Patents Assigned to D
  • Axially-switchable quick release device
    Patent number: 10273997
    Abstract: An axially-switchable quick release device, including: a rod extending in an axial direction; a clutch shaft disposed at an end of the rod and having a meshing teeth portion and an idling ring portion; and a quick release lever having a fitting portion and a turning portion connected to the fitting portion The fitting portion has a fitting teeth portion sleeved onto the clutch shaft and movable along the axial direction and between a meshing position and an idling position. When the quick release lever is at the meshing position, the fitting teeth portion engages with the meshing teeth portion so that the quick release lever and the clutch shaft can rotate synchronously. When the quick release lever is at the idling position, the fitting teeth portion moves to the idling ring portion so that the quick release lever can rotate freely relative to the clutch shaft.
    Type: Grant
    Filed: October 5, 2016
    Date of Patent: April 30, 2019
    Assignee: J.D COMPONENTS CO., LTD.
    Inventors: Chun-Wei Huang, Chen-Kuie Liu
  • Micro-stimulation and data acquisition from biological cells
    Patent number: 10274452
    Abstract: The present invention relates to a method for fabricating a semiconductor device for stimulation and/or data recording of biological material to a such semiconductor device. The method comprises providing a semiconductor substrate comprising a first insulating layer; providing a patterned conductive layer on top of the first insulating layer; depositing and patterning a second insulating layer atop the patterned conductive layer; growing carbon nano-sheets atop the second insulating layer; and defining carbon nano-sheet electrode areas on the second insulating layer by etching away the carbon nano-sheets outside of the carbon nano-sheet electrode areas.
    Type: Grant
    Filed: June 12, 2013
    Date of Patent: April 30, 2019
    Assignees: IMEC, KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D
    Inventors: Nadine Collaert, Daire J. Cott, Michael De Volder
  • CYS80 conjugated immunoglobulins
    Patent number: 10273310
    Abstract: Provided herein are methods for generating conjugated immunoglobulins, the method comprising: decapping a cysteine at amino acid position 80 (“Cys80”) in a light chain variable region of an immunoglobulin, wherein the immunoglobulin comprises a heavy chain variable region and the light chain variable region; and conjugating a thiol-reactive compound to the Cys80, wherein the thiol-reactive compound comprises a thiol-reactive group. Antigen-binding molecules and methods for generating the same, immunoglobulins as well as nucleic acid molecules encoding the immunoglobulins and host cells comprising the nucleic acid molecules, conjugated immunoglobulins, and light chain variable regions for use in a conjugated immunoglobulin are also provided.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: April 30, 2019
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Luigi Grasso, Jared Spidel, James Bradford Kline, Earl Albone
  • Lightly opening and bufferably closing door closer
    Patent number: 10273732
    Abstract: A door closer includes: a cylinder secured on a door frame and having a cylinder head formed on a proximal end of the cylinder; a main value and a check valve respectively formed on the cylinder head to control the air in-and-out volume through the valves for lightly opening the door; a piston secured to a rod member slidably reciprocating within the cylinder with the rod member secured to a door; a restoring spring secured between the cylinder head and the rod member for normally resiliently restoring the rod member and the piston towards the cylinder head in order to close the door to the door frame normally as restored by the restoring spring; and at least a buffer member secured between the cylinder head and the piston so as to dampen the inertia force of the closing door to eliminate the noise or damage thus possibly caused.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: April 30, 2019
    Assignee: D&D Builders Hardware Co., Ltd.
