Patents Assigned to Curators of University of Missouri
  • Nanopore-facilitated single molecule detection of nucleic acids
    Patent number: 10273527
    Abstract: The present invention provides a new and improved oligonucleotide detection method based on the nanopore technology with a probe containing a complementary sequence to the target oligonucleotide and a terminal extension at the probe's 3? terminus, 5? terminus, or both termini. The improved nanopore sensor with the probe enables sensitive, selective, and direct detection, differentiation and quantification of target oligonucleotides such as miRNAs. The inventive detection method may also be employed as a non-invasive and cost-effective diagnostic method for cancer detection based on miRNA levels in the patient's blood sample.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: April 30, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Li-Qun Gu, Yong Wang, Kai Tian
  • High sensitivity impedance sensor
    Patent number: 10274492
    Abstract: Disclosed herein are example embodiments of a transformative sensor apparatus that is capable of detecting and quantifying the presence of a substance of interest such as a specified bacteria within a sample via changes in impedance exhibited by a detection electrode array. In an example embodiment, sensitivity is improved by including a focusing electrode array in a rampdown channel to focus a concentration of the substance of interest into a detection region. The focusing electrodes include an opposing pair of electrodes in a rampdown orientation. The focusing electrode may also include tilted thin film finger electrodes extending from the rampdown electrodes. In another example embodiment, trapping electrodes are positioned to trap a concentration of the substance of interest onto the detection electrode array.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: April 30, 2019
    Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Mahmoud Almasri, Shibajyoti Ghosh Dastider, Shuping Zhang, Majed El Dweik, Nuh Sadi Yuksek, Ibrahem Jasim, Jiayu Liu
  • Method and apparatus for fabricating ceramic and metal components via additive manufacturing with uniform layered radiation drying
    Patent number: 10259158
    Abstract: A freeform extrusion fabrication process for producing three-dimensional ceramic, metal and functionally gradient composite objects, including the steps of filling a plurality of paste sources with a respective plurality of aqueous paste compositions, operationally connecting respective syringes containing respective aqueous paste compositions to a mixing chamber, moving a first aqueous paste composition from a first respective paste source into the mixing chamber, moving a second aqueous paste composition from a second respective paste source into the mixing chamber, mixing the first and second aqueous paste compositions to define a first admixture having a first admixture composition, extruding the first admixture onto a surface to define an extruded layer having a first admixture composition, surrounding the sides of the extruded layer with an oil bath, radiatively drying the extruded layer.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: April 16, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Ming C Leu, Amir Ghazanfari, Wenbin Li, Gregory E. Hilmas, Robert G Landers
  • POLYARYLATION OF POLYHEDRAL BORANES
    Publication number: 20190100539
    Abstract: A polyarylborane comprising a substituted polyhedral borane comprising at least 3 exohedrally bonded aryl groups, wherein the substituted polyhedral borane is homo- or hetero-, and each exohedrally bonded aryl group is independently homo- or hetero-, substituted or unsubstituted, and monocyclic or polycyclic. Also, molecules and materials comprising the polyarylborane, and methods for making the polyarylboranes.
    Type: Application
    Filed: March 6, 2017
    Publication date: April 4, 2019
    Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventor: Mark W. Lee, Jr.
  • Crop resistance to nematodes
    Patent number: 10246722
    Abstract: Methods of inhibiting plant parasitic nematodes, methods of obtaining transgenic plants useful for inhibiting such nematodes, and transgenic plants that are resistant to plant parasitic nematodes through inhibition of plant nematode CLAVATA3/ESR (CLE) peptide receptor genes are provided. Methods for expressing genes at plant parasitic nematode feeding sites with plant nematode CLE peptide receptor gene promoters are also provided, along with nematode CLE peptide receptor gene promoters that are useful for expressing genes in nematode feeding sites as well as transgenic plants and nematode resistant transgenic plants comprising the promoters.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: April 2, 2019
    Assignees: The Curators of the University of Missouri, Cornell University, The United States of America, as Represented by the Secretary of Agriculture
    Inventors: Melissa G. Mitchum, Amy Replogle, Jianying Wang, Xiaohong Wang, Shiyan Chen, Ping Lang
  • INHIBITORS OF HEPATITIS B VIRUS TARGETING CAPSID ASSEMBLY
    Publication number: 20190092742
    Abstract: The present invention provides novel compounds and methods for treating, preventing or inhibiting hepatitis B virus (HBV).
