Abstract: Isolated peptides and compositions comprising same are provided. Further, methods for targeting mitochondria in a cell, methods for assessing mitochondrial function in a cell and methods for diagnosing mitochondria associated diseases are provided.

Abstract: A sensing device that may include a substrate; a single-ended SPAD; first electrical components; second electrical components; and capacitors. The SPAD, the first electrical components and the second electrical components are formed on the substrate. The SPAD and the first electrical components belong to a high voltage domain of the sensing device. The high voltage domain is configured to receive a high supply voltage that exceeds a breakdown voltage of the SPAD. The second electrical components belong to a low voltage domain of the sensing device. The capacitors are coupled between the low voltage domain and the high voltage domain. The first electrical components and the second electrical components belong to an electrical circuit that is configured to perform quenching of the SPAD.

Abstract: The present invention relates to a process for the selective removal of nitrates from ground water using a hybrid nanofiltration (NF)—reverse osmosis (RO) filtration system. The process generates product water that is low in nitrate and can be used for drinking, irrigation and other purposes, as well as waste water that is relatively low in salinity and can be safely discarded to sewage systems and recycled, e.g., for irrigation purposes.

Abstract: A simulated-evolution-based macro refinement method includes evaluating a score of each placed macro cell to be refined; generating a random number; determining whether the score satisfies a predetermined condition; placing the macro cell into a queue if the score associated with the macro cell satisfies the predetermined condition; and sorting and placing macro cells of the queue according to scores of the macro cells in the queue.

Abstract: A gas sensing device that includes a (a) gas reactive element that has a gas dependent temperature parameter; and (b) a semiconductor temperature sensing element that is spaced apart from the gas reactive element and is configured to sense radiation emitted from the gas reactive element and generate detection signals that are responsive to a temperature of the gas reactive element; wherein the gas reactive element and the semiconductor temperature sensing element are of microscopic scale.

Abstract: A compositions-of-matter in the form of HIPE-templated hydrogels, comprising a crosslinked polymer of zwitterionic monomers, which exhibit unusual antipolyelectrolyte characteristics, dual pH-, and temperature-responsiveness, as well as processes of obtaining the same and using the same.

Abstract: A novel method to reduce B-cell lymphoma cell migration to and engraftment of the spleen in patients with JAM-C positive B-cell lymphomas is described. In certain aspects, a method for identifying and treating JAM-C positive B-cell lymphoma patients with anti-JAM-C antibodies is provided. Recombinant antibody molecules that specifically bind to JAM-C are also disclosed.

Abstract: An analog to digital converter comprises an input for receiving an analog input signal; a plurality of outputs for outputting parallel bits of a digital signal that represents said analog input signal; and a neural network layer providing connections between each of said outputs respectively, each connection having an adjustable weighting. The synapses of the neural networks may be memristors and training may use online gradient descent.

Abstract: A method for locating a vessel, the method comprising illuminating at least a portion of the vessel with a background light having a substantially high susceptibility to absorption by particles in said portion of the vessel; detecting backscattered light from said illuminated portion of the vessel; reproducing an image from said backscattered light; and identifying dark regions within said reproduced image.

Abstract: A geometric camera calibration system includes an extrinsic iterative closest point (ICP) device that generates an estimated extrinsic matrix by adjusting an initial extrinsic matrix according to first 3D points in camera coordinates; and an intrinsic ICP device that receives 3D points in chessboard coordinates and accordingly generates an error metric between the 3D points in chessboard coordinates and predetermined second reference 3D points. The extrinsic ICP device performs ICP operation to minimize difference between the 3D points in camera coordinates and predetermined first reference 3D points. A current intrinsic matrix is then outputted as an updated intrinsic matrix if a current error metric is not greater than a previous error metric.

