Patents Assigned to Daiichi Seiyaku, Co., Ltd.
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Patent number: 4933349Abstract: A preventing and treating agent for heart failure is disclosed, which comprises a compound represented by formula (I): ##STR1## wherein R represents an imidazolyl group, a thiazolyl group or a pyridyl group; n represents 1 or 2; and m represents an integer of from 1 to 4, or a pharmaceutically acceptable salt thereof as an active ingredient.Type: GrantFiled: June 28, 1988Date of Patent: June 12, 1990Assignee: Daiichi Seiyaku Co., Ltd.Inventors: Kiyoshi Irie, Satoshi Kunitada, Shinichiro Ashida
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Patent number: 4923862Abstract: A topical preparation containing, as an active ingredient, 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[ 1,2,3][1,4]-benzoxazine-6-carboxylic acid or a salt thereof.Type: GrantFiled: December 17, 1987Date of Patent: May 8, 1990Assignee: Daiichi Seiyaku Co., Ltd.Inventor: Sadao Hirota
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Patent number: 4900815Abstract: A sulfated polysaccharide DS4152 useful as an angiogenesis inhibitor or antitumor agent is provided selectively. As the sodium salt, it has the following physicochemical characteristics. Molecular weight by the gel filtration method: 29,000.+-.3,000. Elemental analysis: C: 24.42-25.76%, H: 3.34-3.98%, N: 0.51-0.89%, S: 10.6-11.7% and P: 0.77-1.06%. Sugar and protein contents: Sugar content (%): 57.+-.3 (by phenol sulfuric acid method; standard: galactose). Protein content (%): 1.+-.0.5 (by the Lowry-Folin's method; standard: bovine serum albumin). Specific rotatory power [.alpha.].sub.D.sup.25 : -37.degree..+-.1.degree. (0.5% aq. solution). Characteristic absorption bands in infrared absorption spectrum: 1240, 840 (shoulder), 810 (cm.sup.-1 ; KBr).Type: GrantFiled: May 20, 1987Date of Patent: February 13, 1990Assignee: Daiichi Seiyaku Co., Ltd.Inventors: Noriko Tanaka, Kazuhiro Inoue, Hiroshi Korenaga, Hidemasa Ogawa
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Patent number: 4898943Abstract: Novel tricyclic triazolopyrimidine compounds represented by formula (I) shown in the specification and physiologically acceptable salts thereof are disclosed. These compounds have an excellent anti-allergic activity and are useful for treatment and prophylaxis of allergic diseases.Type: GrantFiled: February 8, 1988Date of Patent: February 6, 1990Assignee: Daiichi Seiyaku Co., Ltd.Inventors: Sumiro Isoda, Shunzo Aibara, Tamotsu Miwa, Hiroyuki Fujiwara, Shuichi Yokohama, Hiroo Matsumoto
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Patent number: 4880926Abstract: The invention relates to a process for producing a (.+-.)-3-alkyl-3,4-dihydro-2H-[1,4]benzoxazine derivate of formula (II) by stepwise racemization procedure. ##STR1## The invention further provides a process for optical resolution through the formation of a salt between a (.+-.)-benzoxazine compound and an optically active form of camphor-10-sulfonic acid. Without requiring the conventional expensive resolution reagents, this process not only assures production of an optically active isomer of compound (II) in high purity but also permits reuse of the optical resolution reagent.Type: GrantFiled: August 3, 1988Date of Patent: November 14, 1989Assignee: Daiichi Seiyaku Co., Ltd.Inventors: Toshihiro Fujiwara, Hideaki Tsurumi, Yukio Sato
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Patent number: 4874772Abstract: An agent for treatment and prevention of asthma comprising 2-[2-phenyl-2-(2-pyridyl)]ethyl-2-imidazoline or a salt thereof as an active ingredient is disclosed.Type: GrantFiled: April 27, 1988Date of Patent: October 17, 1989Assignee: Daiichi Seiyaku Co., Ltd.Inventors: Setsuo Kobayashi, Tsugio Nakazawa, Yasumasa Yoshie, Yasushi Abiko, Kinya Kameda
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Patent number: 4873227Abstract: A novel therapeutic agent for skin ulcers comprising as its active component adenosine-3',5'-cyclic phosphate or a derivative thereof, and a method for the treatment of skin ulcers by using the agent.The therapeutic agent is prepared into various forms such as emulsions, ointments and creams, and is externally applied to the affected part.Type: GrantFiled: June 11, 1987Date of Patent: October 10, 1989Assignee: Daiichi Seiyaku Co., Ltd.Inventors: Junji Ikada, Eiko Mano
