Patents Assigned to Diagnostics, Inc.
  • Patent number: 11287367
    Abstract: A method and system is described that includes obtaining a whole blood sample and obtaining a first light absorbance profile of the whole blood sample. Next, the whole blood sample is hemolyzed to generate a hemolyzed sample of blood and a second light absorbance profile of the hemolyzed sample of blood is obtained. The level of hemolysis in the whole blood sample is determined by comparing the first light absorbance profile and the second light absorbance profile.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: March 29, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Jeffrey Jasperse
  • Patent number: 11289176
    Abstract: This invention relates to a binomial calculation of copy number of data obtained from a mixed sample having a first source and a second source.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: March 29, 2022
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: Craig Struble, John Stuelpnagel
  • Patent number: 11288805
    Abstract: A computer-implemented method and a data processing apparatus provide and apply a trained probabilistic graphical model for verifying and/or improving the consistency of labels within the scope of medical image processing. Also provided are a computer-implemented method for verifying and/or improving the consistency of labels within the scope of medical imaging processing, a data processing apparatus embodied to verify and/or improve the consistency of labels within the scope of medical image processing, and a corresponding computer program product and a computer-readable medium.
    Type: Grant
    Filed: April 1, 2020
    Date of Patent: March 29, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Markus Michael Geipel, Florian Büttner, Gaby Marquardt, Daniela Seidel, Christoph Tietz
  • Publication number: 20220091068
    Abstract: An acoustic analyzer system is provided that includes an acoustic analyzer having a reusable glass flow cell positioned within the acoustic analyzer. A disposable card body may be inserted into the acoustic analyzer and deliver sample fluid to the glass flow cell so that acoustic-wave assisted measurements may be performed on the sample fluid. The disposable card body may also deliver wash fluid to the glass flow cell, and receive waste sample fluid and waste wash fluid from the glass flow cell to prepare the glass flow cell for subsequent sample fluids. Numerous other embodiments are provided.
    Type: Application
    Filed: March 20, 2020
    Publication date: March 24, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Ryan Irving, Peter Paulicka
  • Publication number: 20220091139
    Abstract: A method of spectroscopically measuring percent glycated hemoglobin or a glycated hemoglobin:total hemoglobin ratio in a biological sample is disclosed. The method includes the use of a turbidity normalization algorithm to normalize the total hemoglobin concentration calculated from the spectroscopic measurements to substantially remove any turbidity interference therefrom. The turbidity normalization eliminates the negative bias observed with intralipid/lipemia and thus provides a glycated hemoglobin assay with no significant interference from intralipid/lipemia.
    Type: Application
    Filed: November 15, 2019
    Publication date: March 24, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Justin Jones, Jian Dai, Candice Robinson
  • Patent number: 11280804
    Abstract: Embodiments are directed to a carrier configured to hold and transport a vessel with a barcode label in an automation system in in vitro diagnostics (IVD) environment, with a plurality of peripheral readers able to read the barcode label. The reading of the barcode label on the vessel loaded into the carrier is achieved without the need to align (either manually or automatically) the barcode to the peripheral readers. A dual spring arrangement provides for consistent vessel capture when loading the vessel into the carrier and for retention in the carrier during transport operations. A centrally-located spring housing provides efficient space utilization. A mirrored dual slot design is provided so that an unobstructed space for each slot is complimentary such that a completely unobstructed view of the vessel is constructed by imaging the same vessel in both slots (one after another) and fusing the resulting data.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: March 22, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Ilya Malyarov, Benjamin S. Pollack
  • Patent number: 11272872
    Abstract: An extended wear electrocardiography and physiological sensor monitor recorder is provided. A set of electrical contacts extend from a bottom surface of a proximal end of a sealed housing. The sealed housing includes electronic circuitry, including an electrographic front end circuit to sense electrocardiographic signals and a micro-controller interfaced to the electrocardiographic front end circuit to sample the electrocardiographic signals. A patient feedback button located is on a top surface of the proximal end of the sealed housing and positioned above the feedback bottom on the distal end.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: March 15, 2022
    Assignee: Bardy Diagnostics, Inc.
    Inventors: Jason Felix, Jon Mikalson Bishay, Gust H. Bardy
  • Publication number: 20220073468
    Abstract: The present invention provides compounds used in the synthesis of chemiluminescent acridinium compounds and methods of producing these compounds. Specifically, methods are provided for the N-alkylation of acridan compounds using alkylating reagents. Typically, these alkylating reagents comprise a protected sulfonate group protected with an acid-labile protecting group.
    Type: Application
    Filed: November 15, 2021
    Publication date: March 10, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Anand Natrajan
  • Publication number: 20220076829
    Abstract: Disclosed are methods and systems for processing medical image data. The method comprising inputting, with one or more processors of one or more computation devices, medical image data into an encoder stage of an encoder-decoder pair (EDP) as a first input among one or more inputs; calculating, with the one or more processors, a latent space representation of the one or more inputs using the encoder stage of the EDP; providing, from a latent space database stored within one or more storage devices accessible by the one or more computation devices, latent space representations of other inputs; and determining, with the one or more processors, a classification based on the latent space representation of the one or more inputs and at least one latent space representation of the other inputs.
    Type: Application
    Filed: September 10, 2020
    Publication date: March 10, 2022
    Applicant: Delineo Diagnostics, Inc.
    Inventors: Scott Anderson MIDDLEBROOKS, Adrianus Cornelis KOOPMAN, Ari David GOLDBERG, Henricus Wilhelm VAN DER HEIJDEN
  • Patent number: 11268085
    Abstract: The invention provides novel methods and kits for isolating nucleic acids from biological samples, including cell-free DNA and/or cell-free DNA and nucleic acids including at least RNA from microvesicles, and for extracting nucleic acids from the microvesicles and/or from the biological samples.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: March 8, 2022
    Assignee: Exosome Diagnostics, Inc.
