Abstract: The present invention relates to a novel amphiphilic block copolymer and the preparation method thereof, as well as a micellar drug-loaded system formed by said copolymer and an anti-tumor drug. Said amphiphilic block copolymer comprises a hydrophilic segment and a hydrophobic segment, and the end group of said hydrophobic segment is end-capped with a hydrophobic group. Methoxypolyethylene glycol (or polyethylene glycol)-polyester block copolymer which has recognized safety is used as a fundamental material of the amphiphilic block copolymer of the present invention, and the terminal hydroxyl group of the polyester segment is modified with a hydrophobic group, whereby the compatibility between the drug molecule and the hydrophobic segments of the block copolymer is improved, and the interaction therebetween is enhanced. Moreover, a larger space for accommodating the drug molecules is provided.

Abstract: The present invention is directed to aminopyridine derived compounds of formula (A) The compounds are considered useful for the treatment of diseases associated with LRRK2 such as a Lewy body dementia, Parkinson's disease or cancer.

Abstract: Systems and methods to solve combinatorial problems employ a permutation network which may be modeled after a sorting network where comparators are replaced by switches that controllably determine whether inputs are swapped or are left unchanged at the outputs. A quantum processor may be used to generate permutations by the permutation network by mapping the state of each switch in the network to the state of a respective qubit in the quantum processor. In this way, a quantum computation may explore all possible permutations simultaneously to identify a permutation that satisfies at least one solution criterion. The Travelling Salesman Problem is discussed as an example of a combinatorial problem that may be solved using these systems and methods.

Abstract: A 3-d projection system including first and second projectors generates left and right eye image beams. There is a first beam-splitting element to split the left-eye image beam into a primary left-eye image beam and two secondary left-eye image-beams and a second beam-splitting element to split the right-eye image beam into a primary right-eye image beam and two secondary right-eye image beams. The primary and secondary image beams have first and second linear polarization states, respectively. There is a first optical quarter waveplate device configured to receive the primary left-eye image beam and two secondary left-eye image beams and to convert their linear polarization states to a first circular polarization orientation. There is a second optical quarter waveplate device configured to convert the primary right-eye image beam and two secondary right-eye image beams to a second circular polarization orientation. The first and second circular polarization orientations are mutually orthogonal.

Abstract: Wiper blade for windscreen wiper modules for vehicles and in a design as a flat wiper blade, with a wiping rubber forming a wiping lip with at least one spring rail connected to the wiping rubber and in addition with at least one spoiler profile connected to the wiping rubber and to the at least one spring rail and manufactured as an independent profile.

Abstract: [Problem] The purpose of the present invention is to provide a neckband-type earphone that can be worn for a long time without subjecting the wearer to discomfort of wearing a neckband-type earphone, and in which the extent of hazard to the wearer when worn is lowered and locations that break are reduced. [Solution] A neckband-type earphone provided with: earphone parts which are inserted into the pinnae of the wearer and which output an audio signal; ear holder parts which connect to the earphone parts and which abut the upper side of the pinnae of the wearer; holder bodies provided with the ear holder parts; earphone drivers provided with the holder bodies; and a neck band connecting the two earphone drivers; the holder bodies being provided with a cushion part at a portion that comes into contact with the head of the wearer in the vicinity of the pinnae.

Abstract: Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4?-(morpholinomethyl)-[1,1?-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound.

Abstract: A sun-tracking light distributor system for use in one of an open-ended system and a closed photo-bioreactor for a photosynthetic culture having an aqueous liquid is described. The system comprises: two light distribution walls made of a transparent material allowing sunlight to pass therethrough, the two light distribution walls creating an elongated channel with an interior space adapted to receive the sunlight and an exterior surface adapted to be partly immersed in the aqueous liquid in use; and a displacement system operatively connected to at least one of the two light distribution walls, the displacement system being adapted to change an orientation of the at least one of the two light distribution walls to track a solar position with respect to at least one axis.

Abstract: A vehicle front spoiler comprises a flexible airflow guiding element provided in a region of a front part of the vehicle and extending in a transverse direction Y of the vehicle, and an actuating member, configured to move the airflow guiding element relative to said part of the vehicle between an extended operative position and a retracted inoperative position in which the airflow guiding element is folded rearwards to behind said vehicle part. The airflow guiding element is made of a rubber composition comprising an anisotropic textile structure of reinforcement cord having an elongation at break in the Y-direction of from 5% to 50%, and an elongation at break in the Z-direction lower than the elongation at break in the Y-direction, and is readily moved between the operative and the inoperative position with relatively low hysteresis losses.

Abstract: The invention concerns a photoelectric conversion device comprising: at least one photoconversion element comprising at least one organic photoconversion layer or an inorganic layer comprising quantum dots or perovskites; at least a first grating structure arranged on a first side of the photoconversion element; and at least a second grating structure arranged on a second side of the photoconversion element; wherein said at least a first grating structure is arranged so as to direct a near-infra-red light portion of light incident on said first grating structure into said photoconversion element, the said at least a second grating structure being arranged to reflect at least a part of said near-infra-red light portion back into said photoconversion element and to pass visible light out of the photoelectric conversion device.

