Abstract: A delivery system for deploying an implantable medical device to a target location of a body vessel can include a tubular body with a lumen extending therethrough, a pull wire extending through the lumen, and a proximal support tube disposed within the lumen and engaged to the pull wire such that proximal translation of the support tube causes proximal translation of the pull wire. The proximal support tube can include a marked distal section that is not visible to an operator of the delivery system prior to the release of the implant and that becomes visible when the proximal support tube is pulled proximally a sufficient distance to cause the delivery system to release the implant.

Abstract: Sensor-enabled surgical retractor devices, systems, and methods are disclosed herein that can be coupled to a surgical robot during a robotic or robot-assisted surgical procedure to maintain health of retracted anatomy and prolong the amount of time until a surgical procedure must be interrupted to adjust a retractor. In some embodiments, interruption of a surgical procedure can be avoided by providing for minor and, in some cases, automatically administered, adjustment of retractor devices to alleviate pressure on retracted tissue without requiring surgeon attention or intervention. Fine (e.g., minor) adjustments to the retractor can be made automatically over the course of a surgical procedure to prevent damage to retracted anatomy and increase the time until a major adjustment of the retractor is needed.

Abstract: An adjustable spinal fusion intervertebral implant including upper and lower body portions each having proximal and distal surfaces at proximal and distal ends thereof. The implant can include a proximal wedge member disposed at the proximal ends of the respective ones of the upper and lower body portions, and a distal wedge member disposed at the distal ends of the respective ones of the upper and lower body portions. First and second linkages can connect the upper and lower body portions. Rotation of an actuator shaft can cause the distal and proximal wedge members to be drawn together such that longitudinal movement of the distal wedge member against the distal surfaces and the longitudinal movement of the proximal wedge member against the proximal surfaces causes separation of the upper and lower body portions.

Abstract: The disclosed technology generally relates to braided implants for aneurysm therapy. The disclosed technology can include a system having a tubular braid comprising an open end, a pinched end, and a predetermined shape. In the predetermined shape, the tubular braid can include a first segment extending from the open end to a first inversion, a second segment extending from the first inversion to a second inversion and forming a bag comprising a semi-frustoconically-shaped portion proximate the first inversion such that the semi-frustoconically-shaped portion defines an inner channel forming an opening to the bag, and a third segment surrounded by the second segment and extending from the second inversion to the pinched end. The system can include a catheter having a lumen therethrough, a distal end, and an outer diameter at the distal end being sized to be inserted into the bag through the opening of the bag.

Abstract: An intramedullary bone fixation device that includes a shaft with a flexible region. The flexible region may be configured to flex from a first shape to a second shape as the shaft moves along a curved medullary canal. For example, the bone fixation device may include a distal bone screw that is configured to move along the curved medullary canal of first and second segments of a fractured bone (e.g., two segments of a broken rib) and fasten to the segment bone segment. The bone fixation device may include a locking member (e.g., a proximal bone screw) that is configured to lock the shaft to the first bone segment. For example, the shaft may be fixed to the distal bone screw and ratchetably coupled to the shaft such that the first and second bone segments can be compressed together by urging together the distal bone screw and the locking member.

Abstract: A multi-basket clot capturing device that includes a distal basket connected to a wire. The distal basket may be positionable distal of the clot and operable to capture a distal portion of a clot. A proximal basket may be connected to a hypotube that is slidably axially connected to the wire. The proximal basket may be positionable proximal of the clot and operable to capture a proximal portion of the clot. A cage can form between the proximal and distal baskets around multiple portions of the clot for capturing the clot. Sliding the wire distally, or microcatheter proximally, relative to the clot causes the distal basket to move from a collapsed state to an expanded state. The cage may be around at least two portions of the clot that are opposed.

Abstract: Disclosed herein are various exemplary systems and methods for deploying an implant to a target location of a body vessel. The delivery member can include a tubular body including a lumen and compressed distal portion. The delivery member can include a loop wire with a loop opening positioned approximate the compressed distal portion. The delivery member can include a pull wire that has a proximal pull wire portion and a distal pull wire portion connected by a suture linkage. The suture linkage can include a proximal suture knot engaged to the proximal pull wire portion and a distal suture knot engaged to the distal pull wire portion. Pull wire beads positioned on the proximal pull wire and distal pull wire portion can retain the suture knots during proximal translation of the pull wire. The suture linkage can include slack that is effective to prevent premature deployment of the implant.

Abstract: A separate nub component between the plate and an intervertebral fusion cage, wherein the nub is attached to the plate. The nub lessens the undesired pivotal movement of the plate. It is believed that when the nub fits snugly between the endplates of the adjacent vertebral bodies, it acts as a stop against the undesired pivotal movement of the plate.

Abstract: An imaging sensor that optimizes a pixel array area on a substrate using a stacking scheme for placement of related circuitry with minimal vertical interconnects between stacked substrates and associated features are disclosed. Embodiments of maximized pixel array size/die size (area optimization) are disclosed, and an optimized imaging sensor providing improved image quality, improved functionality, and improved form factors for specific applications common to the industry of digital imaging are also disclosed. Embodiments of the above may include systems, methods and processes for staggering ADC or column circuit bumps in a column or sub-column hybrid image sensor using vertical interconnects are also disclosed.

Abstract: An endovascular detachment mechanism can include an endovascular implant including an open end and a pinched end, a connector positioned approximate the pinched end, a lock wire, and an outer coil surrounding the lock wire. The lock wire can include a distal end engaged within the connector and a threaded portion having a radius larger than the lock wire. The outer coil be engaged to the threaded portion. Axial rotation of the threaded portion can cause the lock wire to translate proximally with respect to the outer coil to thereby disengage the distal end of the lock wire from the connector. The mechanism can include an inner coil and an outer coil, and axial rotation of the inner coil with respect to the outer coil can cause the distal end of the lock wire to disengage from the connector.