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Patent number: 4871852Abstract: Novel 4-oxoguinoline-3-carboxylic acid derivatives having the formula ##STR1## wherein X.sup.1 represents a halogen or hydrogen atom, X.sup.2 represents a halogen or hydrogen atom, X.sup.3 represents a halogen atom, and R.sup.1, R.sup.2 and R.sup.3 each represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, and physiologically acceptable salts thereof, are disclosed. These compounds have excellent antibacterial activity against gram-positive and gram-negative bacteria and beneficial pharmacokinetic properties.Type: GrantFiled: November 27, 1987Date of Patent: October 3, 1989Assignee: Daiichi Seiyaku Co., Ltd.Inventors: Isao Hayakawa, Shohgo Atarashi, Shuichi Yokohama, Masazumi Imamura
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Patent number: 4841076Abstract: A benzopyran derivative represented by formula ##STR1## wherein: R.sub.1 and R.sub.2 each represents a hydrogen atom, a lower alkyl group, a substituted or unsubstituted cyclic alkyl group, a mono- or di-lower alkylamino group, a substituted or unsubsituted cyclic amino group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aralkyl group;Y.sub.1 and Y.sub.2 each represents a hydrogen atom, a lower alkyl group, a halogen atom or a trihalomethyl group;Z represents a caroxyl group, a lower alkoxy-carbonyl group, a tetrazolyl group, a hydroxyl group or --CONR.sub.3 R.sub.4 wherein R.sub.3 and R.sub.4 each represents a hydrogen atom or a lower alkyl group;n represents an integer of from 1 to 6; andthe bond between the 2- and 3-positions represents a single bond or a double bond;provided that a combination wherein Y.sub.1, Y.sub.2, and R.sub.2 each represents a hydrogen atom, R.sub.Type: GrantFiled: June 4, 1987Date of Patent: June 20, 1989Assignee: Daiichi Seiyaku Co., Ltd.Inventors: Masayuki Kitagawa, Makoto Tanaka
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Patent number: 4833242Abstract: Novel cephalosporin derivatives and salts thereof are disclosed. These compounds exhibit excellent antimicrobial activity against a wide variety of Gram-negative and Gram-positive bacteria and also have other excellent characteristics as a medicine such as stability and low toxicity. These compounds can be administered in a form of subcutaneous, intravenous or intramuscular injections.Type: GrantFiled: April 17, 1985Date of Patent: May 23, 1989Assignee: Daiichi Seiyaku Co., Ltd.Inventors: Minoru Furukawa, Hiroaki Tagawa, Takeshi Hayano, Akio Ejima
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Patent number: 4826687Abstract: This invention relates to a novel influenza vaccine comprising a complex of HANA antigen and an MDP derivative.The novel vaccine is prepared by mixing an influenza HANA antigen and at least one MDP derivative in a suitable medium; solubilizing the resulting mixture with a surface active agent capable of being removed by dialysis, the solubilization being conducted in the presence or absence of cholesterol, lecithin and dicetyl phosphate or a mixture thereof; and then removing the surface active agent therefrom by dialysis to obtain an influenza vaccine comprising artificial vesicle-like particles of a complex of HANA antigen and MDP derivative, where the MDP derivative forms a membrane of the particle (corresponding to the lipid membrane of natural influenza virus particle) on the surface of which there exists the HANA antigen being bonded to the MDP derivative so as to form the complex.Type: GrantFiled: May 28, 1986Date of Patent: May 2, 1989Assignees: National Institute of Health, Daiichi Seiyaku Co., Ltd., Juridical Foundation the Chemo-Sero-Therapeutic Research InstituteInventors: Kuniaki Nerome, Akira Oya, Kunio Ohkuma, Atsuo Inoue
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Patent number: 4778891Abstract: A pyranoindolizine derivative represented by the following general formula (I): ##STR1## wherein R means a hydrogen atom or hydroxyl group and Q denotes >C.dbd.O or ##STR2## with a proviso that Q is other than >C.dbd.O when R is a hydrogen atom. Its preparation process is also described.Type: GrantFiled: October 16, 1986Date of Patent: October 18, 1988Assignees: Daiichi Seiyaku Co., Ltd., Kabushiki Kaisha Yakult HonshaInventors: Hiroaki Tagawa, Hirofumi Terasawa, Akio Ejima
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Patent number: 4777257Abstract: Benzocycloalkane derivatives of the formula (I) ##STR1## wherein: Z represents a methylene group or an ethylene group, either one of R.sup.1 and R.sup.2 represents --(CH.sub.2).sub.m --COOR.sup.3 and the other represents ##STR2## wherein R.sup.3 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, n represents an interger of 1 to 6 and m represents an interger of 0 to 5, and the physiologically acceptable salts thereof; having a strong and selective inhibition activity of thromboxane A.sub.2 synthesis.Type: GrantFiled: August 29, 1986Date of Patent: October 11, 1988Assignee: Daiichi Seiyaku Co., Ltd.Inventor: Munefumi Kanao
