Abstract: An improvement in an injection bulb device in an assembly for administration of parenteral solutions is disclosed. The device is a tubular elastomeric member having an enlarged intermediate section whose bore is larger than the bores in the two end sections. A plurality of flat-surfaced projections or rings extend inwardly from the walls of the bores in the end sections which compressively grip the end of a rigid needle adapter and flexible tubing inserted respectively within these end sections. The end of the tubing flares outwardly into the enlarged bore of the intermediate section and this configuration assists in increasing the strength of mechanical engagement between the tubing and the injection bulb.

Abstract: Plasma Protein Fraction substantially free of bradykinin, kininogen and prekallikrein activators is obtained by treating Cohn Supernatant II plus III at about neutrality with a siliceous substance for a period of time sufficient to bring about essentially complete conversion of intrinsic kininogen into bradykinin. Subsequently, after being separated from Cohn Fraction IV-1, the Plasma Protein Fraction is reconstituted and held for a period of time sufficient to allow substantially complete destruction of bradykinin by kininase. Methods are disclosed for the destruction of prekallikrein activators which may be present in Plasma Protein Fraction.

Abstract: A syringe for dispensing medicaments includes a barrel with a discharge end and an open end for receiving a plunger. The plunger has a head with engagement means for receiving a plunger seal. The plunger seal is a tubular member which is severed along a generally longitudinal direction providing a slit which allows the seal to be expanded for fitting onto the plunger head. Preferably the slit has an irregularity at the forward end which provides a locking configuration which prevents the seal from being twisted away from its normally tubular shape. For metered dose application, the shank of the plunger may be threaded for the desired placement of a stop ring threaded on the shank. In one form, the ring and barrel have interlocking means to prevent the ring from moving backward when pressure is applied to the plunger after the ring has reached the barrel.

Abstract: An overpressure device is disclosed for use in a liquid infusion set for the purpose of detecting excessive pressures which may occur during infusion. The device comprises a tubular member with an inlet and an outlet, a closed pressure chamber and a bridging portion containing a small bore passage which connects the pressure chamber with the tubular member. In a preferred form, the interconnecting passage takes a tortuous path. An optical sensor positioned on the pressure chamber will detect the presence of liquid at a predetermined position in the chamber, when the liquid rises as a result of excessive pressure in the set, and respond by stopping the flow of liquid in the set.

Abstract: Low concentration pyrogens in fat emulsions can be determined by using Limulus lysate test procedures. A preferred lysate was observed to have a relatively low calcium ion concentration.

Abstract: A previously undescribed hydrolytic enzyme has been successfully isolated from human plasma and purified to homogeneity. The enzyme has a molecular weight of about 70,000 daltons, has a Km for the substrate H-D-Phe-Pip-Arg-PNA of about 0.057 mM, a K.sub.I for benzamidine of about 1.1.times.10.sup.-5 M, is bindable to and elutable from insoluble barium salts, is inhibited by antithrombin III, especially in the presence of heparin, and, in vitro, has been found to activate and degrade human Factor VIII, activate human Factor V, and inhibit platelet aggregation induced by ADP, epinephrine, or collagen, thus providing a substance useful for antithrombotic studies.

Abstract: Improvements in inner and outer closures for containers are disclosed. The outer closure is characterized by a cap member having a top wall, a side wall and a base adapted for sealing to the neck of a container. Two score lines extend across the top wall with finger gripping means attached at the apex where the two score lines meet. One score line extends down the side wall to connect with a third score line near the base which extends completely around the cap. The other score line extends down the side wall to an intermediate position and diverges away and terminates a short distance from the one score line. By pulling on the finger gripping means, the entire cap member above the third score line is removed in one piece. The inner closure comprises a plastic member sealed at its periphery to the mouth of the neck and includes a vertically aligned spike-entry port and an additive port which is oriented at an angle away from the entry port.

Abstract: An improvement in a closure system for containers in which a cap member sealed at its base to an annular flange about the neck of the container is removeable by a cutting ring. The cap includes an upwardly projecting brim at the base separated from the side wall of the cap to provide an annular groove. The groove has at least one tapered recess. The cutting ring which can be positioned around the side wall of the cap has at least one depending tab with an inwardly directed sharpened projection. Normally, the tab rests in the recess of the groove. Upon rotation of the cutting ring, the tab is forced inwardly causing the sharpened projection to sever the side wall of the closure.

Abstract: An improvement in a fluid flow valve is disclosed. The valve comprises a combination of flexible tubing joined to a tubular member having a membrane closing off the passageway in the tubular member. A pointed spike having at least three radially projecting ribs extending longitudinally is located within the tubing adjacent the membrane and is movable by external manipulation of the tubing whereby the spike ruptures the membrane and creates a passageway permitting fluid to flow freely through the tubular member and adjoining tubing.

