Patents Assigned to Dartmouth College
  • Regulatory T cell mediator proteins and uses thereof
    Patent number: 8231872
    Abstract: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates ?CD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon ?CD3/?GITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed. In particular methods of using these proteins and compounds, preferably antibodies, which bind or modulate (agonize or antagonize) the activity of these proteins, as immune modulators and for the treatment of cancer, autoimmune disease, allergy, infection and inflammatory conditions, e.g. multiple sclerosis is disclosed.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: July 31, 2012
    Assignee: The Trustees of Dartmouth College
    Inventors: Randolph J. Noelle, Li Wang
  • Free electron laser, and associated components and methods
    Patent number: 8228959
    Abstract: A system generates FIR laser radiation. An electron source generates an electron beam. A grating horn interacts with the electron beam to produce the FIR laser radiation. The grating horn may comprise a flat base and a pair of grating elements attached to the base, each of the grating elements being ruled with a grating period, the grating elements oriented in phase and in substantial symmetry about a normal to the flat base.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: July 24, 2012
    Assignee: The Trustees of Dartmouth College
    Inventor: James Hayden Brownell
  • Compositions and Methods for Treating Cancer
    Publication number: 20120165365
    Abstract: The present invention embraces bis-acridine and bis-quinoline intercalators having a bis(4-aminophenyl)ether tether, and diglycolate salts thereof, for selectively decreasing colon cancer and glial cell proliferation and preventing or treating colon cancers and gliomas.
    Type: Application
    Filed: July 13, 2010
    Publication date: June 28, 2012
    Applicant: Trustees of Dartmouth College
    Inventors: Gordon W. Gribble, Dmitry A. Androsov
  • Imaging by magnetic resonance adsorption, elastography and tomography
    Patent number: 8207733
    Abstract: A microwave imaging system provides superior breast imaging resolution by combining MR microwave absorption and MR-compatible microwave tomography calculations. These techniques may also be supplemented with magnetic resonance elastography techniques, for example, to facilitate quick multispectral imaging.
    Type: Grant
    Filed: October 6, 2008
    Date of Patent: June 26, 2012
    Assignee: The Trustees of Dartmouth College
    Inventors: Paul M. Meaney, Keith D. Paulsen, John B. Weaver
  • MicroRNA biomarkers for human breast and lung cancer
    Patent number: 8207325
    Abstract: The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
    Type: Grant
    Filed: May 6, 2009
    Date of Patent: June 26, 2012
    Assignees: Univ. of Copenhagen, Trustees of Dartmouth College
    Inventors: Ethan Dmitrovsky, Xi Liu, Sarah Freemantle, Lorenzo Sempere, Charles Cole, Sakari Kauppinen, Mads Bak, Mette Christensen
  • Method for Identifying an Agent that Inhibits Candida albicans-Mediated Host Cell Differentiation
    Publication number: 20120156697
    Abstract: The present invention features a method for identifying an agent that inhibits Candida albicans-mediated differentiation of keratinocytes. Agents identified by the screening assay of the invention find application in the prevention and treatment of candidiasis.
    Type: Application
    Filed: August 13, 2010
    Publication date: June 21, 2012
    Applicant: Trustees of Dartmouth College
    Inventor: Paula Sundstrom
  • Composition and Method for Prevention, Mitigation or Treatment of an Enteropathogenic Bacterial Infection
    Publication number: 20120157529
    Abstract: The present invention embraces the use of palmitoleic acid, or a derivative, mimetic, or extract containing the same, to decrease the expression of bacterial virulence factors thereby preventing, mitigating, or treating bacterial infection.
    Type: Application
    Filed: July 21, 2010
    Publication date: June 21, 2012
    Applicant: Trustees of Dartmouth College
    Inventors: F. Jon Kull, Ronald K. Taylor, Michael Lowden, Karen Skorupski, Jessica Day, Gabriela Kovacikova
  • Compositions for Inhibiting Growth of Cancer Stem Cells
    Publication number: 20120156312
    Abstract: The present invention is a biomarker of chemotherapeutic drug-resistant cancer stem cells and a method of inhibiting the growth of drug-resistant cancer stem cells. In one embodiment the cancer stem cells are testicular cancer germ cells. In another embodiment the present invention is a method of overcoming drug resistance in cancer treatment where the combination of low dose decitabine and administration of a chemotherapeutic drug to which cancer cells were resistant results in successful cancer treatment.
