Patents Assigned to D
  • Markers for determining tumor hypoxia
    Patent number: 11814688
    Abstract: The present application relates to the field of cancer, particular to hypoxic tumors. It was found that hypoxia is an important driver for hypermethylation of (promoters of) tumor suppressor genes. As this hypermethylation is a stable signature that is also present in circulating tumor DNA in peripheral blood, detecting this methylation pattern is a surrogate marker for tumor hypoxia. This can be used to adapt therapy as well.
    Type: Grant
    Filed: April 25, 2022
    Date of Patent: November 14, 2023
    Assignees: VIB VZW, Katholieke Universiteit Leuven, K.U. Leuven R & D, Life Sciences Research Partners VZW
    Inventors: Diether Lambrechts, Bernard Thienpont
  • Handle bending razor
    Patent number: 11813761
    Abstract: A handle bending razor includes a grip portion, a razor head, and a head coupling portion. The razor head has a blade body, a blade assembly body, a connecting portion, and an elastic support body. The handle bending razor includes a switching mechanism which can change an angle formed by a contact surface and an up-down direction and, when an external force is not applied, switches between a first state in which a neutral angle formed by the contact surface and the up-down direction is a first angle, and the contact surface and the up-down direction become substantially parallel and a second state in which the neutral angle is a second angle larger than the first angle. In the second state, when the external force is applied, the blade assembly body is tiltable to a position where the contact surface and the up-down direction become substantially perpendicular.
    Type: Grant
    Filed: March 22, 2021
    Date of Patent: November 14, 2023
    Assignee: KAI R&D CENTER CO., LTD.
    Inventor: Masashi Usuda
  • SURGICAL GUIDE AND FIXATION INSERTION DEVICE
    Publication number: 20230355250
    Abstract: A surgical guidance device is cannulated for passage of a guidewire or pin and includes a hand grip and differential control assembly for driving the guidewire or pin and differentially driving a screw, such as but not limited to a pedicle screw, into bone. The differential control assembly resides in a housing, and includes a differential control assembly for gripping and locking or releasing the guidewire or pin and effecting directional movement (relative to the user holding the surgical guidance device) either distally into the bone or proximally away from bone to thereby drive or retract the guidewire. The differential control assembly also allows distal or proximal drive of a screw, such that one or both the guidewire and screw can be passed proximally or distally alone or together.
    Type: Application
    Filed: April 12, 2023
    Publication date: November 9, 2023
    Applicant: INTEGRITY IMPLANTS INC. d/b/a ACCELUS
    Inventors: Wyatt Drake GEIST, John SOUZA, SR.
  • STATE-OF-CHARGE INDICATOR
    Publication number: 20230358816
    Abstract: A pluggable state-of-charge (SOC) indicator and methods of use are disclosed. The pluggable SOC indicator includes at least one voltage input jack for connecting to a battery, at least one instance of control electronics, and at least one SOC indicator, such as a 5-bar liquid crystal display (LCD). Embodiments of the pluggable SOC indicator include, but are not limited to, a pluggable single-connector SOC indicator, a pluggable dual-connector SOC indicator, a pluggable tri-connector SOC indicator, and a pluggable quad-connector SOC indicator. Further, the control electronics are programmable for any input voltage range and/or battery discharge characteristics.
    Type: Application
    Filed: July 18, 2023
    Publication date: November 9, 2023
    Applicant: LAT Enterprises, Inc., d/b/a MediPak Energy Systems
    Inventor: Laura Thiel
  • FLUID SPRAYING DEVICE FOR CLEANING A SURFACE OF A MOTOR VEHICLE
    Publication number: 20230356240
    Abstract: The present invention relates to a fluid spraying device for a system for cleaning a surface of a motor vehicle, the spraying device includes a solenoid valve configured to allow or prevent the passage of fluid towards a spraying member, the solenoid valve includes a hydraulic system and an electromagnetic system, the hydraulic system includes at least one fluid dispensing member that includes at least a fluid inlet end-fitting, a circulation chamber and a fluid outlet end-fitting in fluid communication with the spraying member, the electromagnetic system being configured to allow or prevent the passage of fluid through the circulation chamber, and the spraying member includes at least a connecting tube and a spray nozzle, the connecting tube being fastened directly to the fluid outlet end-fitting.
