Abstract: A method for controlling a controlled system by a control device, the method may include transmitting multiple actuation signals to multiple degree of freedom (DOF) points of the controlled system; wherein the multiple actuation signals comprise multiple alternating current (AC) components that are mutually orthogonal; measuring at least one feedback signal from at least one probe point of the controlled system; wherein a number of DOF points exceeds a number of the at least one probe point; determining, based upon the at least one feedback signal, values of line search pulses to be sent to the multiple DOF points during at least one line search iteration; and performing the at least one line search iteration.

Abstract: A transistor structure is configured as a vertical type transistor. The transistor structure has a patterned electrode located between a gate electrode and a channel region of the transistor structure. The patterned electrode has one or more regions of discontinuity of the electrode. The patterned source electrode has at least two layers having at least a first and second barriers for injection of charge carriers into the channel region. The patterned electrode is configured such that a second layer having a second, higher, barrier for injection of charge carriers is configured to provide a physical barrier for flow of charge carriers from the electrode into the channel region.

Abstract: Exemplary embodiments of the present disclosure include a combined catheter-based optical coherence tomography-two-photon luminescence (OCT-TPL) imaging system. Exemplary embodiments further include methods to detect, and further characterize the distribution of cellular components (e.g., macrophage, collagen/elastin fiber, lipid droplet) in thin-cap fibroatheromas with high spatial resolution in vivo.

Abstract: A system and method for generating hydrogen gas from an aqueous solution are disclosed herein. The system comprises a compartment with a working electrode for reducing water in response to an applied voltage to generate hydrogen and a redox-active electrode capable of reversibly undergoing oxidation and reduction. The system may further comprise a second compartment with a working electrode for generating oxygen and redox-active electrode electrically connectable to the redox-active electrode in the first compartment. The method comprises applying a voltage between a working electrode and a redox-active electrode of a system described herein and/or between comprising a working electrode of one compartment and a working electrode of a second compartment of a system described herein.

Abstract: Provided are methods for the diagnosis and treatment of liver cancers such as hepatocellular carcinoma (HCC). In some aspects, the methods comprise administering an inhibitor of STEAP2 to a subject to treat a liver cancer. In some embodiments, a STEAP2 targeting siRNA or antibody is administered to a subject to treat HCC.

Abstract: A successive approximation register (SAR) analog-to-digital converter (ADC) with high linearity for generating an n-bit converted output includes a first capacitor digital-to-analog (DAC) and a second capacitor DAC. One of the first capacitor DAC and the second capacitor DAC that has greater output signal is defined as a higher-voltage capacitor DAC, and the other as an un-switching capacitor DAC. In an m-th conversion phase, an (m?1)-th capacitor of the un-switching capacitor DAC is switched according to a comparison between output signals of the higher-voltage capacitor DAC and the un-switching capacitor DAC.

Abstract: The present invention relates to a gripper system comprising fingers. The gripper fingers are connectable to a gripper arm. The gripper fingers comprise a roller configured to spin around its central axis or a ball element rotatable in any direction; a stopper configured to stop and/or prevent the spinning of the roller or ball. The present invention also relates to a method for grasping and displacing an object.

Abstract: Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain are provided. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fc domain that selectively binds C1q, and optionally activating Fc receptors, but that is significantly reduced for binding to the inhibitory Fc?RIIb receptor. Furthermore, methods and compositions are provided for promoting complement dependent cytotoxicity (CDC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or a different non-Fc binding domain.

Abstract: Logic gates are made from first and second resistive elements connected together to form a voltage divider. One or both of the resistive elements is a unipolar memristor. OR and NOT gates may be constructed to make a digital logic system.

Abstract: Provided herein is a superabsorbent polyHIPE composition-of-matter comprising a majority of ionizable pendant groups, capable of absorbing up to 300-fold by mass water while exhibiting a notable mechanical strength in both the dry and wet form, as well as various uses thereof.

Abstract: A pressurized, fluid-filled channel network embedded in an elastic structure, asymmetrically to the neutral plane, is used to create a deformation field within the structure by the pressurization of the embedded fluidic network, which can be applied in accordance with external forces acting on the structure. The deformation of the structure resulting from the liquid pressure and geometry of the network is related to a continuous deformation-field function. This enables the design of networks creating steady arbitrary deformation fields as well as to eliminate deformation created by external time varying forces, thus increasing the effective rigidity of the beam. By including the effects of the deformation created by the channel network on the beam inertia, the response of the beam to oscillating forces can be modified, enabling the design of channel networks which create pre-defined oscillating deformation patterns in response to external oscillating forces.

