Abstract: The invention provides methods and compositions for treatment of spinal muscular atrophy (SMA). In one aspect of the invention, a series of compositions comprising an antisense oligonucleotide targeting the Element 1 site on the SMN2 pre-mRNA and a Morpholino backbone is disclosed. In another aspect of the invention, a method of treating SMA patients by modulating the splicing of SMN2 pre-mRNA to increase the amount of full-length SMN is disclosed. Certain embodiments of the inventive method comprise administering an E1-targeting antisense oligonucleotide, such as Morpholino based antisense oligonucleotide, to a SMA subject.

Abstract: An energy harvesting device for generating electrical power from low-frequency oscillations includes a high-frequency cantilever, a plurality of low-frequency cantilevers each configured to contact the high-frequency cantilever in response to environmental vibrations having a frequency within a near-resonance frequency range associated with said low-frequency cantilever, an a generator that produces electrical power in response to contact between at least one of the plurality of low-frequency cantilevers and the high-frequency cantilever. The energy harvesting device may also include an impact mass coupled to a free end of each of the plurality of low-frequency cantilevers. Some aspects may include a common base to which the high-frequency cantilever and the plurality of low-frequency cantilevers are coupled. Other aspects may include the generator comprising one or more of an induction coil and magnet, a variable distance capacitor, or a piezo-electric material.

Abstract: Combining the functionality of sleep transistors with logic devices in power-gating circuits by utilizing fully depleted silicon-on-insulator (FDSOI) transistors. In an embodiment, a back gate of a FDSOI transistor controls the threshold voltage to eliminate the need for standalone sleep transistors.

Abstract: A process for manufacturing an iron-based alloy comprising forming targeted fine oxide and/or carbide dispersoids in a melt, and sequentially precipitating transition-metal nitrides on the dispersoids for heterogeneous nucleation of equiaxed grains. An iron-based cast alloy having a highly equiaxed fine grain structure.

Abstract: Method, system and media for authenticating a subject as a user. Embodiments generate visual stories specific to the user and for which the subject must select the corresponding images from among a plurality of decoy images. Gaze tracking can be used to determine which images the user has selected without allowing an observer to learn which images have been selected. Images for the visual story can be retrieved from the user's social networking profile, and corresponding text storied generated to indicate which images should be selected. Multiple security levels are possible by varying the number of story images and decoy images.

Abstract: Systems and methods for the controlled delivery of laser light to target tissue using an improved waveguide. A waveguide controls transmission of wave energy to a target based on direct contact with the target. The waveguide comprises a propagation medium, a cladding causing the electromagnetic wave to be internally reflected in the medium, and an interface formed in the cladding and configured for direct contact with the target. A portion of the laser light penetrates through the cladding at the interface and propagates into the target while a portion internally reflects within the propagation medium.

Abstract: Increased sensitivity of spectrometers through reducing noise in independent voltage signals via a differential voltage analyzer utilizing a reference wavelength from a wavelength region in which the optical absorption of the sample is negligible. In an embodiment, a grating permits selection of a reference wavelength. In another embodiment, filters permit selection of a reference wavelength. In yet another embodiment, both a grating and a filter permit selection of a reference wavelength. In an aspect, the differential voltage analyzer reduces noise by minimizing a differential voltage between the independent voltage signals and the reference voltage signal by adjusting the value of a cancellation coefficient.

Abstract: The present disclosure relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present disclosure provides compounds as therapeutic agents against bacterial infections (e.g., biofilms). The present disclosure also provides topical formulations for use in methods for treating bacterial infections.

Abstract: An energy harvesting device for generating electrical power from low-frequency oscillations includes a high-frequency cantilever, a plurality of low-frequency cantilevers each configured to contact the high-frequency cantilever in response to environmental vibrations having a frequency within a near-resonance frequency range associated with said low-frequency cantilever, an a generator that produces electrical power in response to contact between at least one of the plurality of low-frequency cantilevers and the high-frequency cantilever. The energy harvesting device may also include an impact mass coupled to a free end of each of the plurality of low-frequency cantilevers. Some aspects may include a common base to which the high-frequency cantilever and the plurality of low-frequency cantilevers are coupled. Other aspects may include the generator comprising one or more of an induction coil and magnet, a variable distance capacitor, or a piezo-electric material.

Abstract: Embodiments relate to a cerium-containing nano-coating composition, the composition including an amorphous matrix including one or more of cerium oxide, cerium hydroxide, and cerium phosphate; and crystalline regions including one or more of crystalline cerium oxide, crystalline cerium hydroxide, and crystalline cerium phosphate. The diameter of each crystalline region is less than about 50 nanometers.

Abstract: A tool for use in assisting soft tissue mobilization and bodily tissue amelioration, such as stimulation of superficial tissue, deep tissue mobilization, breaking up scar tissue, and soft tissue massaging, are described. The tool comprises a device for application to bodily tissue that includes a body having a substantially teardrop shape in a vertical section. In a longitudinal aspect, the body includes a first and a second portion. The first portion of the device corresponds at least in part to a substantially bulbous handle part of the teardrop shape of the vertical section and is adapted for ease of grasping and manipulation at the first end. The second portion of the device corresponds at least in part to a substantially tapered converging double-beveled linear edge of the teardrop shape of the vertical section and is adapted for facilitated application of the device to bodily tissue at the second end.

