Patents Assigned to Curators of the University
  • METHOD FOR SEPARATION OF CHEMICALLY PURE OS FROM METAL MIXTURES
    Publication number: 20170058381
    Abstract: A method for separating an amount of osmium from a mixture containing the osmium and at least one other additional metal is provided. In particular, method for forming and trapping OsO4 to separate the osmium from a mixture containing the osmium and at least one other additional metal is provided.
    Type: Application
    Filed: November 15, 2016
    Publication date: March 2, 2017
    Applicant: The Curators of the University of Missouri
    Inventors: Hendrik P. Engelbrecht, Cathy S. Cutler, Leonard Manson, Stacy Lynn Wilder
  • DEVICE AND METHOD FOR ALLOGRAFTING
    Publication number: 20170056023
    Abstract: In one embodiment, a cutting guide is disclosed for use in a surgical procedure to removed damaged tissue from a patient and form a recipient site configured and dimensioned to receive a donor graft. The cutting guide includes a first arm that abuts a section of the damaged tissue to be removed, and a second arm including a hole and a slot that receives a cutting implement, the first arm and the slot defining a distance therebetween corresponding to a desired dimension of the recipient site. In another embodiment, a cutting guide is disclosed for use in forming a donor graft from donor tissue. The cutting guide includes a body that receives the donor tissue, and a shaping member that is rotatably secured to the body. The shaping member includes at least one vane that shapes the donor tissue so as to form the donor graft.
    Type: Application
    Filed: March 12, 2015
    Publication date: March 2, 2017
    Applicant: The Curators of the University of Missouri
    Inventors: Ferris M. Pfeiffer, James L. Cook, James P. Stannard
  • HIGH VOLTAGE GAIN DC/DC POWER ELECTRONIC CONVERTERS
    Publication number: 20170054364
    Abstract: A DC/DC power converter provides high voltage gain using integrated boost and voltage multiplier (VM) stages. The boost cell operates according to a switching sequence to alternately energize and discharge a primary winding. A VM cell electrically coupled to the primary winding of the boost cell charges a multiplier capacitor to a DC output voltage greater than the input voltage when the primary winding is energized and discharges the multiplier capacitor when primary winding is discharged.
    Type: Application
    Filed: August 17, 2016
    Publication date: February 23, 2017
    Applicant: The Curators of the University of Missouri
    Inventors: Mehdi Ferdowsi, Venkata Anand Kishore Prabhala
  • Nanopore-facilitated single molecule detection of nucleic acids
    Patent number: 9574228
    Abstract: The present invention provides a new and improved oligonucleotide detection method based on the nanopore technology with a probe containing a complementary sequence to the target oligonucleotide and a terminal extension at the probe's 3? terminus, 5? terminus, or both termini. The improved nanopore sensor with the probe enables sensitive, selective, and direct detection, differentiation and quantification of target oligonucleotides such as miRNAs. The inventive detection method may also be employed as a non-invasive and cost-effective diagnostic method for cancer detection based on miRNA levels in the patient's blood sample.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: February 21, 2017
    Assignee: The Curators of the University of Missouri
    Inventors: Li-Qun Gu, Yong Wang, Kai Tian
  • METHOD OF PREDICTING CROP YIELD LOSS DUE TO N-DEFICIENCY
    Publication number: 20170039449
    Abstract: A method for determining the yield loss of a crop using remote sensor data is described. The yield loss is determined using the reflectivity of light by the crop canopy measured from remote sensor data such as an aerial photograph. Pixel color values from the aerial photograph, expressed relative to pixel values from nitrogen-sufficient areas of the field, are transformed to yield losses using a transformation that was developed using empirical data. A similar method is described to determine recommended nitrogen fertilization rates for the crop fields. The yield loss data is useful for nitrogen fertilization management decisions, as it allows a producer of crops to weigh the expense of fertilization against the loss of revenue due to yield loss induced by nitrogen deficiency.
    Type: Application
    Filed: October 25, 2016
    Publication date: February 9, 2017
    Applicant: The Curators of the University of Missouri
    Inventors: Peter Clifton Scharf, Victoria Cacnio Hubbard
  • Scaffold for tissue regeneration in mammals
    Patent number: 9561250
    Abstract: A three-dimensional scaffold with interconnected pores for repair of tissue comprising a scaffold body for structural support of the tissue scaffold, where the scaffold body comprises scaffold body components bonded to each other and made from component materials comprising about 40 to about 90 wt % B2O3, and two or more other oxides, wherein the scaffold body has a porosity between about 15 and about 90 vol %.
