Abstract: A latch assembly comprising: a latch operable to adopt a latched condition and an unlatched condition; a magnet imparting a magnetic field; a sensor adapted to sense the magnetic field; the latch, magnet and sensor being configured such that a change in the condition of the latch effects a variance in the magnetic field sensed by the sensor to distinguish between the latched condition and the unlatched condition, wherein the latch includes a latch member that is moveable relative to both the sensor and the magnet when the latch changes from the unlatched condition to the latched condition and the proximity of the latch member to the magnet changes the strength of the magnetic field sensed by the sensor.

Abstract: The present invention discloses a novel composition of the elution mobile phase for virus purification by immunoaffinity chromatography which is consisting of one or more amino acids: L-serine, L-asparagine, or L-glutamine, or their salts with pharmaceutically acceptable acids; one or more auxiliary ingredients: L-arginine, glycine or imidazole, or their salts with pharmaceutically acceptable acids; one or more pharmaceutically acceptable pH adjusting agents for correcting the pH value of the mobile phase from pH=6.0-8.0; and purified water, up to 100% w/w of the mobile phase composition. The invention provides the use of immunoaffinity chromatography as a key step in the production of viral vaccines and/or viral vectors, in separation of infectious from non-infectious viral particles, and for enrichment of the viral suspension in infectious viral particles.

Abstract: Breathing mask for supplying a breathing gas to a user of a mask includes a sealing lip to seal a mask support zone, a mask base body to form a mask interior chamber and a connector to connect at least one breathing gas line. The mask base body and/or the connector is provided with at least one de-coupling structure formed of an elastomer material. The de-coupling structure allows a relative movement between a mask body-sided circumferential foot portion of the sealing lip and the breathing gas line in at a tilt angle of at least 5°.

Abstract: A single automated accounting and business analysis system is employed to acquire, organize, record, analyze and plan all the relevant financial and non-financial metrics utilized by an individual or group. This includes all the internally generated metrics and external metrics such as data related to the economy, a particular industry, weather conditions, etc. The system employs heuristics to learn from previous associations and links data based on previous associations.

Abstract: Computational systems implement problem solving using hybrid digital/quantum computing approaches. A problem may be represented as a problem graph which is larger and/or has higher connectivity than a working and/or hardware graph of a quantum processor. A quantum processor may be used determine approximate solutions, which solutions are provided as initial states to one or more digital processors which may implement classical post-processing to generate improved solutions. Techniques for solving problems on extended, more-connected, and/or “virtual full yield” variations of the processor's actual working and/or hardware graphs are provided. A method of operation in a computational system comprising a quantum processor includes partitioning a problem graph into sub-problem graphs, and embedding a sub-problem graph onto the working graph of the quantum processor. The quantum processor and a non-quantum processor-based device generate partial samples.

Abstract: A method is for producing seals on faces of electrochemical reactor components intended to be stacked in order to form an electrochemical reactor Each component is in the form of a plate and having a first face and an opposing second face. The first face is designed to receive a first seal and the second face is designed to receive a second seal. The method includes shaping the first seals on the first faces of the components, the first seals being at least partially polymerized; depositing the second seals on the second face of the components; and shaping the second seals by compressing a stack formed from the components alternating with molding plates.

Abstract: A nanogel comprising a self-organizing peptide, a chitosan and polyethylene glycol is described.

Abstract: A storage container commonly referred to a “tackle box,” that detachably secures an elongate fishing lure, such as a tube fly or the like, within a chamber of a case using a mandrel for detachably engaging the lure and a mandrel anchor for detachably engaging the mandrel. In a disclosed embodiment, the mandrel anchor is formed of foam with slits received therein for receiving one or more mandrels. A distal end of each mandrel may include a clip for snugly engaging the lure to further hold the lure in place in the container.

Abstract: Disclosed is a freezer cabinet (10) for storing frozen confectionery products, the freezer cabinet comprising: a chamber having an opening substantially sealed by an upper surface panel (18, 20); and a further panel (22, 24) inside the chamber being spaced away from the upper surface panel and substantially parallel to the upper surface panel in at least one direction and creating a quiescent region between the upper surface panel and further panel wherein the quiescent region is in gaseous communication with the air in the chamber. At least part of the upper surface panel and further panel is transparent such that at least part of the inside of the chamber is visible through the upper surface panel and further panel; the upper surface panel comprises at least one slideably openable section (18, 20); the further panel comprises at least one slideably openable section (22, 24); and the chamber comprises a side wall (12, 14) and a coolant evaporator (40) mounted in and/or on the side wall.