    Inventor: Tien-Lin Hung
  • Connectors for a windscreen wiper of a vehicle
    Patent number: 10276991
    Abstract: Electrical, hydraulic and mechanical connectors for a windscreen wiper of a vehicle are disclosed. The electrical connector includes a body bearing electrical plugs and detachable fixing means which are configured to cooperate with the mechanical connector. The hydraulic connector does not comprise such means and is fixed to the mechanical connector solely by the interlocking of its small tubes in the mechanical connector. The mechanical connector comprises two substantially parallel tabs having at their free ends notches for the fixing means of the electrical connector to be resiliently clipped thereto.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: April 30, 2019
    Assignee: Valeo Systémes d'Essuyage
    Inventors: Gérald Caillot, Vincent Izabel, Jean-Michel Jarasson, Guillaume Barret, Xavier Bousset, Denis Thebault
  • Method for estimating the dose administered by an external radiotherapy system
    Patent number: 10272268
    Abstract: The invention relates to a method for estimating the dose administered by an external radiotherapy system. The portal image supplied by the EPID detector is converted into a dose at a depth of reference in water, by means of a simple conversion formula. Conversely, the corresponding portal image can be determined from a distribution of a nominal dose, under the same irradiation conditions. The invention can especially be applied to the verification of a treatment plan.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: April 30, 2019
    Assignee: SAS D.R.E.A.M.
    Inventor: Christine Boutry-Duthil
  • BISPECIFIC CHIMERIC ANTIGEN RECEPTORS AND ENCODING POLYNUCLEOTIDES THEREOF
    Publication number: 20190119382
    Abstract: The invention is directed to a bispecific chimeric antigen receptor, comprising: (a) at least two antigen-specific targeting regions; (b) an extracellular spacer domain; (c) a transmembrane domain; (d) at least one co-stimulatory domain; and (e) an intracellular signaling domain, wherein each antigen-specific targeting region comprises an antigen-specific single chain Fv (scFv) fragment, and binds a different antigen, and wherein the bispecific chimeric antigen receptor is co-expressed with a therapeutic control. The invention also provides methods and uses of the bispecific chimeric antigen receptors.
    Type: Application
    Filed: January 4, 2019
    Publication date: April 25, 2019
    Applicant: Seattle Children's Hospital d/b/a Seattle Children's Research Institute
    Inventor: Michael Jensen
  • ADAPTER FOR A MOTOR VEHICLE WINDSCREEN WIPER AND WIPER COMPRISING SUCH AN ADAPTER
    Publication number: 20190118779
    Abstract: The invention proposes an adapter (26) for a wiper (10) comprising a body (25) of elongate shape which is shaped to be mounted in a complementary yoke (28) of inverted U-shaped cross section belonging to a wiper arm, characterized in that the body (1025) of the adapter (1026) comprises at least one elastic tab (1132a, 1132b) which is deformable in the transverse direction so as to retract as the adapter (1026) is being assembled and/or dismantled with respect to the yoke (28), the elastic tab (1132a, 1132b) being borne by a lateral wall (1026a, 1026b) of the body (1025) of the adapter.
    Type: Application
    Filed: October 11, 2018
    Publication date: April 25, 2019
    Applicant: Valeo Systèmes d'Essuyage
    Inventors: Eric Poton, Vincent Gaucher
  • METHODS AND CIRCUITS TO REDUCE POP NOISE IN AN AUDIO DEVICE
    Publication number: 20190123694
    Abstract: A class D amplifier receives and amplifies a differential analog signal which is then differentially integrated. Two pulse width modulators generate pulse signals corresponding to the differentially integrated analog signal and two power units generate output pulse signals. The outputs the power units are coupled to input terminals of integrators via a resistor feedback network. An analog output unit converts the pulse signals to an output analog signal. The differential integration circuitry implements a soft transition between mute/un-mute. In mute, the integrator output is fixed. During the soft transition, the PWM outputs change slowly from a fixed 50% duty cycle to a final value to ensure that no pop noise is present in the output as a result of mode change.
    Type: Application
    Filed: December 17, 2018
    Publication date: April 25, 2019
    Applicant: STMicroelectronics (Shenzhen) R&D Co. Ltd
    Inventors: Ru Feng DU, Qi Yu LIU
  • SOLAR MODULE AND METHOD OF MANUFACTURING THE SAME
    Publication number: 20190123227
    Abstract: A solar module includes an encapsulant and solar cells in the encapsulant. The encapsulant includes a colored encapsulant on one side of the solar cells and a transparent encapsulant on the other side of the solar cells. An interface between the colored encapsulant and the transparent encapsulant is located more on the one side than a main surface of the other side of the solar cells and located more on the other side than a center in a thickness direction of the solar cells.
