Patents Assigned to Curators of the University
  • Suppression of SARS replication by SARS helicase inhibitors
    Patent number: 9266844
    Abstract: The present invention relates to compounds, compositions, and methods, for treating subjects suspected of needing treatment for a Nidovirales virus infection. In certain embodiments, the compounds comprise Nidovirales helicase inhibitors that do not significantly affect helicase ATPase enzymatic activity or nucleic acid binding activity of the helicase.
    Type: Grant
    Filed: June 17, 2013
    Date of Patent: February 23, 2016
    Assignee: The Curators of the University of Missouri
    Inventors: Stefan G. Sarafianos, Adeyemi O. Adedeji, Kamlendra Singh
  • Flow-through filter to remove aluminum from medical solutions
    Patent number: 9259670
    Abstract: A flow through filter assembly includes a trivalent and tetravalent metal ion capturing agent and a flow controller providing a predetermined flow rate which allows capture of the trivalent and tetravalent metal ions by the capturing agent.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: February 16, 2016
    Assignees: The University of Kentucky Research Foundation, The Curators of the University of Missouri, Alkymos, Inc.
    Inventors: Robert A. Yokel, Wesley R. Harris, Christopher D. Spilling, Robert Joseph Kuhn, Vasiliy Paul Abramov, Jason Matthew Lone
  • PEPTIDE WITH GOLD BINDING AND EGFR RECEPTOR AFFINITY AND SAME ATTACHED TO GOLD NANOSTRUCTURE
    Publication number: 20160041188
    Abstract: An embodiment of the invention is a peptide comprising four domains, wherein domain I consists of thioctyl or monocytl, domain II consists of 2 to 3 positively charged amino acids selected from the group consisting of lysine and arginine, domain III consists of a dimeric ethylene unit; and domain IV comprises the peptide with SEQ ID No. 1 or a sequence having at least 90% identity to SEQ ID No. I. The peptide is preferably attached to a gold nanostructure, preferably a gold nanorod to provide an EFGR kit. An EFGR detection kit of the invention employs a gold nanostructure attached to a peptide sequence, the peptide sequence includes a binding sequence with an affinity toward EGFR, a ligand bound to gold atoms of the nanorod, a positively charged amino acid that maintains activity of the binding sequence, and a unit that increases hydrophilicity of the peptide sequence.
    Type: Application
    Filed: March 13, 2013
    Publication date: February 11, 2016
    Applicant: The Curators of the University of Missouri
    Inventors: Raghuraman Kannan, Gerald Arthur, Charles W. Caldwell, Jr., Charles Caldwell, Ajit Zambre, Mythilil Ramachandran
  • SOYBEAN RESISTANT TO CYST NEMATODES
    Publication number: 20160032315
    Abstract: A transgenic soybean resistant to soybean cyst nematode (SCN), or parts thereof, including an artificial DNA construct encoding a serine hydroxymethyltransferase protein (e.g., GmSHMT). Also provided are GmSHMT alleles containing mutations R130P and Y358N along with research and breeding methods and compositions including such.
    Type: Application
    Filed: May 30, 2013
    Publication date: February 4, 2016
    Applicants: The Curators of the University of Missouri, Board of Trustees of Southern Illinois University
    Inventors: Khalid Meksem, Shiming Liu, Pramod Kaitheri Kandoth, Melissa G. Mitchum
  • MULTIPLEX ASSAY FOR DETECTION OF BACTERIAL SPECIES IN BIOLOGICAL SAMPLES
    Publication number: 20160032366
    Abstract: The invention provides a rapid, accurate, sensitive, and low-cost detection method for screening a biological sample for one or more desired bacterial species. The inventive method employs a two-step multiplex real-time PCR assay that comprises an internal amplification control and specific primer sets to detect and discriminate bacterial species based the unique melting temperatures of specific DNA sequences of each strain.
    Type: Application
    Filed: July 27, 2015
    Publication date: February 4, 2016
    Applicant: The Curators of the University of Missouri
    Inventors: Azlin Mustapha, Prashant Singh
  • Gold coated lanthanide nanoparticles
    Patent number: 9242016
    Abstract: The present invention is directed ?-particle emitting nanoparticles that comprise a lanthanide phosphate sequestration shell enclosing an ?-emitting-radioisotope-doped lanthanide phosphate core such that the shell allows at least some of the ? emissions from the ?-emitting radioisotope to pass therethrough and prevents at least some radioactive decay products of the ?-emitting radioisotope from exiting the ?-particle emitting nanoparticle. Further, such ?-particle emitting nanoparticles may be coated with gold and functionalized. Additionally, a method for making and using the same are disclosed.
    Type: Grant
    Filed: January 3, 2012
    Date of Patent: January 26, 2016
    Assignee: The Curators of the University of Missouri
    Inventors: John David Robertson, Mark F. McLaughlin, Paul H. Pevsner
  • Tissue preservation system
    Patent number: 9220258
    Abstract: The present invention provides a method and apparatus for tissue, such as an allograft, storage and preservation for extended periods of time at room temperature in a sterile tissue culture chamber. The invention further provides a process for maintaining the sterility of tissue using the apparatus as described.
