Abstract: A solid composition comprising: a) from 15 to 90 wt. %, based on the total weight of the solid composition, free acid equivalent of aminopolycarboxylate; and b) from 1 to 25 wt. %, based on the total weight of the solid composition, free acid equivalent of inorganic acid; and c) from 2 to 30 wt. %, based on the total weight of the solid composition, of water; and wherein the pH of a solution made by dissolving the solid in water at 1 wt. % is at least 5.0 as measured at 25 degrees Celsius; and wherein the pH of a solution made by dissolving the solid in water in a 1:1: weight ratio is at most 10 as measured at 25 degrees Celsius, wherein at least 10 wt. % of the ingredient a), based on the total weight of the ingredient a) is non-crystalline; and wherein at least 10 wt. % of ingredient b), based on the total weight of the ingredient b) is non-crystalline.

Abstract: An inner drum cover is provided at a drum opening of an inner drum of a washing machine, the inner drum cover is used to open or close the drum opening, so that the inner drum forms a closed container after the drum opening is closed by the inner drum cover. The inner drum can perform washing after the inner drum cover is correspondingly fastened to the drum opening, so that clothes only come into contact with washing water in the sealed inner drum in a washing process. In this way, a case in which the clothes are contaminated because washing water between the inner drum and an outer drum flows into the inner drum is avoided, washing cleanliness of the washing machine is greatly improved, and incomplete washing of the clothes caused by contamination of the washing water between the inner drum and the outer drum is avoided.

Abstract: A probe of a target identification system can be extended via a first lumen of a viewing instrument, such as for illuminating an area beyond a distal end of the viewing instrument via an optical path of the viewing instrument. An optical response to the illumination of the area can be received via an optical path of the probe and can be split from other optical signals of the optical path. The optical response information can be used to identify characteristics of a target and to adjust parameters of a working instrument such as a working instrument contemporaneously using the probe.

Abstract: A window assembly includes a transparent substrate, an electrical conductor provided on a surface of the substrate, and a solderless electrical connector for energizing the electrical conductor. The solderless electrical connector includes a connector body adhered to the substrate and a metallic element elastically compressed between the connector body and the electrical conductor to facilitate an electrical connection.

Abstract: Apparatus and methods are described including placing a first portion of a biological sample into a source sample portion chamber of a sample carrier, and placing a second portion of the biological sample into a diluted sample portion chamber. The second portion of the biological sample is diluted with respect to the first portion of the biological sample. Using an optical measurement device, a bulk-level measurand of the sample that relates to a parameter of the biological sample as a whole is measured, by performing a measurement upon the first portion of the biological sample. Microscopic images of the second portion of the biological sample are acquired. Other applications are also described.

Abstract: Disclosed herein are populations of microvesicles containing or otherwise associated with viral particles, methods of producing these purified populations, and methods of using these purified populations in a variety of diagnostic, therapeutic and/or prophylactic indications.

Abstract: Provided herein are compounds of Formula I useful as FGFR4 inhibitors, as well as methods of use of the same.

Abstract: In an embodiment, a power switch controller for driving a back-to-back power switch includes: an amplifier having a supply terminal configured to receive a supply voltage, an output configured to be coupled to a gate terminal of the back-to-back power switch, a first input configured to be coupled a source terminal of the back-to-back power switch, and a second input coupled to the output of the amplifier. The amplifier is configured to generate an output voltage at the output of the amplifier, the output voltage being an offset voltage higher than a voltage at the first input of the amplifier.

Abstract: Disclosed is a method for diagnosing allergy in a human or animal patient, wherein the level of species-specific lipocalin, especially lipocalin 2 in a human patient, is measured in a sample of said patient and wherein a lowered level of said lipocalin compared to the level of said lipocalin in the corresponding sample of a human or animal that has no allergy, is indicative of an allergy, as well as a kit for performing this method, and a kit for quality control of allergen molecules or extracts used for immunotherapy of allergy by determining its siderophore-iron ligand load and thus immunomodulatory potency. Further, lipocalin proteins for use in treatment or prevention of allergies are provided, preferably complexed with siderophore-iron ligands.

