Abstract: A bio-risk determination system is provided. The system includes a database including information on an individual, the database configured to receive data relating to an activity the individual is to participate in at a future time at a location. The system includes a processing device configured to receive a first input at a user interface of a mobile electronic device from the individual in response to a first query during a first temporal period prior to the activity, and receive a second input at the user interface from the individual in response to a second query during a second temporal period prior to the activity. The processing device is configured to generate a bio-risk of the individual based on the first and second inputs in real-time, and display a report in the user interface of a mobile electronic device, the report indicating the bio-risk generated for the individual.

Abstract: Compositions comprising binding competitors that can be used in assays for macrophilin-binding pharmaceuticals in samples are disclosed, as well as kits containing same and methods of use thereof.

Abstract: A device including a housing, a zone and a means for testing a fluid sample within the housing is disclosed. The housing is constructed of a fluid impermeable material, and defines a first fluid port, and a second fluid port. The first fluid port is configured to connect to a fluid collection device to receive a fluid sample from the fluid collection device into the housing. The second port is configured to pass the fluid sample from the housing into a testing instrument. The zone is formed in the housing. The zone is constructed of a material that allows an analysis of the fluid sample positioned within the housing, and located adjacent to the zone.

Abstract: Embodiments are directed to a simple, tool-less, and automated connection between a transfer probe and a capacitive liquid level detection printed circuit assembly (PCA) for use in a clinical analyzer in an in vitro diagnostics (IVD) environment in a hospital or laboratory setting. Advantageously, a single user connection is required: a fitting that is used to attach fluid tubing of the transfer arm to a probe, resulting in a mechanical, fluid, and electrical connection between the probe and the transfer arm. A PCA comprises a plurality of spring-loaded pins and capacitive liquid level detection circuity. A probe comprises a primary tube nested within a secondary tube, wherein the primary tube and the secondary tube comprise respective heads at respective top portions thereof forming a set of electrically isolated surfaces. The fitting secures the probe within a transfer arm and establishes the connection between the PCA and the probe.

Abstract: Methods, compositions and kits are disclosed directed at levetiracetam derivatives, immunogens, signal generating moieties, antibodies that bind levetiracetam and immunoassays for detection of levetiracetam.

Abstract: Disclosed is a system for qualifying medical images submitted by user for diagnostic analysis comprising: an image input module, configured to receive one or more image input by a user; an image protocol conformation module, configured to receive the one or more images from the image input module, and further configured to analyze each of the one or more images for conformity with a predefined protocol and wherein images that do not conform to the predefined protocol are flagged as non-conforming images; an image output module, configured to identify to the user each of the one or more images flagged as non-conforming and prompting the user to resubmit a new image for each of the non-conforming images; and an image resubmission module, configured to receive the user resubmitted image and provide the resubmitted image to the image protocol conformation module.

Abstract: A blood testing device for detecting hemolysis in a blood sample is described. The blood testing device comprises an housing for containing the blood sample. The housing has a treatment window and an optical zone formed therein. The blood testing device further includes an acoustic transducer positioned to selectively generate acoustic forces directed into the treatment window of the housing and a control unit for selectively actuating and deactuating the acoustic transducer to permit colorimetric analysis of plasma within the blood sample.

Abstract: A flow cell for oscillating flow PCR has pumping action via thermally-induced internal pressure variations. Rapid movement of a sample comprised of target DNA and associated reagents between heated zones within the flow cell for oscillating flow PCR is achieved without mechanical moving parts and without contamination. A channel extends from a loading port to first and second heated zones and to a central air chamber. The sample is movable between the heated zones in response to central air chamber pressure changes induced by external thermal changes. The flow cell is insertable into a flow cell process heater for heating each heated zone to a respective temperature. The central air chamber is aligned above a flow control heater for thermally inducing the internal pressure changes in the channel.

Abstract: A computer-implemented method for calibrating a photometer in an in-vitro diagnostics analyzer includes generating a cuvette map of a reaction ring identifying a plurality of cuvette locations. The cuvette map is used to identify a plurality of reference measurement areas between the plurality of cuvette locations. A plurality of reference measurements are acquired in the reference measurement areas using the photometer. The photometer is automatically calibrated based on a comparison of the reference measurements to a predetermined standard setup of the photometer.