Abstract: The invention provides a method of assessing the potential colour protecting effect in vivo of a test formulation such as rinse-off hair treatment formulation, the method comprising the steps of: providing a sample of the test formulation to be assessed; providing a model substrate in the form of a hair switch which has been artificially coloured; applying the test formulation to the hair switch; subsequently rinsing the test formulation from the hair switch; collecting the rinse liquor and analysing it for the presence of eluted colour; characterised in that the artificial colour used to colour the hair switch is a permanent hair colorant with a shade level 1 or 2 according to the International Colour Chart (I.C.C.). The method provides improved sensitivity and differentiation, and enables the tester to compare different technologies in terms of effectiveness.

Abstract: A navigation method for a wearer of a see-through head mounted device, the method comprising: •—a wearer visualization parameter providing step (S1), during which at least one wearer visualization parameter is provided, •—a geo-position determining step (S2), during which the geo-position of the wearer along a route is determined, •—a geo-position comparing step during which the geo-position of the wearer determined during the geo-position determining step is compared to stored geo-positions along the route and •—a navigation visual aid function adapting step (S3) during which upon matching of the geo-position of the wearer with one of the stored geo-positions, the navigation visual aid function is adapted based on the wearer vision parameter and the geo-position of the wearer to facilitate the guiding of the wearer

Abstract: optical module for use in a motion responsive system includes a support and a proof mass mechanically coupled and displaceable relative to the support along at least one sensing axis in response to a motion experienced by the support. The module also includes an optical monitoring assembly for monitoring the proof mass with an optical beam impinging on the proof mass, the beam including a plurality of dedicated spectral components. The module further includes an optical spectral filter including a plurality of filtering regions, each being associated with a corresponding dedicated spectral component and having a spectral profile including a distinct dedicated filtering band encompassing the spectral component, such that a displacement of the proof mass along the at least one sensing axis produces, after filtering of the beam, a change in optical power of the spectral components indicative of the motion experienced by the support.

Abstract: The invention relates to a solid cosmetic antiperspirant composition comprising (a) antiperspirant active, (b) hydroxyalkyl urea, and, (c) a carrier material, selected from: a natural oil that comprises a triglyceride of an unsaturated carboxylic acid; polyalkylene glycol; or a mixture thereof; and a method of production of the antiperspirant composition.

Abstract: The present disclosed is directed to systems, methods, and devices for obtaining feedback information from individuals to reveal group preferences and to systems, methods, and devices for enabling providers to provide outcomes which utilize, at least in part, the preferences of the group. For example, a system comprising a plurality of devices, wherein at least one device of the plurality of devices captures at least one feedback in one substantially simple transaction; and the at least one device of the plurality of devices sends the at least one captured feedback to at least one computer; and the at least one computer receives the least one feedback; and the at least one feedback can be given at one or more of the following: periodic time intervals, predefined time intervals, random time intervals, substantially random time intervals and substantially any time.

Abstract: Composite electrodes are disclosed that comprise an active electrode material and a solid electrolyte, wherein the solid electrolyte is a composite electrolyte. The composite electrolyte comprises an electrically insulating material having a plurality of pores and a solid electrolyte material covering inner surfaces of the plurality of pores. The active electrode material may comprise a plurality of active electrode material particles in electrical contact with each other, and the composite electrolyte may be located in spaces between the plurality of active electrode material particles. The present disclosure is further related to solid-state batteries comprising a stack of an anode, a solid electrolyte layer, and a cathode, wherein at least one of the anode and the cathode is a composite electrode according to the present disclosure. The present disclosure further provides methods for fabricating such composite electrodes and solid-state batteries.

Abstract: The invention relates to a process of manufacture of a solid cosmetic antiperspirant in the form of a stick comprising from 0.0005 to 3 wt. % of a hydroxyalkyl urea, the process comprising the steps of comprising: (a) providing a stick dispenser comprising a stick barrel; (b) providing a first mixture comprising a solvent and gellant and heating the mixture to a temperature above the melting point of the gellant; (c) providing a second mixture comprising a hydroxyalkyl urea and a carrier material selected from the group consisting of: a natural oil that comprises a triglyceride of an unsaturated carboxylic acid, and polyalkylene glycols having a molecular weight of up to 650 Daltons, and heating this mixture to a temperature of 65° C. or above; (d) mixing together of the first and second mixtures; (e) addition of an antiperspirant active to the mixture (d); and, (f) filling a stick barrel with a portion of the mixture (e).

Abstract: An adjustable cosmetic applicator including a handle unit with a rod unit coupled thereto and defining a rod with a rod central axis. An applying unit includes a brush rod with a brush central axis and a brush extending from the brush rod. A flexible portion interconnects the rod and the brush rod such that the applying unit may be rotated relative to the rod unit with the brush central axis angled relative to the rod central axis.

Abstract: A splitboard boot binding system with single multi-angle climbing wire. The pivotable climbing wire is configured for use with any compatible ski tour interface, and folds away under the boot binding baseplate when the bindings are transferred to a ride mode interface. In ski tour mode, the baseplate pivots on a toe axis and is supported by the climbing wire when the heel is raised. Advantageously, the climbing wire is very lightweight and seats interchangeably in a plurality of detent positions on a compatible heelblock. There are no interferences with conjoint use of a slide-in crampon seated between the heelblock and the toe pivot or with use in systems having a heel locker. Surprisingly, in some combinations the climbing wire may also be used to retain the slider track in ride mode. The combinations and sub-combinations require no tools for adjustment or operation and operate cooperatively.