    Type: Application
    Filed: September 27, 2018
    Publication date: March 28, 2019
    Applicants: THE CURATORS OF THE UNIVERSITY OF MISSOURI, Regents of the University of MInnesota
    Inventors: Stefan G. Sarafianos, Zhengqiang Wang, Andrew D. Huber, Jing Tang
  • Biodegradable composite scaffold for repairing defects in load-bearing bones
    Patent number: 10238772
    Abstract: A tissue scaffold for repair and regeneration of bone hard tissue or muscle, skin, or organ soft tissue, including load-bearing bone tissue, the scaffold comprising a core of biocompatible, biodegradable inorganic glass fibers; and a biocompatible, biodegradable, flexible polymer film surrounding the core and adhered to the core.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: March 26, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Delbert E. Day, Ali Mohammadkhah
  • Increasing the content of long chain fatty acids in seed oil
    Patent number: 10240163
    Abstract: Provided are plants that express, or overexpress, a pPLAIII? protein. Constitutive or seed-specific expression of pPLAIII? protein in Arabidopsis increases seed oil content, the amount of C20 and C22 fatty acids, and the amount of C56, C58, and C60 triacylglycerols, effectively resulting in significantly higher oil yield per plant. Use of pPLAIII? is therefore an effective biotechnological tool to significantly increase plant yield, including oil, and the amount of high value long chain fatty acids in agricultural and horticultural crops, especially oilseed crops.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: March 26, 2019
    Assignees: Donald Danforth Plant Science Center, The Curators of the University of Missouri
    Inventors: Xuemin Wang, Maoyin Li
  • 3D PRINTED ZEOLITE MONOLITHS FOR CO2 REMOVAL
    Publication number: 20190083954
    Abstract: Carbon dioxide (CO2) capture materials comprising one or more 3D-printed zeolite monoliths for the capture and or removal of CO2 from air or gases in enclosed compartments, including gases or mixtures of gases having less than about 5% CO2. Methods for preparing 3D-printed zeolite monoliths useful as CO2 capture materials and filters, as well as methods of removing CO2 from a gas or mixture of gases in an enclosed compartment using 3D-printed zeolite monoliths are provided.
    Type: Application
    Filed: September 20, 2018
    Publication date: March 21, 2019
    Applicant: The Curators of the University of Missouri
    Inventors: Fateme Rezaei, Harshul V. Thakkar
  • Wireless beacon collision warning system
    Patent number: 10235884
    Abstract: A system, a method, and a computer program for utilizing a WiFi beacon for low-latency communication with smart computing devices. Embodiments of the invention use beacon-stuffed network announcement broadcast signals to promptly convey urgent safety information to pedestrians and other vulnerable road users and to warn them of approaching vehicles. This information can then be used to generate visual or audible alerts that are presented on a smart computing device of the vulnerable road user. Similarly, beacon-stuffed network announcement broadcast signals transmitted by pedestrians' smart computing devices can be used to warn vehicle operators of pedestrians in their path.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: March 19, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Sejun Song, Baek-young Choi, Kaustubh Dhondge
  • Nematode resistant crops
    Patent number: 10231383
    Abstract: Methods of inhibiting plant parasitic nematodes, methods of obtaining transgenic plants useful for inhibiting such nematodes, and transgenic plants that are resistant to plant parasitic nematodes through inhibition of plant nematode CLAVATA3/ESR (CLE) peptide receptor genes are provided. Methods for expressing genes at plant parasitic nematode feeding sites with plant nematode CLE peptide receptor gene promoters are also provided, along with nematode CLE peptide receptor gene promoters that are useful for expressing genes in nematode feeding sites as well as transgenic plants and nematode resistant transgenic plants comprising the promoters.
