Patents Assigned to Daiichi Pharmaceutical Co., LTD
  • Pharmaceutical composition
    Publication number: 20050152975
    Abstract: The present invention relates to a granular pharmaceutical composition comprising a drug having a disagreeable taste, a wax and a sugar alcohol; a method for preparing the same; and a pharmaceutical product for oral administration, comprising the granular composition. The product excellently masks a disagreeable taste possessed by a drug and provides good sensation upon oral administration, and therefore is easily ingested by even the elderly, children, and patients suffering dysphagia. Moreover, the product is suitable for administration using tube.
    Type: Application
    Filed: October 7, 2004
    Publication date: July 14, 2005
    Applicant: DAIICHI PHARMACEUTICAL CO., LTD.
    Inventors: Hiroaki Nakagami, Tatsuya Suzuki, Hideo Kobayashi, Akira Kurosawa
  • Process for porducing quinolonecarboxylic acid derivative
    Publication number: 20050143407
    Abstract: Through a production process according to the following reaction scheme, compounds (2) which are useful for antibacterial agents can be provided at low cost and high yield.
    Type: Application
    Filed: May 16, 2003
    Publication date: June 30, 2005
    Applicant: DAIICHI PHARMACEUTICAL CO., LTD
    Inventors: Naoki Ohta, Toshifumi Akiba
  • Quinolonecarboxylic acid derivative
    Patent number: 6900225
    Abstract: (?)-7-[(7S)-7-Amino-5-azaspiro[2.4]heptan-5-yl]-6-fluoro-1-[(1R, 2S)-2-fluoro-1-cyclopropyl]-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid.1HCl.1H2O and antibacterial compositions containing this compound. The compound of the present invention exhibits not only excellent antibacterial activity and safety, but also remarkable stability against light and humidity, and is thus useful as an antibacterial agent.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: May 31, 2005
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Makoto Takemura, Hisashi Takahashi, Katsuhiro Kawakami, Masao Itoh, Tetsuya Suzuki, Tsuyoshi Ohtani, Masayasu Sekiguchi, Rie Miyauchi, Isao Hayakawa
  • Process for producing benzoxazine derivative and production intermediate thereof
    Patent number: 6872823
    Abstract: Processes for producing antibacterial agents and intermediates useful in producing antibacterial agents are provided and include producing compound (VI-a) in accordance with the following reaction schema, as well as production intermediates thereof.
    Type: Grant
    Filed: September 7, 2000
    Date of Patent: March 29, 2005
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Kouji Sato, Yoshihiro Takayanagi, Katsuhiko Okano, Keiji Nakayama, Akihiro Imura, Mikihiro Itoh, Tsutomu Yagi, Yukinari Kobayashi, Tomoyuki Nagai
  • Drugs for liver diseases
    Publication number: 20050053603
    Abstract: Preventives and/or remedies for liver diseases, which comprise monocyte chemoattractant protein-1 (MCP-1) function inhibitors as active ingredients, respectively. Administration of the MCP-1 function inhibitors brings about effects in preventing and/or remedying liver diseases.
    Type: Application
    Filed: September 28, 2001
    Publication date: March 10, 2005
    Applicant: DAIICHI PHARMACEUTICAL CO., LTD
    Inventors: Kensuke Egashira, Akira Takeshita, Masamichi Koyanagi, Makoto Nakamuta, Ken-ichi Nishida
  • Highly absorptive solid preparation
    Patent number: 6861071
    Abstract: A solid preparation improved in oral absorption and reduced in fluctuations of oral absorption can be obtained by incorporating an organic acid, particularly tartaric acid, in a solid preparation having, as an active ingredient, a high content of a quinolone compound, particularly sitafloxacin, having poor water solubility at pH around neutrality.
    Type: Grant
    Filed: August 7, 2001
    Date of Patent: March 1, 2005
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Katsuo Kataoka, Hiroshi Kikuchi, Tatsuya Suzuki, Takahiro Shimaya, Hideo Kobayashi, Akira Kurosawa, Koichi Ishido
  • Novel protein and processes for producing the same
    Publication number: 20050026253
    Abstract: A novel protein and a process of producing the protein is provided. The protein is a glycoprotein having activity of suppressing the differentiation and/or maturation of adipocyte, having a molecular weight of about 45 kD under non-reducing conditions and about 28 kD and/or 23 kD under reducing conditions, and exhibiting affinity to heparin. A process of producing the protein comprising culturing human fibroblasts and purifying the culture broth by chromatography using an ion exchange column, affinity column, and reverse phase column. A cDNA encoding the protein and a process of producing the protein using the cDNA are also provided. The protein of the present invention is useful as a pharmaceutical composition for preventing or treating obesity or as an antigen for establishing immunological diagnosis, etc.
    Type: Application
    Filed: July 28, 2004
    Publication date: February 3, 2005
    Applicant: DAIICHI PHARMACEUTICAL CO., LTD.