    Type: Grant
    Filed: July 8, 2013
    Date of Patent: February 7, 2017
    Assignee: The Curators of the University of Missouri
    Inventors: Delbert E. Day, Steven B. Jung, Roger F. Brown
  • Controlling calcium compound formation in biocompatible materials for tissue regeneration and repair in mammals
    Patent number: 9561303
    Abstract: A biocompatible composition for tissue repair or regeneration in mammals comprising one or more glass former compounds selected from the group consisting of B2O3, P2O5, and SiO2 and director elements selected from the group consisting of Cu, Sr, Zn, Fe, Mn, Cr, V, Nb, Mo, W, Ba, Co, S, Al, Ti, Y, Mg, Si and/or Ni to promote in vivo calcium compound formation of calcium carbonate or other calcium compounds other than hydroxyapatite. Upon direct application of the biocompatible composition to a mammalian host, calcium carbonate or other calcium compounds other than hydroxyapatite form upon bioreaction of the composition with bodily fluids.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: February 7, 2017
    Assignee: The Curators of the University of Missouri
    Inventors: Steven B. Jung, Delbert E. Day
  • Force detection for microscopy based on direct tip trajectory observation
    Patent number: 9562927
    Abstract: With example embodiments described herein, a probe tip of a scanning probe microscope (such as an atomic force microscope (AFM)) is directly detected as it moves in a tapping mode to determine the tip positions over time, and a force for the tip is computed from these determined tip positions.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: February 7, 2017
    Assignee: The Curators of the University of Missouri
    Inventors: Gavin McLean King, Krishna Prasad Sigdel
  • OPTICAL POLARIZATION TRACTOGRAPHY SYSTEMS, METHODS AND DEVICES
    Publication number: 20170031143
    Abstract: High-resolution 3D optical polarization tractography (OPT) images of the internal fiber structure of a target tissue. Manipulation of dual-angle imaging data of the fiber orientation inside a target tissue leads to the determination of 3D imaging properties of the target tissue, allowing transmission of the 3D image properties of the target tissue to an OPT processor to produce high-resolution 3D images.
    Type: Application
    Filed: July 29, 2016
    Publication date: February 2, 2017
    Applicant: The Curators of the University of Missouri
    Inventors: Gang Yao, Dongsheng Duan, Yuanbo Wang
  • Device for Subdividing Magnetic Field and Simultaneous Detection of Magnetic Resonance Signals from Multiple Sample Compartments
    Publication number: 20170030985
    Abstract: Devices and methods are provided for simultaneously interrogating multiple samples using NMR spectroscopy. A first magnetic field is induced. A flow of electricity is induced through a conductive material. The flow of electricity has a direction that is perpendicular to the first magnetic field, and the flow of electricity induces a second magnetic field. A first sample is placed in an additive magnetic field region, where a direction of the first magnetic field and a direction of the second magnetic field are aligned within the additive magnetic field region. A second sample is placed in a canceling magnetic field region, where the direction of the first magnetic field and the direction of the second magnetic field are opposed within the canceling magnetic field region. A free induction decay (FID) of at least the first and second samples is induced.
    Type: Application
    Filed: July 29, 2016
    Publication date: February 2, 2017
    Applicant: The Curators of the University of Missouri
    Inventor: Rex E. Gerald, II
  • Self-assembling multicellular bodies and methods of producing a three-dimensional biological structure using the same
    Patent number: 9556415
    Abstract: Structures and methods for tissue engineering include a multicellular body including a plurality of living cells. A plurality of multicellular bodies can be arranged in a pattern and allowed to fuse to form an engineered tissue. The arrangement can include filler bodies including a biocompatible material that resists migration and ingrowth of cells from the multicellular bodies and that is resistant to adherence of cells to it. Three-dimensional constructs can be assembled by printing or otherwise stacking the multicellular bodies and filler bodies such that there is direct contact between adjoining multicellular bodies, suitably along a contact area that has a substantial length. The direct contact between the multicellular bodies promotes efficient and reliable fusion. The increased contact area between adjoining multicellular bodies also promotes efficient and reliable fusion.
    Type: Grant
    Filed: April 3, 2014
    Date of Patent: January 31, 2017
    Assignee: The Curators of the University of Missouri
    Inventors: Gabor Forgacs, Francoise Suzanne Marga, Cyrille Norotte
  • Stabilized gold nanoparticle and contrast agent
    Patent number: 9549998
    Abstract: A kit for providing a contrast enhancer in a mammal for contrasting during imaging of the mammal comprises functionalized gold nanoparticles configured to be directed to one or more of a target organ, tissue and lesion of the mammal.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: January 24, 2017
    Assignee: The Curators of the University of Missouri
    Inventors: Vijaya Kattumuri, Kattesh V. Katti, Evan Boote, Raghuraman Kannan, Stan Casteel, Robert Churchill
  • Flexible to rigid nanoporous polyurethane-acrylate (PUAC) type materials for structural and thermal insulation applications
    Patent number: 9550846
    Abstract: Novel urethane-acrylate (UAC) Star monomers and polyurethane-acrylate (PUAC) aerogel polymers derived therefrom are described herein, along with other novel, related monomers and polymers. Also described herein are processes for preparing the UAC Star monomers, the PUAC aerogel polymers, and the other related monomers and polymers. The PUAC and related polymers herein are useful in various applications including in structural and thermal insulation.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: January 24, 2017
    Assignee: The Curators of the University of Missouri
    Inventors: Nicholas Leventis, Chariklia Sotiriou-Leventis, Abhishek Bang
  • WOUND CARE COMPOSITIONS
    Publication number: 20170014542
    Abstract: Glass-based particles of a biocompatible material which comprises 40 to about 80 wt % borate (B2O3) intermixed into a carrier which is an ointment, cream, or surgical glue.