    Type: Grant
    Filed: January 12, 2012
    Date of Patent: December 29, 2015
    Assignees: The Curators of the University of Missouri, The Trustees of Columbia University in the City of New York
    Inventors: James L. Cook, Clark T. Hung, Eric Lima, Aaron Stoker
  • Cluster boron compounds and uses thereof
    Patent number: 9217002
    Abstract: The present invention relates to novel cluster boron compounds and their use as sodium channel blockers. In particular, the novel cluster boron compounds may be lidocaine analogs where the aromatic ring of the lidocaine molecule is replaced with a cluster boron group. The invention also provides methods for making the cluster boron compounds comprising contacting a halogenated cluster boron with an amino acetamide in the presence of a catalyst, a proton acceptor, and a ligand.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: December 22, 2015
    Assignee: The Curators of the University of Missouri
    Inventors: George R. Kracke, Yulia Sevryugina, Marion Frederick Hawthorne
  • Soybean variety S06-4649RR
    Patent number: 9204606
    Abstract: A novel soybean variety designated S06-4649RR is herein disclosed. This disclosure relates to the seeds of soybean variety S06-4649RR, to the plants of soybean S06-4649RR to plant parts of soybean variety S06-4649RR and to methods for producing a soybean plant produced by crossing plants of the soybean variety S06-4649RR with another soybean plant, using S06-4649RR as either the male or the female parent.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: December 8, 2015
    Assignee: The Curators of the University of Missouri
    Inventor: James Grover Shannon
  • Soybean variety S05-11482
    Patent number: 9204603
    Abstract: A novel soybean variety designated S05-11482 is herein disclosed. This disclosure relates to the seeds of soybean variety S05-11482, to the plants of soybean S05-11482 to plant parts of soybean variety S05-11482 and to methods for producing a soybean plant produced by crossing plants of the soybean variety S05-11482 with another soybean plant, using S05-11482 as either the male or the female parent.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: December 8, 2015
    Assignee: The Curators of the University of Missouri
    Inventors: James Grover Shannon, David Alan Sleper, James Allen Wrather
  • Method and apparatus for cancer screening
    Patent number: 9207205
    Abstract: A method and apparatus for detection of pteridine levels in a biological sample using CE-LIF which is useful for early cancer screening involving fully oxidizing pteridine compounds in a sample such as a urine sample, subjecting to CE-LIF to assess compound concentration, and compare to expected levels in for healthy or cancer-bearing patients.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: December 8, 2015
    Assignee: The Curators of the University of Missouri
    Inventors: Yinfa Ma, Stephen Gibbons
  • Method to develop high oleic acid soybeans using conventional soybean breeding techniques
    Patent number: 9198365
    Abstract: The present invention is directed to a soybean plant with mutations in FAD2-1A and FAD2-1B. Moreover, the present invention is directed to seeds from said plants with altered ratios of monosaturated and polyunsaturated fats. In particular, the present invention is directed to plants where the plants exhibit elevated levels of oleic acid.
    Type: Grant
    Filed: January 17, 2012
    Date of Patent: December 1, 2015
    Assignees: The Curators of the University of Missouri, The United States of America, as Represented by the Secretary of Agriculture
    Inventors: Kristin D. Bilyeu, James Grover Shannon, Jeong-Dong Lee, Anh Tung Pham
  • Method of predicting crop yield loss due to n-deficiency
    Patent number: 9195891
    Abstract: A method for determining the yield loss of a crop using remote sensor data is described. The yield loss is determined using the reflectivity of green light by the crop canopy measured from remote sensor data such as an aerial photograph that is digitized and spatially referenced to the field's longitude and latitude. Green pixel values from the aerial photograph, expressed relative to green pixel values from well-fertilized areas of the field, are transformed to yield losses using a linear transformation that was developed using empirical data. A similar method is described to determine recommended nitrogen fertilization rates for the crop fields. The yield loss data is useful for nitrogen fertilization management, as it allows a producer of crops to weigh the expense of fertilization against the loss of revenue due to yield loss.
    Type: Grant
    Filed: August 5, 2013
    Date of Patent: November 24, 2015
    Assignee: The Curators of the University of Missouri
    Inventors: Peter Clifton Scharf, Victoria Cacnio Hubbard
  • Reusable PCR amplification system and method
    Patent number: 9181571
    Abstract: A DNA amplification device utilizing a polydimethylsiloxane (PDMS) and silicon substrate coated with spin-on glass (SOG) is provided. This PDMS layer is irreversibly bonded to the SOG layer of the silicon substrate using oxygen plasma. The amplification device is an inexpensive, microfluidic device, which can be utilized as a portable thermo-cycler to perform PCR amplification of DNA in the field.