    Type: Application
    Filed: July 30, 2021
    Publication date: November 9, 2023
    Applicant: VALEO SYSTEMES D'ESSUYAGE
    Inventors: Maxime BAUDOUIN, Giuseppe GRASSO, Denis THEBAULT, Yoann DOLLE, Adrien PERET
  • BONE GRAFT DELIVERY SYSTEM AND METHOD FOR USING SAME
    Publication number: 20230355407
    Abstract: The present disclosure relates to kits for bone graft delivery, and specifically, for near-simultaneous and integrated delivery of bone graft material during the placement of surgical cages or other medical implants in a patient's spine. The kits include integrated fusion cage and graft delivery devices that deliver and disperse biologic material through a fusion cage to a disc space and, that may, without withdrawal from the surgical site, allow for selectively detaching the fusion cage for deposit to the same disc space. The integrated fusion cage and graft delivery device is formed such that a hollow tube and plunger selectively and controllably place bone graft material and a fusion cage in or adjacent to the bone graft receiving area. The kits also include a cover plate that secures to the fusion cage.
    Type: Application
    Filed: July 6, 2023
    Publication date: November 9, 2023
    Applicant: Spinal Surgical Strategies, Inc., A Nevada Corporation D/B/A Kleiner Device Labs
    Inventors: Jeffrey Kleiner, Edward J. Grimberg, JR., Gregory Causey, Alan Burkholder
  • METHOD FOR SELECTING PERSONALIZED SKIN CARE COMPOSITION
    Publication number: 20230355502
    Abstract: Disclosed is a method for selecting a personalized skin care composition for the benefit of pore reduction for an individual, the method comprising the steps of determining the color of a skin surface in need of treatment of the individual, and choosing a skin care composition having substantially same color as the skin surface in need of treatment.
    Type: Application
    Filed: November 23, 2021
    Publication date: November 9, 2023
    Applicant: Conopco, Inc., d/b/a UNILEVER
    Inventors: Chenyang FU, Lei SUN, Xiaoli WANG
  • LENGTH ADJUSTABLE MODULAR SCREW SYSTEM
    Publication number: 20230355286
    Abstract: A length adjustable modular screw includes a neck assembly and a shank. The neck assembly has proximal and distal ends and includes an expander component and a collet component that are slidably engagable by insertion of the expander component in a through channel of the collet component along a common axis. The length adjustable modular screw also includes a shank suitable for insertion and retention within a bone, the shank including a threaded portion between proximal and distal ends and a socket adapted to coaxially receive at least a portion of the distal end of the neck assembly. The length adjustable modular screw has a length that is selected by splaying at least a portion of the distal end of the engaged expander and collet components of the neck assembly within the socket of the shank.
    Type: Application
    Filed: April 11, 2023
    Publication date: November 9, 2023
    Applicant: INTEGRITY IMPLANTS INC. d/b/a ACCELUS
    Inventors: Wyatt Drake GEIST, John SOUZA, SR.
  • MACROCYCLIC COMPOUND
    Publication number: 20230357271
    Abstract: A compound represented by the general formula (1) or a salt thereof, which has a superior IRAK-4 inhibitory activity, and is useful as active ingredients of medicaments for prophylactic treatment and/or therapeutic treatment of diseases relating to IRAK-4 inhibition.
