Patents Assigned to Dartmouth College
  • Patent number: 8348936
    Abstract: A thermal treatment system with acoustic monitoring applies substantially constant electromagnetic energy superposed with pulsed electromagnetic energy to targeted tissue. The pulsed electromagnetic energy reacts with tissue to create an acoustic pressure wave within the tissue. The acoustic pressure wave is sensed by an acoustic sensor, and a sensor signal indicative of the acoustic pressure wave is generated and processed to determine changes in tissue composition.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: January 8, 2013
    Assignee: The Trustees of Dartmouth College
    Inventors: B. Stuart Trembly, Jason M. Dahlstrom
  • Publication number: 20130005747
    Abstract: The present invention provides a method for determining whether or not a cancer subject is suitable for treatment with a purine-based roscovitine-like inhibitor, which method comprises the step of determining the ras status of the cancer, wherein a determination that the subject has mutant ras status is indicative that the subject is suitable for treatment with a purine-based roscovitine-like inhibitor.
    Type: Application
    Filed: December 21, 2011
    Publication date: January 3, 2013
    Applicants: Cyclacel Limited, The General Hospital Corporation d/b/a Massachusetts General Hospital, The Trustees of Dartmouth College
    Inventors: Simon Richard GREEN, Judy H. CHIAO, Jeffery SETTLEMAN, Ethan DMITROVSKY, Fabrizio Vittorio GALIMBERTI
  • Patent number: 8341424
    Abstract: One aspect of the present invention is a method of playing multi-media content through a personal computer. The personal computer includes a processor and memory, with the memory having software instructions stored therein. The processor executes the instructions to carry-out the method. The method includes: receiving data representing multi-media content at the personal computer; receiving at the personal computer an initial set of data representing a base set of usage rights that is associated with the multi-media content, wherein the initial set of data defines a first set of rights that is permissible without upgrading or renewing the base set of usage rights; and upon receiving a request to perform an action involving the multi-media content, checking the initial set of data representing the base set of usage rights to determine whether the action is permissible, and providing an option to a user through the personal computer to contact a remote computer to negotiate for an upgraded set of usage rights.
    Type: Grant
    Filed: May 4, 2004
    Date of Patent: December 25, 2012
    Assignee: Trustees of Dartmouth College
    Inventor: John S. Erickson
  • Publication number: 20120294857
    Abstract: The present invention embraces a bi-specific fusion protein composed of an effector cell-specific antibody-variable region fragment operably linked to at least a portion of a natural killer cell receptor. Methods for using the fusion protein in the treatment of cancer and pathogenic infections are also provided.
    Type: Application
    Filed: January 7, 2011
    Publication date: November 22, 2012
    Applicant: Trustees of Dartmouth College
    Inventors: Charles L. Sentman, Tong Zhang
  • Patent number: 8314137
    Abstract: The present invention features monocyclic cyanoenone compositions and methods for using the same in the treatment of diseases such as cancer, inflammatory diseases and neurodegenerative diseases.
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: November 20, 2012
    Assignee: Trustess of Dartmouth College
    Inventors: Tadashi Honda, Emilie David, Dale Mierke
  • Publication number: 20120281947
    Abstract: A multi-mode to single mode optical interface device includes an optically pumped edge emitting semiconductor laser device and a lens. The optically pumped edge emitting semiconductor laser device includes (1) a gain area, and (2) an edge located single mode output. The lens focuses a multi-mode optical fiber output beam into a substantially line shaped output beam focused onto the gain area of the optically pumped edge emitting semiconductor laser device. A method for converting a multi-mode optical signal into a single mode optical signal includes (1) focusing the multi-mode optical signal onto a gain area of an optically pumped edge emitting semiconductor laser using at least a line focusing lens, and (2) converting the multi-mode optical signal into the single mode optical signal using the semiconductor laser.
