Patents Assigned to Daiichi Pharmaceutical Co., LTD
  • Process for preparing halogenated cyclopropane derivatives
    Patent number: 6596898
    Abstract: A process for preparing compounds represented by the following general formula (I) wherein X represents chlorine atom, bromine atom, or iodine atom, and R includes alkoxy group and amino group which comprises the step of allowing a compound represented by the formula: CH2═CXF react with a compound represented by the formula: N2CHCOR in the presence of a catalyst containing a metal atom such as a transition metal of group 8 together with chiral carboxylic-type or amide-type ligands to preferentially obtain a stereoisomer of the compound of the general formula (I) wherein the stereochemical configuration at the 1-position is S-configuration
    Type: Grant
    Filed: February 27, 1998
    Date of Patent: July 22, 2003
    Assignees: Daiichi Pharmaceutical Co., Ltd., Sumitomo Chemical Co., Ltd.
    Inventors: Tsutomu Ebata, Toshifumi Akiba, Takanobu Ikeya, Ryuhei Wakita, Mikio Sasaki
  • Preventives/remedies for multiple organ failure
    Patent number: 6596754
    Abstract: The present invention relates to a preventive and/or therapeutic drug for hypercytokinemia, liver diseases, and syndromes caused by the aggravation of sepsis, containing an anti-thrombin agent and/or a thrombin production inhibitor as an active ingredient. The present invention is applicable to prevention of or therapy for diseases such as sepsis, severe sepsis, septic shock, and multiple organ dysfunction syndrome. More particularly, the present invention is useful for an emergency medical service, for treatment of injury caused by a traffic accident, burns, heat attacks, or severe infective diseases. In addition, the present invention is useful for prevention and treatment for hypercytokinemia and liver diseases.
    Type: Grant
    Filed: March 2, 2001
    Date of Patent: July 22, 2003
    Assignee: Daiichi Pharmaceuticals Co., Ltd.
    Inventors: Tsuyoshi Hara, Kazuko Fujiwara
  • Novel benzothiophene derivatives
    Publication number: 20030130340
    Abstract: The present invention relates to novel benzothiophene derivatives represnted by the following formula (I) or salts thereof, inhibitors of steroid 17&agr;-hydroxylase and/or C17-20 lyase, and pharmaceutical compositions containing the benzothiophene derivative or the salt.
    Type: Application
    Filed: November 18, 2002
    Publication date: July 10, 2003
    Applicant: Daiichi Pharmaceutical Co. Ltd.
    Inventors: Shin?apos;ichi Shimada, Shin Nomoto, Masayuki Okue, Ken?apos;ichi Kimura, Junji Nakamura, Yoshikazu Ikeda, Takeko Takada
  • Tricyclic amine derivatives
    Patent number: 6586604
    Abstract: The present invention relates to a compound having a tricyclic amine substituent which may have various substituents, the compound being represented by formula (I), a salt or hydrate thereof, and a hydrate of the salt and a drug containing them as an active ingredient. They exhibit excellent antimicrobial activity against Gram negative bacteria and Gram positive bacteria with a satisfactory fate and safety and are useful in the treatment of infectious diseases.
    Type: Grant
    Filed: June 8, 2001
    Date of Patent: July 1, 2003
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Makoto Takemura, Hisashi Takahashi, Kenichi Kimura, Rie Miyauchi, Hitoshi Ohki, Katsuhiro Kawakami
  • Cycloalkyl-substituted aminomethylpyrrolidine derivatives
    Patent number: 6573260
    Abstract: This invention provides a quinolone derivative which exerts strong antibacterial action upon various bacteria and has high safety, and it relates to a compound having a structure of formula (I), its salts and hydrates thereof: {R1 and R2: hydrogen, alkyl; n: 1 to 4; Q: following structure (Ia): [R3: alkyl, alkenyl, halogenoalkyl, cyclic alkyl, aryl, heteroaryl, alkoxyl, alkylamino; R4: hydrogen, alkylthio; R5: hydrogen, amino, hydroxyl, thiol, halogenomethyl, alkyl, alkenyl, alkynyl, alkoxyl; X1: halogen, hydrogen, A1: nitrogen, structure of formula (II): (X2: hydrogen, amino, halogen, cyano, halogenomethyl, halogenomethyl, alkyl, alkenyl, alkynyl, alkoxyl; R4 and R3 or X2 and R3 may together form a cyclic structure; Y: hydrogen, various ester forming groups]}.