    Type: Application
    Filed: September 30, 2020
    Publication date: November 9, 2023
    Applicants: Asahi Kasei Pharma Corporation, Vernalis (R&D) Limited
    Inventors: Takahiko ITO, Misato TAKASHIMA, Masakazu ATOBE, Koichiro ARAI, Tomohisa TOYAMA, Yu YOSHII, Andrew John POTTER, Daniel Paul MADDOX, Stuart RAY, Nicolas FOLOPPE
  • Cellular microcompartment and preparation processes
    Patent number: 11807870
    Abstract: The invention relates to a cellular microcompartment comprising successively, organized around a lumen, at least one layer of pluripotent cells, an extracellular matrix layer and an outer hydrogel layer. The invention also relates to processes for preparing such cellular microcompartments.
    Type: Grant
    Filed: November 23, 2017
    Date of Patent: November 7, 2023
    Assignees: UNIVERSITE DE BORDEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT D'OPTIQUE THEORIQUE ET APPLIQUEE
    Inventors: Maxime Feyeux, Kevin Alessandri, Pierre Nassoy, Laurent Cognet, Gaëlle Recher, Erwan Bezard
  • Chromatographic methods for purification of proteins from plasma
    Patent number: 11807666
    Abstract: The present invention relates to the field of chromatography. More closely, the invention relates to a chromatographic method for purification of proteins, such as Factor VIII, von Willebrand factor and Factor IX. The chromatographic method is performed on a matrix comprising an inner porous core and outer porous lid surrounding said core.
    Type: Grant
    Filed: November 29, 2022
    Date of Patent: November 7, 2023
    Assignee: Cytiva BioProcess R&D AB
    Inventors: Martin Hall, Karolina Busson, Jean-Luc Maloisel, Helena Skoglar
  • Vehicle seat with compensation system
    Patent number: 11807136
    Abstract: A seat comprising a temperature or a humidity sensor, a foam and a measurement system comprising a capacitive sensor in contact with the foam and adapted for measuring pressure exerted on the foam by the user, a compensation suited to the measured pressure being determined based on a temperature or a humidity provided by the temperature or the humidity sensor.
    Type: Grant
    Filed: July 14, 2020
    Date of Patent: November 7, 2023
    Assignee: FAURECIA Sièges d'Automobile
    Inventor: Mamadou Saliou Balde
  • Oral use of coriander seed oil for a soothing effect on reactive skin
    Patent number: 11806377
    Abstract: An oil from seeds of at least one umbelliferous plant, coriander, in ingestible form for preventing or slowing the appearance of dysesthetic sensations on sensitive human skin.
    Type: Grant
    Filed: May 2, 2019
    Date of Patent: November 7, 2023
    Assignee: SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC
    Inventor: Catherine Kern
  • Multistage micromechanical timepiece and method for making same
    Patent number: 11809136
    Abstract: A micromechanical timepiece, and a method for making the same, having a plurality of mutually secured functional sub-assemblies stacked in a direction (Z) to form a multistage assembly, wherein each functional sub-assembly comprises a single semiconductor material and is secured to another sub-assembly via bridges made of the semiconductor material, and in that at least one sub-assembly comprises at least two portions, the portions being movable relative to each other and relative to another sub-assembly to which at least one of the portions is secured via at least one deformable link integrally formed between the portions.
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: November 7, 2023
    Assignee: CSEM Centre Suisse d'Electronique et de Microtechnique SA—Recherche et Développment
    Inventors: Michel Despont, Philippe Niedermann
  • PROCESS FOR THE MANUFACTURE OF AN AQUEOUS DISPERSION COMPRISING MUSTARD BRAN AND OIL-IN-WATER EMULSION CONTAINING SUCH DISPERSION
    Publication number: 20230345987
    Abstract: This relates to an aqueous dispersion comprising mustard bran and water in which a high pressure homogenisation treatment has been applied to alter the sugar moiety ratio of the mustard bran particles. Thus mustard bran is in the form of particles. This aqueous dispersion can be used to structure an emulsion.