    Type: Application
    Filed: November 12, 2010
    Publication date: November 8, 2012
    Applicant: The Trustees of Dartmouth College
    Inventor: Elsa Garmire
  • Patent number: 8304401
    Abstract: The present invention features methods for decreasing fat mass, increasing energy expenditure, increasing resistance to obesity, and lowering blood glucose levels in a subject with an agent that inhibits the expression or activity of type III deiodinase. In this regard, agents of the invention are useful in treating diabetes and obesity.
    Type: Grant
    Filed: September 1, 2009
    Date of Patent: November 6, 2012
    Assignee: Trustees of Dartmouth College
    Inventors: Donald L. St. Germain, Arturo Hernandez
  • Publication number: 20120277163
    Abstract: The present invention embraces microRNA-antagonists and activators of homeobox D10 protein; Zinc finger, MYND domain containing 11 protein; or RB1-inducible coiled-coil 1 protein for use in decreasing glial tumor cell proliferation and treating glioma.
    Type: Application
    Filed: October 21, 2010
    Publication date: November 1, 2012
    Applicant: Trustees of Dartmouth College
    Inventors: Arti B. Gaur, Mark A. Israel
  • Patent number: 8299046
    Abstract: The present invention concerns methods for stimulating the growth and repair of bone and cartilage using synthetic triterpenoids and tricyclic-bis-enones. Examples of suitable triterpenoids include CDDO, CDDO-Me, CDDO-Im, and CDDO-Ethylamide. Examples of tricyclic-bis-enones include TBE-31 and TBE-34.
    Type: Grant
    Filed: November 16, 2007
    Date of Patent: October 30, 2012
    Assignees: Trustees of Dartmouth College, Osteoscreen, Inc., The Regents of the Universtiy of California
    Inventors: Michael B. Sporn, Karen T. Liby, Tadashi Honda, Gregory Mundy, Ross Garrett, Hari Reddi, Gordon W. Gribble, Takahiro Niikura
  • Patent number: 8293224
    Abstract: Uracil auxotroph mutants of apicomplexans are provided which lack a functional carbamoyl phosphate synthase II (CPSII) enzyme. Also provided are T. gondii autoxtroph mutants which express exogenous antigens, and methods of protecting an animal against a T. gondii and non-T. gondii disease.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: October 23, 2012
    Assignee: Trustees of Dartmouth College
    Inventors: David Bzik, Barbara Fox
  • Patent number: 8282942
    Abstract: The present invention provides attenuated Toxoplasma gondii knockout mutants of the de novo pyrimidine synthesis pathway and use of the same in vaccines and methods of providing an immune response and protecting a subject against infection by T. gondii and a non-T. gondii disease.
    Type: Grant
    Filed: April 6, 2010
    Date of Patent: October 9, 2012
    Assignee: Trustees of Dartmouth College
    Inventors: David J. Bzik, Barbara A. Fox
  • Patent number: 8283113
    Abstract: Compositions and methods of using compositions that induce UBE1L or a ubiquitin-like protein ISG15, or inhibit a deconjugase UBP43 to degrade oncogenic proteins and enhance apoptosis of cancer (neoplastic) or pre-cancerous (pre-neoplastic) cells are provided. Methods for the prevention or treatment of cancer via administration of these compositions are also provided.
    Type: Grant
    Filed: October 31, 2008
    Date of Patent: October 9, 2012
    Assignee: Trustees of Dartmouth College
    Inventors: Ethan Dmitrovsky, Bret A. Hassel, Sutisak Kitareewan, Ian Pitha-Rowe
  • Publication number: 20120251463
    Abstract: The present invention relates to isolated nicotinamide riboside kinase (Nrk) nucleic acid sequences, vectors and cultured cells containing the same, and Nrk polypeptides encoded thereby. Methods for identifying individuals or tumors susceptible to nicotinamide riboside-related prodrug treatment and methods for treating cancer by administering an Nrk nucleic acid sequence or polypeptide in combination with a nicotinamide riboside-related prodrug are also provided. The present invention further provides screening methods for isolating a nicotinamide riboside-related prodrug and identifying a natural source of nicotinamide riboside.