    Type: Application
    Filed: August 30, 2010
    Publication date: June 21, 2012
    Applicant: Trustees of Dartmouth College
    Inventors: Michael Spinella, Maroun J. Beyrouthy
  • Nicotinamide riboside kinase compositions and methods for using the same
    Patent number: 8197807
    Abstract: The present invention relates to isolated nicotinamide riboside kinase (Nrk) nucleic acid sequences, vectors and cultured cells containing the same, and Nrk polypeptides encoded thereby. Methods for identifying individuals or tumors susceptible to nicotinamide riboside-related prodrug treatment and methods for treating cancer by administering an Nrk nucleic acid sequence or polypeptide in combination with a nicotinamide riboside-related prodrug are also provided. The present invention further provides screening methods for isolating a nicotinamide riboside-related prodrug and identifying a natural source of nicotinamide riboside.
    Type: Grant
    Filed: April 20, 2006
    Date of Patent: June 12, 2012
    Assignee: Trustees of Dartmouth College
    Inventor: Charles M. Brenner
  • Method for enantioselective synthesis of phosphorus-stereogenic phosphines
    Patent number: 8193392
    Abstract: The present invention relates to a process for preparing an enantioenriched phosphorus-stereogenic, tertiary phosphine. Secondary phosphines are contacted with an alkyl halide and base in the presence of a chiral metal catalyst thereby producing the enantioenriched phosphorus-stereogenic, tertiary phosphine for subsequent use in homogeneous catalysis reactions.
    Type: Grant
    Filed: July 28, 2006
    Date of Patent: June 5, 2012
    Assignee: Trustees of Dartmouth College
    Inventors: Corina Scriban, David S. Glueck
  • Methods for Screening for Antibiotic Compounds
    Publication number: 20120115157
    Abstract: The present invention is a method for screening drugs for antibiotic activity by screening a drug for activity to disrupt a toxin-antitoxin complex in a bacterial cell.
    Type: Application
    Filed: July 1, 2010
    Publication date: May 10, 2012
    Applicant: Trustees of Dartmouth College
    Inventors: Ambrose Cheung, Zhibiao Fu
  • Joining of parts via magnetic heating of metal-aluminum powders
    Patent number: 8172126
    Abstract: A method of joining at least two parts includes steps of dispersing a joining material comprising a multi-phase nanocrystalline magnetic metal-aluminum powder at an interface between the at least two parts to be joined and applying an alternating magnetic field (AMF). The AMF has a magnetic field strength and frequency suitable for inducing magnetic hysteresis losses in the metal-aluminum powder and is applied for a period that raises temperature of the metal-aluminum powder to an exothermic transformation temperature. At the exothermic transformation temperature, the metal-aluminum powder melts and resolidifies as a metal aluminide solid having a non-magnetic configuration.
    Type: Grant
    Filed: May 19, 2009
    Date of Patent: May 8, 2012
    Assignee: The Trustees of Dartmouth College
    Inventor: Ian Baker
  • Systems and methods that detect changes in incident optical radiation
    Patent number: 8174253
    Abstract: Systems, methods and sensors detect changes in incident optical radiation. Voltage is applied across one or more active areas of a detector while the incident optical radiation illuminates the active areas. Current is sensed across one or more of the active areas, a change in the current being indicative of the changes in incident optical radiation.
    Type: Grant
    Filed: February 22, 2011
    Date of Patent: May 8, 2012
    Assignee: The Trustees of Dartmouth College
    Inventors: Elsa Garmire, Ashifi Gogo, Jonathan T. Bessette
  • Nutraceutical Composition and Methods for Preventing or Treating Multiple Sclerosis
    Publication number: 20120094950
    Abstract: The present invention embraces nutraceutical compositions containing isolated Bacteroides fragilis capsular polysaccharide A for use in methods of preventing or treating multiple sclerosis.