    Type: Application
    Filed: July 10, 2023
    Publication date: November 2, 2023
    Applicant: Conopco, Inc., d/b/a UNILEVER
    Inventors: Edwin BERGWERFF, Jadwiga Malgorzata BIALEK, Stephan Georg SCHUMM, Jacob NIJSSE
  • MULTIPLE CIRCUIT BOARD TESTER
    Publication number: 20230349966
    Abstract: The present invention is directed to a system for testing printed circuit boards. The system is configured to test the simultaneously test a multiplicity of printed circuit boards. The system examines the electrical characteristics of a printed circuit board and is operable to identify if a printed circuit board meets a desired characteristic.
    Type: Application
    Filed: July 12, 2023
    Publication date: November 2, 2023
    Applicant: LAT Enterprises Inc., d/b/a MediPak Energy Systems
    Inventors: Laura Thiel, Carlos Cid, Michael Tran, Giancarlo Urzi
  • CHIMERIC ANTIGEN RECEPTORS (CARS) TARGETING NATURAL KILLER CELLS
    Publication number: 20230348854
    Abstract: The current disclosure provides chimeric antigen receptors (CARs) that bind a natural killer (NK) cell surface marker, resulting in destruction of the bound NK cell. The NK cell surface markers include an activating NK cell receptor, and an inhibitory NK cell receptor. Cells that are genetically modified to express these CARs and uses of the CAR modified cells are also described.
    Type: Application
    Filed: May 7, 2021
    Publication date: November 2, 2023
    Applicant: Seattle Children's Hospital d/b/a Seattle Children's Research Institute
    Inventors: Thor Wagner, Floriane Ngako Kameni
  • PACKAGING FOR PERFUME PARTICLES
    Publication number: 20230348821
    Abstract: A packaged laundry product comprising packaging and perfume particles contained in said packaging; wherein the packaging comprises a cylindrical receptacle formed from a material comprising cellulosic fibres, wherein the receptacle comprises a mechanism for impeding a child's access to the container; and wherein the perfume particles comprise carrier material and perfume components.
    Type: Application
    Filed: September 15, 2021
    Publication date: November 2, 2023
    Applicant: Conopco, lnc., d/b/a UNILEVER
    Inventors: Ross David ASHTON, Geoffrey Stephen MAWTUS, Kieran Dean OWENS, Jessica Frances Sophia PEAKE, Mark Lee VERHAEGE, Christopher Paul WEIR, Glen James WILLIAMS
  • TREATMENT OF NEUROMUSCULAR DISEASES VIA GENE THERAPY THAT EXPRESSES KLOTHO PROTEIN
    Publication number: 20230346977
    Abstract: The present disclosure provides gene constructs containing a nucleic acid sequences encoding a mammalian s-KL, operatively linked to a muscle cell-specific promoter, for use in the treatment of motor impairment that may manifest, for example, in a neuromuscular disorder or disease, utilizing viral and non-viral vectors with muscle cell and motor neuron tropisms containing gene constructs containing a nucleic acid sequence encoding a mammalian s-KL, operatively linked to a promoter such as a muscle cell-specific promoter, is delivered in pharmaceutical compositions containing the expression vector, isolated cells containing the expression vector, and methods of treating motor impairment and motor neuron diseases.
    Type: Application
    Filed: April 13, 2023
    Publication date: November 2, 2023
    Applicants: Universitat Autònoma de Barcelona, Consorcio Centro de Investigación Biomédica en Red, Institució Catalana de Recerca i Estudis Avançats, Fundació Hospital Universitari Vall d’Hebron-Institut de Recerca
    Inventors: Assumpció Bosch Merino, Sergi Verdés Franquesa, Mireia Herrando Grabulosa, Xavier Navarro Acebes, Miguel Chillon Rodriguez
  • Davit structural beam
    Patent number: D1004140
    Type: Grant
    Filed: November 12, 2021
    Date of Patent: November 7, 2023
    Assignee: SAYFA R&D PTY LTD
    Inventors: Barry Voss, Murray Voss