    Type: Application
    Filed: April 12, 2012
    Publication date: October 4, 2012
    Applicant: Trustees of Dartmouth College
    Inventor: Charles M. Brenner
  • Patent number: 8278107
    Abstract: Compositions and methods for regulating CD154 gene expression are provided that rely on the interaction of hnRNP L with the CA-dinucleotide rich sequence of the 3?-untranslated region of CD154.
    Type: Grant
    Filed: February 3, 2010
    Date of Patent: October 2, 2012
    Assignee: Trustees of Dartmouth College
    Inventor: William F. C. Rigby
  • Patent number: 8273701
    Abstract: The present invention relates to the constitutive activity of the Hedgehog pathway in non-small cell lung carcinoma (NSCLC). A method for diagnosing NSCLC by detecting the level of a component of the Hedgehog pathway is provided, as is a method for identifying subjects that will respond positively to treatment with a Hedgehog pathway antagonist. Methods for treating subjects with cancer or cancers resistant to Hedgehog pathway antagonists are also provided.
    Type: Grant
    Filed: August 14, 2006
    Date of Patent: September 25, 2012
    Assignee: Trustees of Dartmouth College
    Inventors: David J. Robbins, Ziqiang Yuan, John A. Goetz
  • Publication number: 20120220055
    Abstract: The present invention relates to a method of detecting cardiac ischemia by measuring the levels of BNP or NTproBNP. Increases in BNP or NTproBNP levels in an individual are indicative of cardiac ischemia.
    Type: Application
    Filed: May 3, 2012
    Publication date: August 30, 2012
    Applicant: Trustees of Dartmouth College
    Inventors: Robert S. Foote, Kiang-Tech Jërry Yeo
  • Patent number: 8252914
    Abstract: The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a protein associated therewith, fused to an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif. Methods for using the chimeric receptors are further provided.
    Type: Grant
    Filed: June 8, 2011
    Date of Patent: August 28, 2012
    Assignee: Trustees of Dartmouth College
    Inventors: Tong Zhang, Charles L. Sentman
  • Publication number: 20120214732
    Abstract: The present invention is an inhibitor of the trypsin-like ?2/?2i sites of the proteasome. The inhibitor is characterized as being a peptide-based epoxyketone or vinyl sulfone that contains an arginine or 4-aminomethylene-L-phenylalanine at the C-terminus (i.e., at the P1 position). Methods for using the inhibitor to inhibit the activity of the ?2/?2i site of a proteasome and treat a proteasome-mediated disease or condition are also described.
    Type: Application
    Filed: February 17, 2012
    Publication date: August 23, 2012
    Applicant: Trustees of Dartmouth College
    Inventors: Alexei Kisselev, Dmitry V. Filippov, Herman Overkleeft
  • Publication number: 20120215093
    Abstract: A method for providing patient registration without fiducials comprises the steps of: spatially placing an ultrasound image of a patient randomly at different starting positions relative to a preoperative image; creating an independent registration corresponding to each different starting positions, by optimizing a spatial transformation between the preoperative image and the ultrasound image to provide a first batch of registrations; executing a second registration to fine-tune the alignment between the preoperative image and the ultrasound image; and concatenating the spatial transformation to obtain spatial transformation between the patient in an operating room and a corresponding preoperative image.
    Type: Application
    Filed: August 27, 2010
    Publication date: August 23, 2012
    Applicant: Dartmouth College
    Inventors: Songbai Ji, David W. Roberts, Alex Hartov, Keith D. Paulsen
  • Patent number: 8236304
    Abstract: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates ?CD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon ?CD3/?GITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed.
    Type: Grant
    Filed: April 24, 2006
    Date of Patent: August 7, 2012
    Assignee: Trustees of Dartmouth College
    Inventors: Randolph J. Noelle, Li-Fan Lu, Sergio Quezada, David Gondek