    Type: Grant
    Filed: September 17, 2014
    Date of Patent: November 10, 2015
    Assignee: The Curators of the University of Missouri
    Inventors: Venumadhav Korampally, Shubhra Gangopadhyay, Keshab Gangopadhyay, Sheila A. Grant, Steven B. Kleiboeker, Shantanu Bhattacharya, Yuanfang Gao
  • Capillary wall coupled whispering gallery mode microresonator
    Patent number: 9176281
    Abstract: A microresonator structure comprises a waveguide and a microsphere. The waveguide is of elongated cylindrical shape and includes a first section of optical transmission material and a cavity section axially aligned with the first section. The cavity section includes a first cavity and a second cavity. The first cavity is adjacent to the first section and includes a first sidewall of optical transmission material with an inner surface that tapers inward to an apex positioned adjacent to the first section. The second cavity is positioned adjacent to the first cavity of hollow cylindrical shape and includes a circumferential second sidewall of optical transmission material that abuts the first sidewall. The microsphere has a spherical outer surface and is positioned within the cavity section such that the outer surface contacts a portion of the first sidewall and a portion of the second sidewall.
    Type: Grant
    Filed: April 22, 2013
    Date of Patent: November 3, 2015
    Assignee: The Curators of the University of Missouri
    Inventors: Hai Xiao, Hanzheng Wang
  • Apparatus and method for sternal closure
    Patent number: 9173693
    Abstract: The present disclosure provides a sternal closure fixation device. The fixation device includes a first sternum implant disposable within an interior cavity of a first half of a severed sternum such that the first implant contacts opposing anterior and posterior faces of the cavity. The fixation device additionally includes, a second sternum implant disposable within an interior cavity of a second half of a severed sternum such that the second implant contacts opposing anterior and posterior faces of the cavity. Furthermore, the fixation device includes a rigid fixation pin sized and structured to be disposed within an internal bore of the first implant and within an internal bore of the second implant, whereby when the first and second halves of the severed sternum are joined together, the first and second halves of the sternum are prevented from shear movement in any direction relative to each other.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: November 3, 2015
    Assignee: The Curators of the University of Missouri
    Inventors: Wayne C. McDaniel, Joseph T. Walls, Janet L. Rettenmaier
  • Multiple phase flow system for detecting and isolating substances
    Patent number: 9151709
    Abstract: A multiple flow system and method for detecting substances in a fluid is provided. More specifically, a first fluid tube containing a first fluid and a second fluid tube containing a second fluid are coupled to a common fluid tube via a connector, such that alternating discrete compartments of the first fluid and the second fluid flow through the common fluid tube. The first and second fluids are immiscible. A substance detector, having a flow chamber with an internal wall, is coupled to the common fluid tube. The alternating discrete compartments of the first and second fluids flow through the flow chamber and are analyzed by the substance detector.
    Type: Grant
    Filed: September 8, 2011
    Date of Patent: October 6, 2015
    Assignee: The Curators of the University of Missouri
    Inventors: Christine Mary O'Brien, Sagar K. Gupta, John Andrew Viator, Shramik Sengupta, Jeff Mosley, Kyle Rood
  • FLEXIBLE TO RIGID NANOPOROUS POLYURETHANE-ACRYLATE (PUAC) TYPE MATERIALS FOR STRUCTURAL AND THERMAL INSULATION APPLICATIONS
    Publication number: 20150266983
    Abstract: Novel urethane-acrylate (UAC) Star monomers and polyurethane-acrylate (PUAC) aerogel polymers derived therefrom are described herein, along with other novel, related monomers and polymers. Also described herein are processes for preparing the UAC Star monomers, the PUAC aerogel polymers, and the other related monomers and polymers. The PUAC and related polymers herein are useful in various applications including in structural and thermal insulation.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 24, 2015
    Applicant: The Curators of the University of Missouri
    Inventors: Nicholas Leventis, Chariklia Sotiriou-Leventis, Abhishek Bang
  • Chelating compounds and immobilized tethered chelators
    Patent number: 9139456
    Abstract: Novel compounds useful as chelators, intermediates for their production and methods for removing trivalent and tetravalent metal ions from solution are presented.
    Type: Grant
    Filed: October 21, 2011
    Date of Patent: September 22, 2015
    Assignee: The Curators of the University of Missouri
    Inventors: Robert A. Yokel, Wesley R. Harris, Christopher D. Spilling, Robert Joseph Kuhn, Surendra Dawadi
  • based delivery system and methods of use
    Patent number: 9133251
    Abstract: Herein a Bacillus exosporium antigen delivery (BEAD) system that provides a means to introduce recombinant proteins or small molecules into the exosporium of members of the B. cereus family of bacteria, i.e. B. anthracis, B. cereus, and B. thuringiensis, is disclosed. The system results in the surface display of recombinant proteins or small molecules such that they can stimulate an immune response. In addition, methods of making and using the system are described.
    Type: Grant
    Filed: February 23, 2009
    Date of Patent: September 15, 2015
    Assignee: The Curators of the University of Missouri
    Inventors: George C. Stewart, Brian Matthew Thompson