Abstract: Provided are nanoparticle conjugates comprising a drug encapsulated in a gelatin nanoparticle the surface of which is functionalized with an antibody to which a siRNA is linked. Methods with the nanoconjugates for treating diseases are provided as well.

Abstract: Described herein is the discovery of novel PSMA-specific peptides, which were identified through a novel combinatorial biopanning method. One of the novel PSMA-specific peptides discovered, GTIQPYPFSWGY (or GTI) (SEQ ID NO: 2), exhibits high binding affinity and selectivity to PSMA and PSMA-positive prostate cancer cells. It was found that GTI can mediate internalization of the apoptotic KLA peptide (SEQ ID NO: 10) to PSMA-positive LNCaP cells and induce cell death. Moreover, a FAM-labeled GTI peptide shows a high and specific tumor uptake in nude mice bearing human prostate cancer xenografts. It was demonstrated that the GTI peptide can be employed as a PSMA-specific ligand for prostate cancer diagnosis and/or for targeted drug delivery to prostate cancer cells.

Abstract: The present invention generally relates to genetically modified swine wherein at least one allele of a SIGLEC1 gene has been inactivated and/or at least one allele of a CD163 gene has been inactivated. Genetically modified swine having both alleles of the SIGLEC1 gene and/or both alleles CD163 gene inactivated are resistant to porcine reproductive and respiratory syndrome virus (PRRSV). Methods for producing such transgenic swine are also provided.

Abstract: A magnetic artificial honeycomb lattice comprising a multiplicity of connecting elements separated by hexagonal cylindrical pores, wherein: (a) the hexagonal cylindrical pores: (i) have widths that are substantially uniform and an average width that is in a range of about 15 nm to about 20 nm; and (ii) are substantially equispaced and have an average center-to-center distance that is in a range of about 25 nm to about 35 nm; and (b) the connecting elements comprise a magnetic material layer, and the connecting elements have: (i) lengths that are substantially uniform and an average length that is in a range of about 10 nm to about 15 nm; (ii) widths that are substantially uniform and an average width that is in a range of about 4 nm to about 8 nm; and (iii) a thickness of the magnetic material layer that is substantially uniform and an average thickness that is in a range of about 2 nm to about 8 nm; and (c) the magnetic artificial honeycomb lattice has a surface area, disregarding the presence of th

Abstract: The invention provides methods, devices and systems for excimer fluorescence energy conversion from isotopes. Unprocessed spent nuclear fuel can be used as an isotope, and processed spent nuclear fuel can be used as an isotope. A method includes placing an excimer in the path of radiation decay from the isotope. The excimer is selected according to the isotope to absorb the radiation decay and emit photons in response. Surrounding environment is shielded from the radiation decay. Photons generated from the fluorescence of the excimer are received with photovoltaic material to generate electrical energy. The electrical energy is applied to a load. Systems of the invention can be based upon spent storage casks and handle unprocessed spent nuclear fuel, or can be greatly reduced in size and handle processed fuel, with single isotope isolation allowing consumer battery sized systems.

Abstract: An energy storage system reaction cell configured for distribution throughout a transport system. The length of the reaction cell is substantially greater than its width and is looped throughout the transport system in a serpentine configuration. A membrane within the reaction cell has a length substantially equal to the length of the reaction cell such that surface area of the membrane is maximized relative to volume of the reaction cell to increase electrical power provided to an electrical load of the transport system.

Abstract: In some examples, a technique may include positioning a first part comprising a ceramic or ceramic matrix composite and a second part comprising a ceramic or a CMC adjacent to each other to define a joint region at the interface of the first part and the second part. In some examples, the joint region may be heated using at least one of a laser or a plasma arc source to heat the joint region to an elevated temperature. The first and second parts may be pressed together and cooled to join the first and second parts at the joint region. In other examples, a solid braze material including a filler material and a metal or alloy may be delivered to the joint region and locally heated to cause a constituent of the filler material and a constituent of the metal or alloy to react. When reacted, the constituents may form a solid material, which may join the first and second parts.

Abstract: A solid state method of producing inorganic nanoparticles using glass is disclosed. The nanoparticles may not be formed until the glass is reacted with or degraded by contact with a fluid in vivo or in vitro.

Abstract: According to the embodiments described herein, a series of biological materials for treatment/therapy of DMD and/or BMD through the recovery of sarcolemmal nNOS is provided. The biological material comprises the complete dystrophin repeats R16 and R17 or certain domains, sections, or fragments of the dystrophin repeats R16 and R17. In some aspects, such domains, sections, or fragments may be selected from sequence motifs including dystrophin R17 ?1 helix, ?2 and ?3 helices of both R16 and R17, or a combination thereof.