Patents Assigned to Development Center for Biotechnology
  • MUTATED E. COLI HEAT-LABILE ENTEROTOXIN
    Publication number: 20080220519
    Abstract: This invention relates to a mutant E. coli heat-labile enterotoxin (LT) subunit A that can be used as an adjuvant. This subunit A mutant contains an amino acid substitution at a position corresponding to position 61 of a wild-type LT. An LT containing this mutated subunit A exhibits reduced toxicity compared to its wild type counterpart.
    Type: Application
    Filed: May 15, 2008
    Publication date: September 11, 2008
    Applicant: Development Center For Biotechnology
    Inventors: Yu-Shen Hsu, Young-Sun Lin, Ta-Tung Yuan
  • MUTATED E. COLI HEAT-LABILE ENTEROTOXIN
    Publication number: 20080102078
    Abstract: This invention relates to a mutant E. coli heat-labile enterotoxin (LT) subunit A that can be used as an adjuvant. This subunit A mutant contains an amino acid substitution at a position corresponding to position 61 of a wild-type LT. An LT containing this mutated subunit A exhibits reduced toxicity compared to its wild type counterpart.
    Type: Application
    Filed: July 18, 2007
    Publication date: May 1, 2008
    Applicant: Development Center for Biotechnology
    Inventors: Yu-Shen Hsu, Young-Sun Lin, Ta-Tung Yuan
  • Zero-discharge of water glass effluents by alkaline biotreatment techniques
    Patent number: 7335303
    Abstract: The present invention relates to the collection of alkalophilic/alkaline-tolerant microbes and use of said microbes in water glass wastewater treatment. The wastewater is treated directly with alkalophilic/alkaline-tolerant microbes cultured on granular activated carbon without any prior pH adjustment. Subsequently, water glass is separated from the biotreated water by lowering its pH. Alternatively, water glass is separated from biotreated water by distilling the water as water and water glass have different boiling points.
    Type: Grant
    Filed: October 23, 2003
    Date of Patent: February 26, 2008
    Assignee: Development Center for Biotechnology
    Inventors: Ru-rong Wu Hsiao, Mei-hsien Yeh, Hsiu-ping Pearl Lin
  • Aqueous inhalation pharmaceutical composition
    Publication number: 20070140976
    Abstract: An aqueous inhalation pharmaceutical composition comprising a polypeptide or protein is provided. The composition of the present invention can improve the bioavailability of the polypeptide and protein, and avoid inducing toxicity in the lung.
    Type: Application
    Filed: May 25, 2006
    Publication date: June 21, 2007
    Applicant: Development Center For Biotechnology
    Inventors: Pao-Nien Chen, Shyh-Fong Chen, Shu-Chien Liu, Fan-Jung Liu
  • Solid phase method for synthesis peptide-spacer-lipid conjugates, conjugates synthesized thereby and targeted liposomes containing the same
    Patent number: 7153933
    Abstract: A solid phase synthesis method for preparing peptide-spacer-lipid conjugates, the peptide-spacer-lipid conjugates synthesized by the method, and liposomes containing the peptide-spacer-lipid conjugates. The present invention provides a convenient solid phase synthesis method for preparing peptide-spacer-lipid conjugates and provides various linkage groups (such as amide group) for conjugating peptide, spacer and lipid, wherein the spacer may comprise PEG. Several advantages can be achieved, such as the synthetic procedure can be simplified, the synthesis process can be set to automation, the purification is easier in each reaction step, and the product losses can be reduced to minimal during synthesis.
    Type: Grant
    Filed: December 3, 2002
    Date of Patent: December 26, 2006
    Assignee: Development Center for Biotechnology
    Inventors: Shih-Kwang Wu, Ting-Gung Chang, Chin-Lu Tseng, Li-Jung Chen, Kae-Shyang Shih
  • Antigenic fragment of human T-lymphotropic virus
    Patent number: 7033751
    Abstract: Antigenic fragments of human T-lymphotropic virus (HTLV), their fusion proteins with glutathione S-tranferase (GST) or thioredoxin (Thio), and a process for producing the fusion proteins thereof. The antigenic fragment of HTLV comprises the amino acid sequence of SEQ ID Nos: 3 or 4.
    Type: Grant
    Filed: April 25, 2003
    Date of Patent: April 25, 2006
    Assignee: Development Center for Biotechnology
    Inventors: Hsin-Yu Lin, Ching-Long Hwong
  • Practical syntheses of chiral trans-3, 4-disubstituted piperidines and the intermediates
    Patent number: 6833458
    Abstract: A new method for the preparation of chiral 4-substituted 2-piperidinones, trans-3,4-disubstituted 2-piperidinones, and trans-3,4-disubstituted piperidines is invented. Chiral paroxetine can be obtained from a chiral trans-3,4-disubstituted piperidine intermediate in high purity and good selectivity.
