Abstract: The present invention provides compounds of Formulae (A), (B), (C), and (D), pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof, pharmaceutical compositions thereof, and kits thereof. The present invention further provides methods of using the compounds to treat or prevent neurological disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, ALS (amyotrophic lateral sclerosis), traumatic brain injury, ischemic brain injury, stroke, frontal temporal dementia, Pick's disease, corticobasal degeneration, supra cerebral palsy, prion diseases (e.g., Creutzfeldt-Jakob disease, Gerstmann-Straussler-Scheinker syndrome, Fatal Familial Insomnia, and Kuru), Nieman Pick type C, spinal cerebellar ataxia, spinal muscular dystrophy, ataxia telangiectasia, hippocampal sclerosis, Cockayne syndrome, Werner syndrome, xeroderma pigmentosaum, and Bloom syndrome.

Abstract: A laundry product comprising; polyethylene glycol having a molecular weight of 2 000 to 30 000; and free oil perfume comprising phenolic aldehyde, characterised in that the composition further comprises at least 1 w.t. % of starch or starch derivative.

Abstract: A system and method that generate a first sensor network of first communication apparatuses that include first communication units to transmit communication messages to form the first sensor network and second communication units. The first sensor network is formed by acquiring identification information of the communication apparatuses via second communication units that are general-purpose communication units in substantially parallel communication, and selecting by a first information processing apparatus two or more of the plurality of first communication apparatuses. The first setting information is transmitted to the second communication units such that the selected first communication apparatuses communicate to form the first sensor network.

Abstract: The present invention relates to a process for producing a food article consisting of an edible composition having an elongated member extending therefrom, the edible composition having a water content of less than 5 wt. %. The present invention also relates an edible composition and to the of the edible composition for preparing a meal or snack.

Abstract: In some embodiments, a method can comprise using personalization logic configured to be adaptable among two or more channels to evaluate one or more user conditions of a user to determine one or more user segment and evaluate an experience based at least in part on the one or more user segments. The method may further comprise executing, on a webserver, the personalization logic when the user visits a channel of the two or more channels in order to facilitate display of personalized content based at least in part on the experience wherein each of the two or more channels comprise a channel type of a website channel type or a non-website channel type, wherein the non-website channel type comprises applications and internet capable devices and the channel type of at least one of the two or more channels is a non-website channel type.

Abstract: In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.

Abstract: The present invention relates to an improved method and apparatus for image compression and particularly to an improved block coding apparatus and method for compression for use with the JPEG2000 standard, although not limited to this. Methods for coding and decoding blocks and subbands samples derived from still images video frames or related media, involving three bit-streams and the partitioning of samples from the blocking to define groups, is provided. A first bit-stream encodes the significance of whole groups. A second bit-stream encodes the significance of individual samples within each group. The second bit-stream also encodes an unsigned residual value for each significant group. A third bit stream provides a sign bit and any additional magnitude bits required to represent the significant sample values. Exponent predictors are computal using both exponent bounds and the additional magnitude bits associated with previous samples in the block.

Abstract: A method for managing flow of particles into an array of pairwise-point-interaction-module includes receiving a first set of particles into a first queue. The first set is a proper subset of a second set of particles that comprises all particles that are to be passed into an array of pairwise-point-interaction-modules during a current time period. Prior to having received all particles from the second set, particles from the first set are allowed to pass from the first queue into the array.

Abstract: An extensible electroconductive wiring material includes a flexible electroconductive material and insulating elastic bodies and, wherein the flexible electroconductive material having an electroconductive layer has vent peripheral edge portions in which vent holes and/or vent slits are penetrated and aligned in series and/or in parallel along an energization direction of the electroconductive layer while the vent peripheral edge portions are energizably linked, and the vent peripheral edge portions is sealed and covered by the insulating elastic bodies, so as not to be exposed; and the insulating elastic bodies, have penetration slits, and/or penetration holes which penetrate therethrough while matching the vent peripheral edge portions and are smaller than the vent holes and the vent slits. The extensible electroconductive wiring module has a plurality of these extensible electroconductive wiring materials.

Abstract: Computational systems and methods employ characteristics of a quantum processor determined or sampled between a start and an end of an annealing evolution per an annealing schedule. The annealing evolution can be reinitialized, reversed or continued after determination. The annealing evolution can be interrupted. The annealing evolution can be ramped immediately prior to or as part of determining the characteristics. The annealing evolution can be paused or not paused immediately prior to ramping. A second representation of a problem can be generated based at least in part on the determined characteristics from an annealing evolution performed on a first representation of the problem. The determined characteristics can be autonomously compared to an expected behavior, and alerts optionally provided and/or the annealing evolution optionally terminated based on the comparison. Iterations of annealing evolutions may be performed until an exit condition occurs.

