Abstract: The bottom of a household appliance is provided with leveling feet. The leveling foot comprises a fixed part and a movable part, and a hollow chamber is formed between the fixed part and the movable part. The hollow chamber is provided with a hydraulic medium. Under the action of pressure, the hydraulic medium can be circulated in the hollow chamber inside the leveling foot and/or the hollow chamber between leveling feet to realize the expansion and contraction of the movable part, to execute automatic leveling. The leveling device of a household appliance of the present disclosure, according to the hydraulic principle, is provided with a hydraulic medium in the leveling foot. Under different pressures, the leveling foot is made to automatically adjust adaptively due to the fluidity of the hydraulic medium.

Abstract: Approaches useful to operation of scalable processors with ever larger numbers of logic devices (e.g., qubits) advantageously take advantage of QFPs, for example to implement shift registers, multiplexers (i.e., MUXs), de-multiplexers (i.e., DEMUXs), and permanent magnetic memories (i.e., PMMs), and the like, and/or employ XY or XYZ addressing schemes, and/or employ control lines that extend in a “braided” pattern across an array of devices. Many of these described approaches are particularly suited for implementing input to and/or output from such processors. Superconducting quantum processors comprising superconducting digital-analog converters (DACs) are provided. The DACs may use kinetic inductance to store energy via thin-film superconducting materials and/or series of Josephson junctions, and may use single-loop or multi-loop designs. Particular constructions of energy storage elements are disclosed, including meandering structures.

Abstract: The invention relates to a foot pedal control unit for an ophthalmic surgery system. The unit has a base and a treadle that is configured for pivotal pitch movement and for pivotal yaw movement relative to the base for generating control signals to an ophthalmic surgery system. The unit further comprises an inlay cover that is removably placed on the treadle. Optionally, the unit comprises a locking element that is movable between a lock position wherein the treadle is locked against pivotal yaw movement and a release position wherein the treadle is enabled to perform pivotal yaw movement.

Abstract: A water treatment system comprising a mechanical vapour compression apparatus (11), the mechanical vapour apparatus having a evaporation/condensation vessel (11a) and a recirculation circuit (20) whereby recirculated water is pumped from an outlet (18a) of the evaporation/condensation vessel (11A) to an inlet (18B) of the evaporation/condensation vessel (11A), wherein the recirculation circuit (20) comprises a fluidized bed crystallizer (22), and at least part of the recirculated brine is passed through the fluidized bed crystallizer (22) to remove dissolved minerals therefrom.

Abstract: The invention relates to glucuronide prodrug compounds of Janus kinase (JAK) inhibitors having formula I: where W1, R1 and A1 are as defined. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds to treat gastrointestinal inflammatory diseases; and processes and intermediates for preparing such compounds.

Abstract: Methods and systems for improving resource content mapping for an electronic learning system. The methods can include: receiving, by the electronic learning system, a resource for satisfying at least one learning objective of the one or more learning objectives, the resource comprising a content having a content data convertible into a text data and one or more resource property fields defining at least one characteristic of the resource; sectioning the content data into one or more content portions based on an analysis of at least one of the content data and the one or more resource property fields; and assigning at least one content portion of the one or more content portions to at least one learning objective.

Abstract: A filtering circuit for filtering a pulse width modulated (PWM) signal includes a D flip-flop having an input terminal configured to be coupled to a logic high signal and having an output terminal coupled to an output terminal of the filtering circuit; and a circuit coupled between an input terminal of the filtering circuit and the D flip-flop, the circuit configured to, for a first pulse of the PWM signal having a duty cycle within a pre-determined range: generate a positive pulse at a clock terminal of the D flip-flop as a clock signal of the D flip-flop; and generate a negative pulse at a reset terminal of the D flip-flop as a reset signal of the D flip-flop, wherein a duration between a rising edge of the positive pulse and a falling edge of the negative pulse is equal to a duration of the first pulse of the PWM signal.

Abstract: An application of omega-3 and/or omega-6 fatty acid(s) for the therapeutic treatment of the human or animal body in the case of an impaired sphingolipid metabolism, in particular in the case of impaired sphingolipid synthesis and/or excessive sphingolipid degradation. The agent is applied in the case of missing, reduced and/or defective formation of a sphingomyelin synthase enzyme in the body, in particular the enzyme sphingomyelin synthase 1 or the enzyme sphingomyelin synthase 2. The application has proved to be useful in the case of a defect of the sphingomyelin synthase 1 gene or of the sphingomyelin synthase 2 gene. The omega-3 and/or omega-6 fatty acid(s) preferably comprise(s) polyunsaturated omega-3 and/or omega-6 fatty acid(s), preferably EPA, DHA, DPA, ETA, 21:5n3 and/or SDA. A method for determining a cause of a disease in an animal or a human being and a device for carrying out the method are also provided.

