Abstract: An apparatus dispenses and/or aspirates a predetermined volume of fluid from a chamber. The chamber includes a lower portion for containing fluid and an upper portion for containing gas. The apparatus includes a controllable valve arranged to be in fluid communication with the lower portion of the chamber, a pressure sensor arranged to be in fluid communication with the upper portion of the chamber, a pump configured to be in fluid communication between a source of gas and the upper portion of the chamber, and a controller in operative connection with the controllable valve, the pressure sensor, and the pump. The controller is configured to receive signals from the pressure sensor and to control operation of the pump and operation of the controllable valve based on said signals from the pressure sensor. A method for dispensing and/or aspirating a predetermined volume of fluid utilizes this apparatus.

Abstract: Arm (14) for driving a blade (12) of a wiper (10) of a vehicle, particularly a motor vehicle, comprising an end piece (28) for fixing to the wiper blade, the arm further comprising a spray nozzle (40) for spraying a fluid, such as a washer fluid, characterized in that the spray nozzle is mounted to pivot about a pivot pin which is directly fixed or attached to the said end piece, and in that the said spray nozzle comprises means configured to collaborate with the said blade to cause the spray nozzle to pivot about the said pin.

Abstract: Machinery and methods are described whereby a free flying, remotely operated vehicle (ROV) can safely capture and take on board lightly managed seismic sensor devices (payload) while they are in-transit via a surface vessel in a (deep) water column. ROV payload can be replenished without the need for the ROV to return to the surface vessel to receive additional payload and to do so without the need for heavy launch and recovery machinery. The reverse process of returning payload from the ROV to the surface vessel is also disclosed.

Abstract: A group III-N lateral Schottky diode is disclosed. The diode may include a substrate, a nucleation layer formed on the substrate, a buffer layer formed on the nucleation layer, and a group III-N channel stack formed on the buffer layer. The diode may further include, on the channel stack, a group III-N barrier containing aluminum, where the aluminum content of the barrier decreases towards the channel stack. The diode may further include a passivation layer formed on the group III-N barrier, a cathode formed in an opening through the passivation layer where the opening at least extends to the barrier, and an anode formed in another opening through the passivation layer partially extending into the barrier, the anode forming a Schottky contact with the barrier.

Abstract: A non-transitory processor-readable medium stores code representing instructions configured to cause a processor to send a first signal to cause a client device to display an instruction directing a user to perform a task associated with a user profile of an online entity. The code is configured to cause the processor to produce a query formatted according to an API associated with the online entity. The code is configured to cause the processor to send a second signal including the query to at least one of the client device or the online entity, and receive a third signal including a datum associated with the task. The code is configured to cause the processor to update a status of the indicated task based on the datum, and send a fourth signal to cause the client device to produce an indication associated with the status of the task.

Abstract: The invention relates to a hydraulic connector for a wiper system, said wiper system also comprising a blade holder intended to move a blade over the surface to be wiped, a blade (3) and a mechanical connector (10) fixed to said blade in order to attach it to the blade holder, said hydraulic connector (30) having at least one line (31, 32) for supplying a liquid to the blade (3) via the mechanical connector (10). Said hydraulic connector is characterized in that it comprises at least one guide means (34) able to engage with a corresponding element (14) of the mechanical connector (10) in order to be aligned thereon while the blade (3) is being fitted on the blade holder.

Abstract: In this disclosure, a method is described wherein the method comprises mixing a therapeutic gas or a therapeutic liquid or a combination thereof and a liquid carrier in a high shear device to produce a dispersion; and administering the produced dispersion intravenously to a patient; wherein the produced dispersion contains nanobubbles of the therapeutic gas or droplets of the therapeutic liquid with a mean diameter of less than about 1.5 ?m. In this disclosure, a system is also described wherein the system comprises a therapeutic gas source or a therapeutic liquid source or a combination thereof; a liquid carrier source; a high shear device (HSD) having an inlet, an outlet, at least one rotor, and at least one stator separated by a shear gap; and a pump configured to control the flow rate and residence time of a fluid passing through the high shear device.

Abstract: A method of operating a speaker system including a speaker coupled to an amplifier, and a dedicated digital speaker protection circuit includes turning on the amplifier in a mute mode, after a first delay period, issuing a play command to the amplifier to place the amplifier in a play mode, but without an input signal during a second delay period, and performing a speaker offset detection during the second delay period, wherein, if there is an offset, then the amplifier is forced back into the mute mode, and if there is no offset, then the amplifier is allowed to continue to operate in the play mode. The method also includes issuing a speaker protection control signal or command if an offset is detected.

Abstract: In general, the invention features compounds useful for the synthesis of analogs of halichondrin B, such as eribulin or pharmaceutically acceptable salts thereof, e.g., eribulin mesylate.