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Patent number: 4766126Abstract: An agent for treatment and prevention of nephritis comprising at least one imidazoquinazoline compound represented by formula ##STR1## wherein R.sub.1 represents a dialkylamino group having 1 to 6 carbon atoms in each alkyl moiety, or an unsubstituted or substituted cyclic amino group; and R.sub.2 represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 6 carbon atoms, or an alkoxy group having 1 to 6 carbon atoms, or a salt thereof as an active ingredient.Type: GrantFiled: January 6, 1987Date of Patent: August 23, 1988Assignee: Daiichi Seiyaku Co., Ltd.Inventor: Mitsutaka Takami
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Patent number: 4746668Abstract: A method for treating and preventing retinopathy which comprises administering a therapeutically effective amount of 2-(2-phenyl-2-(2-pyridyl))ethyl-2-imidazoline or a pharmaceutically acceptable salt thereof to a patient having retinopathy is disclosed.Type: GrantFiled: August 14, 1986Date of Patent: May 24, 1988Assignee: Daiichi Seiyaku Co., Ltd.Inventors: Takao Sato, Shinichiro Ashida, Kyoko Sakuma
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Patent number: 4687661Abstract: A method for producing liposomes which comprises mixing liposome membrane components with a water-soluble non-volatile solvent and, then, dispersing the mixture in an aqueous medium. The pharmaceutically acceptable liposome preparation as a drug delivery system can thus be produced with efficiency on an industrial scale.Type: GrantFiled: June 27, 1984Date of Patent: August 18, 1987Assignee: Daiichi Seiyaku Co., Ltd.Inventors: Hiroshi Kikuchi, Hitoshi Yamauchi
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Patent number: 4681856Abstract: Muramyldipeptide active ester derivatives represented by the formula: ##STR1## wherein R.sub.1 represents a straight or branched chain fatty acid residue having 2 to 30 carbon atoms; R.sub.2 represents an active ester residue; and "Acyl" represents an acyl group having 2 to 6 carbon atoms. These compounds are applicable as haptens for the immunotherapy and exhibit antitumor activity.Type: GrantFiled: August 20, 1984Date of Patent: July 21, 1987Assignee: Toshiyuki Hamaoka Daiichi Seiyaku Co., Ltd.Inventors: Toshiyuki Hamaoka, Hiromi Fujiwara, Tsuneo Kusama
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Patent number: 4672106Abstract: Muramylpeptide active ester derivatives represented by the formula: ##STR1## wherein R.sub.1 represents a hydrogen atom or a fatty acid residue having from 2 to 10 carbon atoms; --COR.sub.2 represents an active ester group; R.sub.3 represents a fatty acid residue having from 1 to 10 carbon atoms; X represents an alanine, N-methylalanine or valine residue; "Acyl" represents a fatty acid residue having from 2 to 6 carbon atoms; and n represents an integer of from 1 to 6. These compounds are applicable as haptens for the immunotherapy and exhibit antitumor activity.Type: GrantFiled: August 29, 1985Date of Patent: June 9, 1987Assignees: Toshiyuki Hamaoka, Daiichi Seiyaku Co., Ltd.Inventors: Toshiyuki Hamaoka, Hiromi Fujiwara, Tsuneo Kusama, Masahiro Komiya
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Patent number: 4665188Abstract: Benzocycloalkane derivatives of the formula (I) ##STR1## wherein: Z represents a methylene group or an ethylene group, either one of R.sup.1 and R.sup.2 represents --(CH.sub.2).sub.m --COOR.sup.3 and the other represents ##STR2## wherein R.sup.3 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, n represents an interger of 1 to 6 and m represents an interger of 0 to 5, and the physiologically acceptable salts thereof; having a strong and selective inhibition activity of thromboxane A.sub.2 synthesis.Type: GrantFiled: August 27, 1984Date of Patent: May 12, 1987Assignee: Daiichi Seiyaku Co., Ltd.Inventor: Munefumi Kanao
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Patent number: 4652646Abstract: Novel triazolopyrimidine compounds represented by the formula (I) and physiologically acceptable salts thereof are disclosed. These compounds have an excellent anti-allergic activity in oral administration and are useful for treatment and prophylaxis of allergic diseases such as bronchial asthma, allergic gastro-intestinal disorders, allergic rhinitis, hay fever, urticaria and the like.Type: GrantFiled: April 25, 1985Date of Patent: March 24, 1987Assignee: Daiichi Seiyaku Co., Ltd.Inventors: Sumiro Isoda, Norio Suzuki, Tamotsu Miwa, Shunzo Aibara