    Type: Application
    Filed: June 17, 2011
    Publication date: April 19, 2012
    Applicant: Trustees of Dartmouth College
    Inventors: Lloyd H. Kasper, Javier Ochoa-Reparaz
  • Modulators of the ABC transporter family and methods for their use
    Patent number: 8153597
    Abstract: An isolated factor derived from the bacterium Pseudomonas aeruginosa and confirmed by proteomics to be a protein that reduces expression of ABC transmembrane proteins and active fragments and mimetics thereof are provided. Also provided is a method for inhibiting expression of ABC transmembrane proteins in cells by administering to the cells the isolated factor or protein or active fragment thereof or a mimetic thereof. Such methods are useful in the enhancing delivery of small molecule therapeutic agents to the CNS and in treating cancers, particularly multidrug resistant cancers, and secretory diarrhea. In addition, compositions, methods for identifying compositions and methods for use of compositions that inhibit suppression of ABC transmembrane protein expression or reduce epoxide hydrolase activity by this factor are provided. Such compositions and methods are useful in treatment of cystic fibrosis.
    Type: Grant
    Filed: February 25, 2010
    Date of Patent: April 10, 2012
    Assignee: Trustees of Dartmouth College
    Inventors: Bruce Stanton, George O'Toole, Jr., Agnieszka Swiateck-Urban, Daniel P. MacEachran, Sophie Moreau Marquis
  • Compositions And Methods For Treating Pancreatic Cancer
    Publication number: 20120077867
    Abstract: The present invention provides a method of treating pancreatic cancer by inhibiting the activity cyclin D1 activity in tumor cells. The invention is based on the finding that cyclin D1 shRNA molecules are capable of attenuating tumor growth and interfering with tumor angiogenesis.
    Type: Application
    Filed: June 8, 2010
    Publication date: March 29, 2012
    Applicant: Trustees od Dartmouth College
    Inventor: Murray Korc
  • Compositions and Methods for Inhibiting the Interaction Between CFTR and CAL
    Publication number: 20120071396
    Abstract: The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides peptides and peptidomimetics that selectively inhibit the interaction between CAL and mutant CFTR proteins, thereby stabilizing the CFTR and facilitating transport of the same to the cell surface.
    Type: Application
    Filed: November 9, 2011
    Publication date: March 22, 2012
    Applicant: Trustees of Dartmouth College
    Inventors: Dean R. Madden, Patrick R. Cushing, Prisca Boisguearin, Rudolph Volkmer, Lars Vouilleme
  • Method for inhibiting or reversing non-enzymatic glycation
    Patent number: 8138227
    Abstract: The present invention relates to a method for inhibiting or reversing non-enzymatic glycation of the first intermediate of a biological moiety using an ?-thiolamine. By inhibiting or reversing non-enzymatic glycation of the biological moiety, conditions such as aging and diabetic complications can be prevented or reversed.
    Type: Grant
    Filed: June 1, 2007
    Date of Patent: March 20, 2012
    Assignee: Trustees of Dartmouth College
    Inventor: Benjamin Szwergold
  • Synthetic triterpenoids and methods of use in the treatment of disease
    Patent number: 8129429
    Abstract: The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease using synthetic triterpenoids, optionally in combination with a second treatment or prophylaxis.
    Type: Grant
    Filed: January 12, 2009
    Date of Patent: March 6, 2012
    Assignees: Reata Pharmaceuticals, Inc., Trustees of Dartmouth College
    Inventors: Michael B. Sporn, Karen T. Liby, Gordon W. Gribble, Tadashi Honda, Robert M. Kral, Colin J. Meyer
  • Compositions and methods for destabilizing lysosomes to increase oncogenic or aberrant protein degradation
    Patent number: 8124371
    Abstract: The present invention relates to compositions for destabilizing lysosomes to increase the degradation of oncogenic or aberrant proteins for the prevention or treatment of disease. Methods for identifying agents which destabilize lysosomes are also provided as are agents identified in accordance with the screening method.
    Type: Grant
    Filed: July 30, 2004
    Date of Patent: February 28, 2012
    Assignee: Trustees of Dartmouth College
    Inventors: Sutisak Kitareewan, Roger Sloboda, Ethan Dmitrovsky