Abstract: The single-use disposable spectrophotometer described herein can measure one or more blood chemistry analytes from a drop of whole blood. A passive filtration system takes whole blood and delivers plasma along with a dissolved reporter molecule to one or more spectrophotometers which can operate with narrow band optical spectrum centered on an optical detection frequency. The spectrophotometer detects the changes in absorption of the plasma as a result of a chemistry reaction to determine the concentration or activity of one or more analytes.

Abstract: Provided herein are antigenic molecules that can be used to generate antibodies capable of binding to a vitamin D derivative, such as 25-hydroxyvitamin D2 and/or 25-hydroxyvitamin D3, or a 25-hydroxyvitamin D analog, such as a vitamin D-C22 immunogenic molecule or compound. Antibodies produced using these antigenic molecules, and related antigenic compounds, are also described. In addition, disclosed herein are methods for detecting vitamin D deficiency in a subject, methods for treating a subject suspected of having a vitamin D deficiency, methods for monitoring progression of vitamin D deficiency in a subject, and methods for monitoring treatment of vitamin D deficiency in a subject in need thereof. The methods involve the detection or quantification of 25-hydroxyvitamin D2 and D3.

Abstract: The present disclosure relates to a device comprising a container having an inner wall and at least one opening, containing a mixture containing at least one reagent, and at least one additive, a method of producing this device, and a method of extracting a substance from a sample, enriching a substance in a sample, and/or detecting a substance in a sample using the device.

Abstract: A method for visualizing sub-pleural regions of an anatomical structure of interest from a set of volumetric data includes receiving the set of volumetric data representative of the anatomical structure. The anatomical structure can comprise an outer surface and a plurality of sub-pleural regions with each of the plurality of sub-pleural regions being a region of the anatomical structure which is distant from the outer surface by a corresponding sub-pleural depth. The method further includes determine a first sub-pleural region of the anatomical structure of interest and extracting, from the set of volumetric data, the portions of volumetric data representative of the first sub-pleural region. The method also includes rendering a display image based upon the first sub-pleural region and the extracted volumetric data.

Abstract: A sample probe system has a sample probe assembly, an air supply assembly, and a control system. The sample probe assembly has a transducer and a sample probe. The air supply assembly has a piezoelectric pump configured to supply an air flow to the sample probe assembly such that the air flow exits the sample probe. The control system determines a relative location of the sample probe based on pressure changes in the air flow detected by the transducer.

Abstract: Disclosed herein are compositions and methods for removing interfering substances from biological samples, biochemical assays, or reagents used in biological samples using porous liposomes that capture and in some instances enrich said interfering substances within the liposomes.

Abstract: The present invention relates to methods and compositions to remove or reduce biotin interference from certain assays.

Abstract: Disclosed herein is a method of synthesizing a target nucleic acid preferentially relative to a nucleic acid with one or more nucleotides that differ from the target nucleic acid. Also disclosed are systems and kits for the same.

Abstract: The present disclosure provides compositions, methods and kits for internal controls of microvesicle isolations. The compositions, methods and kits can comprise enveloped viruses, including, but not limited to, inactive mouse hepatitis virus (MHV).

Abstract: A method of patient-centric load planning for a diagnostic laboratory having a plurality of instruments includes receiving a list of patient samples, a list of requested tests to be performed for each of the patient samples, and patient-centric information for the patient providing each patient sample. The received data is used to determine a load plan for the instruments, the load plan including a menu of selected tests assigned to each instrument and an ordering of patient samples according to a priority score based on at least a portion of the electronic health record (EHR) of the patient providing the patient sample. A system for patient-centric load planning includes a plurality of instruments controlled by a system controller and computer server to formulate and execute the load plan.

Abstract: The present disclosure provides methods and systems for systematic elimination of background DNA in a DNA mixture sample. Often, the DNA of interest is in a heavy background of DNAs from other tissues. For example, a majority of DNA in plasma cell-free DNA originates from white blood cells. The present disclosure exploits genome-wide background DNA methylation to systematically eliminate DNA from white blood cells and normal tissue(s), therefore enriching non-background DNA for diagnostics, for example, the diagnostics of cancer and infectious diseases. The methods and systems may comprise the selection of targeted regions to generate one or more hybrid capture panels, digest nucleic acid molecules of specific methylation status with one or more restriction enzymes, retrieve the remaining DNA using the hybrid capture panel, sequence the captured DNA, analyze the sequencing data of the captured DNA, and diagnose diseases.