Abstract: The disclosure relates to a draining structure of a washing machine and a draining method. An inner drum is installed in a housing of the washing machine. The inner drum is a tapered drum with a smaller diameter at one end and a larger diameter at the other end. A draining flow passage is arranged at the larger diameter end. One end of the draining flow passage communicates with the larger diameter end. The other end of the draining flow passage penetrates the inner drum and communicates with a drain pipe. The inner drum rotates and washing water flows to the larger diameter end along the tapered inner wall by centrifugal force. Washing water is drained out from the inner drum through the draining flow passage arranged at the larger diameter end and then drained out through the drain pipe to realize the discharge of washing water.

Abstract: Compositions comprising a lactam and an alkyl lactate. The compositions are suitable for use as anti-microbial, anti-biofilm and bacteriostatic compositions.

Abstract: The invention provides compounds of formula (I): wherein X is and the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: The application relates to a cleaning system configured for cleaning of cavities filled with a liquid, including fragmentation, debridement, material removal, irrigation, disinfection, and decontamination. The cleaning system includes an electromagnetic radiation system and a liquid. A treatment handpiece irradiates the liquid within a cavity with a radiation beam, producing a first vapor bubble using first pulse, and, at a different location, a second vapor bubble using a second pulse. The pulse repetition time is adjusted to ensure efficacy, for example such that an onset time of the second vapor bubble is within the first contraction phase of the first vapor bubble, when the first vapor bubble has contracted from its maximal volume to a size in a range from about 0.7 to about 0.1 of the maximal volume.

Abstract: The present invention concerns an in vitro process for diagnosing joint disease in a mammal and/or determining the type of joint disease and/or determining the stage of said disease and/or predicting the course of said disease, comprising the following steps: a) depositing a drop of a synovial fluid sample from said mammal onto a flat substrate made of an inorganic material, such as glass; b) drying the drop deposited in step a); c) measuring at least one parameter indicative of the morphological features of the drop dried in step b), whereby a value for said parameter is obtained, and d) comparing each value measured in step c) with a reference value representative of a reference synovial fluid, characterized in that said parameter is selected from (i) the maximum height (H) of the bead formed on the surface of the drop, (ii) the area of the drop and (iii) the surface profile (Z) of the drop.

Abstract: The present invention relates to polyhydroxylated benzophenone compounds useful in the treatment of neurodegenerative, neurological, psychiatric, and cognitive diseases, in particular those associated with a deficiency in HDAC1 deacetylase activity.

Abstract: The present invention relates to a time-multiplexed stereoscopic 3d projection system that provides a higher level of on-screen image-brightness and image quality as compared to other prior-art technologies based on a single-beam architecture. The invention is based on the insight that a polarization beam-splitting element can be arranged to split an incident image-beam generated by a projector into one transmitted image-beam and at least one reflected image-beam, wherein each of said transmitted and reflected image-beams possess the same common state of polarization. Furthermore, by utilization of at least one reflecting surface, polarization rotator, polarization modulator, polarization-preserving projection-screen and passive polarized viewing-glasses, a stereoscopic 3d projection system is disclosed that provides for a high level of on-screen image-brightness and image quality.

Abstract: The invention relates to aqueous skin cleansing compositions. Specific amounts and chain length of acyl glycinate and acyl glutamate when used in specified ratios, have been found to unexpectedly enhance lather volume and texture, as well as provide superior mildness.

Abstract: There is described a method of manufacturing a reflector unit on a photonic chip. The method generally has a step of providing a substrate having a top surface with a region of interest, the region of interest being covered with a bulge of a removable material; monolithically integrating a layer of metallic material over a portion of the top surface adjacent to the bulge and over a portion of the bulge, the layer of metallic material forming a base monolithically integrated to the top surface and a pocket monolithically integrated over the bulge in a manner leaving a portion of the bulge uncovered; and removing the bulge of the removable material to form a reflector unit for reflecting light incoming from the region of interest or towards the region of interest.

Abstract: The invention relates to a medical imaging system having microwave emitting antennas and antennas for receiving the electromagnetic field, which are arranged around a space for receiving a human tissue medium to be observed, and comprising: an array (3) of emitting antennas and an array (4) of receiving antennas, wherein said two arrays (3, 4) are independent, and motors capable of angularly rotating and of translating the emitting array (3) and/or the receiving array (4) relative to the space under observation, in order to enable the scanning thereof.

Abstract: Described are methods for removing a proteolytic cleavage site, the HCHWA-D mutation or the amino acids encoded by a trinucleotide repeat expansion from a protein comprising providing a cell that expresses pre-mRNA encoding the protein with an anti-sense oligonucleotide that induces skipping of the exonic sequence that comprises the proteolytic cleavage site, HCHWA-D mutation or trinucleotide repeat expansion, respectively, the method further comprising allowing translation of mRNA produced from the pre-mRNA.