    Type: Application
    Filed: December 20, 2018
    Publication date: April 25, 2019
    Applicant: Panasonic Intellectual Property Management Co., Lt d.
    Inventor: Masanori MAEDA
  • AN ANTIMICROBIAL COMPOSITION COMPRISING THYMOL, TERPINEOL AND A CATIONIC PHOSPHOLIPID
    Publication number: 20190117538
    Abstract: The present invention relates to an antimicrobial composition and more particularly an antimicrobial composition for leave-on applications. The present invention discloses an antimicrobial composition comprising; a) 0.01 to 2% by weight of thymol; b) 0.01 to 2% by weight of terpineol; and c) 0.1 to 2% by weight of a cationic phospholipid complex.
    Type: Application
    Filed: March 30, 2017
    Publication date: April 25, 2019
    Applicant: Conopco, Inc., d/b/a UNILEVER
    Inventors: Anindya DASGUPTA, Qiong GU, Kevin David HERMANSON, Teanoosh MOADDEL, Neha SALGAONKAR, Bo SHEN, Qiang QIU
  • ANTIBODY RECOGNIZING HUMAN LEUKEMIA INHIBITORY FACTOR (LIF) AND USE OF ANTI-LIF ANTIBODIES IN THE TREATMENT OF DISEASES ASSOCIATED WITH UNWANTED CELL PROLIFERATION
    Publication number: 20190119373
    Abstract: The invention relates to antibodies directed against human Leukemia Inhibitory Factor (LIF) and to a hybridoma cell line producing said antibodies. The invention also relates to a method for blocking/inhibiting the proliferation of stem cells, and to an in vitro method for the diagnosis of diseases associated with unwanted cell proliferation in a subject or for determining the predisposition of a subject to suffer from said disease associated with unwanted cell proliferation, or for prognosis of average life expectancy of a subject suffering from said disease. The therapeutic potential of said antibodies is based on observing that the inhibition of LIF can be used in therapeutic compositions for the treatment of diseases associated with unwanted proliferation.
    Type: Application
    Filed: May 14, 2018
    Publication date: April 25, 2019
    Applicants: FUNDACIO PRIVADA INSTITUT D'INVESTIGACIÓ ONCOLÒGICA VALL D'HEBRON (VHIO), FUNDACIO PRIVADA INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS (ICREA)
    Inventors: Joan Seoane Suarez, Judit Anido Folgueira, Andrea Saez Borderias
  • ADAPTER FOR A MOTOR VEHICLE WINDSCREEN WIPER AND WIPER COMPRISING SUCH AN ADAPTER
    Publication number: 20190118777
    Abstract: The invention proposes an adapter (26) for a wiper (10) comprising a body (25) of elongate shape which is shaped to be mounted in a complementary yoke (28) of inverted U-shaped cross section belonging to a wiper arm, characterized in that the body (25) of the adapter (26) comprises: a locking tab (100, 102) which extends projecting above the upper face of the body (25), which is configured to be received through a hole (39b) in the yoke (28), which bears a rear contact surface (110) for contact with an edge (39b) of the hole (38b) in the yoke (28), and which is connected to the body (25) by an elastically deformable vertical connecting part (114a, 114b).