Abstract: In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.

Abstract: Apparatus, methods, and computer-readable media are provided for segmentation, processing (e.g., preprocessing and/or postprocessing), and/or feature extraction from tissue images such as, for example, images of nuclei and/or cytoplasm. Tissue images processed by various embodiments described herein may be generated by Hematoxylin and Eosin (H&E) staining, immunofluorescence (IF) detection, immunohistochemistry (IHC), similar and/or related staining processes, and/or other processes. Predictive features described herein may be provided for use in, for example, one or more predictive models for treating, diagnosing, and/or predicting the occurrence (e.g., recurrence) of one or more medical conditions such as, for example, cancer or other types of disease.

Abstract: The invention relates to compounds of formula I: where a, R1, and R3-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

Abstract: The present invention is directed to aminopyridine derived compounds of formula (A) The compounds are considered useful for the treatment of diseases associated with LRRK2 such a Lewy body dementia, Parkinson's disease or cancer.

Abstract: A simple and compact microchemical chip has a fine flow path formed therein through which a specimen is made to flow; is break resistance; makes it possible to flow the fluid sample to the flow path; makes it possible to analyze a useful substance and cause it to react; and can be produced with a high yield. A microchemical chip includes: a rubber sheet having a penetrated flow path which chemically reacts a pressurized fluid sample selected from a specimen and a reagent by flowing thereinto; substrate sheets which sandwich the rubber sheet and bond to both faces thereof by direct bond or by chemical bond through a silane-coupling agent and are selected from metal, ceramics, glass, and resin; and a hole for injecting the fluid sample into the flow path and a hole for draining the fluid sample flowed therefrom which are opened into the substrate sheet.

Abstract: A low dropout amplifier may include an error amplifier having first and second inputs coupled to a reference signal and a feedback signal, respectively. The error amplifier may be configured to generate first and second error signals at first and second outputs, respectively, with the first and second error signals based upon a difference between the reference signal and the feedback signal. A sink stage may be coupled to the first output and configured to generate a sink current based upon the first error signal. A source stage may be coupled to the second output and configured to generate a source current based upon the second error signal. An output node may be coupled to receive the sink and source currents.

Abstract: A sintered refractory product having the form of a block and consisting—of a granulate formed by all the grains having a size larger than 100 ?m, referred to as “coarse grains”, and—a matrix binding said coarse grains and consisting of the grains having a size smaller than or equal to 100 ?m, the granulate representing between 45% and 90% by mass of the product, said product having a composition such that, in a mass percentage based on the oxides: —Al2O3>80%, —SiO2<15%, —Na2O<0.15% —Fe2O3<0.05%, —CaO<0.1%,—the other oxides forming the remainder up to 100%, the Na2O content in the matrix being greater than 0.010%, in a mass percentage based on the mass of the product.

Abstract: The system and method for streaming media to a viewer and managing the media comprises an enhanced service routing processor (ESRP), a real time switch management system (RTSMS), a name routing processor (NRP), and a managed media switch (MMS). The RTSMS has a reservation system. The ESRP receives media from an owner, manages the media according to media rules and order rules defined by the owner, and distributes the media to one or more switches, such as the MMS, according to the media rules and the order rules. The RTSMS is configured to receive the media rules and to receive a viewer's media request via the reservation server. The reservation system of the RTSMS processes the media request according to the media rules and builds a reservation for the requested media. The RTSMS generates the reservation to the viewer and to the NRP. The NRP receives the reservation data from the viewer and from the RTSMS. The NRP processes the reservation data and locates an MMS that can stream the media to the viewer.

Abstract: The present invention provides antibodies directed against ICOS or a derivative thereof which neutralize ICOS engagement on Treg by inhibiting the fixation between ICOS and ICOS-L and abrogate proliferation of Treg induced by plasmacytoid dendritic cells. The present invention further provides antibodies directed against ICOS or a derivative thereof which induce IL-10 and IFN? production, induce CD4+ T cells proliferation, reduce Tconv proliferation, and increase the immunosuppressive function of Treg.

Abstract: A water craft able to offer fast rescue includes a water craft provided with a pressurization pump and a high pressure air reservoir to have air pressurized and poured into the high pressure air reservoir and stored therein. The water craft is formed with a concealed storage space having an uninflated rescue device received therein. The rescue device communicates with the high pressure air reservoir so that the rescue device can be inflated via the high pressure air reservoir. Thus, before inflated, the rescue device can be entirely received in the concealed storage space, letting the water craft have good maneuverability and, after inflated, the rescue device will be ejected out of the concealed storage space for carrying many persons thereon, thus advantageous to carry out rescue mission.