Abstract: Systems and methods for performing minimally invasive surgical procedures, especially for removal of tumors, and especially for brain tumors, using a robotically inserted therapeutic probe, which first detects tumorous tissue on a pre-planned path through the patient's tissue, before performing therapeutic procedures on the tissue, such as ablation. This pre-treatment detection procedure is thus able to avoid the destruction of healthy tissue. This also ensures that the therapeutic process indicated in a preoperative surgical plan is only performed on tumorous tissue, without sole reliance on preoperative image indications. This is important for neurosurgical operations performed on the brain, since preoperative images may not be accurate due to brain shift occurring during the procedure. Detection can be performed optically or ultrasonically, and treatment by laser or RF ablation. The probe insertion can be performed at 90° to the insertion axis of the device, thus minimizing passage through healthy tissue.

Abstract: A method for treating cancer and/or preventing or reducing metastasis or treating angiogenesis related disorders comprising the step of administering IL-31 or peptide which is at least about 70%, homologous to the IL-31 sequence as set forth in SEQ ID No. 1.

Abstract: The present invention provides a photo-electrochemical (PEC) cell electrode having a surface portion and a bulk portion composed of the same material, wherein at least one of the bulk portion and the surface portion of the electrode is doped with at least one dopant, and wherein said doping is non-uniform along an axis perpendicular to the surface portion. The non-uniform doping can include different concentrations and/or types of the dopants in the bulk portion and in the surface portion of the electrode. There is further provided a PEC cell comprising said electrode and an electrolyte, wherein the surface portion of the electrode faces the electrolyte.

Abstract: A dialogue system includes: a storage configured to store a parameter tree including at least one parameter used for performing an action; a speech input device configured to receive speech from a user an input processor configured to apply a natural language understanding algorithm to the received speech to generate a speech recognition result; a dialogue manager configured to determine an action corresponding to the received speech based on the speech recognition result, to retrieve a parameter tree corresponding to the action from the storage, and to determine additional information needed to perform the action based on the retrieved parameter tree; and a result processor configured to generate a dialogue response for requesting the additional information.

Abstract: Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. Methods and compositions for treating lapatinib or trastuzumab-resistant cancers are also provided.

Abstract: A method of recovering a vehicle panel using a shape memory polymer, may include: applying an impact load to a panel of a shape memory polymer material at a temperature equal to or lower than a glass transition temperature; removing the impact load from the panel; providing a high-temperature environment at the glass transition temperature or greater than the glass transition temperature to the panel; and cooling the panel to room temperature.

Abstract: A robotic device for performing intracranial procedures, comprising a baseplate for mounting on the subject's skull and a rotatable base element rotating on the baseplate. The rotatable base element has a central opening through which a cannulated needle can protrude such that it can rotate around an axis perpendicular to the baseplate. This cannulated needle is robotically controlled to provide motion into and out of the subject's skull. A flexible needle is disposed coaxially within the cannulated needle, and it is controlled to move into and out of a non-axial aperture in the distal part of the cannulated needle. Coordinated control of the insertion motion of the cannulated and flexible needles, and rotation of the combined cannulated/flexible needle assembly enables access to be obtained to a volume of a region of the brain having lateral dimensions substantially larger than the width of the cannulated needle.

Abstract: A neural network accelerator includes an operator that calculates a first operation result based on a first tiled input feature map and first tiled filter data, a quantizer that generates a quantization result by quantizing the first operation result based on a second bit width extended compared with a first bit width of the first tiled input feature map, a compressor that generates a partial sum by compressing the quantization result, and a decompressor that generates a second operation result by decompressing the partial sum, the operator calculates a third operation result based on a second tiled input feature map, second tiled filter data, and the second operation result, and an output feature map is generated based on the third operation result.

Abstract: Composites comprising a metal carbonate and organic agent included within a crystal lattice of the metal carbonate are disclosed. Process of preparing the composites is also disclosed. Uses of the composites, in medicine, are also disclosed.

Abstract: There is provided a method of generating instructions for manufacturing a microstructure by a manufacturing device, comprising: providing a representation of a freeform tile, providing a representation of a deformation map that maps a parameter space to a space of an object, arranging a plurality of instances of the freeform tile within at least a portion of a domain of the deformation map to create a tile arrangement, creating a representation a microstructure of the object by composing the tile arrangement into the deformation map, and providing code instructions for execution by a manufacturing device controller of a manufacturing device for manufacturing the microstructure.