number: 6770461Abstract: The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.Type: GrantFiled: April 5, 2000Date of Patent: August 3, 2004Assignees: Genome Therapeutics Corporation, Creighton University School of MedicineInventors: John P. Carulli, Randall D. Little, Robert R. Recker, Mark L. Johnson
-
Patent number: 6756205Abstract: This invention relates to antagonists of calcitonin gene related peptide and in particular the invention relates to amino terminal modifications to peptides to improve their ability to bind to a member of the CGRP-receptor superfamily.Type: GrantFiled: March 20, 2001Date of Patent: June 29, 2004Assignee: Creighton UniversityInventors: Derek David Smith, Shankar Saha, Peter W. Abel
-
Publication number: 20040002080Abstract: Oliognucleotide primers are provided that are specific for nucleic acid characteristic of certain beta-lactamases. The primers can be employed in methods to identify nucleic acid characteristic of family-specific beta-lactamase enzymes in samples, and particularly, in clinical isolates of Gram-negative bacteria.Type: ApplicationFiled: December 13, 2002Publication date: January 1, 2004Applicant: Creighton UniversityInventor: Nancy D. Hanson
-
Patent number: 6664369Abstract: The present invention provides peptides and pharmacologically active compounds including gonadotropin-releasing hormone (GnRH) analogues according to formulas of the invention, wherein the compounds show an antitumor effect. The invention additionally provides compositions including these peptides and compounds.Type: GrantFiled: July 27, 2000Date of Patent: December 16, 2003Assignee: Creighton UniversityInventors: Sandor Lovas, Richard F. Murphy, Geza Toth, Adrienn Kalnay, Istvan Palyi, Gizella Turi, Borbala Vincze, Imre Mezom, Zsolt Vadasz, Istvan Teplan, Janos Seprodi, Melinda Mora