Patents Assigned to Cyberonics, Inc.
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Publication number: 20200254259Abstract: A method for assessing a patient's suitability for receiving a vagus nerve stimulation therapy includes receiving a criterion regarding the patient's suitability for receiving a vagus nerve stimulation therapy; controlling a stimulation device to provide stimulation to a vagus nerve of the patient; receiving, from a sensor, response data indicative of a physiological response of the patient to the stimulation of the vagus nerve; and determining the patient's suitability for receiving the vagus nerve stimulation therapy based on the criterion and the physiological response of the patient to the stimulation.Type: ApplicationFiled: March 31, 2017Publication date: August 13, 2020Applicant: Cyberonics, Inc.Inventors: Imad LIBBUS, Bruce H. KENKNIGHT, Christine HENRY
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Publication number: 20190151656Abstract: Devices, systems and methods of neurostimulation for treating obstructive sleep apnea.Type: ApplicationFiled: October 18, 2018Publication date: May 23, 2019Applicant: CYBERONICS, INC.Inventors: Stephen L. Bolea, Thomas B. Hoegh, Brian D. Kuhnley, Dale G. Suilmann, Bruce J. Persson, John P. Beck, Sidney F. Hauschild, Paula M. Kaplan, Adam K. Hoyhtya, Wondimeneh Tesfayesus, Robert E. Atkinson
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Publication number: 20190076656Abstract: A method of neurostimulation titration. The method includes setting titration parameters for an electrical signal delivered by an implantable medical device, initiating titration with the titration parameters and an aggressiveness profile, performing titration by increasing at least one of a current amplitude, a frequency, a pulse width or a duty cycle of the electrical signal until a threshold is reached or a side effect is detected, pausing the titration while waiting for commands from the patient or caregiver, and resuming the titration in response to receiving authorization from an external device.Type: ApplicationFiled: November 9, 2018Publication date: March 14, 2019Applicant: CYBERONICS, INC.Inventors: Scott Stubbs, Imad Libbus, Scott Mazar, Bruce H. KenKnight, Badri Amurthur
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Publication number: 20190070415Abstract: A method includes determining a measurement indicative of a synchrony between one or more regions of a patient's autonomic nervous system (e.g., the NTS) and one or more regions of the patient's central nervous system (e.g., the thalamus, the cortex) based on body parameter data. The method also includes adjusting a cranial nerve stimulation parameter based on the measurement.Type: ApplicationFiled: November 8, 2018Publication date: March 7, 2019Applicant: CYBERONICS, INC.Inventors: Shivkumar Sabesan, Steven E. Maschino
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Publication number: 20190046804Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients. A titration process is used to gradually increase the stimulation intensity to a desired therapeutic level until a target T-wave alternans change from a baseline T-wave alternans is achieved.Type: ApplicationFiled: October 12, 2018Publication date: February 14, 2019Applicant: CYBERONICS, INC.Inventors: Imad Libbus, Bruce H. KenKnight
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Patent number: 10195438Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for recording the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time.Type: GrantFiled: October 13, 2017Date of Patent: February 5, 2019Assignees: Cyberonics, Inc., East Tennessee State UniversityInventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell
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Patent number: 10195437Abstract: An implantable neurostimulator-implemented method for managing tachyarrhythmias through vagus nerve stimulation is provided. An implantable neurostimulator, including a pulse generator, is configured to deliver electrical therapeutic stimulation in a manner that results in creation and propagation (in both afferent and efferent directions) of action potentials within neuronal fibers of a patient's cervical vagus nerve. Operating modes of the pulse generator are stored. A maintenance dose of the electrical therapeutic stimulation is delivered to the vagus nerve via the pulse generator to restore cardiac autonomic balance through continuously-cycling, intermittent and periodic electrical pulses. A restorative dose of the electrical therapeutic stimulation is delivered to prevent initiation of or disrupt tachyarrhythmia through periodic electrical pulses delivered at higher intensity than the maintenance dose.Type: GrantFiled: September 18, 2017Date of Patent: February 5, 2019Assignee: Cyberonics, Inc.Inventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight
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Patent number: 10188856Abstract: An implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction is provided. A stimulation therapy lead includes helical electrodes configured to conform to an outer diameter of a cervical vagus nerve sheath, and a set of connector pins electrically connected to the helical electrodes. A neurostimulator includes an electrical receptacle into which the connector pins are securely and electrically coupled. The neurostimulator also includes a pulse generator configured to therapeutically stimulate the vagus nerve through the helical electrodes in alternating cycles of stimuli application and stimuli inhibition that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes by triggering bi-directional action potentials.Type: GrantFiled: December 7, 2011Date of Patent: January 29, 2019Assignee: Cyberonics, Inc.Inventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight
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Publication number: 20180361158Abstract: Multi-modal stimulation therapy may be utilized in which two or more stimulation therapies having different stimulation parameters may be delivered to a single patient. This can preferentially stimulate different nerve fiber types and drive different functional responses in the target organs. The stimulation parameters that may vary between the different stimulation therapies include, for example, pulse frequency, pulse width, pulse amplitude, and duty cycle.Type: ApplicationFiled: June 14, 2018Publication date: December 20, 2018Applicants: Cyberonics, Inc., East Tennessee State UniversityInventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell, Gregory A. Ordway
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Publication number: 20180345013Abstract: Devices and methods for improving the coupling between the soft palate and the genioglossus. This may be accomplished, for example, but shortening or stiffening the palatoglossal arch. Improved coupling between the soft palate and the genioglossus may be beneficial to a patient suffering from obstructive sleep apnea (OSA) as a stand-alone procedure, or in combination procedures and devices that cause anterior displacement of the tongue such as hypoglossal nerve stimulation, genioglossus advancement surgery, mandibular advancement surgery, mandibular advancement (oral) appliances, etc.Type: ApplicationFiled: August 13, 2018Publication date: December 6, 2018Applicant: Cyberonics, Inc.Inventors: Stephen Bolea, Wondimeneh Tesfayesus, John Beck, Thomas Hoegh, Robert Atkinson, Sidney Hauschild
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Patent number: 10124169Abstract: A method includes determining a measurement indicative of a synchrony between one or more regions of a patient's autonomic nervous system (e.g., the NTS) and one or more regions of the patient's central nervous system (e.g., the thalamus, the cortex) based on body parameter data. The method also includes adjusting a cranial nerve stimulation parameter based on the measurement.Type: GrantFiled: June 26, 2014Date of Patent: November 13, 2018Assignee: Cyberonics, Inc.Inventors: Shivkumar Sabesan, Steven E. Maschino
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Patent number: 10124170Abstract: A method of neurostimulation titration. The method includes setting titration parameters for an electrical signal delivered by an implantable medical device, initiating titration with the titration parameters and an aggressiveness profile, performing titration by increasing at least one of a current amplitude, a frequency, a pulse width or a duty cycle of the electrical signal until a threshold is reached or a side effect is detected, pausing the titration while waiting for commands from the patient or caregiver, and resuming the titration in response to receiving authorization from an external device.Type: GrantFiled: June 13, 2016Date of Patent: November 13, 2018Assignee: Cyberonics, Inc.Inventors: Scott Stubbs, Imad Libbus, Scott Mazar, Bruce H. KenKnight, Badri Amurthur
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Publication number: 20180304080Abstract: An implantable neurostimulator-implemented method for managing tachyarrhythmias upon a patient's awakening from sleep through vagus nerve stimulation is provided. An implantable neurostimulator, including a pulse generator, is configured to deliver electrical therapeutic stimulation in a manner that results in creation and propagation (in both afferent and efferent directions) of action potentials within neuronal fibers comprising the cervical vagus nerve of a patient. Operating modes of the pulse generator are stored. An enhanced dose of the electrical therapeutic stimulation is parametrically defined and tuned to prevent initiation of or disrupt tachyarrhythmia upon the patient's awakening from a sleep state through at least one of continuously-cycling, intermittent and periodic ON-OFF cycles of electrical pulses. Other operating modes, including a maintenance dose and a restorative dose are defined.Type: ApplicationFiled: June 22, 2018Publication date: October 25, 2018Applicant: CYBERONICS, INC.Inventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight
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Patent number: 10105538Abstract: Devices, systems and methods of neurostimulation for treating obstructive sleep apnea.Type: GrantFiled: December 29, 2010Date of Patent: October 23, 2018Assignee: Cyberonics, Inc.Inventors: Stephen L. Bolea, Thomas B. Hoegh, Brian D. Kuhnley, Dale G. Suilmann, Bruce J. Persson, John P. Beck, Sidney F. Hauschild, Paula M. Kaplan, Adam K. Hoyhtya, Wondimeneh Tesfayesus, Robert E. Atkinson
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Patent number: 10099055Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients. A titration process is used to gradually increase the stimulation intensity to a desired therapeutic level until a target T-wave alternans change from a baseline T-wave alternans is achieved.Type: GrantFiled: November 11, 2015Date of Patent: October 16, 2018Assignee: Cyberonics, Inc.Inventors: Imad Libbus, Bruce H. KenKnight
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Patent number: 10080895Abstract: A method includes determining sleep cycle information related to a sleep cycle of a patient based on body parameter data. The method also includes adjusting a cranial nerve stimulation parameter based on the sleep cycle information.Type: GrantFiled: July 6, 2017Date of Patent: September 25, 2018Assignee: Cyberonics, Inc.Inventor: Shivkumar Sabesan
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Publication number: 20180264257Abstract: A medical device includes a pulse generator and a filter. The pulse generator is configured to generate a stimulation signal and to provide the stimulation signal to tissue of a patient via an implantable lead assembly. The filter is configured to couple to the implantable lead assembly. A combined impedance of the implantable lead assembly and the filter with respect to a current induced by an external electro-magnetic field satisfies an impedance threshold when the external electro-magnetic field has a first frequency and when the external electro-magnetic field has a second frequency. The combined impedance has a peak impedance value when the external electro-magnetic field has a third frequency that is between the first frequency and the second frequency.Type: ApplicationFiled: May 18, 2018Publication date: September 20, 2018Applicant: Cyberonics, Inc.Inventors: David L. Thompson, Jason F. Lindh
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Publication number: 20180243566Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A computer-implemented control system is operated to automatically identify a neural fulcrum zone based on a monitored patient physiological response. Ongoing neurostimulation therapy is delivered within the neural fulcrum zone.Type: ApplicationFiled: April 20, 2018Publication date: August 30, 2018Applicants: Cyberonics, Inc., East Tennessee State UniversityInventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell
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Patent number: 10052484Abstract: Devices and methods for improving the coupling between the soft palate and the genioglossus. This may be accomplished, for example, but shortening or stiffening the palatoglossal arch. Improved coupling between the soft palate and the genioglossus may be beneficial to a patient suffering from obstructive sleep apnea (OSA) as a stand-alone procedure, or in combination procedures and devices that cause anterior displacement of the tongue such as hypoglossal nerve stimulation, genioglossus advancement surgery, mandibular advancement surgery, mandibular advancement (oral) appliances, etc.Type: GrantFiled: September 11, 2017Date of Patent: August 21, 2018Assignee: Cyberonics, Inc.Inventors: Stephen Bolea, Wondimeneh Tesfayesus, John Beck, Thomas Hoegh, Robert Atkinson, Sidney Hauschild
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Publication number: 20180200512Abstract: Devices, systems and methods of neurostimulation for treating obstructive sleep apnea. The system is adapted to send an electrical signal from an implanted neurostimulator through a stimulation lead to a patient's nerve at an appropriate phase of the respiratory cycle based on input from a respiration sensing lead. External components are adapted for wireless communication with the neurostimulator. The neurostimulator is adapted to deliver therapeutic stimulation based on inputs.Type: ApplicationFiled: March 12, 2018Publication date: July 19, 2018Applicant: Cyberonics, Inc.Inventors: Stephen L. Bolea, Thomas B. Hoegh, Brian D. Kuhnley, Dale G. Suilmann, Bruce J. Persson, John P. Beck, Sidney F. Hauschild, Wondimeneh Tesfayesus, Jason J. Skubitz, Mark R. Bosshard, Daniel A. Parrish, Robert E. Atkinson