    Type: Application
    Filed: October 12, 2018
    Publication date: April 25, 2019
    Applicant: Valeo Systèmes d'Essuyage
    Inventors: Eric Poton, Vincent Gaucher
  • 8-AZABICYCLO[3.2.1]OCTANE COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS
    Publication number: 20190119267
    Abstract: The invention provides novel 8-azabicyclo[3.2.1]octane compounds of formula (I): wherein R1, R2, R3, A, and G are defined in the specification, or a pharmaceutically-acceptable salt or solvate thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: August 16, 2018
    Publication date: April 25, 2019
    Applicant: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventors: Daniel D. Long, John R. Jacobsen, Lan Jiang, Daisuke Roland Saito, Ioanna Stergiades
  • METHOD FOR CONTROLLING THE DISTRIBUTION OF THE RF MAGNETIC FIELD IN A MAGNETIC RESONANCE IMAGING SYSTEM
    Publication number: 20190120917
    Abstract: A method for controlling the distribution of the RF magnetic field in a magnetic resonance imaging system, having steps of: placing a cage coil in a permanent magnet supplying a permanent magnetic field along a first axis, and supplying an RF signal to the cage coil in order for the coil to generate an RF magnetic field rotating in a plane that runs perpendicular to the first axis; and putting in place an electromagnetic resonator, the resonance mode of which is excited by the rotating magnetic field, the resonator being placed in a position inside or outside the cage coil and at a distance from a region to be analyzed of an object to be placed in the cage coil, the resonance mode and the position of the resonator in relation to the volumetric antenna being suitable for adjusting the intensity of the rotating magnetic field in an area of the region to be analyzed.
    Type: Application
    Filed: March 29, 2017
    Publication date: April 25, 2019
    Applicants: UNIVERSITÉ D'AIX-MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE CENTRALE DE MARSEILLE, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Redha ABDEDDAIM, Stefan ENOCH, Pierre SABOUROUX, Gérard Henri Jacques TAYEB, Nicolas BONOD, Alexandre Christian VIGNAUD, Benoit LARRAT, Elodie Virginia Emilia GEORGET, Lisa Marie Anna LEROI
  • MECHANICAL PRESS-TYPE SWITCH VALVE CORE
    Publication number: 20190120403
    Abstract: The disclosure provides a mechanical press-type switch valve core, which subverts usage of traditional switch valve core in control of water, switches from rotary switch to press-type switch, and reduces damage of switch handle during use. You can use other parts of body to press the switch (such as arms) when hands are inconvenient in use process. The appearance is relatively simple and generous in the use of the product. The mechanical press-type switch valve core is provided a compression spring between the pressing assembly and the blocking assembly for up-and-down movement acting on the water-blocked rod, and at the same time overcoming water pressure force of the water-blocked rod and O-shape sealing ring when the valve core is opened. The mechanical press-type switch valve core is sealed with the O-shape sealing ring, which is a static seal, and has high sealing life.
    Type: Application
    Filed: December 12, 2017
    Publication date: April 25, 2019
    Applicant: Guangzhou Seagull Kitchen and Bath Products Co.,Lt d.
    Inventors: Shuqi Gao, Qianfeng Peng, Rongbao Wei, Tao Luo
  • PLECTIN-1 BINDING ANTIBODIES AND USES THEREOF
    Publication number: 20190119397
    Abstract: Aspects of the disclosure provide compositions and methods for treating cancer characterized by surface expression of plectin-1. In some embodiments, the disclosure provides anti-plectin-1 antibodies. In some embodiments, the anti-plectin-1 antibodies are conjugated to a targeted moiety (e.g., a therapeutic moiety or a detectable label).
    Type: Application
    Filed: April 7, 2017
    Publication date: April 25, 2019
    Applicant: iTi Health, Inc. d/b/a ZielBio
    Inventors: Kimberly A. Kelly, Julien Dimastromatteo
  • Brush
    Patent number: D846888
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: April 30, 2019
    Assignee: J & D BRUSH CO., LLC
    Inventor: Jeffrey S. Rosenzweig
  • Instrument strap holder
    Patent number: D847016
    Type: Grant
    Filed: July 20, 2017
    Date of Patent: April 30, 2019
    Assignee: D'Addario & Company, Inc.
    Inventor: Zachary Stringham
  • Hook for musical instrument strap
    Patent number: D847252
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: April 30, 2019
    Assignee: D'Addario & Company, Inc.
    Inventor: Zachary Stringham