    Type: Grant
    Filed: May 24, 2001
    Date of Patent: June 3, 2003
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Makoto Takemura, Hisashi Takahashi, Rie Miyauchi, Toshiyuki Takeda, Isao Hayakawa
  • Pyrazole derivatives and salts thereof
    Patent number: 6573377
    Abstract: This invention provides compounds having antitumor effect, namely a compound represented by the following formula (I) or (Ia) having various substituents in which G and G1 are condensed tricyclic heterocyclic rings or salts thereof, and a compound represented by the following formula (Ib) having various substituents or salts thereof.
    Type: Grant
    Filed: January 24, 2001
    Date of Patent: June 3, 2003
    Assignee: Daiichi Pharmaceuticals Co., Ltd.
    Inventors: Akio Ejima, Satoru Ohsuki, Hitoshi Ohki, Hiroyuki Naito, Chie Makino
  • Drug efflux pump inhibitor
    Publication number: 20030092720
    Abstract: A medicament for preventive and/or therapeutic treatment of a microbial infection which comprises as an active ingredient a compound represented by the following general formula (I): 1
    Type: Application
    Filed: April 26, 2001
    Publication date: May 15, 2003
    Applicant: DAIICHI PHARMACEUTICAL CO., LTD
    Inventors: Kiyoshi Nakayama, Masami Ohtsuka, Haruko Kawato, William Watkins, Jason Zhang, Monica Palme, Aesop Cho
  • Dihydronaphthalene compounds
    Patent number: 6559157
    Abstract: Dihydronaphthalene compounds have excellent 17&agr;-hydroxylase/C17-20-lyase inhibiting activity, thromboxan A2 synthesis inhibiting activity, and aromatase inhibiting activity and are thereby are useful as preventive and/or therapeutic agents for various male sex hormone- and female sex hormone-dependent diseases such as prostate cancer, prostatomegaly, masculinization, breast cancer, mastopathy, uterine cancer, endometriosis, and ovarian cancer, as well as myocardial infarction, angina pectoris, and bronchial asthma.
    Type: Grant
    Filed: May 25, 2001
    Date of Patent: May 6, 2003
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Rolf Wolfgang Hartmann, Bertil Wachall, Makoto Yoshihama, Masamichi Nakakoshi, Shin Nomoto, Yoshikazu Ikeda
  • Methods using TCF II
    Publication number: 20030082134
    Abstract: The present invention provides an agent for preventing and/or treating cachexia comprising T-CF-II as an effective ingredient. An agent for preventing and treating cachexia caused by cancer, acquired immunodeficient syndrome (AIDS), cardiac diseases, infectious disease, shock, burn, endotoxinemia, organ inflammation, surgery, diabetes, collagen diseases, radiotherapy, chemotherapy is provided by the present invention.
    Type: Application
    Filed: October 9, 2002
    Publication date: May 1, 2003
    Applicant: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Masamichi Kojiro, Hirohisa Yano, Akihiro Iemura
  • VLA-4 inhibitor compounds
    Publication number: 20030078249
    Abstract: Compounds that selectively inhibit the binding of ligands to &agr;4&bgr;1 integrin (VLA-4) and methods for their preparation are disclosed.
    Type: Application
    Filed: December 28, 2001
    Publication date: April 24, 2003
    Applicant: Daiichi Pharmaceutical Co., LTD.