Abstract: Methods for detection and quantitative measurement of proteins with a Coomassie Brilliant Blue Assay with improved sensitivity and maintaining high linearity over a broad measuring range are provided herein. In particular, a method of detecting a protein in a protein-containing sample is provided. The method includes providing a sample including a protein, a reagent including Coomassie Brilliant Blue and having a pH between 0.85 and 1.1, combining the sample and the reagent, and determining absorption at first and second wavelength to determine the amount of protein in the sample. The ratio of the absorption value at the first wavelength between about 580 to 620 nm to the absorption value at the second wavelength between about 520 to 370 nm is used in the spectral photometric determination of the amount of protein.

Abstract: Disclosed are optical interrogation apparatus that can produce lens-free images using an optoelectronic sensor array to generate a holographic image of sample objects, such as microorganisms in a sample. Also disclosed are methods of detecting and/or identifying microorganisms in a biological sample, such as microorganisms present in low levels. Also disclosed are methods of using systems to detect microorganisms in a biological sample, such as microorganisms present in low levels. In addition or as an alternative, the methods of using systems may identify microorganisms present in a sample and/or determine antimicrobial susceptibility of such microorganisms.

Abstract: An in vivo human-tissue analysis and communication system produces a quantitative diagnostic indicator for human-tissue analyzed by the system. The system includes a human-tissue-analyzer subsystem with at least one human-tissue analyzer constructed to analyze human tissue and to produce a quantitative-diagnostic indicator. There is also a two-way communication subsystem constructed to allow the human-tissue-analyzer subsystem to send and receive information relevant to the quantitative-diagnostic indicator. The human-tissue-analyzer subsystem includes at least one tissue diffractometer operatively coupled to a computer database over a network, and configured for acquisition of human-tissue data and transfer to the computer database over the network.

Abstract: An animal-tissue analysis and communication system produces a quantitative-diagnostic indicator for animal-tissue analyzed by the system. The system includes an animal-tissue-analyzer subsystem with at least one animal-tissue analyzer constructed to analyze animal tissue and to produce an quantitative-diagnostic indicator. The system also includes a two-way communication subsystem constructed to allow the animal-tissue-analyzer subsystem to send and receive information relevant to the quantitative-diagnostic indicator. The animal-tissue-analyzer subsystem includes at least one tissue diffractometer operatively coupled to a computer database over a network, and is configured for acquisition and transfer of animal-tissue data, and transfer to the computer database over the network.

Abstract: A sensor assembly for analysis of physical parameters and chemical constituents of small volume samples of bodily fluids with at least two analyte sensors. The sensor assembly including a separation panel with an upper surface and a lower surface and upper and lower fluid channels disposed within the upper and lower surfaces respectively. The fluid channels extending substantially between the first and second ends and when in an operating mode bodily fluid is in fluid communication with both the upper and lower fluid channels. The sensor assembly including a potentiometric chip positioned atop and an amperometric chip positioned beneath the separation panel with at least one analyte sensor positioned above and beneath each of the fluid channels and when the sensor assembly is in an operating mode the fluid is in fluid communication with the analyte sensors. A bonding media is disposed beneath the amperometric chip.

Abstract: The invention relates generally to the use of microvesicle RNA signatures for diagnosis, predicting, and/or to monitor treatment efficacy, including patients who are candidates for renal transplant and/or who have received a renal transplant.

Abstract: Disclosed herein are compositions comprising oxygen, a sugar or sugar alcohol, and an amino acid, wherein the amino acid is present in an amount sufficient to stabilize the oxygen. Also provided are aqueous diagnostic quality controls or calibration reagents and methods of stabilizing oxygen in a liquid solution.

Abstract: Methods of operating a gripper are provided. The methods include providing a robot including the gripper, the gripper moveable by the robot and including gripper fingers, providing a sample rack including receptacles accessible by the gripper, at least some of the receptacles adapted to contain specimen containers, providing data, obtained by imaging, regarding the sample rack and the specimen containers therein, and determining, based on the data, an accessible target receptacle for one of a pick operation or a place operation. Apparatus and systems configured to carry out the methods are provided, as are other aspects.

Abstract: Processes for quantifying an amount of functional groups immobilized on a solid support are described herein. The processes allow for determining whether sufficient functional groups are provided on a solid support for the attachment of a first binding pair member for the detection of a target analyte.

Abstract: The present invention provides detection systems and methods for detection of loci and genomic regions in a sample, including mixed samples, using hybridization to an array.

Abstract: The present invention provides compounds used in the synthesis of chemiluminescent acridinium compounds and methods of producing these compounds. Specifically, methods are provided for the N-alkylation of acridan compounds using alkylating reagents. Typically, these alkylating reagents comprise a protected sulfonate group protected with an acid-labile protecting group.