    Inventors: Johan Karl Olov Skog, Daniel Enderle, Aparna Ramachandran, Haoheng Yan, Emily Berghoff, Tai-Fen Wei, Mikkel Noerholm
  • Patent number: 11268133
    Abstract: Disclosed herein are methods of detecting presence of a gene fusion in a sample from a subject. In some embodiments, the methods of detecting presence of a fusion gene in a sample from a subject utilize a fusion probe that spans the point of fusion between two nucleic acids or genes. In other embodiments, the methods of detecting presence of a fusion gene in a sample from a subject utilize two or more probes that flank the point of fusion between two nucleic acids or genes. In additional embodiments, the methods can include determining the percentage of gene fusion in the sample relative to the first nucleic acid or the second nucleic acid.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: March 8, 2022
    Assignee: HTG Molecular Diagnostics, Inc.
    Inventors: Bruce A. Seligmann, BJ Kerns, John Luecke, Matt Rounseville, Ihab Botros, Mark Schwartz
  • Patent number: 11270781
    Abstract: The present invention provides methods for non-invasive determination of X and/or Y chromosomal abnormalities indicative of aneuploidy or sex mosaicisms in a maternal sample by detecting and determining the relative contribution of genetic sequences from the X chromosome and/or the Y chromosome in the maternal sample.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: March 8, 2022
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: Craig Struble, Arnold Oliphant, Eric Wang
  • Patent number: 11268907
    Abstract: Methods of detecting compromise of at least one analyte reagent upon reaction with a test sample are disclosed. Also disclosed are reflectance spectroscopic diagnostic instruments that perform the method, and systems that contain same.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: March 8, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Lloyd Schulman, Christopher Zimmerle, Julie Chaney
  • Publication number: 20220066390
    Abstract: Disclosed are optical interrogation apparatus that can produce lens-free images using an optoelectronic sensor array to generate a holographic image of sample objects, such as microorganisms in a sample. Also disclosed are methods of detecting and/or identifying microorganisms in a biological sample, such as microorganisms present in low levels. Also disclosed are methods of using systems to detect microorganisms in a biological sample, such as microorganisms present in low levels. In addition or as an alternative, the methods of using systems may identify microorganisms present in a sample and/or determine antimicrobial susceptibility of such microorganisms.
    Type: Application
    Filed: September 13, 2021
    Publication date: March 3, 2022
    Applicant: Accelerate Diagnostics, Inc.
    Inventor: Oleg Gusyatin
  • Patent number: 11260388
    Abstract: A system that include an sample analyzer having a sensor array. The sensor array includes a housing having a base, a top spaced above the base, and an outer wall that extends from the base to the top. The sensor array includes an inlet that is sized to receive a sample of the fluid, and a plurality of partitions arranged around the fluid inlet. Each partition has a port at the fluid inlet for receiving a portion of the sample of fluid received by the fluid inlet. The sensor array includes at least one sensor in each partition. The sensor array is configured to selectively direct the sample of fluid received by the fluid inlet into one or more of the plurality of partitions into contact the at least one sensor.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: March 1, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Jennifer Samproni
  • Patent number: 11262350
    Abstract: Disclosed herein are methods of detecting ascorbic acid in a urine sample from a subject, including contacting at least a portion of the urine sample with a test strip including a reagent pad and detecting whether ascorbic acid is present in the urine sample by measuring an intensity of color on the reagent pad, wherein a reduction in the intensity of color on the reagent pad indicates the presence of ascorbic acid.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: March 1, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Chris Zimmerle, Gary Rheinheimer
  • Patent number: 11262294
    Abstract: An illumination unit is described that includes a first light source positioned on a first axis and a second light source on a second axis that intersects and is angularly offset with respect to the first axis. The illumination unit includes a reflector having an aperture through which the first axis extends and a reflective surface angled with respect to the first axis and second axis.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: March 1, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Jeffrey R. Jasperse
  • Patent number: 11261479
    Abstract: The present disclosure relates to a method of target enrichment and amplification of selective target regions of genomes or nucleic acid samples and further analysis by systems such as NGS. The disclosure provides methods and kits that can be used in numerous downstream procedures including DNA sequencing. The disclosed methods can be utilized to sequence the target nucleic acid sequences such as to detect the presence of genetic variations for biological assays, assessment of disease, to count copies of target regions, and to allow such target enrichment prior to sequencing.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: March 1, 2022
    Assignee: Chapter Diagnostics, Inc.
    Inventors: Chunlin Wang, Zhihai Ma, Baback Gharizadeh
  • Publication number: 20220054063
    Abstract: Disclosed is a syringe apparatus. Syringe apparatus has a barrel including an inner surface, an open end, and an inlet end; a plunger including a plunger head received in slidable sealing contact with the inner surface of the barrel and forming a reservoir therein; and an extensible member, optionally including an additive, is contained in the reservoir. Extensible member can be coupled between the inlet end and the plunger head and is extensible in length L as a bio-liquid (e.g., whole blood) is drawn into the reservoir. Methods of mixing or adding an additive such as an anticoagulant, coagulant, or marker, to a bio-liquid are provided, as are other aspects.
    Type: Application
    Filed: February 25, 2020
    Publication date: February 24, 2022
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Jennifer Samproni
  • Patent number: D946751
    Type: Grant
    Filed: August 12, 2019
    Date of Patent: March 22, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Robert Ebel