Abstract: Well-defined, xeno-free culture media which comprise a TGF-beta isoform or the chimera formed between IL6 and the soluble IL6 receptor (IL6RIL6), which are capable of maintaining stem cells, and particularly, human embryonic stem cells, in an undifferentiated state are provided. Also provided are cell cultures comprising the culture media and the stem cells and methods of expanding and deriving embryonic stem cells in such well-defined, xeno-free culture media. In addition, the present invention provides methods of differentiating ESCs or EBs formed therefrom for the generation of lineage specific cells.

Abstract: A method for automatically calibrating a feedback system, comprising: receiving one or more input parameters associated with a feedback system; applying the one or more input parameters to a model of the feedback system; deriving one or more feedback parameters for the feedback system from the model by: optimizing the model for the feedback parameters, and applying a noise characteristic of the feedback system to the model; and automatically tuning the feedback system using the one or more derived feedback parameters.

Abstract: A channel distribution system has a channel carrying content, and an interactive receiver which receives content and provides to a user. The interactive receiver has an interface to allow the user to interact with the content. The channel also includes a broadcast label superimposed on the content which invites the user to interact with the content. The label includes an interactive link with a digital instruction containing handling information for the interactive receiver device. The handling information tells the interactive receiver how to handle a user interaction coinciding with the label.

Abstract: A method and a sensing device are provided. The sensing device may include a readout circuit, a bulk, a holding element and a heterojunction bipolar transistor; wherein heterojunction bipolar transistor is configured to generate detection signals responsive to a temperature of at least a portion of the heterojunction bipolar transistor; wherein the holding element is configured to support the heterojunction bipolar transistor; wherein the heterojunction bipolar transistor is thermally isolated from the bulk; wherein the readout circuit is electrically coupled to the heterojunction bipolar transistor; and wherein the readout circuit is configured to receive the detection signals and to process the detection signals to provide information about electromagnetic radiation that affected the temperature of the at least portion of the heterojunction bipolar transistor.

Abstract: A pharmaceutical composition and a method of treating, reducing or preventing vascular, cardiovascular arterial or valve calcification in a subject in need comprising administering to the subject an effective amount of an agent that prevents or reduces the expression of HDAC4, an agent that modulates the location of HDAC4, an agent that binds to HDAC4 or an inhibitor of HDAC4 or any combination thereof is provided. In some embodiments, there is provided a pharmaceutical composition comprising: an agent that prevents or reduces the expression of HDAC4, an agent that modulates the location of HDAC4, an agent that binds to HDAC4 or an inhibitor of HDAC4 or any combination thereof; an agent that prevents or reduces the expression of SIK or is an inhibitor of SIK; and/or an agent that prevents or reduces the expression of ENIGMA (Pdlim7) or is an inhibitor of ENIGMA.

Abstract: Provided are methods and kits for determining predisposition of a subject to develop a kidney disease, by identifying in a sample of the subject at least one APOL1 polypeptide variant which is characterized by a higher trypanolytic activity on Trypanosoma brucei rhodesiense as compared to the trypanolytic activity of wild type APOL1 polypeptide as set forth in SEQ ID NO:1 on the Trypanosoma brucei rhodesiense under identical assay conditions; or at least one APOL1 nucleotide mutation in the APLO1 genomic sequence set forth in SEQ ID NO:3, wherein the at least one nucleotide mutation or polypeptide variant being in linkage disequlibrium (LD) with the S342G mutation in the APOL1 polypeptide set forth in SEQ ID NO:1, wherein presence of the APOL1 polypeptide variant indicates increased predisposition of the subject to develop the kidney disease.

Abstract: The invention provides isolated peptides from the protein EMMPRIN (CD147/Basigin) and antibodies directed against antigenic determinants within said peptides. Pharmaceutical compositions comprising said peptides and antibodies are also disclosed as well as methods of their production and use in vaccination, immunotherapy and diagnosis of proliferative, hyperpermeability, inflammatory, and angiogenesis-related diseases and disorders.

Abstract: A microparticle for cell encapsulation is provided, having a core which comprises continuous fibers of decellularized extracellular matrix (ECM) and, optionally, an outer layer. Also provided are methods of encapsulating cells in the microparticle, pharmaceutical compositions comprising the microparticle, and methods of treating disease in animals employing the microparticles of the invention, for example, treating Diabetes.

Abstract: Imaging apparatus (26) includes an image sensor (30), configured to capture an image of radiation at a target wavelength that is incident on a front surface of the image sensor. A metasurface (28) having a negative permittivity and a negative permeability at the target wavelength is fixed to the front surface of the image sensor.