    Type: Grant
    Filed: July 13, 2011
    Date of Patent: March 19, 2019
    Assignees: The Curators of the University of Missouri, Cornell University, North Carolina State University, Iowa State University Research Foundation, Inc., University of Georgia Research Foundation, Inc., The United States of America, as represented by the Secretary of Agriculture
    Inventors: Melissa G. Mitchum, Amy Replogle, Jianying Wang, Xiaohong Wang, Shiyan Chen, Ping Lang, Eric L. Davis, Thomas J. Baum, Richard S. Hussey
  • Lipopolysaccharide-targeted peptide mimic vaccine against Q fever
    Patent number: 10233233
    Abstract: A vaccine and method of vaccination for conferring immunity to Q fever is described. The vaccine comprises a polypeptide with a sequence of SLTWHKHELHRK (SEQ ID NO: 7) (m1E41920) or SPPWHKHELHRK (SEQ ID NO: 8) (m1E44), or at least 90% identity to m1E41920 or m1E44. Constructs are also provided for use in vaccination and treatment of Q fever. A method to identify and generate new vaccines to prevent diseases caused by intracellular Gram-negative bacteria is also described.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: March 19, 2019
    Assignee: The Curators of the University of Missouri
    Inventor: Guoquan Zhang
  • Eccentric weightlifting machine and associated method of use
    Patent number: 10220239
    Abstract: An eccentric weightlifting machine that includes a first pole connected to a first weight and to a device acted on by a user, a second pole connected to a second weight and to a motor, wherein the motor lifts the second pole in response to movement of the first pole by the user, and a latch configured to latch the first pole to the second pole during an eccentric exercise portion of a weightlift.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: March 5, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Adam Rau, John Rayburn, Orr Hadass, Nicholas Ryan Smith
  • Ripple canceling in power conversions circuits
    Patent number: 10224819
    Abstract: A power circuit substantially canceling ripples at the source. The power circuit includes a switching circuit configured to control a power flow between an input and an output, a main storage element electrically connected in series with the switching circuit, and a resonant tank electrically coupled to the switching circuit and configured to compensate for switching ripples in the main storage element. Aspects of the invention can be applied to a converter circuit or to an inverter circuit.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: March 5, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Pourya Shamsi, Mehdi Ferdowsi
  • Near-infrared fluorescent sensors for biological amines
    Patent number: 10222390
    Abstract: A fluorescence sensing compound for separately detecting and visualizing one or more monoamine neurotransmitters in cells, the fluorescence sensing compound having the following formula: wherein R1 and R2 are each independently selected from the group consisting of hydrogen, alkyl, alkylene, aryl, cycloalkyl; wherein R3 is selected from the group consisting of hydrogen, alkyl, alkylene, aryl, cycloalkyl, cyano, azido; and wherein R4 is selected from the group consisting of (CH3)2Si, O, N, S, and CH2.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: March 5, 2019
    Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Timothy Glass, Kenneth Hettie
  • Preparation of acetate salt compositions of pharmaceutical agents
    Patent number: 10213447
    Abstract: Processes for preparing compositions comprising pharmaceutical agents encapsulated in nanoparticles which provide improved physicochemical and biological properties are described. Also described are compositions comprising water soluble pharmaceutical agents which provide extended release of the pharmaceutical agent. Processes are described for preparing compositions which increase the aqueous availability of compounds with low water solubility.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: February 26, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Albert N. Ngo, Bi-Botti C. Youan
  • Boron cluster compounds and uses thereof
    Patent number: 10202406
    Abstract: The present invention relates to novel cluster boron compounds and their use as sodium channel blockers. The invention also provides methods for making and using the compounds.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: February 12, 2019
    Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: George R. Kracke, Yulia Sevryugina, Marion Frederick Hawthorne
  • OPTICAL POLARIZATION TRACTOGRAPHY SYSTEMS, METHODS AND DEVICES
    Publication number: 20190041619
    Abstract: High-resolution 3D optical polarization tractography (OPT) images of the internal fiber structure of a target tissue. Manipulation of dual-angle imaging data of the fiber orientation inside a target tissue leads to the determination of 3D imaging properties of the target tissue, allowing transmission of the 3D image properties of the target tissue to an OPT processor to produce high-resolution 3D images.
    Type: Application
    Filed: October 10, 2018
    Publication date: February 7, 2019
    Applicant: The Curators of the University of Missouri
    Inventors: Gang Yao, Dongsheng Duan, Yuanbo Wang
  • SOYBEAN RESISTANT TO CYST NEMATODES
    Publication number: 20190037795
    Abstract: A transgenic soybean resistant to soybean cyst nematode (SCN), or parts thereof, including an artificial DNA construct encoding a serine hydroxymethyltransferase protein (e.g., GmSHMT).
    Type: Application
    Filed: August 9, 2018
    Publication date: February 7, 2019
    Applicants: Board of Trustees of Southern Illinois University, The Curators of the University of Missouri
    Inventors: Khalid Meksem, Shiming Liu, Pramod Kaitheri Kandoth, Melissa G. Mitchum
  • Artificial oocyte activation
    Patent number: 10190093
    Abstract: The present invention provides novel methods for improving the efficiency of artificial activation of unfertilized mammalian oocytes by reducing the intracellular concentration of Zn2+ in the oocyte. The methods of the invention may additionally comprise a preceding step of increasing the intracellular concentration of Ca2+ in the oocyte prior to reduction of the intracellular Zn2+ concentration. The invention further provides unfertilized oocytes activated by the disclosed methods and viable mammalian animals produced from unfertilized oocytes activated by the disclosed methods.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: January 29, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Kiho Lee, Randall S. Prather