    Inventors: John J. Baldwin, Edward McDonald, Kevin Joseph Moriarty, Christopher Ronald Sarko, Nobuo Machinaga, Atsushi Nakayama, Jun Chiba, Shin Iimura, Yoshiyuki Yoneda
  • Pyrazole derivatives
    Patent number: 6552018
    Abstract: The present invention relates to cis- and trans-forms of pyrazole derivatives, salts thereof, or agents containing the same, and represented by the general formula (I): wherein G represents a nitrogen containing saturated heterocyclic structure represented by the following formula: These compounds exhibit anti-tumor activity on 5-FU-resistant tumors and effects on P glycoprotein expressing, multiple-drug resistant tumors. An example of a pyrazole derivative which demonstrates 50% inhibition of tumor cell growth is 3-[4-(3-chloro-5-fluorophenyl)-1piperazinyl]-1-[1-(3-chloro-2-pyridyl)-5-methyl-4-pyrazolyl)-1-trans-propene hydrochloride. Synthesis of the compounds represented by formula (I) can be prepared by any one of various routes such as a Mannich reaction, a Wittig reaction, reductive amination or substitution by allylation.
    Type: Grant
    Filed: October 17, 2000
    Date of Patent: April 22, 2003
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Akio Ejima, Satoru Ohsuki, Hitoshi Ohki, Hiroyuki Naito
  • Condensed-hexacyclic compounds and a process therefor
    Patent number: 6552197
    Abstract: Disclosed are a process for the preparation of a compound represented by the formula (1), which comprises treating a compound represented by the formula (2) with methanesulfonic acid and then subjecting the thus-treated compound to recrystallization; and Compound (1) so obtained. This Compound (1) is free of hygroscopicity, excellent in filterability and solubility and easy in handling. Furthermore, according to the preparation process of the present invention, an unnecessary isomer can be converted into the target one and separation of the target isomer can be conducted easily.
    Type: Grant
    Filed: June 11, 2001
    Date of Patent: April 22, 2003
    Assignees: Daiichi Pharmaceutical Co., Ltd., Kabushiki Kaisha Yakult Honsha
    Inventors: Shinji Kamihara, Kazuaki Kanai, Shigeru Noguchi, Hirofumi Terasawa, Hiroaki Kitaoka
  • Novel protein and gene encoding the protein
    Publication number: 20030073117
    Abstract: A novel mechanosensitive channel protein derived from mouse or humans which is expressed specifically in the kidney and has the function of non-selectively transporting cation into cells in response to a mechanical stimulus; a DNA encoding these proteins; a method of screening cation channel activity activators or inhibitors with these proteins; and antibodies to these proteins. The above-described proteins are useful as a diagnostic agent or a therapeutic agent for diseases based on abnormalities in the cation channel, such as hypertension or diabetes, or as a tool for screening chemicals for preventing and/or treating these diseases.
    Type: Application
    Filed: August 23, 2002
    Publication date: April 17, 2003
    Applicant: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Makoto Suzuki, Ken?apos;ichi Ishibashi
  • Pentacyclic compound
    Patent number: 6545151
    Abstract: The present invention relates to a novel taxol derivative having an antitumor-activity which is represented by formula (1). [In the formula (I), R1: a phenyl group, R2: an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group or an alkoxyl group, R3: a hydrogen atom, a hydroxyl group, a halogen atom, an alkoxyl group, a group —O—R31, an acyloxy group or a group —O—CO—R31 (in which R31: an alkylamino group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group or a heterocyclic group), R4 and R5: a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group or a heterocyclic group, Z1: a hydrogen atom, a hydroxyl group, a halogen atom or an alkyl group, Z2: a hydrogen atom, a hydroxyl group, a halogen atom or an alkyl group, Z3: an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group or a heterocyclic group].
    Type: Grant
    Filed: January 16, 2001
    Date of Patent: April 8, 2003
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Hirofumi Terasawa, Tsunehiko Soga, Takashi Ishiyama
  • Novel antibiotics RK-1061 and process for preparing the same
    Publication number: 20030050471
    Abstract: Antibiotics RK-1061s having a novel chemical structure and a method of production thereof.