    Type: Application
    Filed: September 29, 2016
    Publication date: January 19, 2017
    Applicant: The Curators of the University of Missouri
    Inventors: Steven B. Jung, Delbert E. Day
  • COMPOSITIONS AND METHODS FOR BORON NEUTRON CAPTURE THERAPY
    Publication number: 20170007700
    Abstract: Provided herein are compositions and methods for boron neutron capture therapy. In particular, the disclosure relates to therapy using liposomal Na3[1-(2?-B10H9)-2-NH3B10H8] and K[nido-7-CH3(CH2)15-7,8-C2B9H11] sources. A composition for boron neutron capture therapy, comprising a liposome having an aqueous core and an encapsulating bilayer, wherein the aqueous core comprises Na3[1-(2?-B10H9)-2-NH3B10H8] (TAC) and the encapsulating bilayer comprises K[nido-7-CH3(CH2)15-7,8-C2B9H11] (MAC) is also provided.
    Type: Application
    Filed: February 23, 2015
    Publication date: January 12, 2017
    Applicant: The Curators of the University of Missouri
    Inventors: Satish S. Jalisatgi, Marion Frederick Hawthorne
  • METHOD FOR ENHANCING AMIDOHYDROLASE ACTIVITY OF FATTY ACID AMIDE HYDROLASE
    Publication number: 20170000748
    Abstract: A method for enhancing amidohydrolase activity of Fatty Acid Amide Hydrolase (FAAH) is disclosed. The method comprising administering a phenoxyacyl-ethanolamide that causes the enhanced activity. The enhanced activity can have numerous effects on biological organisms including, for example, enhancing the growth of certain seedlings.
    Type: Application
    Filed: September 15, 2016
    Publication date: January 5, 2017
    Applicants: Research Foundation of the City University of New York, The Curators of the University of Missouri, University of North Texas
    Inventors: George John, Subbiah Nagarajan, Kent Chapman, Lionel Faure, Peter Koulen
  • Method for separation of chemically pure Os from metal mixtures
    Patent number: 9528169
    Abstract: A method for separating an amount of osmium from a mixture containing the osmium and at least one other additional metal is provided. In particular, method for forming and trapping OsO4 to separate the osmium from a mixture containing the osmium and at least one other additional metal is provided.
    Type: Grant
    Filed: July 21, 2014
    Date of Patent: December 27, 2016
    Assignee: The Curators of the University of Missouri
    Inventors: Hendrik P. Engelbrecht, Cathy S. Cutler, Leonard Manson, Stacy Lynn Wilder
  • Viscous sealing glass compositions for solid oxide fuel cells
    Patent number: 9530991
    Abstract: A sealant for forming a seal between at least two solid oxide fuel cell components wherein the sealant comprises a glass material comprising B2O3 as a principal glass former, BaO, and other components and wherein the glass material is substantially alkali-free and contains less than 30% crystalline material.
    Type: Grant
    Filed: July 23, 2013
    Date of Patent: December 27, 2016
    Assignees: MO-SCI Corporation, The Curators of the University of Missouri
    Inventors: Cheol Woon Kim, Richard K. Brow
  • FORMULATIONS FOR PHARMACEUTICAL AGENTS
    Publication number: 20160361327
    Abstract: Described herein are processes for improving the aqueous availability of poorly soluble bioactive materials and bioactive compounds and compositions formed by those processes.
    Type: Application
    Filed: June 10, 2016
    Publication date: December 15, 2016
    Applicant: The Curators of the University of Missouri
    Inventors: Albert N. Ngo, Bi-Botti C. Youan
  • System and method for linking a web-based resource with an electronic medical record
    Patent number: 9519885
    Abstract: A data processing system and method that, in some cases, include an EMR system and a web server. In some cases, the EMR system includes a plurality of electronic medical records for a plurality of patients. One or more of the electronic medical records may include a URL or HTTP Post message that defines a path to a web-based resource, such as a treatment algorithm or medical calculator. In some embodiments, the URL and/or HTTP Post message is constructed based on information in a patient's medical record.
    Type: Grant
    Filed: August 14, 2012
    Date of Patent: December 13, 2016
    Assignee: The Curators of the University of Missouri
    Inventors: Karl M. Kochendorfer, Jared S. Coberly