Abstract: A surgical instrument assembly may include a processor, a surgical instrument configured to operate on an anatomical structure, and a display coupled to the processor and attached to the surgical instrument. The processor can be configured to determine a position of the medical imaging device, from which the medical imaging device can generate an X-ray image that includes holes of an intramedullary nail shown as circles, for instance perfect circles. In an example, the processor identifies the intramedullary nail, so as to determine an intramedullary nail identity, and determines the position of the medical imaging device based on a portion of at least two locking holes of the intramedullary nail and based on the intramedullary nail identity.

Abstract: A device can detect and retrieve a blood clot by advancing a catheter with a clot sensing element through a patient's vascular system. The catheter can map, using an electromagnetic sensor disposed at a distal end of the clot sensing element, the patient's vascular system. A force sensor can generate a position signal indicating the clot sensing element contacted the clot in the patient's vascular system. Once located, a blood clot retrieval device can be deployed through the catheter and a lumen in the clot sensing element to remove the clot from the patient's vascular system.

Abstract: Surgical instrument calibration methods, systems, and devices are provided that allow a virtual representation of a surgical instrument to be modified to adjust for any variations in a distal tip of a surgical instrument. For example, an instrument calibration system is provided that can have a surgical instrument, a calibration instrument, and a monitoring system. The surgical instrument can have a distal tip and an orientation element thereon, and the calibration instrument can have a pivot point thereon and a calibration reference element attached thereto. The monitoring system can be configured to record movement of the surgical instrument with respect to the calibration instrument when the tip of the surgical instrument is inserted into the pivot point of the calibration instrument, and to calculate a deviation of the tip of the surgical instrument from a predefined ideal tip based on the recorded movement.

Abstract: An example apparatus is provided for placing a first anchor in a first bone, and a locking assembly in a second bone, the first anchor and locking assembly being connected by a flexible segment that provides substantial tensile stabilization but offers little or no resistance to bending, rotation, or shear motion of the first anchor and locking assembly with respect to each other. The first anchor can include a proximal end and a distal end configured for insertion into a first hole in the first bone. The locking assembly can include a proximal end and a distal end configured for insertion into a second hole in the second bone. The flexible segment can be configured to adjust a distance between the first and second bones, while the locking assembly releasably engages the flexible segment to fix the distance between the first and second bones.

Abstract: An orthopaedic prosthetic includes a femoral component including a pair of condyles spaced apart to define an intercondylar notch. A tibial component includes a tray and a platform pivotally coupled to the tray. A modular insert is configured to be selectively coupled to the femoral component to couple the femoral component to the tibial component.

Abstract: A system for monitoring bone ingrowth includes an orthopaedic prosthesis having a circuit configured to transmit force sensor data indicative of an amount of force applied to a stem of the orthopaedic prosthesis in response to receiving power from an external power supply. The force sensor data is indicative of bone ingrowth of the orthopaedic prosthesis. As such, an orthopaedic surgeon may monitored the force sensor data over time to ensure bone ingrowth of the orthopaedic prosthesis has sufficiently occurred.

Abstract: A method of constructing a detachment system for delivering an implantable medical device to a target location of a body vessel is presented. The method includes forming a compressible portion on a distal tube, engaging an implantable medical device with an engagement system, extending the engagement system through the distal tube such that the implantable medical device is distal of a distal end of the distal tube, applying a force to the engagement system to compress the compressible portion to a compressed state, fixing the engagement system to the distal tube to maintain the compressed state of the compressible portion, and joining a proximal end of the distal tube to a distal end of a proximal tube. The engagement system can include a loop wire that is fixed to the distal tube and engages the medical device.

Abstract: A surgical apparatus having a locking mechanism that receives a cutting burr and that may include a loading and running position. The locking mechanism may include a motor driven spindle that carries a locking pawl and a detent pawl that lock the cutting burr in place an prevent the cutting burr from inadvertently falling out of the surgical drill instrument when in its load position. A diamond-shaped portion of the cutting burr may be formed in a six-sided diamond configuration and a perpendicular back end surface. The end of the cutting burr may include another diamond-shaped portion formed in a six-sided diamond shape surface that mates with a complementary surface formed in the receiving end of the spindle of the motor/locking mechanism. In an aspect, the attachment of the cutting burr is such that the cutting burr has substantially zero axial movement and runs true in the running condition.

Abstract: Provided herein are compositions for treating biofilm-derived infections include a cis-monounsaturated fatty acid solubilized in a solvent with a concentration in the range of about 100 ppm (parts per million) to about 1000 ppm, where the composition is configured to produce a bactericidal effect measured as a log reduction of colony forming units (CFU) of a bacteria of at least 1.0 when the composition is applied to a biofilm formed from the bacteria. Also provided are methods for treating the site of a biofilm-derived infection comprising applying a composition as disclosed herein to the site.

Abstract: The objectives for the designs presented herein can be for a variably flexible and kink-resistant catheter for vascular applications. The designs benefit from good compressive and tensile stiffness. A braided wire support structure can be disposed around an inner liner and an outer layer having a plurality of outer jackets of variable durometer. A metallic reinforcing layer can be cut from a hypotube and be used as the primary structure for catheter stiffness, reducing the reliance on and number of jackets to transition stiffness changes along the length of the catheter. The metallic reinforcing layer can have one or more ribbon cut segments and one or more axial hole patterns laser cut into the hypotube to progressively evolve the stiffness from proximally regions with more column stiffness and distal regions with greater lateral flexibility. The polymer jackets can be reflowed to bond the structure together.