Abstract: The present disclosure provides a novel solid state form of pladienolide pyridine compounds having Formula I, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.

Abstract: The invention provides novel 8-azabicyclo[3.2.1]octane compounds of formula (I): wherein R1, R2, R3, A, and G are defined in the specification, or a pharmaceutically-acceptable salt or solvate thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.

Abstract: In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and Z are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.

Abstract: A device is provided for controlling the motion of a movable member such as a sliding door. The device comprises two springs. Each spring has its own catch for releasably holding it in a pre-loaded condition. The catches are releasable by motion of the door to apply force to its closing movement. The catches are arranged so that one of the springs will exert force on the door before the other.

Abstract: The disclosure relates to a layer comprising at least one hydrophilic part and at least one hydrophobic part, the layer comprising self-assembled amphiphilic molecules polymerized with each other on both the hydrophilic part and the hydrophobic part of the layer; a detecting device comprising a substrate and the above-mentioned layer; and a liposome, a micelle, transport system for a substance and a biomimetic system comprising the above-mentioned layer. The disclosure also relates to a process for producing a layer, the process comprising: providing amphiphilic molecules; allowing sufficient time for the amphiphilic molecules to self-assemble and form at least one hydrophilic part and at least one hydrophobic part of the layer; polymerizing the self-assembled amphiphilic molecules with each other on both the hydrophilic part and the hydrophobic part of the layer.

Abstract: The present invention provides antibodies directed against ICOS or a derivative thereof which neutralize ICOS engagement on Treg by inhibiting the fixation between ICOS and ICOS-L and abrogate proliferation of Treg induced by plasmacytoid dendritic cells. The present invention further provides antibodies directed against ICOS or a derivative thereof which induce IL-10 and IFN? production, induce CD4? T cells proliferation, reduce Tconv proliferation, and increase the immunosuppressive function of Treg.

Abstract: A system for a vehicle includes a window assembly adapted to be installed within the front opening of the vehicle frame. The window assembly includes an inner transparent sheet, an outer transparent sheet, and an interlayer of polymer disposed between the inner transparent sheet and the outer transparent sheet. The interlayer is configured wherein a first portion of the interlayer has a first variable thickness profile and wherein a second portion of the interlayer has a second variable thickness profile, with the first portion of the interlayer distinct from the second portion of the interlayer. The system also includes a front-facing camera positioned within the vehicle for receiving light transmissions from an object located outside the vehicle through the first portion. The system may also include a head up display—associated with the second portion of the interlayer.

Abstract: The present invention relates to the technical field of well drilling, and discloses a plugging agent for temperature-resistant calcium-resistant water-based drilling fluid used in oil and gas reservoir protection, a drilling fluid, and uses of the plugging agent and the drilling fluid. The plugging agent for temperature-resistant calcium-resistant water-based drilling fluid used in oil and gas reservoir protection contains acrylamide-diallyldimethylammonium chloride copolymer modified graphene, wherein in the acrylamide-diallyldimethylammonium chloride copolymer, a molar ratio of structural units provided by acrylamide to structural units provided by diallyldimethylammonium chloride is 1:5-15, and the number-average molecular weight of the acrylamide-diallyldimethylammonium chloride copolymer is 15,000-30,000.

Abstract: Packaging comprising: a bottle at least partially transparent, a lighting system placed on the bottle in such a way as to emit a beam of light in a direction of lighting parallel to a central axis of the bottle, a covering film covering at least part of an exterior surface of a lateral wall of the bottle, the covering film comprising at least locally a decoration designed to be back-lit by the beam of light spreading through the liquid, the decoration comprising a plurality of decorative zones, each decorative zone having a degree of illumination, the plurality of decorative zones comprising at least one first contrast zone and at least one second contrast zone, the first contrast zone having a degree of illumination at least 5% lower than the degree of illumination of the second contrast zone.

Abstract: A wipe for detecting the presence of an explosive substance is composed of an absorbent or adsorbent substrate and a chemical detection solution impregnated within the substrate. In one embodiment the chemical detection solution includes a combination of reagents operable, when contacted with a particular explosive substance to undergo a chemical reaction or a series of chemical reactions to produce a compound having a visible color. In another embodiment, the chemical detection solution includes a redox color indicating agent that is operable to exhibit a color change upon reacting with the explosive substance.

Abstract: Disclosed is a personal care composition comprising: a) a porous particle; b) a film forming polymer; and c) a cosmetically acceptable carrier which is a water and oil emulsion; wherein the porous particle has oil absorption value in the range of 50g/100g to 1500g/100g; wherein the porous particle is selected from porous silica, cellulose, acrylic polymer, nylon and ethylene/methacylate copolymer hollow sphere coated with porous silica; wherein the film forming polymer is selected from an acrylate polymer, a methacrylate polymer, a urethane polymer or co-polymers thereof; and wherein the composition comprises whitening pigment in an amount of from 0.001 to 2 wt %.