    Inventors: Masaaki Goto, Akihiro Tomoyasu, Kazuki Yano, Fumie Kobayashi, Nobuaki Nakagawa, Hisataka Yasuda, Kyoji Yamaguchi, Masahiko Kinosaki, Shin-ichi Mochizuki, Tadashi Nakakarumai, Tomonori Morinaga, Eisuke Tsuda, Kanji Higashio
  • Diamine derivatives
    Publication number: 20050020645
    Abstract: A compound represented by the general formula (1): Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4??(1) wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 is a group in which Q5 is an alkylene group having 1 to 8 carbon atoms, or the like; and T0 and T1 are carbonyl groups or the like; a salt thereof, a solvate thereof, or an N-oxide thereof.
    Type: Application
    Filed: February 9, 2004
    Publication date: January 27, 2005
    Applicant: DAIICHI PHARMACEUTICAL CO., LTD.
    Inventors: Toshiharu Ohta, Satoshi Komoriya, Toshiharu Yoshino, Kouichi Uoto, Yumi Nakamoto, Hiroyuki Naito, Akiyoshi Mochizuki, Tsutomu Nagata, Hideyuki Kanno, Noriyasu Haginoya, Kenji Yoshikawa, Masatoshi Nagamochi, Syozo Kobayashi, Makoto Ono
  • Antibiotics RK-1061 and process for preparing the same
    Patent number: 6844183
    Abstract: Antibiotics RK-1061s having a novel chemical structure and a method of production thereof. They have a structural formula represented by general formula(I) wherein A represents R1 or R1CH(OR2)CH2. R2 represents 3-methylglutaric acid residue and R3 represents a sulfate group or a hydrogen atom. The process comprises culturing a ray fungus belonging to the genus Streptomyces and isolating RK-1061s from the culture. Streptomyces sp. SN-1061Ms (FERM BP-5800) is capable of stably producing RK-1061 at a high productivity.
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: January 18, 2005
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Ken-ichi Kimura, Yoshikazu Ikeda, Shinobu Kagami, Hidetoshi Takahashi, Kousaku Takahashi, Makoto Yoshihama, Makoto Ubutaka, Kiyoshi Isono
  • Drug complex
    Patent number: 6838450
    Abstract: A drug complex characterized in that a residue of a drug compound such as antineoplastic agents and a carboxy(C1-4)alkyldextran polyalcohol obtained by treating a dextran under conditions that enable substantially complete polyalcoholization are bound to each other by means of a spacer comprising an amino acid or a spacer comprising peptide-bonded 2 to 8 amino acids. Said complex is characterized in that it has excellent selectivity to tumorous sites so as to exhibit high antineoplastic activity and also achieves reduced appearance of toxicity.
    Type: Grant
    Filed: May 28, 2002
    Date of Patent: January 4, 2005
    Assignees: Daiichi Pharmaceutical Co., LTD, Drug Delivery System Institute, Ltd.
    Inventors: Kazuhiro Inoue, Hiroshi Susaki, Masahiro Ikeda, Hiroshi Kuga, Eiji Kumazawa, Akiko Togo
  • Drug complex and drug delivery system
    Patent number: 6835807
    Abstract: A drug complex useful as a DDS compound, which is represented by the following formula: A-R—NH—Y—CH2—O—CO-Q, wherein A is a polymer as a drug carrier; R is a spacer, wherein the spacer is an amino acid or an oligopeptide comprising 2 to 8 amino acids; Y is phenylene group which may be substituted; and Q is a residue of a drug compound such as antineoplastic agents. The complex provides rapid and site-selective release of a drug compound such as antineoplastic or anti-inflammatory agents and surely exhibits expected efficacy.
    Type: Grant
    Filed: February 13, 2001
    Date of Patent: December 28, 2004
    Assignee: Daiichi Pharmaceuticals Co., Ltd.
    Inventors: Hiroshi Susaki, Kazuhiro Inoue, Hiroshi Kuga
  • Process for producing quinolonecarboxylic acids and intermediates thereof
    Patent number: 6825353
    Abstract: This invention relates to methods for the efficient production of quinolonecarboxylic acid based synthetic antibacterial agents which are expected for applications such as excellent medicaments and agricultural chemicals and to intermediate compounds to be used therein. According to the present invention, an amine substituent as the 7-position substituent of the quinolonecarboxylic acid derivative can be efficiently introduced.
    Type: Grant
    Filed: August 22, 2002
    Date of Patent: November 30, 2004
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Tatsuru Saito, Toshiaki Jouno, Yuichiro Tani, Toshifumi Akiba
  • VLA-4 inhibitor compounds
    Publication number: 20040229858
    Abstract: Compounds that selectively inhibit the binding of ligands to &agr;4&bgr;1 integrin (VLA-4) and methods for their preparation are disclosed.
    Type: Application
    Filed: February 26, 2004
    Publication date: November 18, 2004
    Applicants: Daiichi Pharmaceutical Co., LTD., Pharmacopeia Drug Discovery, Inc.