Abstract: A calibration method is provided including identifying the imaging area on each light panel with respect to each imaging device. A center position of the imaging area of each light panel for each imaging device is determined. An optimal optical center of the imaging apparatus using the center position of the imaging area of each imaging device is determined. A tube calibration tool is installed in a carrier on a track, and the carrier is moved on the track so that a center of the tube calibration tool is located at a closest location to the optimal optical center of the imaging apparatus. The center of the tube calibration tool is used to determine a center of a region of interest (ROI) for backlight calibration. Methods for health checking the calibration and apparatus used to carry out the calibration are provided as well as other aspects.

Abstract: Systems, devices, apparatus, methods, and computer-readable storage media for developmental assessment using eye tracking are provided. In one aspect, a system for development assessment via eye tracking includes: a patient-side computing device having a screen for presenting visual stimuli to a patient, an eye-tracking device integrated with the patient-side computing device and configured to collect eye-tracking data of the patient while the visual stimuli are presented to the patient on the screen of the patient-side computing device, and an operator-side computing device configured to present a user interface for an operator to communicate with the patient-side computing device.

Abstract: Embodiments provide a method of using image-based tube top circle detection based on multiple candidate selection to localize the tube top circle region in input images. According to embodiments provided herein, the multi-candidate selection enhances the robustness of tube circle detection by making use of multiple views of the same tube to improve the robustness of tube top circle detection. With multiple candidates extracted from images under different viewpoints of the same tube, the multi-candidate selection algorithm selects an optimal combination among the candidates and provides more precise measurement of tube characteristics. This information is invaluable in an IVD environment in which a sample handler is processing the tubes and moving the tubes to analyzers for testing and analysis.

Abstract: An example complex includes a solid support and at least two different types of antigens attached to the solid support. The complex includes a carrier protein attached to the solid support. At least one of the different types of antigens is attached to the carrier protein. The at least one of the different types of antigens is attached to the solid support through the carrier protein.

Abstract: Methods of detecting and flagging and/or suppressing aberrant results caused by incomplete dispersion of an immunoassay reagent used in a turbidimetric immunoassay are disclosed.

Abstract: Devices and methods for calculating various coagulation characteristics associated with a patients liquid test sample. The presently disclosed and claimed inventive concept(s) relate to an improved device(s) and method(s) for conducting coagulation assays on a patients liquid test sample, including, without limitation, a patients whole blood sample.

Abstract: A cleaning wizard monitors and provides feedback for cleaning of medical equipment to ensure that cleaning is performed based on best practices. The cleaning wizard receives a video stream comprising an item of medical equipment and inputs a first set of video frames from the video stream into a first machine learning model. The first machine learning model is trained to output whether the first set of video frames corresponds to activity that initiates a cleaning protocol for the item of medical equipment. Responsive to the cleaning protocol being initiated, the cleaning wizard inputs a second set of video frames into a second machine learning model trained to output whether the second set of frames meets criteria of the cleaning protocol. Responsive to all criteria of the cleaning protocol being met, the cleaning wizard transmits a notification to an operator that the cleaning protocol is complete.

Abstract: A medical diagnosis assistance system, a medical diagnosis assistance method, and a training method for training an artificial intelligence entity are disclosed. The medical diagnosis assistance system includes: an input interface configured to receive medical image data of a patient; a computing device configured to implement: a classification module configured to classify parts of interest, POI, comprising objects of interest, OOI, and/or regions of interest, ROI, within the received medical image data, and to assign a corresponding reliability metric to each of the classified POI; and an analysis module configured to determine, based on the POI and the assigned reliability metric, an analysis of the medical image data; and an output interface configured to output an output signal indicating the analysis.

Abstract: An image analysis device (BA) is configured to recognize imaged objects. A plurality of training images (TPIC) assigned to an object type (OT) and an object sub-type (OST) are fed into a first neural network module (CNN) to detect image features. Training output data sets (FEA) of the first neural network module are fed into a second neural network module (MLP) to detect object types using the detected image features. For each object type: training images assigned to the object type (OT1, OT2) are fed into the trained first neural network module, the first neural network module training output data set (FEA1, FEA2) generated for the respective training image is assigned to the object sub-type (OST) of the respective training image, and by means of the aforementioned sub-type assignments, a sub-type detection module (BMLP1, BMLP2) is configured to detect object sub-types.