    Type: Grant
    Filed: May 28, 2002
    Date of Patent: December 21, 2004
    Assignee: Development Center for Biotechnology
    Inventors: Lee Tai Liu, Hsiang-Ling Huang, Pao-Chiung Hong, Shyh-Fong Chen
  • Interference-eliminating membranes, test strips, kits and methods for use in uric acid assay
    Patent number: 6699720
    Abstract: The present invention relates to an interference-eliminating membrane for use in detecting uric acid in a sample, comprising a compound for inhibiting or shading uric acid interfering substances, or derivatives thereof, and a carrier having an absorption property and permeability for the sample; and a process for preparing the interference-eliminating membrane. The present invention also provides a test strip for use in detecting uric acid in a sample, comprising a reagent reaction layer or optional interference-eliminating membranes and/or support layers; and a kit comprising the test strip of the invention.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: March 2, 2004
    Assignee: Development Center for Biotechnology
    Inventors: Tsai Yun Lee, Yi Chih Lei, Shi-Yuan Sheu, Yu Fen Tsai, Tai-Guang Wu, Hung-Hsiu Ho, Ming-Yen Kuo, Jiuan J. Liu, Tong H. Chang, Hsueh-Fang Chen, Liahng-Yirn Liu
  • Solid phase method for synthesis peptide-spacer-lipid conjugates, conjugates synthesized thereby and targeted liposomes containing the same
    Publication number: 20030229017
    Abstract: A solid phase synthesis method for preparing peptide-spacer-lipid conjugates, the peptide-spacer-lipid conjugates synthesized by the method, and liposomes containing the peptide-spacer-lipid conjugates. The present invention provides a convenient solid phase synthesis method for preparing peptide-spacer-lipid conjugates and provides various linkage groups (such as amide group) for conjugating peptide, spacer and lipid, wherein the spacer may comprise PEG. Several advantages can be achieved, such as the synthetic procedure can be simplified, the synthesis process can be set to automation, the purification is easier in each reaction step, and the product losses can be reduced to minimal during synthesis.
    Type: Application
    Filed: December 3, 2002
    Publication date: December 11, 2003
    Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
    Inventors: Shih-Kwang Wu, Ting-Gung Chang, Chin-Lu Tseng, Li-Jung Chen, Kae-Shyang Shih
  • Swine vesicular disease virus expression vectors
    Patent number: 6616929
    Abstract: The invention relates to nucleic acids containing a nucleotide sequence encoding a polypeptide, the polypeptide having (1) the P2 and P3 regions of a swine vesicular disease virus polyprotein, and (2) an amino acid sequence heterologous to the polyprotein. The invention also includes methods of preparing such nucleic acids (e.g., RNA or DNA expression vectors) and methods of using such nucleic acids to express RNA or protein.
    Type: Grant
    Filed: October 6, 2000
    Date of Patent: September 9, 2003
    Assignee: Development Center for Biotechnology
    Inventors: Ching-Long Hwong, Cheng-Kai Lo, Lung-Shen Lin, Li-Yen Edward Chang
  • Strain of streptomyces, and relevant uses thereof
    Patent number: 6509373
    Abstract: Disclosed is a new Streptomyces candidus strain, and relevant uses thereof.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: January 21, 2003
    Assignee: Development Center for Biotechnology
    Inventors: Ming Shiang, Mann Yan Kuo, Kuei Chih Chu, Pao Chi Chang, Hsiu Ying Chang, Hai Ping Lee
  • Rapid test for cell surface antigen
    Publication number: 20020072078
    Abstract: The present invention discloses a diagnostic kit for assaying a cell presenting specific surface specific antigen, comprising: a first complex, comprising a magnetic bead coated with a first ligand specific to the specific cell surface antigen; a second complex, comprising a second ligand specific to the common cell surface antigen and a signal generation means; and a magnetic support. The kit can be used for the quantitative and qualitative analysis of a cell sample containing specific cell surface antigen.
    Type: Application
    Filed: November 19, 2001
    Publication date: June 13, 2002
    Applicant: Development Center for Biotechnology, a Taiwan corporation
    Inventors: Yi-Fen Tsai, Liahng-Yirn Liu, Hsueh-Fang Chen, Tai-Guang Wu, Jiuan Liu, Tong-Hsuan Chang
  • D-amino acid aminotransferase for simultaneously producing glutaryl-7-aminocephalosporanic acid and D-amino acid
    Patent number: 6337190
    Abstract: The present invention relates to mutant D-amino acid aminotransferase, including nucleic acids encoding mutant D-amino acid aminotransferase. The mutant D-amino acid aminotransferase of the present invention is obtained by the substitution of the glutamate residue at position 13 of wild type D-amino acid aminotransferase from Bacillus sphaericus with hydrophobic amino acids. The mutant D-amino acid aminotransferase can be used in the production of D-amino acid and the conversion of glutaryl-7-aminocephalosporanic acid from cephalosporin C. The present invention also includes replica-paper staining method for screening the cells expressing high DAT activity.