    Inventors: John J. Baldwin, Edward McDonald, Kevin Joseph Moriarty, Christopher Ronald Sarko, Nobuo Machinaga, Atsushi Nakayama, Jun Chiba, Shin Iimura, Yoshiyuki Yoneda
  • Method for treating obesity and for inhibiting adipocyte activity
    Patent number: 6815417
    Abstract: A method for treating obesity includes administering to humans or animals a pharmaceutically effective amount of stanniocalcin in the form of a pharmaceutical composition. Stanniocalcin has an excellent activity of inhibiting the differentiation and maturation of adipocytes and therefore is useful as a drug for treating obesity.
    Type: Grant
    Filed: May 17, 2001
    Date of Patent: November 9, 2004
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Masaaki Goto, Akihiro Tomoyasu, Kyoji Yamaguchi, Masahiko Kinosaki, Nobuaki Nakagawa
  • Pharmaceutical compositions containing DDS compounds
    Patent number: 6815435
    Abstract: A pharmaceutical composition having an ensured preservation stability, which contains a compound, wherein a polysaccharide derivative having a carboxyl group is bonded to a camptothecin derivative via a spacer or without mediated by any spacer, and a sugar or a sugar alcohol optionally together with a pH-adjusting substance.
    Type: Grant
    Filed: January 13, 2003
    Date of Patent: November 9, 2004
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Masayuki Takahashi, Shuichi Sugie, Masahito Takeuchi
  • DDS compounds and method for assaying the same
    Patent number: 6811996
    Abstract: A drug delivery system compound comprising a carboxy(C1-4)alkyldextran polyalcohol modified with a saccharide compound and a residue of drug compound bound to the carboxy(C1-4)alkyldextran polyalcohol, and a method for measuring a drug delivery system compound in which a polymer carrier and a residue of drug compound are bound to each other by a spacer comprising 2 to 8 amino acids linked by peptide bond(s), which comprises treating the drug delivery system compound with a peptidase, and measuring the resulting hydrolysate.
    Type: Grant
    Filed: July 2, 2001
    Date of Patent: November 2, 2004
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Kazuhiro Inoue, Hiroshi Kuga, Yoshinobu Shiose, Hiroshi Korenaga
  • Aminomethylpyrrolidine derivatives having aromatic substituents
    Publication number: 20040209940
    Abstract: This invention provides a quinolone derivative having potent antibacterial activity against various bacteria including drug-resistant strains which is a compound of the following formula wherein R1 is an optionally substituted aromatic group, a salt of the same or a hydrate of both.
    Type: Application
    Filed: April 29, 2004
    Publication date: October 21, 2004
    Applicant: DAIICHI PHARMACEUTICAL CO., LTD.
    Inventors: Makoto Takemura, Hisashi Takahashi, Katsuhiro Kawakami, Toshiyuki Takeda, Rie Miyauchi
  • DDS compound and method for measurement thereof
    Publication number: 20040192644
    Abstract: A DDS compound comprising a carboxy(C1-4)alkyldextran polyalcohol modified with a saccharide compound and a residue of drug compound bound to the carboxy(C1-4)alkyldextran polyalcohol, and a method for measuring a DDS compound in which a polymer carrier and a residue of drug compound are bound to each other by means of a spacer comprising 2 to 8 amino acids linked by peptide bond(s), which comprises the steps of treating the DDS compound with a peptidase, and measuring the resulting hydrolysate.
    Type: Application
    Filed: April 13, 2004
    Publication date: September 30, 2004
    Applicant: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Hiroshi Susaki, Kazuhiro Inoue, Hiroshi Kuga, Masahiro Ikeda, Yoshinobu Shiose
  • Quinolonecarboxylic acid derivatives
    Publication number: 20040142957
    Abstract: (−)-7-[(7S)-7-Amino-5-azaspiro[2.4]heptan-5-yl]-6-fluoro-1-[(1R, 2S)-2-fluoro-1-cyclopropyl]-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid.1HCl.1H2O and antibacterial compositions containing this compound. The compound of the present invention exhibits not only excellent antibacterial activity and safety, but also remarkable stability against light and humidity, and is thus useful as an antibacterial agent.
    Type: Application
    Filed: January 9, 2004
    Publication date: July 22, 2004
    Applicant: DAIICHI PHARMACEUTICAL CO., LTD.
    Inventors: Makoto Takemura, Hisashi Takahashi, Katsuhiro Kawakami, Masao Itoh, Tetsuya Suzuki, Tsuyoshi Ohtani, Masayasu Sekiguchi, Rie Miyauchi, Isao Hayakawa
  • Aminomethylpyrrolidine derivatives having aromatic substituents
    Patent number: 6762181
    Abstract: This invention provides a quinolone derivative having potent antibacterial activity against various bacteria including drug-resistant strains which is a compound of the following formula wherein R1 is an optionally substituted aromatic group, a salt of the same or a hydrate of both.
    Type: Grant
    Filed: September 7, 2001
    Date of Patent: July 13, 2004
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Makoto Takemura, Hisashi Takahashi, Katsuhiro Kawakami, Toshiyuki Takeda, Rie Miyauchi