Abstract: The present disclosure discloses a method for manufacturing a backside-illuminated CMOS image sensor structure, the method comprises: providing a silicon substrate which has been subjected to a frontside processing and a back thinning; forming grid-shaped deep trenchs on the back of the silicon substrate; forming an insulating layer on the inner wall surface of the deep trenchs to form a grid-shaped deep trenchs isolation structure; forming a diffusion barrier layer on the surface of the insulating layer; filling metal in the deep trenchs to form a grid-shaped composite structure in which the Metal grid is combined with the deep trenchs isolation structure.

Abstract: The present invention also relates to process for the preparation of N-(4-(6,7-dimethoxy quinolin-4-yloxy)phenyl)-N?-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (S)-malate compound of formula-1a and its polymorphs thereof, represented by the following structural:

Abstract: An automated guided vehicle includes a chassis and a load supporting apparatus positioned on the chassis, the load supporting apparatus including a platform to support a load, one or more weight sensors located in contact with the platform, the one or more weight sensors configured to provide a signal indicative of a weight of the load on the platform, and an electronic processor arranged in electronic communication with the one or more weight sensors. The electronic processor is configured to receive the signal from each of the one or more weight sensors, and the electronic processor is configured to process the signal and determine stability of the load on the platform.

Abstract: Medical devices and methods of treating subjects using such medical devices are described. The medical device may include a housing with at least two chambers including a first chamber adjacent to a second chamber; a barrier between the first chamber and the second chamber; and a soft, flexible base. The first and second chambers may be airtight, the barrier configured to establish fluid communication between the first chamber and the second chamber upon an application of force to the barrier.

Abstract: Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR-133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.

Abstract: The present invention is in the field of antiperspirant compositions, in particular, compositions comprising antiperspirant actives. Disclosed is an anhydrous antiperspirant composition comprising an inorganic polyionic cluster having structure of (I) or (II); where M is Ca or Mg; and wherein the composition is substantially free of abrasives, which means less than 3.0% by weight of the composition; wherein anhydrous means the water content of the composition is less than 3.0%.

Abstract: A nozzle for spraying (20) a fluid, suitable for being arranged on a body of a cleaning device of an optical detection system mounted on a motor vehicle, comprises an internal distribution duct which extends between a proximal end, suitable for being fluidly connected to a fluid distribution channel arranged in the body, and a distal end (38) forming a fluid outlet orifice, the distribution duct being defined at least by a back wall and two opposite lateral walls (64), the nozzle further comprising a ramp (70) arranged on the path of the fluid at the outlet orifice. The lateral walls (64) are arranged at the distal end (38) of the distribution duct so as to be distanced from one another, the distribution duct flaring in the direction of the ramp (70).

Abstract: The treatment of cancer using platinum-based compounds includes certain drawbacks such as biocompatibility, loading efficacy, leakage of drugs during storage and in the bloodstream, more particularly due to the nature of the nanocarriers for platinum delivery. A nanosystem that allows improving platinum-based drug in vivo performance, kinetics and efficacy. In particular, nanoparticles useful as drug delivery system, these nanoparticles being formed from at least: (a) platinum-based drug, (b) poly-L-arginine, and (c) hyaluronic acid. Particularly, these nanoparticles have been tested in terms of entrapment efficiency and also carried out in vitro experiments in 2D cell culture (viability studies on B6KPC3, A549 and HT-29 cells) and 3D cell model (spheroids made of HTC-116) and in vivo experiments (by injecting intravenously to mice the nanoparticles or comparative oxaliplatin solution) to prove their efficiency.

Abstract: An anode, in particular an anode for the use in aluminium electrolysis cells, includes an anode body with a first stub hole for the insertion of a stub for the connection with a voltage source. The anode includes at least a first aluminium core and a second aluminium core that are arranged inside the anode body for the connection with the voltage source. A first distance between the first aluminium core and the bottom of the anode is different from a second distance between the second aluminium core and the bottom of the anode.

Abstract: An eyewear clipping device to fasten the eyewear to the sides of a cap that comprises a first vertical member forming an exterior slot for receiving an earpiece of an eyewear with a first top end and a first bottom end. A second vertical member forms an interior three-sectioned clip with a second top end and a bottom end comprising a central ascending vertical section that forks at the top second end to form two retention wings that extend back downward toward the bottom end that insert behind a hat band of a cap and together with the central ascending vertical section, which is positioned in front of the hat band, create an opposed gripping force on the hat band. The first bottom end and the second bottom end connect together using a U-shaped curve or straight bridge.