    Type: Application
    Filed: August 5, 2002
    Publication date: March 13, 2003
    Applicant: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Ken-Ichi Kimura, Yoshikazu Ikeda, Shinobu Kagami, Hidetoshi Takahashi, Kousaku Takahashi, Makoto Yoshihama, Makoto Ubukata, Kiyoshi Isono
  • Sulfonyl derivatives
    Patent number: 6525042
    Abstract: Sulfonyl derivatives represented by general formula (I), salts of the same, and solvates of both: and application of them as drugs: [wherein R1 is hydrogen, hydroxyl, nitro or the like; R2 and R3 are each independently hydrogen, halogeno or the like; R4 and R5 are each dependently hydrogen, halogeno or the like; Q1 is an optionally substituted saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group or the like; Q2 is a single bond, oxygen or the like; Q3 is, e.g., a group represented by formula (a): T1 is carbonyl or the like; and X1 and X2 are each independently methylidyne or nitrogen]. These compounds exhibit potent Fxa inhibiting activities and serve as excellent anticoagulants which speedily exert satisfactory and persistent anti-thrombotic effects through oral administration and little cause adverse effects.
    Type: Grant
    Filed: March 28, 2000
    Date of Patent: February 25, 2003
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Syozo Kobayashi, Satoshi Komoriya, Masayuki Ito, Tsutomu Nagata, Akiyoshi Mochizuki, Noriyasu Haginoya, Takayasu Nagahara, Haruhiko Horino
  • Process for preparing 2-phenyl-3-naphthylpropionic acid derivatives
    Patent number: 6515142
    Abstract: A process for preparing a compound represented by general formulae (5) and (6) in the following reaction scheme or salts thereof, wherein R1 represents a protective group for a nitrogen atom; R2 represents a methanesulfonyl group or p-toluenesulfonyl group; R1 represents a hydrogen atom, an aralkyl group, or an alkyl group having 1 to 6 carbon atoms; and X represents a halogen atom. The above process is useful as an industrial process for preparing intermediates of anticoagulant aromatic amidine derivatives described in Japanese Patent Application Laid-Open (kokai) No. 208946/1993.
    Type: Grant
    Filed: November 7, 2001
    Date of Patent: February 4, 2003
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Yukio Yokoyama, Tatsuya Kobayashi, Takeo Koyama
  • Condensed-hexacyclic compounds and a process therefor
    Patent number: 6504029
    Abstract: Disclosed are a process for the preparation of a compound represented by the formula (1), which comprises treating a compound represented by the formula (2) with methanesulfonic acid and then subjecting the thus-treated compound to recrystallization; and Compound (1) so obtained. This Compound (1) is free of hygroscopicity, excellent in filterability and solubility and easy in handling. Furthermore, according to the preparation process of the present invention, an unnecessary isomer can be converted into the target one and separation of the target isomer can be conducted easily.
    Type: Grant
    Filed: July 13, 1995
    Date of Patent: January 7, 2003
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Shinji Kamihara, Kazuaki Kanai, Shigeru Noguchi, Hirofumi Terasawa, Hiroaki Kitaoka
  • Remedies for diseases caused by insulin resistance
    Patent number: 6498139
    Abstract: The present invention provides methods of inhibiting or sequestering 14-3-3 protein from binding to the insulin receptor substrate −1 or −2 by administering a substance which inhibits the interaction of these two proteins.
    Type: Grant
    Filed: March 29, 2000
    Date of Patent: December 24, 2002
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Yoshio Yazaki, Tomoichiro Asano, Hideo Kubo, Akira Kanda
  • Process for producing 5-amino-8-alkylquinolonecarboxylic acid derivative and intermediates in the production thereof
    Publication number: 20020193591
    Abstract: The present invention provides a process for producing intermediates of antibacterial agents in accordance with the following steps and intermediates in the production thereof.
    Type: Application
    Filed: July 11, 2002
    Publication date: December 19, 2002
    Applicant: DAIICHI PHARMACEUTICAL CO., LTD.
    Inventors: Makoto Takemura, Hisashi Takahashi