Abstract: The invention provides methods for the synthesis of a halichondrin macrolides through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

Abstract: Methods for encoding data in synthetic DNA include, for an input data sequence, constructing a codebook of a number of unique codewords, of a nucleotide length, which are constructed such that, for each codeword, the codeword is formed from a selection of nucleotide pairs from a first predefined dictionary of nucleotide pairs, and, if the nucleotide length of the codeword is odd, an additional selection of a nucleotide from a second predefined dictionary of individual nucleotides. For each symbol from the input data sequence, at least one codeword is designated as associable therewith, and each symbol is coded as one codeword selected from the designated at least one codeword associable with that symbol. A code is formed from the codewords, arranged in corresponding order to that of their respective symbols in the input data sequence. A DNA sequence is synthetized with nucleotides ordered to match the code.

Abstract: Methods, apparatus, and systems are provided for tracking freight. Embodiments include a tracking device for a trailer containing a load. The tracking device may include a housing including a connector, a main body, and a GPS tracker located within the main body and configured to track the location of the load. Tracking device may include a support member linking the connector and main body. Connector may securely attach to a container on the trailer and attach to a seal such that the container cannot be opened without breaking the seal. Support member may stabilize the housing and protect the tracking device during transit of the load. A tracking system may implement to monitor, gather information and report on the tracking device and the load.

Abstract: The present invention relates in general to the field of recombinant protein expression. In particular, the present invention relates to a method for selecting a suitable candidate cell clone for recombinant protein expression and to a host cell for recombinant protein expression, the host cell exhibiting artificially modified gene expression of at least one gene selected from the group consisting of: Fkbp10, ZdhhC6, Myrip, Actc1, AC124993.19, Runx2, AC158560.4, PlekhB1, Rps6KA2, Sept1, Sprr2k, and Flt1.

Abstract: Colored hard coated edible products characterized by minimal appearance defects in the coating are disclosed. Color and flavor are in substantially separated regions of the coating. Methods of making such products are also disclosed.

Abstract: The present invention relates in general to the field of recombinant protein expression. In particular, the present invention relates to a method for selecting a suitable candidate cell clone for recombinant protein expression and to a host cell for recombinant protein expression, the host cell exhibiting artificially modified gene expression of at least one gene selected from the group consisting of: Hist1h2bc, Egrl, BX842664.2/Hist 1h3c, Dhfr, Fgfr2, AC115880.11, Mmp10, Vsnll (optional), CU459186.17, El 30203 B14Rik, Cspg4, C1qtnf1, Foxp2, and Ptpre.

Abstract: The disclosed apparatus, systems and methods relate to various apparatus, systems and methods relating to associating a tangible item or asset with a specific website by way of a paired signaler and target URL. A wireless communicator and short URL may be used. The system utilizes cloud management platforms and human readable URLs. The signaler may be re-used with multiple target URLs.

Abstract: The invention provides compounds of formula (I): wherein X is and the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: Travel pillow apparatus, storage apparatus for the travel pillow apparatus, and methods of manufacture and use. In one embodiment, the travel pillow apparatus, includes an external covering, the external covering including upper and lower support structures; an air bladder apparatus that includes an expandable open-cell foam within an interior of the air bladder apparatus. The air bladder apparatus is further shorter in length than the external covering, such that the air bladder apparatus is not intended to be positioned towards the back of a neck of a user that is utilizing the travel pillow apparatus. A storage apparatus with a one-way expulsion valve for storage of, for example, the aforementioned travel pillow apparatus. Methods of manufacturing and using the aforementioned apparatus are also disclosed.

Abstract: A handheld clamp work light is disclosed having a light member, a housing member for movement of the light member, a handle member having a handle housing and a clamp member, and the handle housing and the clamp member include feet members which pivot and may be attached to an object.

Abstract: The invention relates to glucuronide prodrug compounds of Janus kinase (JAK) inhibitors having formula I: where W1, R1 and A1 are as defined. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds to treat gastrointestinal inflammatory diseases; and processes and intermediates for preparing such compounds.