    Type: Grant
    Filed: December 17, 1999
    Date of Patent: January 8, 2002
    Assignee: Development Center for Biotechnology
    Inventors: Tzann-Shun Hwang, Szu-Pei Wu, Hsin-Hua Chou, Hwa-Yi Chen, Lung-Shen Lin, Hsin Tsai, Edward Chang
  • Process for preparing amides
    Patent number: 6313294
    Abstract: The present invention provides a process for preparing an amide, which comprises reacting an amine with an ester in a molten form in the absence of a solvent.
    Type: Grant
    Filed: July 8, 1998
    Date of Patent: November 6, 2001
    Assignee: Development Center for Biotechnology
    Inventors: Wen-Chih Chou, Chang-Wei Tan, Shyh-Fong Chen, Hao Ku
  • Preparation of amides and quinazoline derivatives
    Patent number: 6313293
    Abstract: The present invention relates to a process for the preparation of amides, comprising reacting amines with carboxylic acids in the presence of silicon amines. The present invention further relates to a process for the preparation of quinazoline derivatives, comprising reacting amines with carboxylic acids in the presence of silicon amines to obtain amides and contacting the resultant amides with quinazoline.
    Type: Grant
    Filed: March 1, 2000
    Date of Patent: November 6, 2001
    Assignee: Development Center for Biotechnology
    Inventors: Wen-Chih Chou, Ming-Chen Chou, Yann-Yu Lu, Shyh-Fong Chen
  • Strains of streptomyces and relevant uses thereof
    Patent number: 6287845
    Abstract: The invention relates to isolates of Streptomyces orientalis Y31014 and Streptomyces melanogenes Y31042-1 can be effectively control whiteflies. The invention also concerns a novel biopesticide and its use to control pests.
    Type: Grant
    Filed: April 25, 2001
    Date of Patent: September 11, 2001
    Assignee: Development Center for Biotechnology
    Inventors: Li-Hsiu Lai, Mann-Yan Kuo, Ming Shiang
  • Synthetic peptides for the detection of trimethylamine (TMA) and their detection method and device
    Publication number: 20010018188
    Abstract: The present invention describes a peptide and analogs thereof which is a fragment of an olfactory receptor protein capable of selectively binding to trimethylamine so that they are useful for detecting trimethylamine. The present invention further describes a method and a device for detecting trimethylamine by using the peptide and the analogs thereof.
    Type: Application
    Filed: February 6, 2001
    Publication date: August 30, 2001
    Applicant: Development Center for Biotechnology
    Inventors: Heau-Shan Gao, I-Nan Chang, Tzong-Zeng Wu, Ya-Ling Liao, Sung-Sheng Hsiung
  • Strains of Streptomyces and relevant uses thereof
    Patent number: 6274157
    Abstract: The invention relates to isolates of Streptomyces orientalis Y31014 and Streptomyces melanogenes Y31042-1 can be effectively control whiteflies. The invention also concerns a novel biopesticide and its use to control pests.
    Type: Grant
    Filed: May 15, 2000
    Date of Patent: August 14, 2001
    Assignee: Development Center for Biotechnology
    Inventors: Li-Hsiu Lai, Mann-Yan Kuo, Ming Shiang
  • Oral cisapride dosage forms with an extended duration
    Patent number: 6221396
    Abstract: The present invention provides sustained release oral solid dosage forms of cisapride by using a multi-particulate system, which are bioavailable and can provide efficient blood level of cisapride over 24 hours. Unit dosage forms of cisapride which comprise a plurality of substrates containing sustained release cisapride, as well as pharmaceutical compositions containing the dosage forms, are also disclosed herein.
    Type: Grant
    Filed: July 7, 1999
    Date of Patent: April 24, 2001
    Assignee: Development Center for Biotechnology
    Inventors: Shouchung Chao, Wen-Pao Tseng, Hui-Fang Chang, David Chen, Shu-Bin Lu
  • Synthetic peptides for the detection of trimethylamine (TMA) and their detection method and device
    Patent number: 6218507
    Abstract: The present invention describes a peptide and analogues thereof, which is a fragment of an olfactory receptor protein capable of selectively binding to trimethylamine so that they are useful for detecting trimethylamine. The present invention further describes a method and a device for detecting trimethylamine by using the peptide and the analogues thereof.
    Type: Grant
    Filed: August 28, 1998
    Date of Patent: April 17, 2001
    Assignee: Development Center for Biotechnology
    Inventors: Heau-Shan Gao, I-Nan Chang, Tzong-Zeng Wu, Ya-Ling Liao, Sung-Sheng Hsiung