Abstract: Surgically implantable skeletal ligament having secured thereto at least one deformable collar having a velour-like outer surface adapted to invite tissue ingrowth. In use, the collar portion of the ligament is positioned within a surgically prepared passageway in a bone to protect the ligament from bone abrasion and to assist in ligament attachment by accepting tissue ingrowth into the velour-like surface.

Abstract: Composition comprising an aqueous solution of immune serum globulin and maltose, the amount of maltose being sufficient to inhibit "shedding" of the globulin with time.

Abstract: An improved check valve is disclosed for use in a system for sequentially delivering primary and secondary solutions through a common conduit. The check valve comprises a hollow housing with an inlet and an outlet connected to an enlarged intermediate portion. Sealed at its periphery in the enlarged portion is a flexible diaphragm characterized by having foraminous means in at least its outer portion and imperforate means in its central portion. The imperforate means is spaced from a valve seat surrounding the passage at the inner end of the inlet so that when the primary solution flows from the inlet to the outlet, it will pass freely around the imperforate means and through the foraminous means. When an increase in pressure, even though slight, is exerted against the diaphragm caused by flow of the secondary solution in the direction of the outlet to the inlet, the diaphragm moves towards the inlet causing the imperforate means to seal against the valve seat and stop the flow of the primary solution.

Abstract: Semi-solid preparation useful as a boticide and anthelmintic in horses and comprising an effective amount of trichlorfon dispersed in a mineral oil.

Abstract: The device comprises a closed container with a breathing tube and a means for variably adjusting the size of an aperture into the container. A transparent inclined tube is mounted on the container and houses a moveable air flow indicating member. The tube has a passage at the top leading into the container and a vent at the bottom of the tube allows air to enter to move the flow indicating member up the inclined tube. Air drawn from the container by inspiring through the breathing tube is replaced in part by air entering through the variable aperture means and by the air entering through the vent. By adjusting the size of the variable aperture, one can determine inspiratory capacity as correlated with the amount of air necessary to move the flow indicating member to the top of the tube or to an intermediate position in the tube.

Abstract: A finite cell strain is derived from canine fetal lung tissue, the cells of which are fibroblast-like, diploid, and are free of reverse transcriptase and C-type particles. With a nutrient medium the cells provide a cell culture system useful in the cultivation of a number of viruses from which vaccines may be prepared.

Abstract: An improved disc valve in a container for dispensing liquids is disclosed. The disc valve comprises at least two upstanding posts adjacent an outlet passage in the bottom of the container and a floatable disc member with apertures near its periphery through which the posts extend. The posts further have disc-retaining stops at their upper ends. The posts position the disc and the relationship between the size of the apertures and the thickness of the posts assures the disc will seat over the outlet passage to prevent the passage of air when all the liquid has been dispensed.

Abstract: A method for the isolation of albumin which allows the selective adsorption and substantially quantitative elution of albumin from mixtures containing the same. The method comprises contacting a solution which contains albumin with a member of a series of dye-insoluble support compounds in which the insoluble support is a polyhydroxy polymer coupled to a dye by means of a reactive pyrimidine. The albumin which is selectively adsorbed can be readily eluted resulting in essentially a quantitative recovery of pure albumin.

Abstract: An oral dosage medicinal composition for ruminant animals is provided which is processed in a manner to cause a medically effective amount of drug contained therein to be slowly released to the animal by virtue of distribution of the medicament throughout a dry, essentially water-insoluble, slowly digestible matrix. Even slower but therapeutically effective drug release is unexpectedly experienced in feverish animals. A compressed dosage form for oral administration is prepared by first treating an admixture of originally essentially undenatured native milk solids and the drug with a sufficient quantity of an aldehydic agent to insolubilize the milk protein solids.

Abstract: A process and apparatus adapted to automate the conversion of a continuous sheet of flexible plastic film into ported bags. The apparatus includes means for maintaining the film sheet in proper alignment during the various processing steps and functions in a manner which reduces environmental particulate contamination of the bags to a minimum.

Abstract: The device is a disposable compact unit comprising a transparent column with an aperture at its base, an air float within the column and with the column mounted on a closed container. A conduit joins the top of the column to an opening into the container. The container is also equipped with a breathing tube and a variable aperture means for varying the size of another opening into the container. By inhaling through the breathing tube, a patient can judge his capacity for alveolar expansion by the height to which the air float rises. Adjustment to any patient's capacity can be easily made by changing the opening in the variable aperture means.